LOCUS       NM_006116               3198 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens TGF-beta activated kinase 1 (MAP3K7) binding protein 1
            (TAB1), transcript variant alpha, mRNA.
ACCESSION   NM_006116
VERSION     NM_006116.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Zhang,J., Teng,P., Sun,B., Zhang,J., Zhou,X. and Chen,W.
  TITLE     Down-regulated TAB1 suppresses the replication of Coxsackievirus B5
            via activating the NF-kappaB pathways through interaction with
            viral 3D polymerase
  JOURNAL   Virol J 20 (1), 291 (2023)
   PUBMED   38072991
  REMARK    GeneRIF: Down-regulated TAB1 suppresses the replication of
            Coxsackievirus B5 via activating the NF-kappaB pathways through
            interaction with viral 3D polymerase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Ma,M., Dang,Y., Chang,B., Wang,F., Xu,J., Chen,L., Su,H., Li,J.,
            Ge,B., Chen,C. and Liu,H.
  TITLE     TAK1 is an essential kinase for STING trafficking
  JOURNAL   Mol Cell 83 (21), 3885-3903 (2023)
   PUBMED   37832545
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   Maddali,P., Ambesi,A. and McKeown-Longo,P.J.
  TITLE     Induction of pro-inflammatory genes by fibronectin DAMPs in three
            fibroblast cell lines: Role of TAK1 and MAP kinases
  JOURNAL   PLoS One 18 (5), e0286390 (2023)
   PUBMED   37228128
  REMARK    GeneRIF: Induction of pro-inflammatory genes by fibronectin DAMPs
            in three fibroblast cell lines: Role of TAK1 and MAP kinases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 3198)
  AUTHORS   Ortiz,B., Driscoll,A., Menon,R., Taylor,B.D. and Richardson,L.S.
  TITLE     Chlamydia trachomatis antigen induces TLR4-TAB1-mediated
            inflammation, but not cell death, in maternal decidua cells
  JOURNAL   Am J Reprod Immunol 89 (3), e13664 (2023)
   PUBMED   36495029
  REMARK    GeneRIF: Chlamydia trachomatis antigen induces TLR4-TAB1-mediated
            inflammation, but not cell death, in maternal decidua cells.
REFERENCE   6  (bases 1 to 3198)
  AUTHORS   Yamaguchi,K., Nagai,S., Ninomiya-Tsuji,J., Nishita,M., Tamai,K.,
            Irie,K., Ueno,N., Nishida,E., Shibuya,H. and Matsumoto,K.
  TITLE     XIAP, a cellular member of the inhibitor of apoptosis protein
            family, links the receptors to TAB1-TAK1 in the BMP signaling
            pathway
  JOURNAL   EMBO J 18 (1), 179-187 (1999)
   PUBMED   9878061
REFERENCE   7  (bases 1 to 3198)
  AUTHORS   Arch,R.H., Gedrich,R.W. and Thompson,C.B.
  TITLE     Tumor necrosis factor receptor-associated factors (TRAFs)--a family
            of adapter proteins that regulates life and death
  JOURNAL   Genes Dev 12 (18), 2821-2830 (1998)
   PUBMED   9744859
  REMARK    Review article
REFERENCE   8  (bases 1 to 3198)
  AUTHORS   Kurozumi,K., Nishita,M., Yamaguchi,K., Fujita,T., Ueno,N. and
            Shibuya,H.
  TITLE     BRAM1, a BMP receptor-associated molecule involved in BMP
            signalling
  JOURNAL   Genes Cells 3 (4), 257-264 (1998)
   PUBMED   9663660
REFERENCE   9  (bases 1 to 3198)
  AUTHORS   Deacon,K. and Blank,J.L.
  TITLE     Characterization of the mitogen-activated protein kinase kinase 4
            (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated
            by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not
            cause activation of p38 kinase in vivo
  JOURNAL   J Biol Chem 272 (22), 14489-14496 (1997)
   PUBMED   9162092
REFERENCE   10 (bases 1 to 3198)
  AUTHORS   Shibuya,H., Yamaguchi,K., Shirakabe,K., Tonegawa,A., Gotoh,Y.,
            Ueno,N., Irie,K., Nishida,E. and Matsumoto,K.
  TITLE     TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal
            transduction
  JOURNAL   Science 272 (5265), 1179-1182 (1996)
   PUBMED   8638164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050554.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006116.2.
