LOCUS       NM_001057               2715 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tachykinin receptor 2 (TACR2), mRNA.
ACCESSION   NM_001057
VERSION     NM_001057.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Madsen,J.J., Petersen,J.E., Christensen,D.P., Hansen,J.B.,
            Schwartz,T.W., Frimurer,T.M. and Olsen,O.H.
  TITLE     Deciphering specificity and cross-reactivity in tachykinin NK1 and
            NK2 receptors
  JOURNAL   J Biol Chem 299 (12), 105438 (2023)
   PUBMED   37944618
  REMARK    GeneRIF: Deciphering specificity and cross-reactivity in tachykinin
            NK1 and NK2 receptors.
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Xiang,H., Toyoshima,Y., Shen,W., Wang,X., Okada,N., Kii,S.,
            Sugiyama,K., Nagato,T., Kobayashi,H., Ikeo,K., Hashimoto,S.,
            Tanino,M., Taketomi,A. and Kitamura,H.
  TITLE     IFN-alpha/beta-mediated NK2R expression is related to the
            malignancy of colon cancer cells
  JOURNAL   Cancer Sci 113 (8), 2513-2525 (2022)
   PUBMED   35561088
  REMARK    GeneRIF: IFN-alpha/beta-mediated NK2R expression is related to the
            malignancy of colon cancer cells.
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Dai,L., Perera,D.S., Burcher,E. and Liu,L.
  TITLE     Hemokinin-1 and substance P stimulate production of inflammatory
            cytokines and chemokines in human colonic mucosa via both NK1 and
            NK2 tachykinin receptors
  JOURNAL   Neuropeptides 82, 102061 (2020)
   PUBMED   32600668
  REMARK    GeneRIF: Hemokinin-1 and substance P stimulate production of
            inflammatory cytokines and chemokines in human colonic mucosa via
            both NK1 and NK2 tachykinin receptors.
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Gonzalez-Santana,A., Marrero-Hernandez,S., Dorta,I., Hernandez,M.,
            Pinto,F.M., Baez,D., Bello,A.R., Candenas,L. and Almeida,T.A.
  TITLE     Altered expression of the tachykinins substance P/neurokinin
            A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2
            receptors in uterine leiomyomata
  JOURNAL   Fertil Steril 106 (6), 1521-1529 (2016)
   PUBMED   27456549
  REMARK    GeneRIF: Expression substance P/neurokinin A/hemokinin-1 and their
            preferred neurokinin 1/neurokinin 2 receptors are dysregulated in
            uterine leiomyomata.
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Le,D.D., Schmit,D., Heck,S., Omlor,A.J., Sester,M., Herr,C.,
            Schick,B., Daubeuf,F., Fahndrich,S., Bals,R., Frossard,N., Al
            Kadah,B. and Dinh,Q.T.
  TITLE     Increase of Mast Cell-Nerve Association and Neuropeptide Receptor
            Expression on Mast Cells in Perennial Allergic Rhinitis
  JOURNAL   Neuroimmunomodulation 23 (5-6), 261-270 (2016)
   PUBMED   28030866
  REMARK    GeneRIF: This study revealed for the first time an increase of Mast
            Cells -nerve association and NK2R expression on Mast Cells during
            Allergic Rhinitis as well as nerve fibres containing receptors for
            mass cells.
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Maggi,C.A., Giuliani,S., Patacchini,R., Santicioli,P.,
            Theodorsson,E., Barbanti,G., Turini,D. and Giachetti,A.
  TITLE     Tachykinin antagonists inhibit nerve-mediated contractions in the
            circular muscle of the human ileum. Involvement of neurokinin-2
            receptors
  JOURNAL   Gastroenterology 102 (1), 88-96 (1992)
   PUBMED   1370160
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Morten,J.E., Hopkins,B., Powell,S.J. and Graham,A.
  TITLE     Human NK-2 receptor gene maps to chromosome region 10q11-21
  JOURNAL   Hum Genet 88 (2), 200-203 (1991)
   PUBMED   1661704
REFERENCE   8  (bases 1 to 2715)
  AUTHORS   Graham,A., Hopkins,B., Powell,S.J., Danks,P. and Briggs,I.
