LOCUS       NM_001352788            7388 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transforming acidic coiled-coil containing protein 1
            (TACC1), transcript variant 15, mRNA.
ACCESSION   NM_001352788 XM_005273630
VERSION     NM_001352788.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7388)
  AUTHORS   Wang,Y., Li,M., Zhang,L., Chen,Y. and Ha,M.
  TITLE     LINC01140 inhibits nonsmall cell lung cancer progression and
            cisplatin resistance through the miR-4742-5p/TACC1 axis
  JOURNAL   J Biochem Mol Toxicol 36 (7), e23048 (2022)
   PUBMED   35307914
  REMARK    GeneRIF: LINC01140 inhibits nonsmall cell lung cancer progression
            and cisplatin resistance through the miR-4742-5p/TACC1 axis.
REFERENCE   2  (bases 1 to 7388)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7388)
  AUTHORS   Devereaux,K.A., Weiel,J.J., Mills,A.M., Kunder,C.A. and
            Longacre,T.A.
  TITLE     Neurofibrosarcoma Revisited: An Institutional Case Series of
            Uterine Sarcomas Harboring Kinase-related Fusions With Report of a
            Novel FGFR1-TACC1 Fusion
  JOURNAL   Am J Surg Pathol 45 (5), 638-652 (2021)
   PUBMED   33481389
  REMARK    GeneRIF: Neurofibrosarcoma Revisited: An Institutional Case Series
            of Uterine Sarcomas Harboring Kinase-related Fusions With Report of
            a Novel FGFR1-TACC1 Fusion.
REFERENCE   4  (bases 1 to 7388)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7388)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7388)
  AUTHORS   Line,A., Stengrevics,A., Slucka,Z., Li,G., Jankevics,E. and
            Rees,R.C.
  TITLE     Serological identification and expression analysis of gastric
            cancer-associated genes
  JOURNAL   Br J Cancer 86 (11), 1824-1830 (2002)
   PUBMED   12087473
REFERENCE   7  (bases 1 to 7388)
  AUTHORS   Lauffart,B., Howell,S.J., Tasch,J.E., Cowell,J.K. and Still,I.H.
  TITLE     Interaction of the transforming acidic coiled-coil 1 (TACC1)
            protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
  JOURNAL   Biochem J 363 (Pt 1), 195-200 (2002)
   PUBMED   11903063
  REMARK    GeneRIF: Interaction of the transforming acidic coiled-coil 1
            (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple
            TACC1-containing protein complexes in human cells
REFERENCE   8  (bases 1 to 7388)
  AUTHORS   Gergely,F., Karlsson,C., Still,I., Cowell,J., Kilmartin,J. and
            Raff,J.W.
  TITLE     The TACC domain identifies a family of centrosomal proteins that
            can interact with microtubules
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14352-14357 (2000)
   PUBMED   11121038
REFERENCE   9  (bases 1 to 7388)
  AUTHORS   Still,I.H., Hamilton,M., Vince,P., Wolfman,A. and Cowell,J.K.
  TITLE     Cloning of TACC1, an embryonically expressed, potentially
            transforming coiled coil containing gene, from the 8p11 breast
            cancer amplicon
  JOURNAL   Oncogene 18 (27), 4032-4038 (1999)
   PUBMED   10435627
REFERENCE   10 (bases 1 to 7388)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     The third member of the transforming acidic coiled coil-containing
            gene family, TACC3, maps in 4p16, close to translocation
            breakpoints in multiple myeloma, and is upregulated in various
            cancer cell lines
  JOURNAL   Genomics 58 (2), 165-170 (1999)
   PUBMED   10366448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016813.20 and AC067817.10.
            
            On May 31, 2019 this sequence version replaced NM_001352788.1.
            
            Summary: This locus may represent a breast cancer candidate gene.
