LOCUS       NM_175067               1038 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens trace amine associated receptor 6 (TAAR6), mRNA.
ACCESSION   NM_175067
VERSION     NM_175067.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Guo,L., Cheng,J., Lian,S., Liu,Q., Lu,Y., Zheng,Y., Zhu,K.,
            Zhang,M., Kong,Y., Zhang,C., Rong,N., Zhuang,Y., Fang,G., Jiang,J.,
            Zhang,T., Han,X., Liu,Z., Xia,M., Liu,S., Zhang,L., Liberles,S.D.,
            Yu,X., Xu,Y., Yang,F., Li,Q. and Sun,J.P.
  TITLE     Structural basis of amine odorant perception by a mammal olfactory
            receptor
  JOURNAL   Nature 618 (7963), 193-200 (2023)
   PUBMED   37225986
REFERENCE   2  (bases 1 to 1038)
  AUTHORS   Vaganova,A.N., Katolikova,N.V., Murtazina,R.Z., Kuvarzin,S.R. and
            Gainetdinov,R.R.
  TITLE     Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6
            Expression in the Mental Disorder-Related Brain Areas in Human and
            Mouse Brain
  JOURNAL   Biomolecules 12 (9), 1259 (2022)
   PUBMED   36139098
  REMARK    GeneRIF: Public Transcriptomic Data Meta-Analysis Demonstrates
            TAAR6 Expression in the Mental Disorder-Related Brain Areas in
            Human and Mouse Brain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1038)
  AUTHORS   Glyakina,A.V., Pavlov,C.D., Sopova,J.V., Gainetdinov,R.R.,
            Leonova,E.I. and Galzitskaya,O.V.
  TITLE     Search for Structural Basis of Interactions of Biogenic Amines with
            Human TAAR1 and TAAR6 Receptors
  JOURNAL   Int J Mol Sci 23 (1), 209 (2021)
   PUBMED   35008636
  REMARK    GeneRIF: Search for Structural Basis of Interactions of Biogenic
            Amines with Human TAAR1 and TAAR6 Receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1038)
  AUTHORS   Chang,H.S., Heo,J.S., Shin,S.W., Bae,D.J., Song,H.J., Jun,J.A.,
            Kim,J.D., Park,J.S., Park,B.L., Shin,H.D. and Park,C.S.
  TITLE     Association between TAAR6 polymorphisms and airway responsiveness
            to inhaled corticosteroids in asthmatic patients
  JOURNAL   Pharmacogenet Genomics 25 (7), 334-342 (2015)
   PUBMED   25919112
  REMARK    GeneRIF: Among the 15 SNPs and seven haplotypes of TAAR6, rs7772821
            (T>G) on the 3'-UTR showed the strongest correlation with inhaled
            corticosteroid-induced %DeltaFEV1 in asthmatics.
REFERENCE   5  (bases 1 to 1038)
  AUTHORS   Duan,S., Du,J., Xu,Y., Xing,Q., Wang,H., Wu,S., Chen,Q., Li,X.,
            Li,X., Shen,J., Feng,G. and He,L.
  TITLE     Failure to find association between TRAR4 and schizophrenia in the
            Chinese Han population
  JOURNAL   J Neural Transm (Vienna) 113 (3), 381-385 (2006)
   PUBMED   16075187
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1038)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   7  (bases 1 to 1038)
  AUTHORS   Duan,J., Martinez,M., Sanders,A.R., Hou,C., Saitou,N., Kitano,T.,
            Mowry,B.J., Crowe,R.R., Silverman,J.M., Levinson,D.F. and
            Gejman,P.V.
  TITLE     Polymorphisms in the trace amine receptor 4 (TRAR4) gene on
            chromosome 6q23.2 are associated with susceptibility to
            schizophrenia
  JOURNAL   Am J Hum Genet 75 (4), 624-638 (2004)
   PUBMED   15329799
  REMARK    GeneRIF: TRAR4 is preferentially expressed in those brain regions
            that have been implicated in the pathophysiology of schizophrenia.
REFERENCE   8  (bases 1 to 1038)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
REFERENCE   9  (bases 1 to 1038)
  AUTHORS   Kaufmann,C.A., Suarez,B., Malaspina,D., Pepple,J., Svrakic,D.,
            Markel,P.D., Meyer,J., Zambuto,C.T., Schmitt,K., Matise,T.C.,
            Harkavy Friedman,J.M., Hampe,C., Lee,H., Shore,D., Wynne,D.,
            Faraone,S.V., Tsuang,M.T. and Cloninger,C.R.