  TITLE     Isolation and characterisation of the human lung NK-2 receptor gene
            using rapid amplification of cDNA ends
  JOURNAL   Biochem Biophys Res Commun 177 (1), 8-16 (1991)
   PUBMED   1710456
REFERENCE   9  (bases 1 to 2715)
  AUTHORS   Cyr,C., South,V., Saltzman,A., Felder,S., Ricca,G.A., Jaye,M.,
            Huebner,K., Kagan,J., Croce,C.M., Schlessinger,J. et al.
  TITLE     Cloning, expression of the human substance K receptor, and analysis
            of its role in mitogenesis
  JOURNAL   Ann N Y Acad Sci 632, 426-427 (1991)
   PUBMED   1659297
REFERENCE   10 (bases 1 to 2715)
  AUTHORS   Gerard,N.P. and Gerard,C.
  TITLE     Molecular cloning of the human neurokinin-2 receptor cDNA by
            polymerase chain reaction and isolation of the gene
  JOURNAL   Ann N Y Acad Sci 632, 389-390 (1991)
   PUBMED   1659296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA929480.1, BC033742.1 and AC016821.9.
            
            On May 17, 2019 this sequence version replaced NM_001057.2.
            
            Summary: This gene belongs to a family of genes that function as
            receptors for tachykinins.  Receptor affinities are specified by
            variations in the 5'-end of the sequence.  The receptors belonging
            to this family are characterized by interactions with G proteins
            and 7 hydrophobic transmembrane regions.  This gene encodes the
            receptor for the tachykinin neuropeptide substance K, also referred
            to as neurokinin A. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291996.1, BC033742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373306.5/ ENSP00000362403.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                DA929480.1         1-73
            74-699              BC033742.1         1-626
            700-700             AC016821.9         61101-61101         c
            701-1328            BC033742.1         627-1254
            1329-1329           AC016821.9         53811-53811         c
            1330-1940           BC033742.1         1256-1866
            1941-2416           AC016821.9         49084-49559         c
            2417-2715           AC016821.9         48785-49083         c
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..2715
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /note="tachykinin receptor 2"
                     /db_xref="GeneID:6865"
                     /db_xref="HGNC:HGNC:11527"
                     /db_xref="MIM:162321"
     exon            1..987
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..1792
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /note="neurokinin 2 receptor; neurokinin A receptor; NK-2
                     receptor; seven transmembrane helix receptor; NK-2R;
                     neurokinin B receptor"
                     /codon_start=1
                     /product="substance-K receptor"
                     /protein_id="NP_001048.2"
                     /db_xref="CCDS:CCDS7293.1"
                     /db_xref="GeneID:6865"
                     /db_xref="HGNC:HGNC:11527"
                     /db_xref="MIM:162321"
                     /translation="MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALV
                     LVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFG
                     RAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVAL
                     ALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYS
                     VIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQ
                     EDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKED
                     KLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPT
                     KTHVEI"
     exon            988..1182
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1336
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1533