            It is located close to FGFR1 on a region of chromosome 8 that is
            amplified in some breast cancers. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.43656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC016813.20        40343-40432         c
            91-206              AC067817.10        43060-43175
            207-1320            AC067817.10        73878-74991
            1321-1356           AC067817.10        78346-78381
            1357-1417           AC067817.10        79664-79724
            1418-1625           AC067817.10        81524-81731
            1626-1678           AC067817.10        85481-85533
            1679-1804           AC067817.10        90518-90643
            1805-1881           AC067817.10        92826-92902
            1882-1925           AC067817.10        94580-94623
            1926-2086           AC067817.10        96643-96803
            2087-2193           AC067817.10        97645-97751
            2194-2314           AC067817.10        101055-101175
            2315-7388           AC067817.10        102311-107384
FEATURES             Location/Qualifiers
     source          1..7388
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..7388
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="transforming acidic coiled-coil containing protein
                     1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
     exon            1..90
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            91..206
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            207..1320
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..2383
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="isoform 15 is encoded by transcript variant 15;
                     gastric cancer antigen Ga55; taxin-1"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 1 isoform 15"
                     /protein_id="NP_001339717.1"
                     /db_xref="GeneID:6867"
                     /db_xref="HGNC:HGNC:11522"
                     /db_xref="MIM:605301"
                     /translation="MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLR
                     KKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGT
                     LSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQK
                     DGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEG
                     SYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITTTEQVKF
                     LCFLLSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQK
                     SAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLE
                     SSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQ
                     EVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDL
                     FRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIA
                     QVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD"
     exon            1321..1356
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1417
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1625
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1678
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1804
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1881
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1925
