LOCUS       NM_152787               6647 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TGF-beta activated kinase 1 (MAP3K7) binding protein 3
            (TAB3), transcript variant 1, mRNA.
ACCESSION   NM_152787
VERSION     NM_152787.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6647)
  AUTHORS   Li,M., Gao,Z., Wang,S., Zhao,Y. and Xie,H.
  TITLE     miR-27a-3p upregulation by p65 facilitates cervical tumorigenesis
            by increasing TAB3 expression and is involved in the positive
            feedback loop of NF-kappaB signaling
  JOURNAL   Oncol Rep 50 (1) (2023)
   PUBMED   37203408
  REMARK    GeneRIF: miR-27a-3p upregulation by p65 facilitates cervical
            tumorigenesis by increasing TAB3 expression and is involved in the
            positive feedback loop of NF-kappaB signaling.
REFERENCE   2  (bases 1 to 6647)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6647)
  AUTHORS   Li,S., Fang,W., Cui,Y., Shi,H., Chen,J., Li,L., Zhang,L. and
            Zhang,X.
  TITLE     Neddylation promotes protein translocation between the cytoplasm
            and nucleus
  JOURNAL   Biochem Biophys Res Commun 529 (4), 991-997 (2020)
   PUBMED   32819610
  REMARK    GeneRIF: Neddylation promotes protein translocation between the
            cytoplasm and nucleus.
REFERENCE   4  (bases 1 to 6647)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 6647)
  AUTHORS   Li,Y.L., Zhang,X.X., Yao,J.N., Gao,B., Gao,S.L., Wang,C.F.,
            Zhou,H.N. and Zhang,L.F.
  TITLE     ZEB2-AS1 regulates the expression of TAB3 and promotes the
            development of colon cancer by adsorbing microRNA-188
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (8), 4180-4189 (2020)
   PUBMED   32373954
  REMARK    GeneRIF: ZEB2-AS1 regulates the expression of TAB3 and promotes the
            development of colon cancer by adsorbing microRNA-188.
REFERENCE   6  (bases 1 to 6647)
  AUTHORS   Cheung,P.C., Nebreda,A.R. and Cohen,P.
  TITLE     TAB3, a new binding partner of the protein kinase TAK1
  JOURNAL   Biochem J 378 (Pt 1), 27-34 (2004)
   PUBMED   14670075
  REMARK    GeneRIF: Identification of TAB3 as a binding partner of the protein
            kinase TAK1.
REFERENCE   7  (bases 1 to 6647)
  AUTHORS   Ishitani,T., Takaesu,G., Ninomiya-Tsuji,J., Shibuya,H., Gaynor,R.B.
            and Matsumoto,K.
  TITLE     Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
  JOURNAL   EMBO J 22 (23), 6277-6288 (2003)
   PUBMED   14633987
  REMARK    GeneRIF: TAB3 is involved in IL-1-induced NF-kappaB activation by
            physically linking TAK1 to TRAF6.
REFERENCE   8  (bases 1 to 6647)
  AUTHORS   Jiang,Z., Zamanian-Daryoush,M., Nie,H., Silva,A.M., Williams,B.R.
            and Li,X.
  TITLE     Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation
            of NFkappa B and MAP kinase is through an interleukin-1
            receptor-associated kinase (IRAK)-independent pathway employing the
            signaling components TLR3-TRAF6-TAK1-TAB2-PKR
  JOURNAL   J Biol Chem 278 (19), 16713-16719 (2003)
   PUBMED   12609980
  REMARK    Erratum:[J Biol Chem. 2003 Jun 20;278(5):23212]
REFERENCE   9  (bases 1 to 6647)
  AUTHORS   Takaesu,G., Kishida,S., Hiyama,A., Yamaguchi,K., Shibuya,H.,
            Irie,K., Ninomiya-Tsuji,J. and Matsumoto,K.