  TITLE     NIMH Genetics Initiative Millenium Schizophrenia Consortium:
            linkage analysis of African-American pedigrees
  JOURNAL   Am J Med Genet 81 (4), 282-289 (1998)
   PUBMED   9674972
REFERENCE   10 (bases 1 to 1038)
  AUTHORS   Cao,Q., Martinez,M., Zhang,J., Sanders,A.R., Badner,J.A.,
            Cravchik,A., Markey,C.J., Beshah,E., Guroff,J.J., Maxwell,M.E.,
            Kazuba,D.M., Whiten,R., Goldin,L.R., Gershon,E.S. and Gejman,P.V.
  TITLE     Suggestive evidence for a schizophrenia susceptibility locus on
            chromosome 6q and a confirmation in an independent series of
            pedigrees
  JOURNAL   Genomics 43 (1), 1-8 (1997)
   PUBMED   9226366
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY183470.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a seven-transmembrane G-protein-coupled
            receptor that likely functions as a receptor for endogenous trace
            amines. Mutations in this gene may be associated with
            schizophrenia.[provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069157.1, AY183470.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275198.1/ ENSP00000275198.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..1038
                     /gene="TAAR6"
                     /gene_synonym="TA4; taR-4; taR-6; TAR4; TAR6; TRAR4"
                     /note="trace amine associated receptor 6"
                     /db_xref="GeneID:319100"
                     /db_xref="HGNC:HGNC:20978"
                     /db_xref="MIM:608923"
     CDS             1..1038
                     /gene="TAAR6"
                     /gene_synonym="TA4; taR-4; taR-6; TAR4; TAR6; TRAR4"
                     /note="trace amine receptor 4; trace amine receptor 6"
                     /codon_start=1
                     /product="trace amine-associated receptor 6"
                     /protein_id="NP_778237.1"
                     /db_xref="CCDS:CCDS5155.1"
                     /db_xref="GeneID:319100"
                     /db_xref="HGNC:HGNC:20978"
                     /db_xref="MIM:608923"
                     /translation="MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAV
                     LAVFGNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGR
                     SFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILP
                     LMYSGAVFYTGVYDDGLEELSDALNCIGGCQTVVNQNWVLTDFLSFFIPTFIMIILYG
                     NIFLVARRQAKKIENTGSKTESSSESYKARVARRERKAAKTLGVTVVAFMISWLPYSI
                     DSLIDAFMGFITPACIYEICCWCAYYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNS
                     SATMNLFSEHI"
     exon            1..1038
                     /gene="TAAR6"
                     /gene_synonym="TA4; taR-4; taR-6; TAR4; TAR6; TRAR4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagcagca attcatccct gctggtggct gtgcagctgt gctacgcgaa cgtgaatggg
       61 tcctgtgtga aaatcccctt ctcgccggga tcccgggtga ttctgtacat agtgtttggc
      121 tttggggctg tgctggctgt gtttggaaac ctcctggtga tgatttcaat cctccatttc
      181 aagcagctgc actctccgac caattttctc gttgcctctc tggcctgcgc tgatttcttg
      241 gtgggtgtga ctgtgatgcc cttcagcatg gtcaggacgg tggagagctg ctggtatttt
      301 gggaggagtt tttgtacttt ccacacctgc tgtgatgtgg cattttgtta ctcttctctc
      361 tttcacttgt gcttcatctc catcgacagg tacattgcgg ttactgaccc cctggtctat
      421 cctaccaagt tcaccgtatc tgtgtcagga atttgcatca gcgtgtcctg gatcctgccc
      481 ctcatgtaca gcggtgctgt gttctacaca ggtgtctatg acgatgggct ggaggaatta
      541 tctgatgccc taaactgtat aggaggttgt cagaccgttg taaatcaaaa ctgggtgttg
      601 acagattttc tatccttctt tatacctacc tttattatga taattctgta tggtaacata
      661 tttcttgtgg ctagacgaca ggcgaaaaag atagaaaata ctggtagcaa gacagaatca
      721 tcctcagaga gttacaaagc cagagtggcc aggagagaga gaaaagcagc taaaaccctg
      781 ggggtcacag tggtagcatt tatgatttca tggttaccat atagcattga ttcattaatt
      841 gatgccttta tgggctttat aacccctgcc tgtatttatg agatttgctg ttggtgtgct
      901 tattataact cagccatgaa tcctttgatt tatgctttat tttacccatg gtttaggaaa
      961 gcaataaaag ttattgtaac tggtcaggtt ttaaagaaca gttcagcaac catgaatttg
     1021 ttttctgaac atatataa
//
