LOCUS       NM_006283               7770 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transforming acidic coiled-coil containing protein 1
            (TACC1), transcript variant 1, mRNA.
ACCESSION   NM_006283
VERSION     NM_006283.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7770)
  AUTHORS   Wang,Y., Li,M., Zhang,L., Chen,Y. and Ha,M.
  TITLE     LINC01140 inhibits nonsmall cell lung cancer progression and
            cisplatin resistance through the miR-4742-5p/TACC1 axis
  JOURNAL   J Biochem Mol Toxicol 36 (7), e23048 (2022)
   PUBMED   35307914
  REMARK    GeneRIF: LINC01140 inhibits nonsmall cell lung cancer progression
            and cisplatin resistance through the miR-4742-5p/TACC1 axis.
REFERENCE   2  (bases 1 to 7770)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7770)
  AUTHORS   Devereaux,K.A., Weiel,J.J., Mills,A.M., Kunder,C.A. and
            Longacre,T.A.
  TITLE     Neurofibrosarcoma Revisited: An Institutional Case Series of
            Uterine Sarcomas Harboring Kinase-related Fusions With Report of a
            Novel FGFR1-TACC1 Fusion
  JOURNAL   Am J Surg Pathol 45 (5), 638-652 (2021)
   PUBMED   33481389
  REMARK    GeneRIF: Neurofibrosarcoma Revisited: An Institutional Case Series
            of Uterine Sarcomas Harboring Kinase-related Fusions With Report of
            a Novel FGFR1-TACC1 Fusion.
REFERENCE   4  (bases 1 to 7770)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7770)
  AUTHORS   Line,A., Stengrevics,A., Slucka,Z., Li,G., Jankevics,E. and
            Rees,R.C.
  TITLE     Serological identification and expression analysis of gastric
            cancer-associated genes
  JOURNAL   Br J Cancer 86 (11), 1824-1830 (2002)
   PUBMED   12087473
REFERENCE   7  (bases 1 to 7770)
  AUTHORS   Lauffart,B., Howell,S.J., Tasch,J.E., Cowell,J.K. and Still,I.H.
  TITLE     Interaction of the transforming acidic coiled-coil 1 (TACC1)
            protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
  JOURNAL   Biochem J 363 (Pt 1), 195-200 (2002)
   PUBMED   11903063
  REMARK    GeneRIF: Interaction of the transforming acidic coiled-coil 1
            (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
REFERENCE   8  (bases 1 to 7770)
  AUTHORS   Gergely,F., Karlsson,C., Still,I., Cowell,J., Kilmartin,J. and
            Raff,J.W.
  TITLE     The TACC domain identifies a family of centrosomal proteins that
            can interact with microtubules
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14352-14357 (2000)
   PUBMED   11121038
REFERENCE   9  (bases 1 to 7770)
  AUTHORS   Still,I.H., Hamilton,M., Vince,P., Wolfman,A. and Cowell,J.K.
  TITLE     Cloning of TACC1, an embryonically expressed, potentially
            transforming coiled coil containing gene, from the 8p11 breast
            cancer amplicon
  JOURNAL   Oncogene 18 (27), 4032-4038 (1999)
   PUBMED   10435627
REFERENCE   10 (bases 1 to 7770)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     The third member of the transforming acidic coiled coil-containing
            gene family, TACC3, maps in 4p16, close to translocation
            breakpoints in multiple myeloma, and is upregulated in various
            cancer cell lines
  JOURNAL   Genomics 58 (2), 165-170 (1999)
   PUBMED   10366448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB084271.1, AF049910.1,
            AY072876.2 and AY139007.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006283.2.
            
            Summary: This locus may represent a breast cancer candidate gene.