  TITLE     TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK
            by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
  JOURNAL   Mol Cell 5 (4), 649-658 (2000)
   PUBMED   10882101
REFERENCE   10 (bases 1 to 6647)
  AUTHORS   Lee,R.J., Albanese,C., Stenger,R.J., Watanabe,G., Inghirami,G.,
            Haines,G.K. 3rd, Webster,M., Muller,W.J., Brugge,J.S., Davis,R.J.
            and Pestell,R.G.
  TITLE     pp60(v-src) induction of cyclin D1 requires collaborative
            interactions between the extracellular signal-regulated kinase,
            p38, and Jun kinase pathways. A role for cAMP response
            element-binding protein and activating transcription factor-2 in
            pp60(v-src) signaling in breast cancer cells
  JOURNAL   J Biol Chem 274 (11), 7341-7350 (1999)
   PUBMED   10066798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117405.4, DA494641.1,
            AC108359.4, BC032526.2 and AK096786.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_152787.4.
            
            Summary: The product of this gene functions in the NF-kappaB signal
            transduction pathway. The encoded protein, and the similar and
            functionally redundant protein MAP3K7IP2/TAB2, forms a ternary
            complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or
            TRAF6 in response to stimulation with the pro-inflammatory
            cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity
            triggers a signaling cascade leading to activation of the NF-kappaB
            transcription factor. The human genome contains a related
            pseudogene. Alternatively spliced transcript variants have been
            described, but their biological validity has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3628333.1,
                                           SRR14038197.2455197.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288422.4/ ENSP00000288422.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC117405.4         12179-12205         c
            28-202              DA494641.1         168-342
            203-203             AC108359.4         74373-74373
            204-348             DA494641.1         344-488
            349-3176            BC032526.2         1-2828
            3177-6261           AC108359.4         115201-118285
            6262-6647           AK096786.1         2850-3235
FEATURES             Location/Qualifiers
     source          1..6647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     gene            1..6647
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /note="TGF-beta activated kinase 1 (MAP3K7) binding
                     protein 3"
                     /db_xref="GeneID:257397"
                     /db_xref="HGNC:HGNC:30681"
                     /db_xref="MIM:300480"
     exon            1..141
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..244
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..329
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..433
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..625
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..2662
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitogen-activated protein kinase kinase kinase 7
                     interacting protein 3; NFkB activating protein 1;
                     TAK1-binding protein 3; NF-kappa-B-activating protein 1;
                     TGF-beta activated kinase 1 and MAP3K7 binding protein 3;
                     TAB-3; TGF-beta-activated kinase 1-binding protein 3"