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2086
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2193
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2314
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..7388
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7365..7370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="hexamer: AATAAA"
     polyA_site      7388
                     /gene="TACC1"
                     /gene_synonym="Ga55"
                     /note="major polyA site"
ORIGIN      
        1 aggagagatg cgaaatcagc ggtagcaggt ggcgcagaag ggagagggga gcgaccctgg
       61 ggaccgactc tggggaccct cgccgaagag ctcggattct gaaggtaatt ttgagactcc
      121 tgaagctgaa accccgatcc gatcaccttt caaggagtcc tgtgatccat cactcggatt
      181 ggcaggacct ggggccaaaa gccaagaatc acaagaagct gatgaacagc ttgtagcaga
      241 agtggttgaa aaatgttcat ctaagacttg ttctaaacct tcagaaaatg aagtgccaca
      301 gcaggccatt gactctcact cagtcaagaa tttcagagaa gaacctgaac atgattttag
      361 caaaatttcc atcgtgaggc cattttcaat agaaacgaag gattccacgg atatctcggc
      421 agtcctcgga acaaaagcag ctcatggctg tgtaactgca gtctcaggca aggctctgcc
      481 ttccagcccg ccagacgccc tccaggacga ggcgatgaca gaaggcagca tgggggtcac
      541 cctcgaggcc tccgcagaag ctgatctaaa agctggcaac tcctgtccag agcttgtgcc
      601 cagcagaaga agcaagctga gaaagcccaa gcctgtcccc ctgaggaaga aagcaattgg
      661 aggagagttc tcagacacca acgctgctgt ggagggcaca cctctcccca aggcatccta
      721 tcacttcagt cctgaagagt tggatgagaa cacaagtcct ttgctaggag atgccaggtt
      781 ccagaagtct ccccctgacc ttaaagaaac tcccggcact ctcagtagtg acaccaacga
      841 ctcaggggtt gagctggggg aggagtcgag gagctcacct ctcaagcttg agtttgattt
      901 cacagaagat acaggaaaca tagaggccag gaaagccctt ccaaggaagc ttggcaggaa
      961 actgggtagc acactgactc ccaagataca aaaagatggc atcagtaagt cagcaggttt
     1021 agaacagcct acagacccag tggcacgaga cgggcctctc tcccaaacat cttccaagcc
     1081 agatcctagt cagtgggaaa gccccagctt caaccccttt gggagccact ctgttctgca
     1141 gaactcccca cccctctctt ctgagggctc ctaccacttt gacccagata actttgacga
     1201 atccatggat ccctttaaac caactacgac cttaacaagc agtgactttt gttctcccac
     1261 tggtaatcac gttaatgaaa tcttagaatc acccaagaag gcaaagtcgc gtttaataac
     1321 gactactgaa caagtgaaat ttctctgttt tctgttgagt ggctgtaagg tgaagaagca
     1381 tgaaactcag tctctcgccc tggatgcatg ttctcgggat gaaggggcag tgatctccca
     1441 gatttcagac atttctaata gggatggcca tgctactgat gaggagaaac tggcatccac
     1501 gtcatgtggt cagaaatcag ctggtgccga ggtgaaaggt gagccagagg aagacctgga
     1561 gtactttgaa tgttccaatg ttcctgtgtc taccataaat catgcgtttt catcctcaga
     1621 agcaggcata gagaaggaga cgtgccagaa gatggaagaa gacgggtcca ctgtgcttgg
     1681 gctgctggag tcctctgcag agaaggcccc tgtgtcggtg tcctgtggag gtgagagccc
     1741 cctggatggg atctgcctca gcgaatcaga caagacagcc gtgctcacct taataagaga
     1801 agagataatt actaaagaga ttgaagcaaa tgaatggaag aagaaatacg aagagacccg
     1861 gcaagaagtt ttggagatga ggaaaattgt agctgaatat gaaaagacta ttgctcaaat
     1921 gattgaagat gaacaaagga caagtatgac ctctcagaag agcttccagc aactgaccat
     1981 ggagaaggaa caggccctgg ctgaccttaa ctctgtggaa aggtcccttt ctgatctctt
     2041 caggagatat gagaacctga aaggtgttct ggaagggttc aagaagaatg aagaagcctt
     2101 gaagaaatgt gctcaggatt acttagccag agttaaacaa gaggagcagc gataccaggc
