LOCUS       NM_006342               2799 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transforming acidic coiled-coil containing protein 3
            (TACC3), transcript variant 1, mRNA.
ACCESSION   NM_006342
VERSION     NM_006342.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2799)
  AUTHORS   Shen,H., Chen,Y., Xu,M., Zhou,J., Huang,C., Wang,Z., Shao,Y.,
            Zhang,H., Lu,Y., Li,S. and Fu,Z.
  TITLE     Cellular senescence gene TACC3 associated with colorectal cancer
            risk via genetic and DNA methylated alteration
  JOURNAL   Arch Toxicol 98 (5), 1499-1513 (2024)
   PUBMED   38480537
  REMARK    GeneRIF: Cellular senescence gene TACC3 associated with colorectal
            cancer risk via genetic and DNA methylated alteration.
REFERENCE   2  (bases 1 to 2799)
  AUTHORS   Suster,D., Mackinnon,A.C., Ronen,N., Mejbel,H.A., Harada,S. and
            Suster,S.
  TITLE     Non-Small Cell Lung Carcinoma With Clear Cell Features and
            FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next
            Generation Sequencing Study of 7 Cases
  JOURNAL   Am J Surg Pathol 48 (3), 284-291 (2024)
   PUBMED   38084010
  REMARK    GeneRIF: Non-Small Cell Lung Carcinoma With Clear Cell Features and
            FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next
            Generation Sequencing Study of 7 Cases.
REFERENCE   3  (bases 1 to 2799)
  AUTHORS   Guo,E., Yang,J., Li,L., Chen,J. and Liu,H.
  TITLE     TACC3 is an independent prognostic marker, and knockdown of TACC3
            enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer
            cells
  JOURNAL   J Biochem Mol Toxicol 37 (9), e23402 (2023)
   PUBMED   37341435
  REMARK    GeneRIF: TACC3 is an independent prognostic marker, and knockdown
            of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver
            cancer cells.
REFERENCE   4  (bases 1 to 2799)
  AUTHORS   Saatci,O., Akbulut,O., Cetin,M., Sikirzhytski,V., Uner,M.,
            Lengerli,D., O'Quinn,E.C., Romeo,M.J., Caliskan,B., Banoglu,E.,
            Aksoy,S., Uner,A. and Sahin,O.
  TITLE     Targeting TACC3 represents a novel vulnerability in highly
            aggressive breast cancers with centrosome amplification
  JOURNAL   Cell Death Differ 30 (5), 1305-1319 (2023)
   PUBMED   36864125
  REMARK    GeneRIF: Targeting TACC3 represents a novel vulnerability in highly
            aggressive breast cancers with centrosome amplification.
REFERENCE   5  (bases 1 to 2799)
  AUTHORS   Rajeev,R., Mukhopadhyay,S., Bhagyanath,S., Devu Priya,M.R.S. and
            Manna,T.K.
  TITLE     TACC3-ch-TOG interaction regulates spindle microtubule assembly by
            controlling centrosomal recruitment of gamma-TuRC
  JOURNAL   Biosci Rep 43 (3) (2023)
   PUBMED   36790370
  REMARK    GeneRIF: TACC3-ch-TOG interaction regulates spindle microtubule
            assembly by controlling centrosomal recruitment of gamma-TuRC.
REFERENCE   6  (bases 1 to 2799)
  AUTHORS   Piekorz,R.P., Hoffmeyer,A., Duntsch,C.D., McKay,C., Nakajima,H.,
            Sexl,V., Snyder,L., Rehg,J. and Ihle,J.N.
  TITLE     The centrosomal protein TACC3 is essential for hematopoietic stem
            cell function and genetically interfaces with p53-regulated
            apoptosis
  JOURNAL   EMBO J 21 (4), 653-664 (2002)
   PUBMED   11847113
REFERENCE   7  (bases 1 to 2799)
  AUTHORS   McKeveney,P.J., Hodges,V.M., Mullan,R.N., Maxwell,P., Simpson,D.,
            Thompson,A., Winter,P.C., Lappin,T.R. and Maxwell,A.P.
