LOCUS       NM_001352790            7281 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transforming acidic coiled-coil containing protein 1
            (TACC1), transcript variant 17, mRNA.
ACCESSION   NM_001352790 XM_017013774
VERSION     NM_001352790.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7281)
  AUTHORS   Wang,Y., Li,M., Zhang,L., Chen,Y. and Ha,M.
  TITLE     LINC01140 inhibits nonsmall cell lung cancer progression and
            cisplatin resistance through the miR-4742-5p/TACC1 axis
  JOURNAL   J Biochem Mol Toxicol 36 (7), e23048 (2022)
   PUBMED   35307914
  REMARK    GeneRIF: LINC01140 inhibits nonsmall cell lung cancer progression
            and cisplatin resistance through the miR-4742-5p/TACC1 axis.
REFERENCE   2  (bases 1 to 7281)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7281)
  AUTHORS   Devereaux,K.A., Weiel,J.J., Mills,A.M., Kunder,C.A. and
            Longacre,T.A.
  TITLE     Neurofibrosarcoma Revisited: An Institutional Case Series of
            Uterine Sarcomas Harboring Kinase-related Fusions With Report of a
            Novel FGFR1-TACC1 Fusion
  JOURNAL   Am J Surg Pathol 45 (5), 638-652 (2021)
   PUBMED   33481389
  REMARK    GeneRIF: Neurofibrosarcoma Revisited: An Institutional Case Series
            of Uterine Sarcomas Harboring Kinase-related Fusions With Report of
            a Novel FGFR1-TACC1 Fusion.
REFERENCE   4  (bases 1 to 7281)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7281)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7281)
  AUTHORS   Line,A., Stengrevics,A., Slucka,Z., Li,G., Jankevics,E. and
            Rees,R.C.
  TITLE     Serological identification and expression analysis of gastric
            cancer-associated genes
  JOURNAL   Br J Cancer 86 (11), 1824-1830 (2002)
   PUBMED   12087473
REFERENCE   7  (bases 1 to 7281)
  AUTHORS   Lauffart,B., Howell,S.J., Tasch,J.E., Cowell,J.K. and Still,I.H.
  TITLE     Interaction of the transforming acidic coiled-coil 1 (TACC1)
            protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
  JOURNAL   Biochem J 363 (Pt 1), 195-200 (2002)
   PUBMED   11903063
  REMARK    GeneRIF: Interaction of the transforming acidic coiled-coil 1
            (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
REFERENCE   8  (bases 1 to 7281)
  AUTHORS   Gergely,F., Karlsson,C., Still,I., Cowell,J., Kilmartin,J. and
            Raff,J.W.
  TITLE     The TACC domain identifies a family of centrosomal proteins that
            can interact with microtubules
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14352-14357 (2000)
   PUBMED   11121038
REFERENCE   9  (bases 1 to 7281)
  AUTHORS   Still,I.H., Hamilton,M., Vince,P., Wolfman,A. and Cowell,J.K.
  TITLE     Cloning of TACC1, an embryonically expressed, potentially
            transforming coiled coil containing gene, from the 8p11 breast
            cancer amplicon
  JOURNAL   Oncogene 18 (27), 4032-4038 (1999)
   PUBMED   10435627
REFERENCE   10 (bases 1 to 7281)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     The third member of the transforming acidic coiled coil-containing
            gene family, TACC3, maps in 4p16, close to translocation
            breakpoints in multiple myeloma, and is upregulated in various
            cancer cell lines
  JOURNAL   Genomics 58 (2), 165-170 (1999)
   PUBMED   10366448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016813.20 and AC067817.10.
            
            On May 31, 2019 this sequence version replaced NM_001352790.1.
            
            Summary: This locus may represent a breast cancer candidate gene.
            It is located close to FGFR1 on a region of chromosome 8 that is
            amplified in some breast cancers. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2017].