            It is located close to FGFR1 on a region of chromosome 8 that is
            amplified in some breast cancers. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF049910.1, SRR1803617.15172.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317827.9/ ENSP00000321703.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               DB084271.1         33-581
            550-1217            AF049910.1         523-1190
            1218-1977           AY072876.2         802-1561
            1978-2874           AF049910.1         1951-2847
            2875-6299           AY139007.1         1552-4976
            6300-7770           AY139007.1         4978-6448
FEATURES             Location/Qualifiers
     source          1..7770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..7770
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="transforming acidic coiled-coil containing protein
                     1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
     exon            1..508
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..2765
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gastric cancer antigen Ga55; taxin-1"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 1 isoform 1"
                     /protein_id="NP_006274.2"
                     /db_xref="CCDS:CCDS6109.1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
                     /translation="MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDS
                     QAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLV
                     AEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDST
                     DISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNS
                     CPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTS
                     PLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEAR
                     KALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESP
                     SFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNE
                     ILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEK
                     LASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEED
                     GSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEW
                     KKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN
                     SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEK
                     LDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELI
                     AKLGKTD"
     exon            509..624
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1738
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1799
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2007
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2060
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2186
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2263
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2307
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2468
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2575
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2696
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..7770
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7747..7752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="hexamer: AATAAA"