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..2715
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /note="hexamer: AACAAG"
     polyA_site      1947
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /note="major polyA site"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /note="hexamer: AATAAA"
     polyA_site      2137
                     /gene="TACR2"
                     /gene_synonym="NK2R; NKNAR; SKR; TAC2R"
                     /note="major polyA site"
ORIGIN      
        1 agagaacggc agggaagctg cagcgagggc tggcagctgg cagagccctg agcacccagc
       61 acccagcccg gcttgcagcc caaagcctgg agagaggctg ctgcgccatt gacctgtgga
      121 ctccagagac tcccgctgtg cattcctctg atctggaagg tttcctgaat tacgtgacga
      181 gaaacctggg ttcgagtcct aacttgtcac caacttcctg agtgacctgg gctggtcccg
      241 tcccctcttg gaatctctgt cttccatctc ttcagcgaag gggttgattt ataagggtgt
      301 tttctgctct gacactgtga tttgaattct gtgtttccac atgatattcg agaagtctgg
      361 ccggaaggat ggaatctgaa atgacaatgg ttctggactg ggctttgtgc tcagcccagc
      421 tcatctttgc ctgagaccta ggagtggccc caggctctcc tgatgtgcca ccacgcttgg
      481 catctgctcc tctccctgcc cccatattcc catgctctga aggggagttc tctttcatag
      541 caaatccgag aggagccgag gagccaggtc ctttgttcca gacccagaag cagccatggg
      601 gacctgtgac attgtgactg aagccaatat ctcatctggc cctgagagca acaccacggg
      661 catcacagcc ttctccatgc ccagctggca actggcactg tgggccacag cctacctggc
      721 cctggtgctg gtggccgtga cgggtaatgc catcgtcatc tggatcatcc tggcccatcg
      781 gaggatgcgc acagtcacca actacttcat cgtcaatctg gcgctggctg acctctgcat
      841 ggctgccttc aatgccgcct tcaactttgt ctatgccagc cacaacatct ggtactttgg
      901 ccgtgccttc tgctacttcc agaacctctt ccccatcaca gccatgtttg tcagcatcta
      961 ctccatgacc gccattgctg ccgacaggta catggccatc gtccacccct tccagcctcg
     1021 gctttcagct cccagcacca aggcggttat tgctggcatc tggctggtgg ctctcgccct
     1081 ggcctcccct cagtgcttct actccaccgt caccatggac cagggtgcca ccaagtgcgt
     1141 ggtggcctgg cccgaagaca gcgggggcaa gacgctcctc ctgtaccacc tcgtggtgat
     1201 cgccctcatc tacttcctgc cgctcgcggt gatgtttgta gcctacagcg tcatcggcct
     1261 cacgctctgg aggcgcgcag tgcccggaca tcaggcgcac ggtgccaacc tgcgccacct
     1321 gcaggccatg aagaagtttg tgaagaccat ggtgctggtg gtgctgacgt ttgccatctg
     1381 ctggctgccc taccacctct acttcatcct gggcagcttc caggaggaca tctactgcca
     1441 caagttcatc cagcaagtct acctggcact cttctggttg gccatgagct ctaccatgta
     1501 caatcccatc atctactgct gtctcaacca caggtttcgc tctggattcc ggcttgcctt
     1561 ccgctgctgc ccatgggtca cacccaccaa ggaagataag ctcgagctga ctcccacgac
     1621 ctccctctcc acgagagtca acaggtgtca cactaaggag actttgttca tggctgggga
     1681 cacagccccc tccgaggcta ccagtgggga ggcggggcgt ccccaggatg gatcagggct
     1741 atggtttggg tatggtttgc ttgcccccac caaaactcat gttgaaattt gatcccaatg
     1801 tggcagtgtt gggaggtagg ggttagtggg aggtgtttgg gtattgggga tggatccctt
     1861 atgaatagat taatgccttc cagttgaagt gaatcatcac tcttgtggga atggactagt
     1921 tcccaaaata acaagttgtt agaaagagtg tggtgtcctc agtttccctg tcttgcttcc
     1981 tctctcacca tgtgatctct ttgcacacaa cacttccctt ccactttcca ccatgacaag
     2041 aagcagcctg aggccttcac cagatgcagc tgcccaatct tggatattcc agccaccaga
     2101 atcatgagcc aaataaacct cttttcttta taaattacct agtctcaggt attccatgaa
     2161 agcaacacaa atggactgag ataggtgcct attgaaccct gaagccttgt gcctggctgc
     2221 agaatgaggt gtagcaccct ttgagaagta gccaatcgag aagaccacat ctgaaagttc
     2281 agctcatgcc ccatccttca gtataccaat acaaagacaa catggggcca gaactccaga
     2341 aaggatgctg actttaagag gactcagcca cccatctcag agagcacttc agaggatcca
     2401 gtaagggtca gaaaagacag tgtaagctga tatttatcta atttaagaga tgcaagctca
     2461 aatgccttcc tggggcatac aagaatatgt ataaaagaaa aactgcaaat gtgatgataa
     2521 aaggcaactg acttccaccc tcagtttgag ctaataggga atggtggggg ccatggcaac
     2581 ctggagagga caggcattca aaggggacaa gaactactca gctctggaca aacgttgcca
     2641 catgataatg ggagcccact gttgctagat cttctaaatc tttcaagaga agctataaat
     2701 ccacatttgt atgtg
//