            
            Transcript Variant: This variant (17), as well as variants 3, 16,
            and 18, encodes isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.155878.1,
                                           SRR1803612.15834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC016813.20        11605-11739         c
            136-1249            AC067817.10        73878-74991
            1250-1310           AC067817.10        79664-79724
            1311-1518           AC067817.10        81524-81731
            1519-1571           AC067817.10        85481-85533
            1572-1697           AC067817.10        90518-90643
            1698-1774           AC067817.10        92826-92902
            1775-1818           AC067817.10        94580-94623
            1819-1979           AC067817.10        96643-96803
            1980-2086           AC067817.10        97645-97751
            2087-2207           AC067817.10        101055-101175
            2208-7281           AC067817.10        102311-107384
FEATURES             Location/Qualifiers
     source          1..7281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..7281
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="transforming acidic coiled-coil containing protein
                     1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
     exon            1..135
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            136..1249
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..2276
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="isoform 3 is encoded by transcript variant 17;
                     gastric cancer antigen Ga55; taxin-1"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 1 isoform 3"
                     /protein_id="NP_001339719.1"
                     /db_xref="CCDS:CCDS55224.1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
                     /translation="MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLR
                     KKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGT
                     LSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQK
                     DGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEG
                     SYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKK
                     HETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEE
                     DLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSC
                     GGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEY
                     EKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLE
                     GFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAA
                     LHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD"
     exon            1250..1310
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1518
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1571
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1697
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1774
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1818
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1979
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2086