     polyA_site      7770
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="major polyA site"
ORIGIN      
        1 gagtccgcga gccgggagcg ggagcagcag aggtctagca gccgggcgcc gcgggccggg
       61 ggcctgagga ggccacagga cgggcgtctt cccggctagt ggagcccggc gcggggcccg
      121 ctgcggccgc accgtgaggg gaggaggccg aggaggacgc agcgccggct gccggcggga
      181 ggaagcgctc caccagggcc cccgacggca ctcgtttaac cacatccgcg cctctgctgg
      241 aaacgcttgc tggcgcctgt caccggttcc ctccattttg aaagggaaaa aggctctccc
      301 cacccattcc cctgccccta ggagctggag ccggaggagc cgcgctcatg gcgttcagcc
      361 cgtggcagat cctgtccccc gtgcagtggg cgaaatggac gtggtctgcg gtacgcggcg
      421 gggccgccgg cgaggacgag gctggcgggc ccgagggcga ccccgaggag gaggattcgc
      481 aagccgagac caaatccttg agtttcagct cggattctga aggtaatttt gagactcctg
      541 aagctgaaac cccgatccga tcacctttca aggagtcctg tgatccatca ctcggattgg
      601 caggacctgg ggccaaaagc caagaatcac aagaagctga tgaacagctt gtagcagaag
      661 tggttgaaaa atgttcatct aagacttgtt ctaaaccttc agaaaatgaa gtgccacagc
      721 aggccattga ctctcactca gtcaagaatt tcagagaaga acctgaacat gattttagca
      781 aaatttccat cgtgaggcca ttttcaatag aaacgaagga ttccacggat atctcggcag
      841 tcctcggaac aaaagcagct catggctgtg taactgcagt ctcaggcaag gctctgcctt
      901 ccagcccgcc agacgccctc caggacgagg cgatgacaga aggcagcatg ggggtcaccc
      961 tcgaggcctc cgcagaagct gatctaaaag ctggcaactc ctgtccagag cttgtgccca
     1021 gcagaagaag caagctgaga aagcccaagc ctgtccccct gaggaagaaa gcaattggag
     1081 gagagttctc agacaccaac gctgctgtgg agggcacacc tctccccaag gcatcctatc
     1141 acttcagtcc tgaagagttg gatgagaaca caagtccttt gctaggagat gccaggttcc
     1201 agaagtctcc ccctgacctt aaagaaactc ccggcactct cagtagtgac accaacgact
     1261 caggggttga gctgggggag gagtcgagga gctcacctct caagcttgag tttgatttca
     1321 cagaagatac aggaaacata gaggccagga aagcccttcc aaggaagctt ggcaggaaac
     1381 tgggtagcac actgactccc aagatacaaa aagatggcat cagtaagtca gcaggtttag
     1441 aacagcctac agacccagtg gcacgagacg ggcctctctc ccaaacatct tccaagccag
     1501 atcctagtca gtgggaaagc cccagcttca acccctttgg gagccactct gttctgcaga
     1561 actccccacc cctctcttct gagggctcct accactttga cccagataac tttgacgaat
     1621 ccatggatcc ctttaaacca actacgacct taacaagcag tgacttttgt tctcccactg
     1681 gtaatcacgt taatgaaatc ttagaatcac ccaagaaggc aaagtcgcgt ttaataacga
     1741 gtggctgtaa ggtgaagaag catgaaactc agtctctcgc cctggatgca tgttctcggg
     1801 atgaaggggc agtgatctcc cagatttcag acatttctaa tagggatggc catgctactg
     1861 atgaggagaa actggcatcc acgtcatgtg gtcagaaatc agctggtgcc gaggtgaaag
     1921 gtgagccaga ggaagacctg gagtactttg aatgttccaa tgttcctgtg tctaccataa
     1981 atcatgcgtt ttcatcctca gaagcaggca tagagaagga gacgtgccag aagatggaag
     2041 aagacgggtc cactgtgctt gggctgctgg agtcctctgc agagaaggcc cctgtgtcgg
     2101 tgtcctgtgg aggtgagagc cccctggatg ggatctgcct cagcgaatca gacaagacag
     2161 ccgtgctcac cttaataaga gaagagataa ttactaaaga gattgaagca aatgaatgga
     2221 agaagaaata cgaagagacc cggcaagaag ttttggagat gaggaaaatt gtagctgaat
     2281 atgaaaagac tattgctcaa atgattgaag atgaacaaag gacaagtatg acctctcaga
     2341 agagcttcca gcaactgacc atggagaagg aacaggccct ggctgacctt aactctgtgg
     2401 aaaggtccct ttctgatctc ttcaggagat atgagaacct gaaaggtgtt ctggaagggt
     2461 tcaagaagaa tgaagaagcc ttgaagaaat gtgctcagga ttacttagcc agagttaaac