  TITLE     Characterization and localization of expression of an
            erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid
            precursor cells
  JOURNAL   Br J Haematol 112 (4), 1016-1024 (2001)
   PUBMED   11298601
REFERENCE   8  (bases 1 to 2799)
  AUTHORS   Gergely,F., Karlsson,C., Still,I., Cowell,J., Kilmartin,J. and
            Raff,J.W.
  TITLE     The TACC domain identifies a family of centrosomal proteins that
            can interact with microtubules
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14352-14357 (2000)
   PUBMED   11121038
REFERENCE   9  (bases 1 to 2799)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     The third member of the transforming acidic coiled coil-containing
            gene family, TACC3, maps in 4p16, close to translocation
            breakpoints in multiple myeloma, and is upregulated in various
            cancer cell lines
  JOURNAL   Genomics 58 (2), 165-170 (1999)
   PUBMED   10366448
REFERENCE   10 (bases 1 to 2799)
  AUTHORS   Prashar,Y. and Weissman,S.M.
  TITLE     Analysis of differential gene expression by display of 3' end
            restriction fragments of cDNAs
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 659-663 (1996)
   PUBMED   8570611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB098941.1, AF093543.1 and
            AI684124.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006342.2.
            
            Summary: This gene encodes a member of the transforming acidic
            colied-coil protein family. The encoded protein is a motor spindle
            protein that may play a role in stabilization of the mitotic
            spindle. This protein may also play a role in growth a
            differentiation of certain cancer cells. [provided by RefSeq, Nov
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106071.1, BC111771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313288.9/ ENSP00000326550.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DB098941.1         30-61
            33-2744             AF093543.1         17-2728
            2745-2799           AI684124.1         26-80               c
FEATURES             Location/Qualifiers
     source          1..2799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2799
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /note="transforming acidic coiled-coil containing protein
                     3"
                     /db_xref="GeneID:10460"
                     /db_xref="HGNC:HGNC:11524"
                     /db_xref="MIM:605303"
     exon            1..123
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            124..286
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2641
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 3 isoform 1"
                     /protein_id="NP_006333.1"
                     /db_xref="CCDS:CCDS3352.1"
                     /db_xref="GeneID:10460"
                     /db_xref="HGNC:HGNC:11524"
                     /db_xref="MIM:605303"
                     /translation="MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENV
                     PPKNLAKAMKVTFQTPLRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKEN
                     QQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQS
                     PGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPH
                     GAEEECKAETPHGAEEECRHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCP
                     AGVGTPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSG
                     PVKLEFDVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGE
                     DPPMPASRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAG
                     PATEEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEPV
                     PTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPL
                     LRDSPGRPVPVATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPG
                     GPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEV
                     VYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYR
                     KNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQA
                     SLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI"
     exon            287..429
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            430..1509
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1585
