LOCUS       NM_001059               5359 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens tachykinin receptor 3 (TACR3), mRNA.
ACCESSION   NM_001059
VERSION     NM_001059.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5359)
  AUTHORS   Guo,F., Fernando,T., Zhu,X. and Shi,Y.
  TITLE     The overexpression of neurokinin B-neurokinin 3 receptor system
            exerts direct effects on the ovary under PCOS-like conditions to
            interfere with mitochondrial function
  JOURNAL   Am J Reprod Immunol 89 (3), e13663 (2023)
   PUBMED   36453600
  REMARK    GeneRIF: The overexpression of neurokinin B-neurokinin 3 receptor
            system exerts direct effects on the ovary under PCOS-like
            conditions to interfere with mitochondrial function.
REFERENCE   2  (bases 1 to 5359)
  AUTHORS   Schank,J.R.
  TITLE     Neurokinin receptors in drug and alcohol addiction
  JOURNAL   Brain Res 1734, 146729 (2020)
   PUBMED   32067964
  REMARK    GeneRIF: Neurokinin receptors in drug and alcohol addiction.
            Review article
REFERENCE   3  (bases 1 to 5359)
  AUTHORS   Geng,D., Yang,X., Wang,R., Deng,S., Li,L., Hu,X., Jiang,Y. and
            Liu,R.
  TITLE     A novel stopgain mutation c.G992A (p.W331X) in TACR3 gene was
            identified in nonobstructive azoospermia by targeted
            next-generation sequencing
  JOURNAL   J Clin Lab Anal 33 (3), e22700 (2019)
   PUBMED   30390321
  REMARK    GeneRIF: Identified a newly discovered stopgain mutation in
            tachykinin receptor 3 (TACR3) in nonobstructive azoospermia
            paitents.
REFERENCE   4  (bases 1 to 5359)
  AUTHORS   Obata,K., Shimo,T., Okui,T., Matsumoto,K., Takada,H.,
            Takabatake,K., Kunisada,Y., Ibaragi,S., Yoshioka,N., Kishimoto,K.,
            Nagatsuka,H. and Sasaki,A.
  TITLE     Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell
            Carcinoma
  JOURNAL   Anticancer Res 37 (11), 6119-6123 (2017)
   PUBMED   29061792
  REMARK    GeneRIF: High NK-3R expression is associated with Oral Squamous
            Cell Carcinoma.
REFERENCE   5  (bases 1 to 5359)
  AUTHORS   Crandall,C.J., Manson,J.E., Hohensee,C., Horvath,S.,
            Wactawski-Wende,J., LeBlanc,E.S., Vitolins,M.Z., Nassir,R. and
            Sinsheimer,J.S.
  TITLE     Association of genetic variation in the tachykinin receptor 3 locus
            with hot flashes and night sweats in the Women's Health Initiative
            Study
  JOURNAL   Menopause 24 (3), 252-261 (2017)
   PUBMED   28231077
  REMARK    GeneRIF: Three Single-nucleotide polymorphisms (on chromosomes 3
            and 11) were associated with vasomotor menopause symptoms in the
            African American group. However, 14 Single-nucleotide
            polymorphisms, all located on chromosome 4 in the tachykinin
            receptor 3 (TACR3) locus, had similar effect sizes across
            studies/participants' ancestry. Genetic variation in TACR3 may
            contribute to the risk of vasomotor menopause symptoms.
REFERENCE   6  (bases 1 to 5359)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
REFERENCE   7  (bases 1 to 5359)
  AUTHORS   Xie,G.X., Miyajima,A. and Goldstein,A.
  TITLE     Expression cloning of cDNA encoding a seven-helix receptor from
            human placenta with affinity for opioid ligands
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 4124-4128 (1992)
   PUBMED   1315051
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 Aug 1;89(15):7287]
REFERENCE   8  (bases 1 to 5359)
  AUTHORS   Huang,R.R., Cheung,A.H., Mazina,K.E., Strader,C.D. and Fong,T.M.
  TITLE     cDNA sequence and heterologous expression of the human neurokinin-3
            receptor
  JOURNAL   Biochem Biophys Res Commun 184 (2), 966-972 (1992)
   PUBMED   1374246
REFERENCE   9  (bases 1 to 5359)
  AUTHORS   Buell,G., Schulz,M.F., Arkinstall,S.J., Maury,K., Missotten,M.,
            Adami,N., Talabot,F. and Kawashima,E.