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2207
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..7281
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7258..7263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="hexamer: AATAAA"
     polyA_site      7281
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="major polyA site"
ORIGIN      
        1 gcacagccgc ccgccgccca gcacaggagg gtgcagcccc ggccccaagt tctgcgccat
       61 gggaggctcc cactctcaga ccccgagggg ccgggaaccc gccggggaga ggcacccgag
      121 acccacggag accgcaatca caagaagctg atgaacagct tgtagcagaa gtggttgaaa
      181 aatgttcatc taagacttgt tctaaacctt cagaaaatga agtgccacag caggccattg
      241 actctcactc agtcaagaat ttcagagaag aacctgaaca tgattttagc aaaatttcca
      301 tcgtgaggcc attttcaata gaaacgaagg attccacgga tatctcggca gtcctcggaa
      361 caaaagcagc tcatggctgt gtaactgcag tctcaggcaa ggctctgcct tccagcccgc
      421 cagacgccct ccaggacgag gcgatgacag aaggcagcat gggggtcacc ctcgaggcct
      481 ccgcagaagc tgatctaaaa gctggcaact cctgtccaga gcttgtgccc agcagaagaa
      541 gcaagctgag aaagcccaag cctgtccccc tgaggaagaa agcaattgga ggagagttct
      601 cagacaccaa cgctgctgtg gagggcacac ctctccccaa ggcatcctat cacttcagtc
      661 ctgaagagtt ggatgagaac acaagtcctt tgctaggaga tgccaggttc cagaagtctc
      721 cccctgacct taaagaaact cccggcactc tcagtagtga caccaacgac tcaggggttg
      781 agctggggga ggagtcgagg agctcacctc tcaagcttga gtttgatttc acagaagata
      841 caggaaacat agaggccagg aaagcccttc caaggaagct tggcaggaaa ctgggtagca
      901 cactgactcc caagatacaa aaagatggca tcagtaagtc agcaggttta gaacagccta
      961 cagacccagt ggcacgagac gggcctctct cccaaacatc ttccaagcca gatcctagtc
     1021 agtgggaaag ccccagcttc aacccctttg ggagccactc tgttctgcag aactccccac
     1081 ccctctcttc tgagggctcc taccactttg acccagataa ctttgacgaa tccatggatc
     1141 cctttaaacc aactacgacc ttaacaagca gtgacttttg ttctcccact ggtaatcacg
     1201 ttaatgaaat cttagaatca cccaagaagg caaagtcgcg tttaataacg agtggctgta
     1261 aggtgaagaa gcatgaaact cagtctctcg ccctggatgc atgttctcgg gatgaagggg
     1321 cagtgatctc ccagatttca gacatttcta atagggatgg ccatgctact gatgaggaga
     1381 aactggcatc cacgtcatgt ggtcagaaat cagctggtgc cgaggtgaaa ggtgagccag
     1441 aggaagacct ggagtacttt gaatgttcca atgttcctgt gtctaccata aatcatgcgt
     1501 tttcatcctc agaagcaggc atagagaagg agacgtgcca gaagatggaa gaagacgggt
     1561 ccactgtgct tgggctgctg gagtcctctg cagagaaggc ccctgtgtcg gtgtcctgtg
     1621 gaggtgagag ccccctggat gggatctgcc tcagcgaatc agacaagaca gccgtgctca
     1681 ccttaataag agaagagata attactaaag agattgaagc aaatgaatgg aagaagaaat
     1741 acgaagagac ccggcaagaa gttttggaga tgaggaaaat tgtagctgaa tatgaaaaga
     1801 ctattgctca aatgattgaa gatgaacaaa ggacaagtat gacctctcag aagagcttcc
     1861 agcaactgac catggagaag gaacaggccc tggctgacct taactctgtg gaaaggtccc
     1921 tttctgatct cttcaggaga tatgagaacc tgaaaggtgt tctggaaggg ttcaagaaga
     1981 atgaagaagc cttgaagaaa tgtgctcagg attacttagc cagagttaaa caagaggagc
     2041 agcgatacca ggccctgaaa atccacgcag aagagaaact ggacaaagcc aatgaagaga
     2101 ttgctcaggt tcgaacaaaa gcaaaggctg agagtgcagc tctccatgct ggactccgca
     2161 aagagcagat gaaggtggag tccctggaaa gggccctgca gcagaagaac caagaaattg
