LOCUS       NM_001352804            6080 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transforming acidic coiled-coil containing protein 1
            (TACC1), transcript variant 31, mRNA.
ACCESSION   NM_001352804 XM_011544638
VERSION     NM_001352804.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6080)
  AUTHORS   Wang,Y., Li,M., Zhang,L., Chen,Y. and Ha,M.
  TITLE     LINC01140 inhibits nonsmall cell lung cancer progression and
            cisplatin resistance through the miR-4742-5p/TACC1 axis
  JOURNAL   J Biochem Mol Toxicol 36 (7), e23048 (2022)
   PUBMED   35307914
  REMARK    GeneRIF: LINC01140 inhibits nonsmall cell lung cancer progression
            and cisplatin resistance through the miR-4742-5p/TACC1 axis.
REFERENCE   2  (bases 1 to 6080)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6080)
  AUTHORS   Devereaux,K.A., Weiel,J.J., Mills,A.M., Kunder,C.A. and
            Longacre,T.A.
  TITLE     Neurofibrosarcoma Revisited: An Institutional Case Series of
            Uterine Sarcomas Harboring Kinase-related Fusions With Report of a
            Novel FGFR1-TACC1 Fusion
  JOURNAL   Am J Surg Pathol 45 (5), 638-652 (2021)
   PUBMED   33481389
  REMARK    GeneRIF: Neurofibrosarcoma Revisited: An Institutional Case Series
            of Uterine Sarcomas Harboring Kinase-related Fusions With Report of
            a Novel FGFR1-TACC1 Fusion.
REFERENCE   4  (bases 1 to 6080)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6080)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6080)
  AUTHORS   Line,A., Stengrevics,A., Slucka,Z., Li,G., Jankevics,E. and
            Rees,R.C.
  TITLE     Serological identification and expression analysis of gastric
            cancer-associated genes
  JOURNAL   Br J Cancer 86 (11), 1824-1830 (2002)
   PUBMED   12087473
REFERENCE   7  (bases 1 to 6080)
  AUTHORS   Lauffart,B., Howell,S.J., Tasch,J.E., Cowell,J.K. and Still,I.H.
  TITLE     Interaction of the transforming acidic coiled-coil 1 (TACC1)
            protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
  JOURNAL   Biochem J 363 (Pt 1), 195-200 (2002)
   PUBMED   11903063
  REMARK    GeneRIF: Interaction of the transforming acidic coiled-coil 1
            (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
REFERENCE   8  (bases 1 to 6080)
  AUTHORS   Gergely,F., Karlsson,C., Still,I., Cowell,J., Kilmartin,J. and
            Raff,J.W.
  TITLE     The TACC domain identifies a family of centrosomal proteins that
            can interact with microtubules
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14352-14357 (2000)
   PUBMED   11121038
REFERENCE   9  (bases 1 to 6080)
  AUTHORS   Still,I.H., Hamilton,M., Vince,P., Wolfman,A. and Cowell,J.K.
  TITLE     Cloning of TACC1, an embryonically expressed, potentially
            transforming coiled coil containing gene, from the 8p11 breast
            cancer amplicon
  JOURNAL   Oncogene 18 (27), 4032-4038 (1999)
   PUBMED   10435627
REFERENCE   10 (bases 1 to 6080)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     The third member of the transforming acidic coiled coil-containing
            gene family, TACC3, maps in 4p16, close to translocation
            breakpoints in multiple myeloma, and is upregulated in various
            cancer cell lines
  JOURNAL   Genomics 58 (2), 165-170 (1999)
   PUBMED   10366448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016813.20 and AC067817.10.
            
            On May 31, 2019 this sequence version replaced NM_001352804.1.
            
            Summary: This locus may represent a breast cancer candidate gene.
