LOCUS       NM_001058               4779 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens tachykinin receptor 1 (TACR1), transcript variant
            long, mRNA.
ACCESSION   NM_001058
VERSION     NM_001058.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4779)
  AUTHORS   Lambert,J., Petrovitch,D., Himes,K.P., Freiermuth,C.E., Braun,R.S.,
            Brown,J.L., Bischof,J.J., Lyons,M.S., Punches,B.E.,
            Littlefield,A.K., Kisor,D.F. and Sprague,J.E.
  TITLE     Association of genetic variants in CYP3A5, DRD2 and NK1R with
            opioid overdose
  JOURNAL   Chem Biol Interact 403, 111242 (2024)
   PUBMED   39265714
  REMARK    GeneRIF: Association of genetic variants in CYP3A5, DRD2 and NK1R
            with opioid overdose.
REFERENCE   2  (bases 1 to 4779)
  AUTHORS   Al-Keilani,M.S., Almomani,B.A., Jaradat,S.A., Al-Sawalha,N.A. and
            Qawasmeh,M.A.
  TITLE     Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and
            Substance P as Biomarkers for Diagnosis and Disease Activity and
            Severity in Multiple Sclerosis
  JOURNAL   CNS Neurol Disord Drug Targets 23 (4), 512-524 (2024)
   PUBMED   37013432
  REMARK    GeneRIF: Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and
            Substance P as Biomarkers for Diagnosis and Disease Activity and
            Severity in Multiple Sclerosis.
REFERENCE   3  (bases 1 to 4779)
  AUTHORS   Gao,X. and Bayraktutan,U.
  TITLE     TNF-alpha evokes blood-brain barrier dysfunction through activation
            of Rho-kinase and neurokinin 1 receptor
  JOURNAL   Immunobiology 228 (5), 152706 (2023)
   PUBMED   37454559
  REMARK    GeneRIF: TNF-alpha evokes blood-brain barrier dysfunction through
            activation of Rho-kinase and neurokinin 1 receptor.
REFERENCE   4  (bases 1 to 4779)
  AUTHORS   Rosso,P., Fico,E., Colafrancesco,S., Bellizzi,M.G., Priori,R.,
            Cerbelli,B., Leopizzi,M., Giordano,C., Greco,A., Tirassa,P.,
            Severini,C. and Fusconi,M.
  TITLE     Involvement of Substance P (SP) and Its Related NK1 Receptor in
            Primary Sjogren's Syndrome (pSS) Pathogenesis
  JOURNAL   Cells 12 (10), 1347 (2023)
   PUBMED   37408182
  REMARK    GeneRIF: Involvement of Substance P (SP) and Its Related NK1
            Receptor in Primary Sjogren's Syndrome (pSS) Pathogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4779)
  AUTHORS   Kokabi,F., Ebrahimi,S., Mirzavi,F., Ghiasi Nooghabi,N.,
            Hashemi,S.F. and Hashemy,S.I.
  TITLE     The neuropeptide substance P/neurokinin-1 receptor system and
            diabetes: From mechanism to therapy
  JOURNAL   Biofactors 49 (3), 534-559 (2023)
   PUBMED   36651605
  REMARK    GeneRIF: The neuropeptide substance P/neurokinin-1 receptor system
            and diabetes: From mechanism to therapy.
            Review article
REFERENCE   6  (bases 1 to 4779)
  AUTHORS   Fong,T.M., Huang,R.R. and Strader,C.D.
  TITLE     Localization of agonist and antagonist binding domains of the human
            neurokinin-1 receptor
  JOURNAL   J Biol Chem 267 (36), 25664-25667 (1992)
   PUBMED   1281469
REFERENCE   7  (bases 1 to 4779)
  AUTHORS   Fong,T.M., Yu,H., Huang,R.R. and Strader,C.D.
  TITLE     The extracellular domain of the neurokinin-1 receptor is required
            for high-affinity binding of peptides
  JOURNAL   Biochemistry 31 (47), 11806-11811 (1992)
   PUBMED   1280161
REFERENCE   8  (bases 1 to 4779)
  AUTHORS   Takahashi,K., Tanaka,A., Hara,M. and Nakanishi,S.