                     /codon_start=1
                     /product="TGF-beta-activated kinase 1 and MAP3K7-binding
                     protein 3 isoform 1"
                     /protein_id="NP_690000.3"
                     /db_xref="CCDS:CCDS14226.1"
                     /db_xref="GeneID:257397"
                     /db_xref="HGNC:HGNC:30681"
                     /db_xref="MIM:300480"
                     /translation="MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCR
                     ALSQESSKYLYMEYHSPDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSS
                     SDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQP
                     SSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQ
                     IPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQ
                     PSQYSPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQ
                     QGPPSYQKQGSHSVAYLPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPS
                     PRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPN
                     PTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSG
                     SDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTT
                     AIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPP
                     KPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDY
                     EGAPWNCDSCTFLNHPALNRCEQCEMPRYT"
     exon            626..2072
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2233
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2327
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2411
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2513
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..6647
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6468..6473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      6487
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /note="major polyA site"
     polyA_site      6623
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
     regulatory      6626..6631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
                     /note="hexamer: AATAAA"
     polyA_site      6647
                     /gene="TAB3"
                     /gene_synonym="MAP3K7IP3; NAP1"
ORIGIN      
        1 acaccggatc ccggccctgc acggcgcgta ccctgggggt tcgggcgggg aagcggcgcc
       61 ggcccggacc ccccgcggga gtaggcgacg ggcgtgaggg cgaggcggcg gcggcggcgg
      121 ccagagagca gcagccgcct ggacactgtc ttcagccttt tcttcaagtt tttgaccgtg
      181 gattgtgttg tgtcaaactg gatgaattat cttagttgaa ttttcaccag ttgaaaaatt
      241 ggagatttct agactactga aaagaagttg ctttcagagc tggagatgtg aataaaattt
      301 ctgtgccagg gttgataaac catcttgagg attccatcca ggaaacccca tcacagttgg
      361 ttgttatgtc tccttagact cctcttggct gtgacagttt ctcagacttt tgttcttgag
      421 gagtactgat cagaaaatga ctgtggtgct agaagatcat tacttttgga aagccggtta
      481 acatccattt cctaagagaa acttggccac catttgctct ggcatggcgc aaagcagccc
      541 acagcttgat attcaggttc tccatgatct tcgacaacgt ttccctgaaa ttccagaggg
      601 cgtggtgtct cagtgcatgt tacagaataa caacaatctt gaagcctgtt gccgagccct
      661 ttcccaggag agtagcaaat acttatatat ggaataccat agtccagatg acaataggat
      721 gaatagaaat cgccttttac atattaacct gggtatccat tctcctagta gctatcaccc
      781 aggagatgga gcccaactta atggtggtcg aacactggta catagctcaa gtgatggaca
      841 tattgatcct cagcatgcag caggtaaaca gctgatatgt ttagttcaag aaccacactc
      901 agctccagct gttgttgctg ctactcccaa ctacaatcca ttttttatga acgaacagaa
      961 cagaagtgca gctactcctc cttcacaacc acctcaacag ccatcttcca tgcaaacagg