            It is located close to FGFR1 on a region of chromosome 8 that is
            amplified in some breast cancers. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.28046.1,
                                           SRR1803614.274389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC016813.20        11605-11739         c
            136-196             AC067817.10        79664-79724
            197-317             AC067817.10        81524-81644
            318-370             AC067817.10        85481-85533
            371-496             AC067817.10        90518-90643
            497-573             AC067817.10        92826-92902
            574-617             AC067817.10        94580-94623
            618-778             AC067817.10        96643-96803
            779-885             AC067817.10        97645-97751
            886-1006            AC067817.10        101055-101175
            1007-6080           AC067817.10        102311-107384
FEATURES             Location/Qualifiers
     source          1..6080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..6080
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="transforming acidic coiled-coil containing protein
                     1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
     exon            1..135
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1075
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="isoform 23 is encoded by transcript variant 31;
                     gastric cancer antigen Ga55; taxin-1"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 1 isoform 23"
                     /protein_id="NP_001339733.1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
                     /translation="MGGSHSQTPRGREPAGERHPRPTETASGCKVKKHETQSLALDAC
                     SRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGIEKETCQKMEEDGST
                     VLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKK
                     YEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVE
                     RSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDK
                     ANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL
                     GKTD"
     exon            136..196
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            197..317
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            318..370
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            371..496
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            497..573
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            574..617
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            618..778
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            779..885
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1006
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..6080
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6057..6062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="hexamer: AATAAA"
     polyA_site      6080
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="major polyA site"
ORIGIN      
        1 gcacagccgc ccgccgccca gcacaggagg gtgcagcccc ggccccaagt tctgcgccat
       61 gggaggctcc cactctcaga ccccgagggg ccgggaaccc gccggggaga ggcacccgag
      121 acccacggag accgcgagtg gctgtaaggt gaagaagcat gaaactcagt ctctcgccct
      181 ggatgcatgt tctcgggatg aaggggcagt gatctcccag atttcagaca tttctaatag
      241 ggatggccat gctactgatg aggagaaact ggcatccacg tcatgtggtc agaaatcagc
      301 tggtgccgag gtgaaaggca tagagaagga gacgtgccag aagatggaag aagacgggtc