     2161 cctgaaaatc cacgcagaag agaaactgga caaagccaat gaagagattg ctcaggttcg
     2221 aacaaaagca aaggctgaga gtgcagctct ccatgctgga ctccgcaaag agcagatgaa
     2281 ggtggagtcc ctggaaaggg ccctgcagca gaagaaccaa gaaattgaag aactgacaaa
     2341 aatctgtgat gagctgattg caaagctggg aaagactgac tgagacactc cccctgttag
     2401 ctcaacagat ctgcatttgg ctgcttctct tgtgaccaca attatcttgc cttatccagg
     2461 aataattgcc cctttgcaga gaaaaaaaaa aacttaaaaa aagcacatgc ctactgctgc
     2521 ctgtcccgct ttgctgccaa tgcaacagcc ctggaagaaa ccctagaggg ttgcatagtc
     2581 tagaaaggag tgtgacctga cagtgctgga gcctcctagt ttccccctat gaaggttccc
     2641 ttaggctgct gagtttgggt ttgtgattta tctttagttt gttttaaagt catctttact
     2701 ttcccaaatg tgttaaattt gtaactcctc tttggggtct tctccaccac ctgtctgatt
     2761 tttttgtgat ctgtttaatc ttttaatttt ttagtatcag tggttttatt taaggagaca
     2821 gtttggccta ttgttacttc caatttataa tcaagaaggg gctctggatc cccttttaaa
     2881 ttacacacac tctcacacac atacatgtat gtttatagat gctgctgctc ttttccctga
     2941 agcatagtca agtaagaact gctctacaga aggacatatt tccttggatg tgagacccta
     3001 ttttgaaata gagtcctgac tcagaacacc aacttaagaa tttgggggat taaagatgtg
     3061 aagaccacag tcttgggttt tcatatctgg agaagactat ttgccatgac gttttgttgc
     3121 cctggtattt ggacactcct cagctttaat gggtgtggcc cctttagggt tagtcctcag
     3181 actaatgata gtgtctgctt tctgcatgaa cggcaatatg ggactccctc caagctaggg
     3241 tttggcaagt ctgccctaga gtcatttact ctcctctgcc tccatttgtt aatacagaat
     3301 caacatttag tcttcattat cttttttttt ttttttgaga cagagtttcg atctatttta
     3361 agtatgtgaa gaaaatctac ttgtaaaagg ctcagatctt aattaaaagg taattgtagc
     3421 acattaccaa ttataaggtg aagaaatgtt tttttcccaa gtgtgatgca ttgttcttca
     3481 gatgttgaaa agaaagcaaa aaataccttc taacttaaga cagaattttt aacaaaatga
     3541 gcagtaaaag tcacatgaac cactccaaaa atcagtgcat tttgcatatt tttaaacaaa
     3601 gacagcttgt tgaatactga gaagaggagt gcaaggagaa ggtctgtact aacaaagcca
     3661 aattcctcaa gctcttactg gactcagttc agagtggtgg gccattaacc ccaacatgga
     3721 atttttccat ataaatctca atgaattccc tttcatttga ataggcaaac ccaaatccat
     3781 gcaagtgttt taaagcactg tcctgtctta atcttacatg ctgaaagtct tcatggtgat
     3841 atgcactata ttcagtatac gtatgttttc ctacttctct tgtaaaactg ttgcatgatc
     3901 caacttcagc aatgaattgt gcctagtgga gaacctctat agatcttaaa aaatgaatta
     3961 ttctttagca gtgtattact cacatgggtg caatctttag ccccagggag gtcaataatg
     4021 tcttttaaag ccagaagtca cattttacca atatgcattt atcataattg gtgcttaggc
     4081 tgtatattca agcctgttgt cttaacattt tgtataaaaa agaacaacag aaattatctg
     4141 tcatttgaga agtggcttga caatcatttg agctttgaaa gcagtcactg tggtgtaata
     4201 tgaatgctgt cctagtggtc atagtaccaa gggcacgtgt ctccccttgg tataactgat
     4261 ttccttttta gtcctctact gctaaataag ttaattttgc attttgcaga aagaaacatt
     4321 gattgctaaa tctttttgct gctgtgtttt ggtgttttca tgtttacttg ttttatattg
     4381 atctgtttta agtatgagag gcttatagtg ccctccattg taaatccata gtcatctttt
     4441 taagcttatt gtgtttaaga aagtagctat gtgttaaaca gaggtgatgg cagcccttcc
     4501 ctagcacact ggtggaagag accccttaag aacctgaccc cagtgaatga agctgatgca
     4561 cagggagcac caaaggacct tcgttaagtg ataattgtcc tggcctctca gccatgaccg
     4621 ttatgaggaa atatccccca ttcgaactta acagatgcct cctctccaaa gagaattaaa
     4681 atcgtagctt gtacagatca agagaatata ctgggcagaa tgaagtatgt ttgtttattt
     4741 ttctttaaaa ataaaggatt ttggaactct ggagagtaag aatatagtat agagtttgcc
