LOCUS       NM_001077506             718 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens tachykinin precursor 4 (TAC4), transcript variant
            alpha-2, mRNA.
ACCESSION   NM_001077506
VERSION     NM_001077506.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 718)
  CONSRTM   COVID-19 Host Genetics Initiative
  TITLE     Mapping the human genetic architecture of COVID-19
  JOURNAL   Nature 600 (7889), 472-477 (2021)
   PUBMED   34237774
REFERENCE   2  (bases 1 to 718)
  AUTHORS   Nishimori,N., Toyoshima,S., Sasaki-Sakamoto,T., Hayama,K., Terui,T.
            and Okayama,Y.
  TITLE     Serum level of hemokinin-1 is significantly lower in patients with
            chronic spontaneous urticaria than in healthy subjects
  JOURNAL   Allergol Int 70 (4), 480-488 (2021)
   PUBMED   34090787
  REMARK    GeneRIF: Serum level of hemokinin-1 is significantly lower in
            patients with chronic spontaneous urticaria than in healthy
            subjects.
REFERENCE   3  (bases 1 to 718)
  AUTHORS   Dai,L., Perera,D.S., Burcher,E. and Liu,L.
  TITLE     Hemokinin-1 and substance P stimulate production of inflammatory
            cytokines and chemokines in human colonic mucosa via both NK1 and
            NK2 tachykinin receptors
  JOURNAL   Neuropeptides 82, 102061 (2020)
   PUBMED   32600668
  REMARK    GeneRIF: Hemokinin-1 and substance P stimulate production of
            inflammatory cytokines and chemokines in human colonic mucosa via
            both NK1 and NK2 tachykinin receptors.
REFERENCE   4  (bases 1 to 718)
  AUTHORS   Gonzalez-Santana,A., Marrero-Hernandez,S., Dorta,I., Hernandez,M.,
            Pinto,F.M., Baez,D., Bello,A.R., Candenas,L. and Almeida,T.A.
  TITLE     Altered expression of the tachykinins substance P/neurokinin
            A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2
            receptors in uterine leiomyomata
  JOURNAL   Fertil Steril 106 (6), 1521-1529 (2016)
   PUBMED   27456549
  REMARK    GeneRIF: Expression substance P/neurokinin A/hemokinin-1 and their
            preferred neurokinin 1/neurokinin 2 receptors are dysregulated in
            uterine leiomyomata.
REFERENCE   5  (bases 1 to 718)
  AUTHORS   Zhang,Y., Li,X., Li,J., Hu,H., Miao,X., Song,X., Yang,W., Zeng,Q.,
            Mou,L. and Wang,R.
  TITLE     Human hemokinin-1 promotes migration of melanoma cells and
            increases MMP-2 and MT1-MMP expression by activating tumor cell NK1
            receptors
  JOURNAL   Peptides 83, 8-15 (2016)
   PUBMED   27458061
  REMARK    GeneRIF: Kinase activation led to increased MMP-2 and MT1-MMP
            expression and melanoma cell migration induced by hHK-1. Thus,
            hHK-1 and the NK1 receptor are critical to melanoma cell migration
            and each may be a promising chemotherapeutic target
REFERENCE   6  (bases 1 to 718)
  AUTHORS   Page,N.M.
  TITLE     Hemokinins and endokinins
  JOURNAL   Cell Mol Life Sci 61 (13), 1652-1663 (2004)
   PUBMED   15224188
  REMARK    Review article
REFERENCE   7  (bases 1 to 718)
  AUTHORS   Page,N.M., Bell,N.J., Gardiner,S.M., Manyonda,I.T., Brayley,K.J.,
            Strange,P.G. and Lowry,P.J.
  TITLE     Characterization of the endokinins: human tachykinins with
            cardiovascular activity
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6245-6250 (2003)
   PUBMED   12716968
REFERENCE   8  (bases 1 to 718)
  AUTHORS   Kurtz,M.M., Wang,R., Clements,M.K., Cascieri,M.A., Austin,C.P.,
            Cunningham,B.R., Chicchi,G.G. and Liu,Q.
  TITLE     Identification, localization and receptor characterization of novel
            mammalian substance P-like peptides
  JOURNAL   Gene 296 (1-2), 205-212 (2002)
   PUBMED   12383518
REFERENCE   9  (bases 1 to 718)
  AUTHORS   Bellucci,F., Carini,F., Catalani,C., Cucchi,P., Lecci,A., Meini,S.,
            Patacchini,R., Quartara,L., Ricci,R., Tramontana,M., Giuliani,S.
            and Maggi,C.A.