  TITLE     Molecular characterisation, expression and localisation of human
            neurokinin-3 receptor
  JOURNAL   FEBS Lett 299 (1), 90-95 (1992)
   PUBMED   1312036
REFERENCE   10 (bases 1 to 5359)
  AUTHORS   Takahashi,K., Tanaka,A., Hara,M. and Nakanishi,S.
  TITLE     The primary structure and gene organization of human substance P
            and neuromedin K receptors
  JOURNAL   Eur J Biochem 204 (3), 1025-1033 (1992)
   PUBMED   1312928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004065.1, M89473.1 and
            AC105460.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001059.2.
            
            Summary: This gene belongs to a family of genes that function as
            receptors for tachykinins.  Receptor affinities are specified by
            variations in the 5'-end of the sequence.  The receptors belonging
            to this family are characterized by interactions with G proteins
            and 7 hydrophobic transmembrane regions.  This gene encodes the
            receptor for the tachykinin neurokinin 3, also referred to as
            neurokinin B. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M89473.1, BC121806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304883.3/ ENSP00000303325.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC004065.1         111990-112158
            170-207             M89473.1           3-40
            208-208             AC004065.1         112197-112197
            209-1780            M89473.1           42-1613
            1781-1781           AC105460.4         105102-105102       c
            1782-1922           M89473.1           1615-1755
            1923-5359           AC105460.4         101524-104960       c
FEATURES             Location/Qualifiers
     source          1..5359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..5359
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /note="tachykinin receptor 3"
                     /db_xref="GeneID:6870"
                     /db_xref="HGNC:HGNC:11528"
                     /db_xref="MIM:162332"
     exon            1..858
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1708
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /EC_number="2.7.11.14"
                     /note="neurokinin B receptor; neurokinin beta receptor;
                     NK-3 receptor; NK3 receptor"
                     /codon_start=1
                     /product="neuromedin-K receptor"
                     /protein_id="NP_001050.1"
                     /db_xref="CCDS:CCDS3664.1"
                     /db_xref="GeneID:6870"
                     /db_xref="HGNC:HGNC:11528"
                     /db_xref="MIM:162332"
                     /translation="MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQL
                     LDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLG
                     NLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRF
                     QNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQ
                     CLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWG
                     GEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYI
                     QQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRF
                     HPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASAT
                     SSFISSPYTSVDEYS"
     exon            859..1047
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1198
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1395
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..5359