     2221 aagaactgac aaaaatctgt gatgagctga ttgcaaagct gggaaagact gactgagaca
     2281 ctccccctgt tagctcaaca gatctgcatt tggctgcttc tcttgtgacc acaattatct
     2341 tgccttatcc aggaataatt gcccctttgc agagaaaaaa aaaaacttaa aaaaagcaca
     2401 tgcctactgc tgcctgtccc gctttgctgc caatgcaaca gccctggaag aaaccctaga
     2461 gggttgcata gtctagaaag gagtgtgacc tgacagtgct ggagcctcct agtttccccc
     2521 tatgaaggtt cccttaggct gctgagtttg ggtttgtgat ttatctttag tttgttttaa
     2581 agtcatcttt actttcccaa atgtgttaaa tttgtaactc ctctttgggg tcttctccac
     2641 cacctgtctg atttttttgt gatctgttta atcttttaat tttttagtat cagtggtttt
     2701 atttaaggag acagtttggc ctattgttac ttccaattta taatcaagaa ggggctctgg
     2761 atcccctttt aaattacaca cactctcaca cacatacatg tatgtttata gatgctgctg
     2821 ctcttttccc tgaagcatag tcaagtaaga actgctctac agaaggacat atttccttgg
     2881 atgtgagacc ctattttgaa atagagtcct gactcagaac accaacttaa gaatttgggg
     2941 gattaaagat gtgaagacca cagtcttggg ttttcatatc tggagaagac tatttgccat
     3001 gacgttttgt tgccctggta tttggacact cctcagcttt aatgggtgtg gcccctttag
     3061 ggttagtcct cagactaatg atagtgtctg ctttctgcat gaacggcaat atgggactcc
     3121 ctccaagcta gggtttggca agtctgccct agagtcattt actctcctct gcctccattt
     3181 gttaatacag aatcaacatt tagtcttcat tatctttttt tttttttttg agacagagtt
     3241 tcgatctatt ttaagtatgt gaagaaaatc tacttgtaaa aggctcagat cttaattaaa
     3301 aggtaattgt agcacattac caattataag gtgaagaaat gtttttttcc caagtgtgat
     3361 gcattgttct tcagatgttg aaaagaaagc aaaaaatacc ttctaactta agacagaatt
     3421 tttaacaaaa tgagcagtaa aagtcacatg aaccactcca aaaatcagtg cattttgcat
     3481 atttttaaac aaagacagct tgttgaatac tgagaagagg agtgcaagga gaaggtctgt
     3541 actaacaaag ccaaattcct caagctctta ctggactcag ttcagagtgg tgggccatta
     3601 accccaacat ggaatttttc catataaatc tcaatgaatt ccctttcatt tgaataggca
     3661 aacccaaatc catgcaagtg ttttaaagca ctgtcctgtc ttaatcttac atgctgaaag
     3721 tcttcatggt gatatgcact atattcagta tacgtatgtt ttcctacttc tcttgtaaaa
     3781 ctgttgcatg atccaacttc agcaatgaat tgtgcctagt ggagaacctc tatagatctt
     3841 aaaaaatgaa ttattcttta gcagtgtatt actcacatgg gtgcaatctt tagccccagg
     3901 gaggtcaata atgtctttta aagccagaag tcacatttta ccaatatgca tttatcataa
     3961 ttggtgctta ggctgtatat tcaagcctgt tgtcttaaca ttttgtataa aaaagaacaa
     4021 cagaaattat ctgtcatttg agaagtggct tgacaatcat ttgagctttg aaagcagtca
     4081 ctgtggtgta atatgaatgc tgtcctagtg gtcatagtac caagggcacg tgtctcccct
     4141 tggtataact gatttccttt ttagtcctct actgctaaat aagttaattt tgcattttgc
     4201 agaaagaaac attgattgct aaatcttttt gctgctgtgt tttggtgttt tcatgtttac
     4261 ttgttttata ttgatctgtt ttaagtatga gaggcttata gtgccctcca ttgtaaatcc
     4321 atagtcatct ttttaagctt attgtgttta agaaagtagc tatgtgttaa acagaggtga
     4381 tggcagccct tccctagcac actggtggaa gagacccctt aagaacctga ccccagtgaa
     4441 tgaagctgat gcacagggag caccaaagga ccttcgttaa gtgataattg tcctggcctc
     4501 tcagccatga ccgttatgag gaaatatccc ccattcgaac ttaacagatg cctcctctcc
     4561 aaagagaatt aaaatcgtag cttgtacaga tcaagagaat atactgggca gaatgaagta
     4621 tgtttgttta tttttcttta aaaataaagg attttggaac tctggagagt aagaatatag
     4681 tatagagttt gcctcaacac atgtgagggc caaataacct gctagctagg cagtaataaa