  TITLE     Pharmacological profile of the novel mammalian tachykinin,
            hemokinin 1
  JOURNAL   Br J Pharmacol 135 (1), 266-274 (2002)
   PUBMED   11786503
REFERENCE   10 (bases 1 to 718)
  AUTHORS   Zhang,Y., Lu,L., Furlonger,C., Wu,G.E. and Paige,C.J.
  TITLE     Hemokinin is a hematopoietic-specific tachykinin that regulates B
            lymphopoiesis
  JOURNAL   Nat Immunol 1 (5), 392-397 (2000)
   PUBMED   11062498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027801.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 21, 2021 this sequence version replaced NM_001077506.1.
            
            Summary: This gene is a member of the tachykinin family of
            neurotransmitter-encoding genes. Tachykinin proteins are cleaved
            into small, secreted peptides that activate members of a family of
            receptor proteins. The products of this gene preferentially
            activate tachykinin receptor 1, and are thought to regulate
            peripheral endocrine and paracrine functions including blood
            pressure, the immune system, and endocrine gland secretion. The
            products of this gene lack a dibasic cleavage site found in other
            tachykinin proteins. Consequently, the nature of the cleavage
            products generated in vivo remains to be determined. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (alpha-2) uses an alternate
            in-frame splice site in the 5' coding region, compared to variant
            alpha. The resulting protein (isoform alpha-2) is shorter than
            isoform alpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY471574.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2142363 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000436235.6/ ENSP00000399702.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC027801.10        70325-70481         c
            158-251             AC027801.10        66476-66569         c
            252-284             AC027801.10        63964-63996         c
            285-344             AC027801.10        62262-62321         c
            345-718             AC027801.10        60712-61085         c
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..718
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /note="tachykinin precursor 4"
                     /db_xref="GeneID:255061"
                     /db_xref="HGNC:HGNC:16641"
                     /db_xref="MIM:607833"
     exon            1..157
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..376
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /note="isoform alpha-2 precursor is encoded by transcript
                     variant alpha-2; endokinin; preprotachykinin-C; tachykinin
                     4 (hemokinin); tachykinin-4"
                     /codon_start=1
                     /product="tachykinin-4 isoform alpha-2 precursor"
                     /protein_id="NP_001070974.1"
                     /db_xref="CCDS:CCDS45727.1"
                     /db_xref="GeneID:255061"
                     /db_xref="HGNC:HGNC:16641"
                     /db_xref="MIM:607833"
                     /translation="MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWEGAGPSIQL
                     QLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQLEHTFQGLLGKRSLFTEGREDE
                     AQGSE"
     exon            158..251
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /inference="alignment:Splign:2.1.0"
     exon            252..284
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /inference="alignment:Splign:2.1.0"
     exon            285..344
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /inference="alignment:Splign:2.1.0"
     exon            345..718
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      698..703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /note="hexamer: AATAAA"
     polyA_site      718
                     /gene="TAC4"
                     /gene_synonym="EK; HK-1; HK1; PPT-C"
                     /note="major polyA site"
ORIGIN      
        1 atcttcaagc tgagaggggc tcccagagat tccaggacag tgcaggctca ccatgctgcc
       61 ttgcctcgcc ctgcttctcc tgatggagct gtccgtgtgc actgtggcag gtgatggtgg
      121 agaggaacag acactcagca ctgaagcaga gacctgggaa ggcgctggcc ccagcattca
      181 gctccagctg caggaggtga agacgggcaa ggcaagccag ttctttgggc tgatggggaa
      241 gcgagtggga ggaagacctc tgatccagcc aaggagaaaa aaagcatatc agctggaaca
      301 cacgttccag ggcctcctgg gcaagagaag cctgttcaca gaaggcagag aggatgaggc
      361 ccaaggttca gagtaaaagc ccccaccaca gacttcccag aggacacggt gccgcttctt
      421 cctacctgga tgtcacagct gacaagccgg caggccaact ctcttctctg tgtctcctgt
      481 cctcatcgct ggcacttcac acaaggccca cactgaaccc actgggcttc ttcctggact
      541 ctcagtgtca agcagcagtc ctgcataaat gcacagcttc gccgtagcaa gctgcactga
      601 ctctgccctc cctcacactc agagttggca tctcactgca cagcagtgag gagactcgca
      661 cactctgtat cctgtgccta gcacacagta ggcactcaat aaatgagtga ccagtgaa
//