            
            Summary: The protein encoded by this gene was identified as a
            regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is
            known to mediate various intracellular signaling pathways, such as
            those induced by TGF beta, interleukin 1, and WNT-1. This protein
            interacts and thus activates TAK1 kinase. It has been shown that
            the C-terminal portion of this protein is sufficient for binding
            and activation of TAK1, while a portion of the N-terminus acts as a
            dominant-negative inhibitor of TGF beta, suggesting that this
            protein may function as a mediator between TGF beta receptors and
            TAK1. This protein can also interact with and activate the
            mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus
            represents an alternative activation pathway, in addition to the
            MAPKK pathways, which contributes to the biological responses of
            MAPK14 to various stimuli. Alternatively spliced transcript
            variants encoding distinct isoforms have been reported. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (alpha) encodes the longer isoform
            (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038582.1, SRR1163655.271787.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216160.11/ ENSP00000216160.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3198              BC050554.1         40-3237
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..3198
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /note="TGF-beta activated kinase 1 (MAP3K7) binding
                     protein 1"
                     /db_xref="GeneID:10454"
                     /db_xref="HGNC:HGNC:18157"
                     /db_xref="MIM:602615"
     exon            1..56
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1538
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; TAK1-binding protein 1; transforming growth factor
                     beta-activated kinase-binding protein 1; mitogen-activated
                     protein kinase kinase kinase 7-interacting protein 1"
                     /codon_start=1
                     /product="TGF-beta-activated kinase 1 and MAP3K7-binding
                     protein 1 isoform alpha"
                     /protein_id="NP_006107.1"
                     /db_xref="CCDS:CCDS13993.1"
                     /db_xref="GeneID:10454"
                     /db_xref="HGNC:HGNC:18157"
                     /db_xref="MIM:602615"
                     /translation="MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGT
                     ESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADV
                     RRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLER
                     EISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRL
                     SQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQ
                     PLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRV
                     KRIHSDTFASGGERARFCPRHEDMTLLVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSV
                     PYSSAQSTSKTSVTLSLVMPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHT
                     QSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVVTAP"
     exon            57..193
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..347
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..434
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..573
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..687
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..799
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..944
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1167
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1330
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..3198
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3179..3184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /note="hexamer: ATTACA"
     polyA_site      3198
                     /gene="TAB1"
                     /gene_synonym="3'-Tab1; MAP3K7IP1"