     1021 aatgaatccg tctgctatgc aagggccttc accaccaccg ccacctcctt catacatgca
     1081 catacctcgg tatagtacaa atccaattac tgttacagta tcccagaacc tcccttctgg
     1141 acagactgta ccaagagctt tacaaattct tccacaaatt ccaagcaatc tctatgggtc
     1201 tcctggttct atttatatta gacagacatc tcagagttca tcaggaagac aaactcctca
     1261 gagtacgccg tggcagtcct caccacaggg cccagtgcct cactatagcc agcgtccttt
     1321 acctgtttat ccacaccaac agaactatca gccttctcag tattctccca aacagcagca
     1381 gatccctcag tctgcttacc attcaccacc tccttctcaa tgtccttcac ccttcagctc
     1441 tccacagcat caagtgcaac cttcccagtt gggccacatc tttatgccac ctagtccttc
     1501 aactactcca ccccatccat atcaacaagg acctcctagc tatcagaaac agggaagcca
     1561 ttcagtagcc tatcttccat acacagcatc tagtttatcc aaaggttcca tgaagaagat
     1621 agaaattaca gttgaacctt ctcaaagacc tgggacagca attaatagga gtccttcacc
     1681 catcagtaat caaccatctc cacggaatca acactcactg tacacagcca ccacgccacc
     1741 ttcaagttct ccttcaagag ggatatctag tcaaccaaaa cctccattta gtgttaatcc
     1801 tgtgtatatt acatatacac agccaactgg accttcttgt actccatcac catctcctcg
     1861 agtgatacca aacccaacta cagtttttaa aattaccgta ggccgagcaa cgactgaaaa
     1921 tcttttaaat ttagtggacc aagaagagcg ctctgcagca ccagaaccta ttcagcccat
     1981 ttcagtgata ccaggctctg ggggagaaaa gggaagccat aaatatcaga gaagttctag
     2041 ttctggatca gatgactatg cctacacaca agccttgctg ttacatcaac gagcaaggat
     2101 ggagaggtta gcaaagcaac tgaaacttga gaaagaggag ctagagcggt tgaagtctga
     2161 agttaatggt atggagcatg acctgatgca gagacggctc agaagagtca gctgcaccac
     2221 tgcgatccct acgcctgagg aaatgacaag attgagaagc atgaacagac aactccagat
     2281 aaatgttgac tgtacactga aagaagttga cctccttcaa tctagaggaa actttgatcc
     2341 aaaagccatg aataattttt atgacaacat agaacctggc ccagttgtac cacccaagcc
     2401 atctaaaaaa gactcctcag acccctgcac aattgagaga aaagcccgaa gaattagcgt
     2461 gacctccaaa gtacaggcag acatccatga cacccaggca gcagctgcag atgagcatcg
     2521 aactggctcc acacaaagtc ctcggacaca acctcgagat gaagactacg aaggggctcc
     2581 atggaattgt gatagctgca cctttcttaa ccacccagca ctaaatcgct gtgagcagtg
     2641 cgagatgcca cggtacacct gaattcagaa aagtctgcgc caggttgaaa gtgaaacttt
     2701 gagcactacc agaagaaaag gaaacctcgg gactctattc atccacccag ccttttcatt
     2761 ttcgattgca cagcggggag gaggaatggc tttgtggtcg tcgttgtgct cacgaaagga
     2821 aaaatgggga ggtctttttt ttctcctttc ttaactcact acagagtgag agatagaaag
     2881 ggatacttga aactgggaaa ggattcactc tgtgaaagaa tgtacacaca gaagtcaaga
     2941 gctcttctgt ggtggaatcc caattgttaa agttactgct gagtggccct tattttttaa
     3001 agtagtactt tgaatcatag tatgaaatgc tacagtttat gcaaactgtg aattcccaga
     3061 gcagacttac ctggtcaccg ctctctggaa aaccaaggct ccccgtgctt cttcccattg
     3121 cttcctacta aagaggacaa caggaaaaag cacctagaat atttgggggg ggggggcaaa
     3181 ttaattaagg gtatttgtaa ttgctgcttt tttcaggggt aatttccaac acacatacat
     3241 gcacacaaac aaaatgtttt aaaatgtgat ttgtagcagt caggaactag gcatatcatg
     3301 cctttgttta aaagtacaat cagaggtggt aagatgcctt tggcttgtac agtgtgattc
     3361 atcgagctct atcaacactg gtaactaaga cctacttatg ccacataaga gatgcatttt
     3421 tttaagttac tgcatgtttt tattaaggcc attggttttc aaaataacaa gtccttacaa
     3481 agtatgattt tataaatgat attctcgtaa aactgcgctt tgccagtagc acagtgaatg
     3541 tatgccaaat gcaagtccat tccaaaatcc atttggaaat cttgagctca gctgtggttc
     3601 ttaaactttt gcagtccata gggccttttt tttttccttc caattttgtg ataaattcat
     3661 gatgtttaca gcacagataa aactttgtgc cataatccta atttagctga aatcaatatt
     3721 aactgttcaa taaaaactta cttgcatatg ttaacaaacc agtgtgaggg gaattacagt
     3781 tggccaacga caaagttgca cactgcatta tttaggaaag gagggattgt caaaaattat