      361 cactgtgctt gggctgctgg agtcctctgc agagaaggcc cctgtgtcgg tgtcctgtgg
      421 aggtgagagc cccctggatg ggatctgcct cagcgaatca gacaagacag ccgtgctcac
      481 cttaataaga gaagagataa ttactaaaga gattgaagca aatgaatgga agaagaaata
      541 cgaagagacc cggcaagaag ttttggagat gaggaaaatt gtagctgaat atgaaaagac
      601 tattgctcaa atgattgaag atgaacaaag gacaagtatg acctctcaga agagcttcca
      661 gcaactgacc atggagaagg aacaggccct ggctgacctt aactctgtgg aaaggtccct
      721 ttctgatctc ttcaggagat atgagaacct gaaaggtgtt ctggaagggt tcaagaagaa
      781 tgaagaagcc ttgaagaaat gtgctcagga ttacttagcc agagttaaac aagaggagca
      841 gcgataccag gccctgaaaa tccacgcaga agagaaactg gacaaagcca atgaagagat
      901 tgctcaggtt cgaacaaaag caaaggctga gagtgcagct ctccatgctg gactccgcaa
      961 agagcagatg aaggtggagt ccctggaaag ggccctgcag cagaagaacc aagaaattga
     1021 agaactgaca aaaatctgtg atgagctgat tgcaaagctg ggaaagactg actgagacac
     1081 tccccctgtt agctcaacag atctgcattt ggctgcttct cttgtgacca caattatctt
     1141 gccttatcca ggaataattg cccctttgca gagaaaaaaa aaaacttaaa aaaagcacat
     1201 gcctactgct gcctgtcccg ctttgctgcc aatgcaacag ccctggaaga aaccctagag
     1261 ggttgcatag tctagaaagg agtgtgacct gacagtgctg gagcctccta gtttccccct
     1321 atgaaggttc ccttaggctg ctgagtttgg gtttgtgatt tatctttagt ttgttttaaa
     1381 gtcatcttta ctttcccaaa tgtgttaaat ttgtaactcc tctttggggt cttctccacc
     1441 acctgtctga tttttttgtg atctgtttaa tcttttaatt ttttagtatc agtggtttta
     1501 tttaaggaga cagtttggcc tattgttact tccaatttat aatcaagaag gggctctgga
     1561 tcccctttta aattacacac actctcacac acatacatgt atgtttatag atgctgctgc
     1621 tcttttccct gaagcatagt caagtaagaa ctgctctaca gaaggacata tttccttgga
     1681 tgtgagaccc tattttgaaa tagagtcctg actcagaaca ccaacttaag aatttggggg
     1741 attaaagatg tgaagaccac agtcttgggt tttcatatct ggagaagact atttgccatg
     1801 acgttttgtt gccctggtat ttggacactc ctcagcttta atgggtgtgg cccctttagg
     1861 gttagtcctc agactaatga tagtgtctgc tttctgcatg aacggcaata tgggactccc
     1921 tccaagctag ggtttggcaa gtctgcccta gagtcattta ctctcctctg cctccatttg
     1981 ttaatacaga atcaacattt agtcttcatt atcttttttt ttttttttga gacagagttt
     2041 cgatctattt taagtatgtg aagaaaatct acttgtaaaa ggctcagatc ttaattaaaa
     2101 ggtaattgta gcacattacc aattataagg tgaagaaatg tttttttccc aagtgtgatg
     2161 cattgttctt cagatgttga aaagaaagca aaaaatacct tctaacttaa gacagaattt
     2221 ttaacaaaat gagcagtaaa agtcacatga accactccaa aaatcagtgc attttgcata
     2281 tttttaaaca aagacagctt gttgaatact gagaagagga gtgcaaggag aaggtctgta
     2341 ctaacaaagc caaattcctc aagctcttac tggactcagt tcagagtggt gggccattaa
     2401 ccccaacatg gaatttttcc atataaatct caatgaattc cctttcattt gaataggcaa
     2461 acccaaatcc atgcaagtgt tttaaagcac tgtcctgtct taatcttaca tgctgaaagt
     2521 cttcatggtg atatgcacta tattcagtat acgtatgttt tcctacttct cttgtaaaac
     2581 tgttgcatga tccaacttca gcaatgaatt gtgcctagtg gagaacctct atagatctta
     2641 aaaaatgaat tattctttag cagtgtatta ctcacatggg tgcaatcttt agccccaggg
     2701 aggtcaataa tgtcttttaa agccagaagt cacattttac caatatgcat ttatcataat
     2761 tggtgcttag gctgtatatt caagcctgtt gtcttaacat tttgtataaa aaagaacaac
     2821 agaaattatc tgtcatttga gaagtggctt gacaatcatt tgagctttga aagcagtcac
     2881 tgtggtgtaa tatgaatgct gtcctagtgg tcatagtacc aagggcacgt gtctcccctt
     2941 ggtataactg atttcctttt tagtcctcta ctgctaaata agttaatttt gcattttgca
     3001 gaaagaaaca ttgattgcta aatctttttg ctgctgtgtt ttggtgtttt catgtttact
     3061 tgttttatat tgatctgttt taagtatgag aggcttatag tgccctccat tgtaaatcca
     3121 tagtcatctt tttaagctta ttgtgtttaa gaaagtagct atgtgttaaa cagaggtgat
     3181 ggcagccctt ccctagcaca ctggtggaag agacccctta agaacctgac cccagtgaat