     2521 aagaggagca gcgataccag gccctgaaaa tccacgcaga agagaaactg gacaaagcca
     2581 atgaagagat tgctcaggtt cgaacaaaag caaaggctga gagtgcagct ctccatgctg
     2641 gactccgcaa agagcagatg aaggtggagt ccctggaaag ggccctgcag cagaagaacc
     2701 aagaaattga agaactgaca aaaatctgtg atgagctgat tgcaaagctg ggaaagactg
     2761 actgagacac tccccctgtt agctcaacag atctgcattt ggctgcttct cttgtgacca
     2821 caattatctt gccttatcca ggaataattg cccctttgca gagaaaaaaa aaaacttaaa
     2881 aaaagcacat gcctactgct gcctgtcccg ctttgctgcc aatgcaacag ccctggaaga
     2941 aaccctagag ggttgcatag tctagaaagg agtgtgacct gacagtgctg gagcctccta
     3001 gtttccccct atgaaggttc ccttaggctg ctgagtttgg gtttgtgatt tatctttagt
     3061 ttgttttaaa gtcatcttta ctttcccaaa tgtgttaaat ttgtaactcc tctttggggt
     3121 cttctccacc acctgtctga tttttttgtg atctgtttaa tcttttaatt ttttagtatc
     3181 agtggtttta tttaaggaga cagtttggcc tattgttact tccaatttat aatcaagaag
     3241 gggctctgga tcccctttta aattacacac actctcacac acatacatgt atgtttatag
     3301 atgctgctgc tcttttccct gaagcatagt caagtaagaa ctgctctaca gaaggacata
     3361 tttccttgga tgtgagaccc tattttgaaa tagagtcctg actcagaaca ccaacttaag
     3421 aatttggggg attaaagatg tgaagaccac agtcttgggt tttcatatct ggagaagact
     3481 atttgccatg acgttttgtt gccctggtat ttggacactc ctcagcttta atgggtgtgg
     3541 cccctttagg gttagtcctc agactaatga tagtgtctgc tttctgcatg aacggcaata
     3601 tgggactccc tccaagctag ggtttggcaa gtctgcccta gagtcattta ctctcctctg
     3661 cctccatttg ttaatacaga atcaacattt agtcttcatt atcttttttt ttttttttga
     3721 gacagagttt cgatctattt taagtatgtg aagaaaatct acttgtaaaa ggctcagatc
     3781 ttaattaaaa ggtaattgta gcacattacc aattataagg tgaagaaatg tttttttccc
     3841 aagtgtgatg cattgttctt cagatgttga aaagaaagca aaaaatacct tctaacttaa
     3901 gacagaattt ttaacaaaat gagcagtaaa agtcacatga accactccaa aaatcagtgc
     3961 attttgcata tttttaaaca aagacagctt gttgaatact gagaagagga gtgcaaggag
     4021 aaggtctgta ctaacaaagc caaattcctc aagctcttac tggactcagt tcagagtggt
     4081 gggccattaa ccccaacatg gaatttttcc atataaatct caatgaattc cctttcattt
     4141 gaataggcaa acccaaatcc atgcaagtgt tttaaagcac tgtcctgtct taatcttaca
     4201 tgctgaaagt cttcatggtg atatgcacta tattcagtat acgtatgttt tcctacttct
     4261 cttgtaaaac tgttgcatga tccaacttca gcaatgaatt gtgcctagtg gagaacctct
     4321 atagatctta aaaaatgaat tattctttag cagtgtatta ctcacatggg tgcaatcttt
     4381 agccccaggg aggtcaataa tgtcttttaa agccagaagt cacattttac caatatgcat
     4441 ttatcataat tggtgcttag gctgtatatt caagcctgtt gtcttaacat tttgtataaa
     4501 aaagaacaac agaaattatc tgtcatttga gaagtggctt gacaatcatt tgagctttga
     4561 aagcagtcac tgtggtgtaa tatgaatgct gtcctagtgg tcatagtacc aagggcacgt
     4621 gtctcccctt ggtataactg atttcctttt tagtcctcta ctgctaaata agttaatttt
     4681 gcattttgca gaaagaaaca ttgattgcta aatctttttg ctgctgtgtt ttggtgtttt
     4741 catgtttact tgttttatat tgatctgttt taagtatgag aggcttatag tgccctccat
     4801 tgtaaatcca tagtcatctt tttaagctta ttgtgtttaa gaaagtagct atgtgttaaa
     4861 cagaggtgat ggcagccctt ccctagcaca ctggtggaag agacccctta agaacctgac
     4921 cccagtgaat gaagctgatg cacagggagc accaaaggac cttcgttaag tgataattgt
     4981 cctggcctct cagccatgac cgttatgagg aaatatcccc cattcgaact taacagatgc
     5041 ctcctctcca aagagaatta aaatcgtagc ttgtacagat caagagaata tactgggcag
     5101 aatgaagtat gtttgtttat ttttctttaa aaataaagga ttttggaact ctggagagta