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1715
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1768
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1872
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1960
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2065
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2142
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2186
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2347
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2454
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2575
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2799
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /note="hexamer: AATAAA"
     polyA_site      2799
                     /gene="TACC3"
                     /gene_synonym="ERIC-1; ERIC1; maskin; Tacc4"
                     /note="major polyA site"
ORIGIN      
        1 caagggctag aagcgcgacg gcggtagcag ctaggcttgg cccccggcgt ggagcagacg
       61 cggacccctc cttcctggcg gcggcggcgc gggctcagag cccggcaacg ggcgggcggg
      121 cagaatgagt ctgcaggtct taaacgacaa aaatgtcagc aatgaaaaaa atacagaaaa
      181 ttgcgacttc ctgttttcgc caccagaagt taccggaaga tcgtctgttc ttcgtgtgtc
      241 acagaaagaa aatgtgccac ccaagaacct ggccaaagct atgaaggtga cttttcagac
      301 acctctgcgg gatccacaga cgcacaggat tctaagtcct agcatggcca gcaaacttga
      361 ggctcctttc actcaggatg acacccttgg actggaaaac tcacacccgg tctggacaca
      421 gaaagagaac caacagctca tcaaggaagt ggatgccaaa actactcatg gaattctaca
      481 gaaaccagtg gaggctgaca ccgacctcct gggggatgca agcccagcct ttgggagtgg
      541 cagctccagc gagtctggcc caggtgccct ggctgacctg gactgctcaa gctcttccca
      601 gagcccagga agttctgaga accaaatggt gtctccagga aaagtgtctg gcagccctga
      661 gcaagccgtg gaggaaaacc ttagttccta ttccttagac agaagagtga cacccgcctc
      721 tgagacccta gaagaccctt gcaggacaga gtcccagcac aaagcggaga ctccgcacgg
      781 agccgaggaa gaatgcaaag cggagactcc gcacggagcc gaggaggaat gccggcacgg
      841 tggggtctgt gctcccgcag cagtggccac ttcgcctcct ggtgcaatcc ctaaggaagc
      901 ctgcggagga gcacccctgc agggtctgcc tggcgaagcc ctgggctgcc ctgcgggtgt
      961 gggcaccccc gtgccagcag atggcactca gacccttacc tgtgcacaca cctctgctcc
     1021 tgagagcaca gccccaacca accacctggt ggctggcagg gccatgaccc tgagtcctca
     1081 ggaagaagtg gctgcaggcc aaatggccag ctcctcgagg agcggacctg taaaactaga
     1141 atttgatgta tctgatggcg ccaccagcaa aagggcaccc ccaccaagga gactgggaga
     1201 gaggtccggc ctcaagcctc ccttgaggaa agcagcagtg aggcagcaaa aggccccgca
     1261 ggaggtggag gaggacgacg gtaggagcgg agcaggagag gaccccccca tgccagcttc
     1321 tcggggctct taccacctcg actgggacaa aatggatgac ccaaacttca tcccgttcgg
     1381 aggtgacacc aagtctggtt gcagtgaggc ccagccccca gaaagccctg agaccaggct
     1441 gggccagcca gcggctgaac agttgcatgc tgggcctgcc acggaggagc caggtccctg
     1501 tctgagccag cagctgcatt cagcctcagc ggaggacacg cctgtggtgc agttggcagc
     1561 cgagacccca acagcagaga gcaaggagag agccttgaac tctgccagca cctcgcttcc
     1621 cacaagctgt ccaggcagtg agccagtgcc cacccatcag caggggcagc ctgccttgga
     1681 gctgaaagag gagagcttca gagaccccgc tgaggttcta ggcacgggcg cggaggtgga
     1741 ttacctggag cagtttggaa cttcctcgtt taaggagtcg gccttgagga agcagtcctt
     1801 atacctcaag ttcgaccccc tcctgaggga cagtcctggt agaccagtgc ccgtggccac
     1861 cgagaccagc agcatgcacg gtgcaaatga gactccctca ggacgtccgc gggaagccaa
     1921 gcttgtggag ttcgatttct tgggagcact ggacattcct gtgccaggcc cacccccagg
     1981 tgttcccgcg cctgggggcc cacccctgtc caccggacct atagtggacc tgctccagta
     2041 cagccagaag gacctggatg cagtggtaaa ggcgacacag gaggagaacc gggagctgag
     2101 gagcaggtgt gaggagctcc acgggaagaa cctggaactg gggaagatca tggacaggtt
     2161 cgaagaggtt gtgtaccagg ccatggagga agttcagaag cagaaggaac tttccaaagc
     2221 tgaaatccag aaagttctaa aagaaaaaga ccaacttacc acagatctga actccatgga
     2281 gaagtccttc tccgacctct tcaagcgttt tgagaaacag aaagaggtga tcgagggcta
     2341 ccgcaagaac gaagagtcac tgaagaagtg cgtggaggat tacctggcaa ggatcaccca
     2401 ggagggccag aggtaccaag ccctgaaggc ccacgcggag gagaagctgc agctggcaaa
     2461 cgaggagatc gcccaggtcc ggagcaaggc ccaggcggaa gcgttggccc tccaggccag
     2521 cctgaggaag gagcagatgc gcatccagtc gctggagaag acagtggagc agaagactaa
     2581 agagaacgag gagctgacca ggatctgcga cgacctcatc tccaagatgg agaagatctg
     2641 acctccacgg agccgctgtc cccgcccccc tgctcccgtc tgtctgtcct gtctgattct
     2701 cttaggtgtc atgttctttt ttctgtcttg tcttcaactt ttttaaaaac tagattgctt
     2761 tgaaaacatg actcaataaa agtttccttt caatttaaa
//