     3841 taagagaaag gtgaatatag aggactttga aacaactttt aaaatttaac ataactgtat
     3901 ctagaggtca attgagtctc tacaggcagt tcagatcatt ttaaagcact ccttatttat
     3961 gaaatagaac ttcagggtgc ggataagaga tataaagtca tgtgactcac tagggtgcat
     4021 cgctggaaac ttaatagcac atttcattaa ggtctctgcc attgttggag ttccttctta
     4081 gctcagaatt ggagttttgg aatcttcccc tcattttggt gagtataaac agcaataaag
     4141 ttagtaggtt ctcccatcct aaaggatttt acctgaggat atcgtcttag gaatatccat
     4201 agacgctccc atcaggtttc tcccccaacc cccctacacc gcccccccac ttctaattta
     4261 gcagtaatct ctggcagacc tggaaaaaca agctgctctt aatagcataa tgaaaccaaa
     4321 ggcgtaataa ctcatcatag ttttccatca gaatcatttc acactctgcc tacagctttg
     4381 aaaacatttt ttcatatgtg aaaaactccc caaaatatat ccactagtct cccaaaggaa
     4441 gcatggtaat taacactgat aaaaacatct ctcacacaac aactgtggca aaactgtgaa
     4501 aataacggtg agaaagcaga tgggcttaaa agcatggtcc ccaaaacaac gttcttcaaa
     4561 ggtttttgta acactggtct ctgtctccaa taacagtcta gccgtcctac tgttctgtaa
     4621 tatgcctttg cctttgtatg gtttcatatc tctttagtga tggtcaaccc cacttggttt
     4681 taagttacaa tttaggggaa atatatatat atatactgct tggtgtccta gctaaaaggt
     4741 ttaccagtat tcatagtgat atgctgaagt ggaggcaatt aacttggcag ttgtcagttg
     4801 agaatgaaag tagcatgtct gaaaacagtc tgatgcttta taaaaccatg tagatgactt
     4861 taaaactatt gcatgaaaat acatcaaggt taataagctg ttatacagta gatgcatggt
     4921 ttcaatcctt tggtgatatt atctagtcaa tcattgtttt cacctgccag gaaaagagag
     4981 aaaacagtct attggatagg tgtaaagggt ggggtatgcg gtatcagatt gattttaagg
     5041 aagttttgta catgttaatt tttaattgtg cacaagtttc atatgccaac ataggctgta
     5101 ttcagtttta aaataggcaa aatgacttga cactgataaa tctggtatgt ttaactgtgt
     5161 cccatatgta gactgctttt tgcctatgac cagtttgaac aagaattcac ccaactttca
     5221 agatgccttt tcaaaaggat cttgtagtca gttggtatgt acagacaatt ggcatggaag
     5281 tggtaggata taaatcggat gacgcctggc tgctgaggtg ccagctggat cagctggtgc
     5341 acttcttgtt tcttgtaaga ggtttcttta aaatgactag tttgatgtat ctggtaacat
     5401 ataggcctga ctatacattt tacattattt cgctattttg taaactggga ttttagaaag
     5461 cacgtttgcc attttgttaa agtacattgc cccttaaatt ttggagtagt ttttaaaagt
     5521 ttaaaatggt aatagaggag ccagaaactt tttaagcatt gtaaaatgtt ttgaattgat
     5581 attgactttg tttggaagag agtagaggca gggggcttta aagaaacaaa gaaatgcatt
     5641 gtaaaaatgt agttttagag caaattaata atgatggtgg ggaaagtgtt gctaatttgt
     5701 ttatttccct ggaagaaatg ggaagtgtga taagcagttt aatttttaag gagctggtct
     5761 caattttagt actttttaat tatgcaaata aatcaatgtt tccttaaatt ttgtcattgc
     5821 tttgtcacag ttgtctaggg ttcatatcca accttctgtg gcaattcaat tttatatagt
     5881 cttttaagag gtaattgtaa tgtatttctg acagtataaa caaaaagaat ataaggcata
     5941 gaagaattgt cctctaaaaa tatcaatgat gtatcctgga atgtgaagat gtccctttat
     6001 agttaaaaat tgaattattt taatattgta ccattgttag accttgaatg agtccatgtt
     6061 accgtgtgtg tctgtatatc tatctgtaga gaaagaaaaa tgacaactga aatgttactt
     6121 ttaaaaatca gaataaattg ggcactgtct gtgttgcacc actactgtat cttttcgaaa
     6181 gaattaacag tatttgccta ttgtaaaggt taattctgat gacgttttca cattcaccag
     6241 actttttttc ctgtattatt tgcatcccca aatatttaat acaagtagat tctgcatggc
     6301 ttgggcattc agagattaat agaatgatga ctcaatttta attctaaagc catgaaaagt
     6361 tactttgaga ctgaacaatt ctgaattatt tatgataccc aatgtccatg tttctttccc
     6421 tactgtaaaa gaattgatca gtttcttcat taaagcagca aaaacttatt aaatcttgta
     6481 aataccatgt ctcttttaga tttctgtgta tgctgtgaat gaaatcattt tgagatgaaa
     6541 ttgtacaaag gcattttaaa aggctctgca tgcatcgtac ctccaaacag tacatattcg
     6601 gaaagtcaaa gattcctgca aaataaataa actaaaagca aacacta
//