  TITLE     The primary structure and gene organization of human substance P
            and neuromedin K receptors
  JOURNAL   Eur J Biochem 204 (3), 1025-1033 (1992)
   PUBMED   1312928
REFERENCE   9  (bases 1 to 4779)
  AUTHORS   Walsh,D.A., Mapp,P.I., Wharton,J., Rutherford,R.A., Kidd,B.L.,
            Revell,P.A., Blake,D.R. and Polak,J.M.
  TITLE     Localisation and characterisation of substance P binding to human
            synovial tissue in rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 51 (3), 313-317 (1992)
   PUBMED   1374227
REFERENCE   10 (bases 1 to 4779)
  AUTHORS   Fong,T.M., Anderson,S.A., Yu,H., Huang,R.R. and Strader,C.D.
  TITLE     Differential activation of intracellular effector by two isoforms
            of human neurokinin-1 receptor
  JOURNAL   Mol Pharmacol 41 (1), 24-30 (1992)
   PUBMED   1310144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007681.3, DB203452.1,
            M74290.1, AC007400.4 and AW206679.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001058.3.
            
            Summary: This gene belongs to a gene family of tachykinin
            receptors. These tachykinin receptors are characterized by
            interactions with G proteins and contain seven hydrophobic
            transmembrane regions. This gene encodes the receptor for the
            tachykinin substance P, also referred to as neurokinin 1. The
            encoded protein is also involved in the mediation of
            phosphatidylinositol metabolism of substance P. [provided by
            RefSeq, Sep 2008].
            
            Transcript Variant: This variant (long) represents the longer and
            predominant transcript and it encodes the longer protein (isoform
            long).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.36400.1, AK289765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305249.10/ ENSP00000303522.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC007681.3         104583-104583       c
            2-575               DB203452.1         1-574
            576-2075            M74290.1           200-1699
            2076-4389           AC007400.4         99688-102001        c
            4390-4779           AW206679.1         18-407              c
FEATURES             Location/Qualifiers
     source          1..4779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..4779
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /note="tachykinin receptor 1"
                     /db_xref="GeneID:6869"
                     /db_xref="HGNC:HGNC:11526"
                     /db_xref="MIM:162323"
     exon            1..975
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             587..1810
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /note="isoform long is encoded by transcript variant long;
                     tachykinin receptor 1 (substance P receptor; neurokinin-1
                     receptor); NK-1 receptor; NK-1R; neurokinin receptor 1"
                     /codon_start=1
                     /product="substance-P receptor isoform long"
                     /protein_id="NP_001049.1"
                     /db_xref="CCDS:CCDS1958.1"
                     /db_xref="GeneID:6869"
                     /db_xref="HGNC:HGNC:11526"
                     /db_xref="MIM:162323"
                     /translation="MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVV
                     TSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGL
                     FYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALL
                     LAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTV
                     VGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPD
                     LYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGL
                     EMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDS
                     KTMTESFSFSSNVLS"
     exon            976..1170
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1321
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1518
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..4779
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4759..4764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /note="hexamer: AATAAA"
     polyA_site      4779
                     /gene="TACR1"
                     /gene_synonym="NK1R; NKIR; SPR; TAC1R"
                     /note="major polyA site"
ORIGIN      
        1 gagctgagca acccgaaccg agaggtgccc gcgaaactgc aggcggcggc agcggcagca
       61 aaagagaagg aaaaatctcc agctggatac gaagctccag aatcctggcc ataggctcag
      121 aacttttaca ggtcgcgctg caatgggccc ccacttcgct cctaagtcct cacgcagcac
      181 agggctttgc ctttccctgc ggaggaagga gaaataggag ttgcaggcag cagcaggtgc
      241 ataaatgcgg gggatctctt gcttcctaga actgtgaccg gtggaatttc tttccctttt
      301 tcagtttacc gcaagagaga tgctgtctcc agacttctga actcaaacgt ctcctgaagc
      361 ttgaaagtgg aggaattcag agccaccgcg ggcaggcggg cagtgcatcc agaagcgttt
      421 atattctgag cgccagttca gctttcaaaa agagtgctgc ccagaaaaag ccttccaccc
      481 tcctgtctgg ctttagaagg accctgagcc ccaggcgcca gccacaggac tctgctgcag
      541 aggggggttg tgtacagata gtagggcttt accgcctagc ttcgaaatgg ataacgtcct
      601 cccggtggac tcagacctct ccccaaacat ctccactaac acctcggaac ccaatcagtt
      661 cgtgcaacca gcctggcaaa ttgtcctttg ggcagctgcc tacacggtca ttgtggtgac
      721 ctctgtggtg ggcaacgtgg tagtgatgtg gatcatctta gcccacaaaa gaatgaggac
      781 agtgacgaac tattttctgg tgaacctggc cttcgcggag gcctccatgg ctgcattcaa
      841 tacagtggtg aacttcacct atgctgtcca caacgaatgg tactacggcc tgttctactg
      901 caagttccac aacttctttc ccatcgccgc tgtcttcgcc agtatctact ccatgacggc
      961 tgtggccttt gataggtaca tggccatcat acatcccctc cagccccggc tgtcagccac
     1021 agccaccaaa gtggtcatct gtgtcatctg ggtcctggct ctcctgctgg ccttccccca
     1081 gggctactac tcaaccacag agaccatgcc cagcagagtc gtgtgcatga tcgaatggcc
     1141 agagcatccg aacaagattt atgagaaagt gtaccacatc tgtgtgactg tgctgatcta
     1201 cttcctcccc ctgctggtga ttggctatgc atacaccgta gtgggaatca cactatgggc
     1261 cagtgagatc cccggggact cctctgaccg ctaccacgag caagtctctg ccaagcgcaa
     1321 ggtggtcaaa atgatgattg tcgtggtgtg caccttcgcc atctgctggc tgcccttcca
     1381 catcttcttc ctcctgccct acatcaaccc agatctctac ctgaagaagt ttatccagca
     1441 ggtctacctg gccatcatgt ggctggccat gagctccacc atgtacaacc ccatcatcta
     1501 ctgctgcctc aatgacaggt tccgtctggg cttcaagcat gccttccggt gctgcccctt
     1561 catcagcgcc ggcgactatg aggggctgga aatgaaatcc acccggtatc tccagaccca
     1621 gggcagtgtg tacaaagtca gccgcctgga gaccaccatc tccacagtgg tgggggccca
     1681 cgaggaggag ccagaggacg gccccaaggc cacaccctcg tccctggacc tgacctccaa
     1741 ctgctcttca cgaagtgact ccaagaccat gacagagagc ttcagcttct cctccaatgt
     1801 gctctcctag gccacagggc ctttggcagg tgcagccccc actgcctttg acctgcctcc
     1861 cttcatgcat ggaaattccc ttcatctgga accatcagaa acaccctcac actgggactt
     1921 gcaaaaaggg tcagtatggg ttagggaaaa cattccatcc ttgagtcaaa aaatctcaat
     1981 tcttccctat ctttgccacc ctcatgctgt gtgactcaaa ccaaatcact gaactttgct