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3221..3226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /note="hexamer: AATAAA"
     polyA_site      3246
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /note="major polyA site"
     regulatory      5335..5340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /note="hexamer: ATTAAA"
     polyA_site      5359
                     /gene="TACR3"
                     /gene_synonym="HH11; NK-3R; NK3; NK3R; NKR; TAC3R; TAC3RL"
                     /note="major polyA site"
ORIGIN      
        1 agttctccag cctgtgccgg gcagctggca ccctccctac gtgtgatgtg actcgataac
       61 ccttaatctc gggaggatct cattctttct gcctgccaga gccgcaagcg cctctgagaa
      121 agtgcagctg ttgcccctta gccccagctg catcccctaa ccagcaggga ttgcagtatc
      181 tttcagcttc cagtcttatc tgaagactcc ggcaccaaag tgaccaggag gcagagaaga
      241 acttcagagg agtctcgtct tgggctgccc gtgggtgagt gggagggtcc gggactgcag
      301 accggtggcg atggccactc tcccagcagc agaaacctgg atagacgggg gtggaggcgt
      361 gggtgcagac gccgtgaacc tgaccgcctc gctagctgcc ggggcggcca cgggggcagt
      421 tgagactggg tggctgcaac tgctggacca agctggcaac ctctcctcct ccccttccgc
      481 gctgggactg cctgtggctt cccccgcgcc ctcccagccc tgggccaacc tcaccaacca
      541 gttcgtgcag ccgtcctggc gcatcgcgct ctggtccctg gcgtatggtg tggtggtggc
      601 agtggcagtt ttgggaaatc tcatcgtcat ctggatcatc ctggcccaca agcgcatgag
      661 gactgtcacc aactacttcc ttgtgaacct ggctttctcc gacgcctcca tggccgcctt
      721 caacacgttg gtcaatttca tctacgcgct tcatagcgag tggtactttg gcgccaacta
      781 ctgccgcttc cagaacttct ttcctatcac agctgtgttc gccagcatct actccatgac
      841 ggccattgcg gtggacaggt atatggctat tattgatccc ttgaaaccca gactgtctgc
      901 tacagcaacc aagattgtca ttggaagtat ttggattcta gcatttctac ttgccttccc
      961 tcagtgtctt tattccaaaa ccaaagtcat gccaggccgt actctctgct ttgtgcaatg
     1021 gccagaaggt cccaaacaac atttcactta ccatattatc gtcattatac tggtgtactg
     1081 tttcccattg ctcatcatgg gtattacata caccattgtt ggaattactc tctggggagg
     1141 agaaatccca ggagatacct gtgacaagta tcatgagcag ctaaaggcca aaagaaaggt
     1201 tgtcaaaatg atgattattg ttgtcatgac atttgctatc tgctggctgc cctatcatat
     1261 ttacttcatt ctcactgcaa tctatcaaca actaaataga tggaaataca tccagcaggt
     1321 ctacctggct agcttttggc tggcaatgag ctcaaccatg tacaatccca tcatctactg
     1381 ctgtctgaat aaaagatttc gagctggctt caagagagca tttcgctggt gtcctttcat
     1441 caaagtttcc agctatgatg agctagagct caagaccacc aggtttcatc caaaccggca
     1501 aagcagtatg tacaccgtga ccagaatgga gtccatgaca gtcgtgtttg accccaacga
     1561 tgcagacacc accaggtcca gtcggaagaa aagagcaacg ccaagagacc caagtttcaa
     1621 tggctgctct cgcaggaatt ccaaatctgc ctccgccact tcaagtttca taagctcacc
     1681 ctatacctct gtggatgaat attcttaatt ccatttcctg aggtaaaaga ttagtgtgag
     1741 accatcatgg tgccagtcta ggaccccatt ctcctattta ccagtcctgt cctatatacc
     1801 ctctagaaac agaaagcaat ttttaggcag ctatggtcaa attgagaaag gtagtgtata
     1861 aatgtgacaa agacactaat aacatgttag cctccaccca aaataaaatg ggctttaaat
     1921 ttattctttg aaaactctaa attattatat gcaatgaaca aaaatatgtc aggaaaatac
     1981 ttgtaaactc gccagtctat ctcatttaca aattgcaata tacatttgtg acattaaaat
     2041 gatatatagt ttttccaaga gattaaagaa tctttaaaac ataatattgt aagtgaaggg
     2101 aaacaaaatc tgtataaaat ctgtataaaa taggcttttt tgcctagaga tataaaatgg
     2161 gaaaaaaagt taaatgattc attttcccac tagagtaatg gaaaattaac ctcaagaagt
     2221 aggaactgaa aatctttgct caagaaaact cattttgtag aatgtaaaga tttaaagatt
     2281 taaagatttc ttccatggca tttaactgaa aaggaaatct agttaaatca ttaggcaaat
     2341 gtatatttca ttctcttgat tttttttctg agaaagtgaa attttaaaaa attatatact
     2401 ttttgaccat tacttatttt tgaataccaa gctaaaaagt agtcagttaa gaccctaaaa