     4801 tcaacacatg tgagggccaa ataacctgct agctaggcag taataaactc tgttacagaa
     4861 gagaaaaagg gccgggcaca gtggcttatt cctgtaatcc caacactgtg gaaggccgag
     4921 gcaggaggat cacttgagtc caggagtttg aaacctacct aggcaacatg gtgaaacctt
     4981 gtctctacca aaataaaaat tagctgggca tggtggcacg tgcctgtggt cccagctact
     5041 tgggaggctg aggtgggagc ctgggaggtc aaggctgcag tgagccatga tcatgccact
     5101 gcactccatc ctgggtgaca gcaagatctt gtctcaaaaa aaaaaaaaaa aaaaaaaaaa
     5161 ccaggagtga aaaaggaaag tagaaggcag ctgctggcct agatgttggt ttgggaatat
     5221 taggtgatcc tgttgagatt ctggatccag agcaatttct ttagcttttg actttgccaa
     5281 agtgtagata gcctttatcc agcagtattt taagtgggga atgcaacgtg aggccaactg
     5341 aacaattccc cccgtggctg cccagatagt cacagtcaag gttggagagt ctccttccag
     5401 ccagtgacct acccaaacct tttgttctgt aaaactgctc tggaaatacc gggaagccca
     5461 gttttctcac gtggtttcta gcttcttcag actcagccca aattaggaag tgcagaagca
     5521 catgatggtg aaaaacctag gatttggcag ccttccagaa tggtatggaa tctgagggaa
     5581 gatttatgtt tcgttttgga ggatagctca agttgaattt tctttccagc cagttaccct
     5641 ttcaacctac ccatactttg tacaactctt acacaaatac ttagatattt attagatagc
     5701 cctgaattca ctctaattat aaacagggag tgtaaactgc ccccagatgt tcctgggctg
     5761 ggtaaaagca gctggagtga agcactcatt ttccataaag gtaacaaagg gcagctcagt
     5821 ggttactcaa gctcaaaagg gtttttttaa gagcaagcat tggttaagtc tgtgtatact
     5881 gagttggaag tgatttcagc acattctttt ttagtggagt gaaagttctg aagccccctt
     5941 ttaacttcct cttggttttt cattataatt ggtagccatc tcatgaactg tctctgactg
     6001 ttgtctcttt gtggtcatgt gattgtgagc ttgctttctg acttgcattt ctgactttat
     6061 cctgttgtta ggaagataga aactaggttt tgaaagatta catgattcaa gcgagggatt
     6121 ttaaagtaaa gatgtattta ttctgaagaa tctaaaagat aacagattat ttgcttatga
     6181 aagaacaata tagtctggga atcccagaat gtcaagccaa aggtctaaga agtcatctcc
     6241 ttcaaatact ttaataaaga agtatttcga ggagatatct gtccaaaaag gtttgactgg
     6301 cctccagatt ccagttattt ttaaaaagca acttaccact aaatccttga gtctccatag
     6361 agtaacagta aagaaactga tgtaacagac tctcctctca aaggatctcc tctggaagag
     6421 actatcagcg gcagcattct ccagggaaga cccatcccct agtgccagag cttgcatcct
     6481 ggagactaaa gattgcactt ttttgtagtt ttttgtccaa atgcaatccc atttctgtgc
     6541 ctcttagcat gcagttagat ttggacaaac aagattccta aggaatgact ttattaacta
     6601 taatatggtt acagctatta tataaatata tattctggtt atagttctaa tatggagatg
     6661 ttgtgtgcaa tgctggcctg tggtggtctg tgtaatgctt taacttgtat ggaggaggcc
     6721 aggctcagag ctgagatgtg gcctgaacct tccctgtatc gatcctttaa tttagaactg
     6781 tcaagatgtc actttctccc cctctgcctt ttagtggtat ctgacatata ctcaaaacag
     6841 taatttcctg gtcacatcat taactgctaa ttctgtattt ataaagaatt ttcagatgga
     6901 catgtacaaa tttgaactca aaccatcccc agtccagata cagggcagcg tgtaggtgac
     6961 cacaccagag cctcagcctc ggtccttctc agccgtcggg ataggatcca ggcatttctt
     7021 ttaaatctca gaggtagcag taaacttttc agtattgctg ttagcaagtg tgtgtttgcc
     7081 aatagatacc cattatacta atgtgccaag taaatgttca ttgcacatct gcttccactg
     7141 tgttcccacg ggtgccatga agtgtgtgag gagcccctca tctggaggga tgagtgctgc
     7201 gttgactact gctatcagga ttgtgttgtg tggaatattc atctacataa attttatatg
     7261 cacagtaatt tcccttttta tatgtcaagt aactatttgt aaaagttata ctcacaaatt
     7321 attataatga ttactaatat attttttcca tgtttcattg cctgaataaa aactgtttac
     7381 cactgtta
//