     3241 gaagctgatg cacagggagc accaaaggac cttcgttaag tgataattgt cctggcctct
     3301 cagccatgac cgttatgagg aaatatcccc cattcgaact taacagatgc ctcctctcca
     3361 aagagaatta aaatcgtagc ttgtacagat caagagaata tactgggcag aatgaagtat
     3421 gtttgtttat ttttctttaa aaataaagga ttttggaact ctggagagta agaatatagt
     3481 atagagtttg cctcaacaca tgtgagggcc aaataacctg ctagctaggc agtaataaac
     3541 tctgttacag aagagaaaaa gggccgggca cagtggctta ttcctgtaat cccaacactg
     3601 tggaaggccg aggcaggagg atcacttgag tccaggagtt tgaaacctac ctaggcaaca
     3661 tggtgaaacc ttgtctctac caaaataaaa attagctggg catggtggca cgtgcctgtg
     3721 gtcccagcta cttgggaggc tgaggtggga gcctgggagg tcaaggctgc agtgagccat
     3781 gatcatgcca ctgcactcca tcctgggtga cagcaagatc ttgtctcaaa aaaaaaaaaa
     3841 aaaaaaaaaa aaccaggagt gaaaaaggaa agtagaaggc agctgctggc ctagatgttg
     3901 gtttgggaat attaggtgat cctgttgaga ttctggatcc agagcaattt ctttagcttt
     3961 tgactttgcc aaagtgtaga tagcctttat ccagcagtat tttaagtggg gaatgcaacg
     4021 tgaggccaac tgaacaattc cccccgtggc tgcccagata gtcacagtca aggttggaga
     4081 gtctccttcc agccagtgac ctacccaaac cttttgttct gtaaaactgc tctggaaata
     4141 ccgggaagcc cagttttctc acgtggtttc tagcttcttc agactcagcc caaattagga
     4201 agtgcagaag cacatgatgg tgaaaaacct aggatttggc agccttccag aatggtatgg
     4261 aatctgaggg aagatttatg tttcgttttg gaggatagct caagttgaat tttctttcca
     4321 gccagttacc ctttcaacct acccatactt tgtacaactc ttacacaaat acttagatat
     4381 ttattagata gccctgaatt cactctaatt ataaacaggg agtgtaaact gcccccagat
     4441 gttcctgggc tgggtaaaag cagctggagt gaagcactca ttttccataa aggtaacaaa
     4501 gggcagctca gtggttactc aagctcaaaa gggttttttt aagagcaagc attggttaag
     4561 tctgtgtata ctgagttgga agtgatttca gcacattctt ttttagtgga gtgaaagttc
     4621 tgaagccccc ttttaacttc ctcttggttt ttcattataa ttggtagcca tctcatgaac
     4681 tgtctctgac tgttgtctct ttgtggtcat gtgattgtga gcttgctttc tgacttgcat
     4741 ttctgacttt atcctgttgt taggaagata gaaactaggt tttgaaagat tacatgattc
     4801 aagcgaggga ttttaaagta aagatgtatt tattctgaag aatctaaaag ataacagatt
     4861 atttgcttat gaaagaacaa tatagtctgg gaatcccaga atgtcaagcc aaaggtctaa
     4921 gaagtcatct ccttcaaata ctttaataaa gaagtatttc gaggagatat ctgtccaaaa
     4981 aggtttgact ggcctccaga ttccagttat ttttaaaaag caacttacca ctaaatcctt
     5041 gagtctccat agagtaacag taaagaaact gatgtaacag actctcctct caaaggatct
     5101 cctctggaag agactatcag cggcagcatt ctccagggaa gacccatccc ctagtgccag
     5161 agcttgcatc ctggagacta aagattgcac ttttttgtag ttttttgtcc aaatgcaatc
     5221 ccatttctgt gcctcttagc atgcagttag atttggacaa acaagattcc taaggaatga
     5281 ctttattaac tataatatgg ttacagctat tatataaata tatattctgg ttatagttct
     5341 aatatggaga tgttgtgtgc aatgctggcc tgtggtggtc tgtgtaatgc tttaacttgt
     5401 atggaggagg ccaggctcag agctgagatg tggcctgaac cttccctgta tcgatccttt
     5461 aatttagaac tgtcaagatg tcactttctc cccctctgcc ttttagtggt atctgacata
     5521 tactcaaaac agtaatttcc tggtcacatc attaactgct aattctgtat ttataaagaa
     5581 ttttcagatg gacatgtaca aatttgaact caaaccatcc ccagtccaga tacagggcag
     5641 cgtgtaggtg accacaccag agcctcagcc tcggtccttc tcagccgtcg ggataggatc
     5701 caggcatttc ttttaaatct cagaggtagc agtaaacttt tcagtattgc tgttagcaag
     5761 tgtgtgtttg ccaatagata cccattatac taatgtgcca agtaaatgtt cattgcacat
     5821 ctgcttccac tgtgttccca cgggtgccat gaagtgtgtg aggagcccct catctggagg
     5881 gatgagtgct gcgttgacta ctgctatcag gattgtgttg tgtggaatat tcatctacat
     5941 aaattttata tgcacagtaa tttccctttt tatatgtcaa gtaactattt gtaaaagtta
     6001 tactcacaaa ttattataat gattactaat atattttttc catgtttcat tgcctgaata
     6061 aaaactgttt accactgtta
//