     2461 atatgaagaa aattcctatc attttttatt tttcacagat tttttaaata gctagattat
     2521 aaaacagtaa aggtacattc caataaatag aggaagaata ctatttatgt tctcttcctc
     2581 tcccctcact gaaaatagaa taaggactag gagaaaatat cttcaaaggc aactccttag
     2641 ggaaaaaaag tcacaagtgt gacaaaagac tatatggttg aaaaatacca atatatgtta
     2701 catatgagta aactaggcaa ggtgtagaca agtgaattac ctcttagaaa acgaatctgc
     2761 acaatagttt ggatacatgt aaactaataa cagctgagca agagggtgag tttaacacac
     2821 atccttccac agaaagacct tttctttcat ttgcttagat tattcagaag tcttaccaga
     2881 aagaaatgag ataatagtcc taagaaagca tcacatttac tacaagaaga tatatactag
     2941 cacatttctg agactcataa cataacaaga aatactttta agtgtaaaaa gtaacatcca
     3001 ggcctcagtg cttacagatc atctttcctt gaattaggga tactgttaat cctgctcaag
     3061 aaagcagaaa ctttttgaga atgtgaatgt gtagtacaaa cttctccttt aaactcttca
     3121 gtttgatttt taaagatatt tgtctaaaat aatactctct aacaaacact ttactgttgt
     3181 gcctccaccg atattaaaac aaaatatttt tgaagaacag aataaaagca aatattcaat
     3241 ggcaaatcat ggtctatttc tcaaatctct tccctatttt gaagccaaaa ccagaaatat
     3301 ccaattgtta caaaaagttc ggagtctaaa caagctaaac atatgtgttc cagctgaatt
     3361 tcttctgatg ataccaataa acaaagagac acacacacac acacacacac atacaaatgt
     3421 gcctacacat tcaatcattt aatgaatgca acaacttcaa agaattaaaa tcaaatactg
     3481 aaatgataag tggtcattac agcattgcca tatgctcaat aaagtctgtg aagcttgtgt
     3541 gcatgtttta aataagcaaa tttaatatat agtatctaat tgtttgaata taatgttttt
     3601 gaatgttcat tcttaaaaca tatatttatc atacaatgtt aaagtgtcaa gaaaaagcct
     3661 aatatgtaaa aagttattat tttcttaaat ttatgaatga tatggtacta gcattaatta
     3721 atgttttaga catatggaac catattcagc tgtaaaatat gaatatgaag tttagccctc
     3781 aaatttaatg tcatcagcca ctaccaaagt atcatacatt tgaaaaatat aactcctggc
     3841 cctcacatat tagagaaatt cagtagaatt ttctaagaca tttatttcta aggaaaaata
     3901 ctggcctcgt cagttggatt gttggtttgc tttggcttct gtgaacatac atattgttgt
     3961 gttgcttacc gagcacctcc cttctagtgt gacagaaata cccagacagt attttttcaa
     4021 tgctttccag aaaaaaactg gcatcattca ctcactactc atggccctta aactgagacc
     4081 tataggcaga attttttaag ttcaaaaatt taaacgacaa taataaaaca agagtgaaat
     4141 ataaaagaga agatttttca ctcttttgtc tgcattttga caataagaat tacagaataa
     4201 tgcacaaaat caaattcagt gagattcatt tttaaataaa gtcatcccag tgttttcata
     4261 tttgctaagc ttggaaagaa tctgccttca aaatttactc taccctctgt ttctaaagtt
     4321 cagtatgaat ctttccattg tttgaaggca aacactggct cagactacta ggcagatggt
     4381 taaaacagcc caggtttttt tacttagatc agtatcagaa aaattcaaaa tatttttaaa
     4441 caaatatgaa agaatcaaaa aggcttacat cattgtaagt attctctttt aaacaaaata
     4501 cattaaatca aaaataaaca ttgcttacta ttttgcatct ggacaaagta caagatattg
     4561 aaattacctg tatgggaaaa tattaaagcg gacataattg ttacagaatt cactctcaca
     4621 cttttttatt ttttaccaag tacagcacac tgttgcatta ttccatcttc taacttcatg
     4681 atggtgacat ttctgaccca gcagctgaat tcatgtcctt ttccaaatcc tgccaatgtc
     4741 ttagaaacag tgaactgagc aatttcagag tgaaccccgc ccttacaaag cacataaaga
     4801 ataccaagaa gcttggtatc aagcctatga aatacaaaat aaatgtgaaa aataaatgct
     4861 ggccagctca acatttgaat ttagtttttg caaatgcaaa atttcctcta aaaatttatg
     4921 attagtacct ggtaaactat ttcatcaaat agaaaagcag gagacttaca aacatttctc
     4981 acacttctaa cagtaacaat ttcctactta tcattgataa tatgtcaaaa gctaaggaaa
     5041 tccagaatga catggaccat gtagaacaat aaggttggaa taatttccct tagggccaag
     5101 caggaataga gaataaagtt cagaagggct gtacaaggtc attagttttg tgttttcata
     5161 catatatata tatatatgaa aaatctgttt atataagaag taaatgtata taaagtttgt
     5221 agtgaataaa gtattttcaa gttgtggtaa ttatattgaa tatgtttaat gtatttacac
     5281 cctttgcata tgtgataatg tgacagattt aatttctatt ttttctttaa aaacattaaa
     5341 actaatatta aaagtaaaa
//