     2041 gagcctgtaa aataaaaggt cggaccagct tttcccaaaa gcccattcat tccattctgg
     2101 aagtgacttt ggctgcatgc gagtgctcat ttcaggatga attctgcagc acagctgcgg
     2161 acccggaaga ctcattttcc tggagccccg tgttacttca ataaagttat ctcagattag
     2221 cctcctgcag ctggaggctc ctatcacccc agcctacgct tgacagggtg aacaaaagaa
     2281 ggcaccacat aacatctaaa tgaaaaattt agccctgtct tctaagcatc tgtgaaaaga
     2341 aacatatgta ttcccctttt tggcatctca gtatttcagt acatttatac atcatgagat
     2401 tgagaacctc gggcttccac attatgtccc cggtgactgt cctgagcagc cgacgcaagc
     2461 agaatatgtc cactgatacc tgctagttct cttacagacc aggaattggg agacttgcac
     2521 tacatttaat gtgtagttga ccctcttttc ctacttgtaa acaaggggac tgaactagat
     2581 aatctaagtg ttccttcgaa tcttaacatc ccgtggttca aggattgtat gagttttttg
     2641 tttgttttac aaaaaaaaac aaaacgaaga ataaaagaat agaaaagaat aggagcagtg
     2701 agtcttgtaa ctaataccca gttcctggag atgtagcaac tgctaaggcc atctgtaact
     2761 atccatctca gacattctcc gatttatctt aaaatcctga gtacattcct tctcatggaa
     2821 ggttttggct tttgacagag cagaggactt catgccaagg cctgcatcca tccagcttta
     2881 gcaggcagaa tttcatagct gcagaacact gtcagagaag acaaatgtgg gctccctgct
     2941 ttaacctttt gggtatttta gggtgggggc cctaaccttc attcttagtt ttacactagc
     3001 atcgtgctca tatgtgcgac aagcaagaag gctgcacttt gcagctgcac ttctgggaag
     3061 agggcatctt gcatcttccc ttcagactct ctgaatgtct cctccctgct ccatggcttt
     3121 gccagcttcc tgtctctaag gggtagaatg actcatcaac cctaaaggac agtcagtctt
     3181 ccaagagcca tgaactgaat gctttatatc ctaatttaga tttagagttt ccagaaggtg
     3241 agcatgcagt tttgttttgt ttttttttct gtctcccaaa tctgtgtttt ttccagatat
     3301 ggctggaagc agaagcttca tgtaacatcc atgaatgtcc tcctggtagt ttgcataatg
     3361 gatgcacatg tgccgcatcc ataacattaa ggggagaata atgcatggtt tacagccttt
     3421 gccagccctg ctggctctaa ttctaccagg gcatccacag gcctggggga agaagaaaca
     3481 gtataagcca gaaaacctca agaactacat tctctaaagc agcatggaaa gttttaaata
     3541 aactaagtga agccagatca ttgcagatat ataaatggaa gacaaaattt agaagcaaca
     3601 aaagttagtg ccctaagcat tagtcatact tccaatagag aatcttgctg tgtatggatt
     3661 actcactttg gaagaatgta aagagctaac atgattatga gaagtacctg agaagatggt
     3721 gtcaagaagt tggggacacc ccatctatgg aagagaaggt tagagttgag ctcaacgagg
     3781 attaactgag tgcctcctct ggactttgcc ctgaactggg aacacacagc ccctgcagct
     3841 cttgaagagc ctaccttatt ggccatcact aactaactca ccagtcctag tgagtctaag
     3901 ctgcccagca gtcttggagg catctgagag gacagattct ccacagaatt ctaaaaaccc
     3961 acactcaaca tgggcagtca agccaaagac tgggaccttt ggagagcctc tggaatgaga
     4021 gttctctggg gtacttccaa agggagctgg cagtcagtcc aggggaccta aaggaatttg
     4081 gttgaacagt atcatctctg tgcatagtaa gagggaatgt tgggtggtcc gggcagtttc
     4141 caatatggca aagcatctgc ttggacagtg ccagcaagcc ttcctctgac ccagtctcca
     4201 atgtccacta acttataaaa atgtcatcaa ctcccacatg taagaaacac catgatttgt
     4261 actgtgcatg ggtcacattc ttattctaga aatgcatcac cctgtgttta tccaagtgtg
     4321 tttacttggt gtaatgtcca gtagtaatag aatatgaaat atcaaggaac catctttgtt
     4381 acgtgacttc caaaatgtga gatctcattg ctgtcactgt gatatttgta ttgtgtgaat
     4441 ctcttcctcc tcttcctcct catgctttct cagggaggag ccctgatgta tatcatgaac
     4501 tcacagttcc tagaccacag taattgaggg gcggtggggg ggcctttatc ggagaagcta
     4561 gagaacaaga gtccttctcc tccttatccc ccaacaggac actaagagac aaggactgag
     4621 tggaatcctg gagaaagggg actcaggaac tgacctcatt ggcctgattt gtgaggagag
     4681 gagtataagt ggagaggggc cattcctgag gtttccgtgt tttccagcct ggtctcctgg
     4741 aaagaatctt tatacagaaa taaagtatgt gtttcactc
//
