LOCUS       NM_003182               1061 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens tachykinin precursor 1 (TAC1), transcript variant
            beta, mRNA.
ACCESSION   NM_003182
VERSION     NM_003182.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Wang,X., Zheng,J. and Xu,H.
  TITLE     Neural Circuitry Involving Substance P in Male Sexual Behavior
  JOURNAL   Neurosci Bull 40 (4), 544-546 (2024)
   PUBMED   38376747
  REMARK    GeneRIF: Neural Circuitry Involving Substance P in Male Sexual
            Behavior.
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Barde,S., Aguila,J., Zhong,W., Solarz,A., Mei,I., Prud'homme,J.,
            Palkovits,M., Turecki,G., Mulder,J., Uhlen,M., Nagy,C.,
            Mechawar,N., Hedlund,E. and Hokfelt,T.
  TITLE     Substance P, NPY, CCK and their receptors in five brain regions in
            major depressive disorder with transcriptomic analysis of locus
            coeruleus neurons
  JOURNAL   Eur Neuropsychopharmacol 78, 54-63 (2024)
   PUBMED   37931511
  REMARK    GeneRIF: Substance P, NPY, CCK and their receptors in five brain
            regions in major depressive disorder with transcriptomic analysis
            of locus coeruleus neurons.
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Gursoy,G., Karadag,S., Kose,S., Sakaci,T., Kocak,S.Y.,
            Doventas,Y.E., Oktar,A.C. and Bayar,M.D.
  TITLE     The role of calcitonin gene-related peptide and substance P in the
            pathogenesis of dialysis headache
  JOURNAL   Hemodial Int 28 (1), 85-91 (2024)
   PUBMED   37852938
  REMARK    GeneRIF: The role of calcitonin gene-related peptide and substance
            P in the pathogenesis of dialysis headache.
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Madsen,J.J., Petersen,J.E., Christensen,D.P., Hansen,J.B.,
            Schwartz,T.W., Frimurer,T.M. and Olsen,O.H.
  TITLE     Deciphering specificity and cross-reactivity in tachykinin NK1 and
            NK2 receptors
  JOURNAL   J Biol Chem 299 (12), 105438 (2023)
   PUBMED   37944618
  REMARK    GeneRIF: Deciphering specificity and cross-reactivity in tachykinin
            NK1 and NK2 receptors.
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Rosso,P., Fico,E., Colafrancesco,S., Bellizzi,M.G., Priori,R.,
            Cerbelli,B., Leopizzi,M., Giordano,C., Greco,A., Tirassa,P.,
            Severini,C. and Fusconi,M.
  TITLE     Involvement of Substance P (SP) and Its Related NK1 Receptor in
            Primary Sjogren's Syndrome (pSS) Pathogenesis
  JOURNAL   Cells 12 (10), 1347 (2023)
   PUBMED   37408182
  REMARK    GeneRIF: Involvement of Substance P (SP) and Its Related NK1
            Receptor in Primary Sjogren's Syndrome (pSS) Pathogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Bannon,M.J., Poosch,M.S., Haverstick,D.M., Mandal,A., Xue,I.C.,
            Shibata,K. and Dragovic,L.J.
  TITLE     Preprotachykinin gene expression in the human basal ganglia:
            characterization of mRNAs and pre-mRNAs produced by alternate RNA
            splicing
  JOURNAL   Brain Res Mol Brain Res 12 (1-3), 225-231 (1992)
   PUBMED   1312203
REFERENCE   7  (bases 1 to 1061)
  AUTHORS   Chiwakata,C., Brackmann,B., Hunt,N., Davidoff,M., Schulze,W. and
            Ivell,R.
  TITLE     Tachykinin (substance-P) gene expression in Leydig cells of the
            human and mouse testis
  JOURNAL   Endocrinology 128 (5), 2441-2448 (1991)
   PUBMED   1708336
REFERENCE   8  (bases 1 to 1061)
  AUTHORS   McGregor,G.P. and Conlon,J.M.
  TITLE     Characterization of the C-terminal flanking peptide of human
            beta-preprotachykinin
  JOURNAL   Peptides 11 (5), 907-910 (1990)
   PUBMED   2284201
REFERENCE   9  (bases 1 to 1061)
  AUTHORS   Theodorsson-Norheim,E., Jornvall,H., Andersson,M., Norheim,I.,
            Oberg,K. and Jacobsson,G.
  TITLE     Isolation and characterization of neurokinin A, neurokinin A(3-10)
            and neurokinin A(4-10) from a neutral water extract of a metastatic
            ileal carcinoid tumour
  JOURNAL   Eur J Biochem 166 (3), 693-697 (1987)
   PUBMED   3038549
REFERENCE   10 (bases 1 to 1061)
  AUTHORS   Harmar,A.J., Armstrong,A., Pascall,J.C., Chapman,K., Rosie,R.,
            Curtis,A., Going,J., Edwards,C.R. and Fink,G.