     4741 ctctgttaca gaagagaaaa agggccgggc acagtggctt attcctgtaa tcccaacact
     4801 gtggaaggcc gaggcaggag gatcacttga gtccaggagt ttgaaaccta cctaggcaac
     4861 atggtgaaac cttgtctcta ccaaaataaa aattagctgg gcatggtggc acgtgcctgt
     4921 ggtcccagct acttgggagg ctgaggtggg agcctgggag gtcaaggctg cagtgagcca
     4981 tgatcatgcc actgcactcc atcctgggtg acagcaagat cttgtctcaa aaaaaaaaaa
     5041 aaaaaaaaaa aaaccaggag tgaaaaagga aagtagaagg cagctgctgg cctagatgtt
     5101 ggtttgggaa tattaggtga tcctgttgag attctggatc cagagcaatt tctttagctt
     5161 ttgactttgc caaagtgtag atagccttta tccagcagta ttttaagtgg ggaatgcaac
     5221 gtgaggccaa ctgaacaatt ccccccgtgg ctgcccagat agtcacagtc aaggttggag
     5281 agtctccttc cagccagtga cctacccaaa ccttttgttc tgtaaaactg ctctggaaat
     5341 accgggaagc ccagttttct cacgtggttt ctagcttctt cagactcagc ccaaattagg
     5401 aagtgcagaa gcacatgatg gtgaaaaacc taggatttgg cagccttcca gaatggtatg
     5461 gaatctgagg gaagatttat gtttcgtttt ggaggatagc tcaagttgaa ttttctttcc
     5521 agccagttac cctttcaacc tacccatact ttgtacaact cttacacaaa tacttagata
     5581 tttattagat agccctgaat tcactctaat tataaacagg gagtgtaaac tgcccccaga
     5641 tgttcctggg ctgggtaaaa gcagctggag tgaagcactc attttccata aaggtaacaa
     5701 agggcagctc agtggttact caagctcaaa agggtttttt taagagcaag cattggttaa
     5761 gtctgtgtat actgagttgg aagtgatttc agcacattct tttttagtgg agtgaaagtt
     5821 ctgaagcccc cttttaactt cctcttggtt tttcattata attggtagcc atctcatgaa
     5881 ctgtctctga ctgttgtctc tttgtggtca tgtgattgtg agcttgcttt ctgacttgca
     5941 tttctgactt tatcctgttg ttaggaagat agaaactagg ttttgaaaga ttacatgatt
     6001 caagcgaggg attttaaagt aaagatgtat ttattctgaa gaatctaaaa gataacagat
     6061 tatttgctta tgaaagaaca atatagtctg ggaatcccag aatgtcaagc caaaggtcta
     6121 agaagtcatc tccttcaaat actttaataa agaagtattt cgaggagata tctgtccaaa
     6181 aaggtttgac tggcctccag attccagtta tttttaaaaa gcaacttacc actaaatcct
     6241 tgagtctcca tagagtaaca gtaaagaaac tgatgtaaca gactctcctc tcaaaggatc
     6301 tcctctggaa gagactatca gcggcagcat tctccaggga agacccatcc cctagtgcca
     6361 gagcttgcat cctggagact aaagattgca cttttttgta gttttttgtc caaatgcaat
     6421 cccatttctg tgcctcttag catgcagtta gatttggaca aacaagattc ctaaggaatg
     6481 actttattaa ctataatatg gttacagcta ttatataaat atatattctg gttatagttc
     6541 taatatggag atgttgtgtg caatgctggc ctgtggtggt ctgtgtaatg ctttaacttg
     6601 tatggaggag gccaggctca gagctgagat gtggcctgaa ccttccctgt atcgatcctt
     6661 taatttagaa ctgtcaagat gtcactttct ccccctctgc cttttagtgg tatctgacat
     6721 atactcaaaa cagtaatttc ctggtcacat cattaactgc taattctgta tttataaaga
     6781 attttcagat ggacatgtac aaatttgaac tcaaaccatc cccagtccag atacagggca
     6841 gcgtgtaggt gaccacacca gagcctcagc ctcggtcctt ctcagccgtc gggataggat
     6901 ccaggcattt cttttaaatc tcagaggtag cagtaaactt ttcagtattg ctgttagcaa
     6961 gtgtgtgttt gccaatagat acccattata ctaatgtgcc aagtaaatgt tcattgcaca
     7021 tctgcttcca ctgtgttccc acgggtgcca tgaagtgtgt gaggagcccc tcatctggag
     7081 ggatgagtgc tgcgttgact actgctatca ggattgtgtt gtgtggaata ttcatctaca
     7141 taaattttat atgcacagta atttcccttt ttatatgtca agtaactatt tgtaaaagtt
     7201 atactcacaa attattataa tgattactaa tatatttttt ccatgtttca ttgcctgaat
     7261 aaaaactgtt taccactgtt a
//
