LOCUS       NM_053278               1085 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens trace amine associated receptor 8 (TAAR8), mRNA.
ACCESSION   NM_053278
VERSION     NM_053278.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1085)
  AUTHORS   Muhlhaus,J., Dinter,J., Nurnberg,D., Rehders,M., Depke,M.,
            Golchert,J., Homuth,G., Yi,C.X., Morin,S., Kohrle,J., Brix,K.,
            Tschop,M., Kleinau,G. and Biebermann,H.
  TITLE     Analysis of human TAAR8 and murine Taar8b mediated signaling
            pathways and expression profile
  JOURNAL   Int J Mol Sci 15 (11), 20638-20655 (2014)
   PUBMED   25391046
  REMARK    GeneRIF: For the first time is confirmed basal Gi/o signaling
            activity for TAAR8.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1085)
  AUTHORS   Liberles,S.D. and Buck,L.B.
  TITLE     A second class of chemosensory receptors in the olfactory
            epithelium
  JOURNAL   Nature 442 (7103), 645-650 (2006)
   PUBMED   16878137
  REMARK    GeneRIF: Previous studies reported TAAR expression in brain. This
            paper found TAAR expression only in olfactory epithelial cells and
            that each TAAR detects a unique set of amine ligands. TAARs seem to
            function as a family of chemosensory receptors for amines.
REFERENCE   3  (bases 1 to 1085)
  AUTHORS   Lewin,A.H.
  TITLE     Receptors of mammalian trace amines
  JOURNAL   AAPS J 8 (1), E138-E145 (2006)
   PUBMED   16584120
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1085)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   5  (bases 1 to 1085)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
REFERENCE   6  (bases 1 to 1085)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513524.8.
            
            On Aug 3, 2021 this sequence version replaced NM_053278.2.
            
            Summary: This gene is part of the trace amine receptor cluster on
            chromosome 6 and encodes an orphan G-protein coupled receptor.
            Upregulated expression of this gene in astroglial cells upon
            exposure to lipopolysaccharides suggests a function for the encoded
            protein in the brain. [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069166.1, AY183468.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275200.2/ ENSP00000275200.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1085              AL513524.8         38838-39922
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..1085
                     /gene="TAAR8"
                     /gene_synonym="GPR102; TA5; TaR-5; TaR-8; TAR5; TRAR5"
                     /note="trace amine associated receptor 8"
                     /db_xref="GeneID:83551"
                     /db_xref="HGNC:HGNC:14964"
                     /db_xref="MIM:606927"
     exon            1..1085
                     /gene="TAAR8"
                     /gene_synonym="GPR102; TA5; TaR-5; TaR-8; TAR5; TRAR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1050
                     /gene="TAAR8"
                     /gene_synonym="GPR102; TA5; TaR-5; TaR-8; TAR5; TRAR5"
                     /note="trace amine receptor 5; trace amine receptor 8;
                     G-protein coupled receptor 102"
                     /codon_start=1
                     /product="trace amine-associated receptor 8"
                     /protein_id="NP_444508.1"
                     /db_xref="CCDS:CCDS5154.1"
                     /db_xref="GeneID:83551"
                     /db_xref="HGNC:HGNC:14964"
                     /db_xref="MIM:606927"
                     /translation="MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLL
                     AVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAK
                     FCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPL
                     TYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSK
                     IFLIAKQQAIKIETTSSKVESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVD
                     ILIDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASS
                     STISLFLE"
ORIGIN      
        1 caaacaacaa acagcagaac catgaccagc aatttttccc aacctgttgt gcagctttgc
       61 tatgaggatg tgaatggatc ttgtattgaa actccctatt ctcctgggtc ccgggtaatt
      121 ctgtacacgg cgtttagctt tgggtctttg ctggctgtat ttggaaatct cttagtaatg
      181 acttctgttc ttcattttaa gcagctgcac tctccaacca attttctcat tgcctctctg
      241 gcctgtgctg acttcttggt aggtgtgact gtgatgcttt tcagcatggt caggacggtg
      301 gagagctgct ggtattttgg agccaaattt tgtactcttc acagttgctg tgatgtggca
      361 ttttgttact cttctgtcct ccacttgtgc ttcatctgca tcgacaggta cattgtggtt
      421 actgatcccc tggtctatgc taccaagttc accgtgtctg tgtcgggaat ttgcatcagc
      481 gtgtcctgga ttctgcctct cacgtacagc ggtgctgtgt tctacacagg tgtcaatgat
      541 gatgggctgg aggaattagt aagtgctctc aactgcgtag gtggctgtca aattattgta
      601 agtcaaggct gggtgttgat agattttctg ttattcttca tacctaccct tgttatgata
      661 attctttaca gtaagatttt tcttatagct aaacaacaag ctataaaaat tgaaactact
      721 agtagcaaag tagaatcatc ctcagagagt tataaaatca gagtggccaa gagagagagg
      781 aaagcagcta aaaccctggg ggtcacggta ctagcatttg ttatttcatg gttaccgtat
      841 acagttgata tattaattga tgcctttatg ggcttcctga cccctgccta tatctatgaa
      901 atttgctgtt ggagtgctta ttataactca gccatgaatc ctttgattta tgctctattt
      961 tatccttggt ttaggaaagc cataaaactt attttaagtg gagatgtttt aaaggctagt
     1021 tcatcaacca ttagtttatt tttagaataa gtttaagcac taagttgaga aaattaagaa
     1081 tattt
//