  TITLE     cDNA sequence of human beta-preprotachykinin, the common precursor
            to substance P and neurokinin A
  JOURNAL   FEBS Lett 208 (1), 67-72 (1986)
   PUBMED   3770210
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN992454.1, AF050655.1 and
            U37529.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003182.2.
            
            Summary: This gene encodes four products of the tachykinin peptide
            hormone family, substance P and neurokinin A, as well as the
            related peptides, neuropeptide K and neuropeptide gamma. These
            hormones are thought to function as neurotransmitters which
            interact with nerve receptors and smooth muscle cells. They are
            known to induce behavioral responses and function as vasodilators
            and secretagogues. Substance P is an antimicrobial peptide with
            antibacterial and antifungal properties. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Nov 2014].
            
            Transcript Variant: Transcript variant beta encodes the full-length
            form of this gene. It encodes hormones substance P, neurokinin A,
            as well as the neuropeptide K.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018047.1, AK222957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000319273.10/
                                                  ENSP00000321106.5
            Protein has antimicrobial activity :: PMID: 12074933
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               DN992454.1         136-359
            225-486             AF050655.1         1-262
            487-1061            U37529.1           513-1087
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..1061
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /note="tachykinin precursor 1"
                     /db_xref="GeneID:6863"
                     /db_xref="HGNC:HGNC:11517"
                     /db_xref="MIM:162320"
     exon            1..110
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..242
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..509
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /note="isoform beta precursor is encoded by transcript
                     variant beta; neuropeptide gamma; neuropeptide K;
                     tachykinin, precursor 1 (substance K, substance P,
                     neurokinin 1, neurokinin 2, neuromedin L, neurokinin
                     alpha, neuropeptide K, neuropeptide gamma); tachykinin 2;
                     protachykinin; preprotachykinin; neurokinin A;
                     protachykinin-1; PPT"
                     /codon_start=1
                     /product="protachykinin-1 isoform beta precursor"
                     /protein_id="NP_003173.1"
                     /db_xref="CCDS:CCDS5649.1"
                     /db_xref="GeneID:6863"
                     /db_xref="HGNC:HGNC:11517"
                     /db_xref="MIM:162320"
                     /translation="MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEEL
                     PEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDS
                     FVGLMGKRALNSVAYERSAMQNYERRR"
     exon            243..339
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..384
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..408
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..462
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1061
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /note="hexamer: AAGAAA"
     polyA_site      1061
                     /gene="TAC1"
                     /gene_synonym="Hs.2563; NK2; NKNA; NPK; TAC2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgct cggacctcct tcccggcggc agctaccgag agtgcggagc gaccagcgtg
       61 cgctcggagg aaccagagaa actcagcacc ccgcgggact gtccgtcgca aaatccaaca
      121 tgaaaatcct cgtggccttg gcagtctttt ttcttgtctc cactcagctg tttgcagaag
      181 aaataggagc caatgatgat ctgaattact ggtccgactg gtacgacagc gaccagatca
      241 aggaggaact gccggagccc tttgagcatc ttctgcagag aatcgcccgg agacccaagc
      301 ctcagcagtt ctttggatta atgggcaaac gggatgctga ttcctcaatt gaaaaacaag
      361 tggccctgtt aaaggctctt tatggacatg gccagatctc tcacaaaaga cataaaacag
      421 attcctttgt tggactaatg ggcaaaagag ctttaaattc tgtggcttat gaaaggagtg
      481 caatgcagaa ttatgaaaga agacgttaat aaactaccta acattattta ttcagcttca
      541 tttgtgtcaa tgggcaatga caggtaaatt aagacatgca ctatgaggaa taattattta
      601 tttaataaca attgtttggg gttgaaaatt caaaaagtgt ttatttttca tattgtgcca
      661 atatgtattg taaacatgtg ttttaattcc aatatgatga ctcccttaaa atagaaataa
      721 gtggttattt ctcaacaaag cacagtgtta aatgaaattg taaaacctgt caatgataca
      781 gtccctaaag aaaaaaaatc attgctttga agcagttgtg tcagctactg cggaaaagga
      841 aggaaactcc tgacagtctt gtgcttttcc tatttgtttt catggtgaaa atgtactgag
      901 attttggtat tacactgtat ttgtatctct gaagcatgtt tcatgttttg tgactatata
      961 gagatgtttt taaaagtttc aatgtgattc taatgtcttc atttcattgt atgatgtgtt
     1021 gtgatagcta acattttaaa taaaagaaaa aatatcttga a
//