     5161 agaatatagt atagagtttg cctcaacaca tgtgagggcc aaataacctg ctagctaggc
     5221 agtaataaac tctgttacag aagagaaaaa gggccgggca cagtggctta ttcctgtaat
     5281 cccaacactg tggaaggccg aggcaggagg atcacttgag tccaggagtt tgaaacctac
     5341 ctaggcaaca tggtgaaacc ttgtctctac caaaataaaa attagctggg catggtggca
     5401 cgtgcctgtg gtcccagcta cttgggaggc tgaggtggga gcctgggagg tcaaggctgc
     5461 agtgagccat gatcatgcca ctgcactcca tcctgggtga cagcaagatc ttgtctcaaa
     5521 aaaaaaaaaa aaaaaaaaaa aaccaggagt gaaaaaggaa agtagaaggc agctgctggc
     5581 ctagatgttg gtttgggaat attaggtgat cctgttgaga ttctggatcc agagcaattt
     5641 ctttagcttt tgactttgcc aaagtgtaga tagcctttat ccagcagtat tttaagtggg
     5701 gaatgcaacg tgaggccaac tgaacaattc cccccgtggc tgcccagata gtcacagtca
     5761 aggttggaga gtctccttcc agccagtgac ctacccaaac cttttgttct gtaaaactgc
     5821 tctggaaata ccgggaagcc cagttttctc acgtggtttc tagcttcttc agactcagcc
     5881 caaattagga agtgcagaag cacatgatgg tgaaaaacct aggatttggc agccttccag
     5941 aatggtatgg aatctgaggg aagatttatg tttcgttttg gaggatagct caagttgaat
     6001 tttctttcca gccagttacc ctttcaacct acccatactt tgtacaactc ttacacaaat
     6061 acttagatat ttattagata gccctgaatt cactctaatt ataaacaggg agtgtaaact
     6121 gcccccagat gttcctgggc tgggtaaaag cagctggagt gaagcactca ttttccataa
     6181 aggtaacaaa gggcagctca gtggttactc aagctcaaaa gggttttttt aagagcaagc
     6241 attggttaag tctgtgtata ctgagttgga agtgatttca gcacattctt ttttagtgga
     6301 gtgaaagttc tgaagccccc ttttaacttc ctcttggttt ttcattataa ttggtagcca
     6361 tctcatgaac tgtctctgac tgttgtctct ttgtggtcat gtgattgtga gcttgctttc
     6421 tgacttgcat ttctgacttt atcctgttgt taggaagata gaaactaggt tttgaaagat
     6481 tacatgattc aagcgaggga ttttaaagta aagatgtatt tattctgaag aatctaaaag
     6541 ataacagatt atttgcttat gaaagaacaa tatagtctgg gaatcccaga atgtcaagcc
     6601 aaaggtctaa gaagtcatct ccttcaaata ctttaataaa gaagtatttc gaggagatat
     6661 ctgtccaaaa aggtttgact ggcctccaga ttccagttat ttttaaaaag caacttacca
     6721 ctaaatcctt gagtctccat agagtaacag taaagaaact gatgtaacag actctcctct
     6781 caaaggatct cctctggaag agactatcag cggcagcatt ctccagggaa gacccatccc
     6841 ctagtgccag agcttgcatc ctggagacta aagattgcac ttttttgtag ttttttgtcc
     6901 aaatgcaatc ccatttctgt gcctcttagc atgcagttag atttggacaa acaagattcc
     6961 taaggaatga ctttattaac tataatatgg ttacagctat tatataaata tatattctgg
     7021 ttatagttct aatatggaga tgttgtgtgc aatgctggcc tgtggtggtc tgtgtaatgc
     7081 tttaacttgt atggaggagg ccaggctcag agctgagatg tggcctgaac cttccctgta
     7141 tcgatccttt aatttagaac tgtcaagatg tcactttctc cccctctgcc ttttagtggt
     7201 atctgacata tactcaaaac agtaatttcc tggtcacatc attaactgct aattctgtat
     7261 ttataaagaa ttttcagatg gacatgtaca aatttgaact caaaccatcc ccagtccaga
     7321 tacagggcag cgtgtaggtg accacaccag agcctcagcc tcggtccttc tcagccgtcg
     7381 ggataggatc caggcatttc ttttaaatct cagaggtagc agtaaacttt tcagtattgc
     7441 tgttagcaag tgtgtgtttg ccaatagata cccattatac taatgtgcca agtaaatgtt
     7501 cattgcacat ctgcttccac tgtgttccca cgggtgccat gaagtgtgtg aggagcccct
     7561 catctggagg gatgagtgct gcgttgacta ctgctatcag gattgtgttg tgtggaatat
     7621 tcatctacat aaattttata tgcacagtaa tttccctttt tatatgtcaa gtaactattt
     7681 gtaaaagtta tactcacaaa ttattataat gattactaat atattttttc catgtttcat
     7741 tgcctgaata aaaactgttt accactgtta
//