                     /note="major polyA site"
ORIGIN      
        1 gctcccgcag gggttcctcc aagatggcgg cgcagaggag gagcttgctg cagagtgagc
       61 agcagccaag ctggacagat gacctgcctc tctgccacct ctctggggtt ggctcagcct
      121 ccaaccgcag ctactctgct gatggcaagg gcactgagag ccacccgcca gaggacagct
      181 ggctcaagtt caggagtgag aacaactgct tcctgtatgg ggtcttcaac ggctatgatg
      241 gcaaccgagt gaccaacttc gtggcccagc ggctgtccgc agagctcctg ctgggccagc
      301 tgaatgccga gcacgccgag gccgatgtgc ggcgtgtgct gctgcaggcc ttcgatgtgg
      361 tggagaggag cttcctggag tccattgacg acgccttggc tgagaaggca agcctccagt
      421 cgcaattgcc agagggagtc cctcagcacc agctgcctcc tcagtatcag aagatccttg
      481 agagactcaa gacgttagag agggaaattt cgggaggggc catggccgtt gtggcggtcc
      541 ttctcaacaa caagctctac gtcgccaatg tcggtacaaa ccgtgcactt ttatgcaaat
      601 cgacagtgga tgggttgcag gtgacacagc tgaacgtgga ccacaccaca gagaacgagg
      661 atgagctctt ccgtctttcg cagctgggct tggatgctgg aaagatcaag caggtgggga
      721 tcatctgtgg gcaggagagc acccggcgga tcggggatta caaggttaaa tatggctaca
      781 cggacattga ccttctcagc gctgccaagt ccaaaccaat catcgcagag ccagaaatcc
      841 atggggcaca gccgctggat ggggtgacgg gcttcttggt gctgatgtcg gaggggttgt
      901 acaaggccct agaggcagcc catgggcctg ggcaggccaa ccaggagatt gctgcgatga
      961 ttgacactga gtttgccaag cagacctccc tggacgcagt ggcccaggcc gtcgtggacc
     1021 gggtgaagcg catccacagc gacaccttcg ccagtggtgg ggagcgtgcc aggttctgcc
     1081 cccggcacga ggacatgacc ctgctagtga ggaactttgg ctacccgctg ggcgaaatga
     1141 gccagcccac accgagccca gccccagctg caggaggacg agtgtaccct gtgtctgtgc
     1201 catactccag cgcccagagc accagcaaga ccagcgtgac cctctccctt gtcatgccct
     1261 cccagggcca gatggtcaac ggggctcaca gtgcttccac cctggacgaa gccaccccca
     1321 ccctcaccaa ccaaagcccg accttaaccc tgcagtccac caacacgcac acgcagagca
     1381 gcagctccag ctctgacgga ggcctcttcc gctcccggcc cgcccactcg ctcccgcctg
     1441 gcgaggacgg tcgtgttgag ccctatgtgg actttgctga gttttaccgc ctctggagcg
     1501 tggaccatgg cgagcagagc gtggtgacag caccgtaggg cagccggaga atgcagccca
     1561 agcagggcct ggcatggggc aggacagggt ccagcctttt cctaacatct gcctgtgcca
     1621 caacggccag caggtgcccc atcctctgcc cacagcagac tctgtcccat ggctctccgg
     1681 gcagtagagt gtgtgagtgc agactggacc tgtggttcat accttgtcac cacccgggaa
     1741 gctgaaggcc acttcctccc agatggcctc agccaggacc atcgcccttt ctcagagcag
     1801 agggccaggt atagaaaccg cagtgggcct gcaagccgcc cgagcctccc cagcagcctc
     1861 ctacagagca ggaagaggcg ccctgtgaac cctgagtgtt gcaggcccag cagaccctgc
     1921 tgtcccaagc ccacccctcc tcccaccatc acctccctca cctcgggaca gtagccctcc
     1981 acttctccag cctctcagcc ctgtgctcct gcatccagag tggaacccag gctggtgtcc
     2041 gcatctgtcc ctgggcccca cccctggacc tgccttggtt gtgtcatctg ttgtaaacgt
     2101 tcaggaggac cagggcagca tctggggcct gggatggcca cagaaggggc aggccaggtg
     2161 gaaaggagcc agggggaagt ggtctaagag acctggaact gccagaggat ggcggcctgg
     2221 gcttccccag agccaggcgt gcgggagagg tgaggactgg ccccggtggg ctgaggcagg
     2281 ggccgctgtc gtcaggcctg agccagggtg agctggtgcc tgccttgcat tttccttctg
     2341 gtgctgtgaa gaccataggc tggcaggcag ctgagatgaa ctgtctttac cactgatgag
     2401 gggcctctgc cggctgaggg tagcaagcag gggttgtgag tcaggctggg ggacttgttt
     2461 gaaagaaaga ggagtggaaa atggttccag gagggaagag gttctttgag acacagtacc
     2521 ctgggaggca taggagaagg gtcgggccag cccagcccag ggcctgagtt agactatttc
     2581 ccacatgttc tctgccttca gtggggaggg ggtgccacca gggctgtcgg ccaggattgc
     2641 cactcctgtt tcagaggaag caggccgaga gacttgcacc ttggccaagc cacacaatca
     2701 gtggggcagc cagagctcag acctgagcca ttttgtcagt atccaggacc ccccggattc
     2761 tccacgccct ccccatctcc cagtctccct gccccccatg ccccagaccg gcccaccagg
     2821 gactagccgc tgtcgcacag cctctggggt gcttggtctc tgcgaagtca aaggcctgac
     2881 agctctgtgg cctgggaatc cattttcctg cggcagagca gggcctggtg tggaaccagg
     2941 gagctgtggg aagccacagc agaaatggaa gaaaaacagg tctcagccca gggtcctcgc
     3001 tcactccctc actccccact ttgaagccat ctctgttctg caggtgagag gatttaaagt
     3061 cagtcacaaa ggcttgggaa caaaaggaat tctcttccaa gaatgcctct gtggtgctgt
     3121 ttggtctcta gaaacagggt cactttttta atgtagtaaa gaagtaataa atggtggcat
     3181 tacacattgt gatattaa
//
