LOCUS       NM_003967               1150 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens trace amine associated receptor 5 (TAAR5), transcript
            variant 1, mRNA.
ACCESSION   NM_003967
VERSION     NM_003967.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Guo,L., Cheng,J., Lian,S., Liu,Q., Lu,Y., Zheng,Y., Zhu,K.,
            Zhang,M., Kong,Y., Zhang,C., Rong,N., Zhuang,Y., Fang,G., Jiang,J.,
            Zhang,T., Han,X., Liu,Z., Xia,M., Liu,S., Zhang,L., Liberles,S.D.,
            Yu,X., Xu,Y., Yang,F., Li,Q. and Sun,J.P.
  TITLE     Structural basis of amine odorant perception by a mammal olfactory
            receptor
  JOURNAL   Nature 618 (7963), 193-200 (2023)
   PUBMED   37225986
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Vaganova,A.N., Murtazina,R.Z., Shemyakova,T.S., Prjibelski,A.D.,
            Katolikova,N.V. and Gainetdinov,R.R.
  TITLE     Pattern of TAAR5 Expression in the Human Brain Based on
            Transcriptome Datasets Analysis
  JOURNAL   Int J Mol Sci 22 (16), 8802 (2021)
   PUBMED   34445502
  REMARK    GeneRIF: Pattern of TAAR5 Expression in the Human Brain Based on
            Transcriptome Datasets Analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Gisladottir,R.S., Ivarsdottir,E.V., Helgason,A., Jonsson,L.,
            Hannesdottir,N.K., Rutsdottir,G., Arnadottir,G.A., Skuladottir,A.,
            Jonsson,B.A., Norddahl,G.L., Ulfarsson,M.O., Helgason,H.,
            Halldorsson,B.V., Nawaz,M.S., Tragante,V., Sveinbjornsson,G.,
            Thorgeirsson,T., Oddsson,A., Kristjansson,R.P., Bjornsdottir,G.,
            Thorgeirsson,G., Jonsdottir,I., Holm,H., Gudbjartsson,D.F.,
            Thorsteinsdottir,U., Stefansson,H., Sulem,P. and Stefansson,K.
  TITLE     Sequence Variants in TAAR5 and Other Loci Affect Human Odor
            Perception and Naming
  JOURNAL   Curr Biol 30 (23), 4643-4653 (2020)
   PUBMED   33035477
  REMARK    GeneRIF: Sequence Variants in TAAR5 and Other Loci Affect Human
            Odor Perception and Naming.
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Dinter,J., Muhlhaus,J., Wienchol,C.L., Yi,C.X., Nurnberg,D.,
            Morin,S., Gruters,A., Kohrle,J., Schoneberg,T., Tschop,M.,
            Krude,H., Kleinau,G. and Biebermann,H.
  TITLE     Inverse agonistic action of 3-iodothyronamine at the human trace
            amine-associated receptor 5
  JOURNAL   PLoS One 10 (2), e0117774 (2015)
   PUBMED   25706283
  REMARK    GeneRIF: The murine and human TAAR5 (hTAAR5) display significant
            basal activity in the Gq/11 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1150)
  AUTHORS   Wallrabenstein,I., Kuklan,J., Weber,L., Zborala,S., Werner,M.,
            Altmuller,J., Becker,C., Schmidt,A., Hatt,H., Hummel,T. and
            Gisselmann,G.
  TITLE     Human trace amine-associated receptor TAAR5 can be activated by
            trimethylamine
  JOURNAL   PLoS One 8 (2), e54950 (2013)
   PUBMED   23393561
  REMARK    GeneRIF: Human trace amine-associated receptor TAAR5 can be
            activated by trimethylamine.
REFERENCE   6  (bases 1 to 1150)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   7  (bases 1 to 1150)
  AUTHORS   Liberles,S.D. and Buck,L.B.
  TITLE     A second class of chemosensory receptors in the olfactory
            epithelium
  JOURNAL   Nature 442 (7103), 645-650 (2006)
   PUBMED   16878137
  REMARK    GeneRIF: Previous studies reported TAAR expression in brain. This
            paper found TAAR expression only in olfactory epithelial cells and
            that each TAAR detects a unique set of amine ligands. TAARs seem to
            function as a family of chemosensory receptors for amines.
REFERENCE   8  (bases 1 to 1150)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   9  (bases 1 to 1150)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 1150)
  AUTHORS   Zeng,Z., Fan,P., Rand,E., Kyaw,H., Su,K., Madike,V., Carter,K.C.
            and Li,Y.
  TITLE     Cloning of a putative human neurotransmitter receptor expressed in
            skeletal muscle and brain
  JOURNAL   Biochem Biophys Res Commun 242 (3), 575-578 (1998)
   PUBMED   9464258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513524.8.
            
            On Dec 30, 2020 this sequence version replaced NM_003967.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC112211.1, AF021818.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258034.4/ ENSP00000258034.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              AL513524.8         74758-75907         c
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..1150
                     /gene="TAAR5"
                     /gene_synonym="PNR; taR-5"
                     /note="trace amine associated receptor 5"
                     /db_xref="GeneID:9038"
                     /db_xref="HGNC:HGNC:30236"
                     /db_xref="MIM:607405"
     exon            1..1150
                     /gene="TAAR5"
                     /gene_synonym="PNR; taR-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1069
                     /gene="TAAR5"
                     /gene_synonym="PNR; taR-5"
                     /note="putative neurotransmitter receptor; trace amine
                     receptor 5"
                     /codon_start=1
                     /product="trace amine-associated receptor 5"
                     /protein_id="NP_003958.2"
                     /db_xref="CCDS:CCDS5156.1"
                     /db_xref="GeneID:9038"
                     /db_xref="HGNC:HGNC:30236"
                     /db_xref="MIM:607405"
                     /translation="MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAG
                     MLIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFF
                     GDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWG
                     VPAAYTSLFLYTDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISL
                     YVKIFVVATRQAQQITTLSKSLAGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDS
                     LLHFITPPLVFDIFIWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDL
                     YQE"
ORIGIN      
        1 ccctccagtg gagaaggtgg ccagttctca gacagaggaa gagtagaaat cataaatgag
       61 agctgtcttc atccaaggtg ctgaagagca ccctgcggca ttctgctacc aggtgaatgg
      121 gtcttgcccc aggacagtac atactctggg catccagttg gtcatctacc tggcctgtgc
      181 agcaggcatg ctgattatcg tgctagggaa tgtatttgtg gcatttgctg tgtcctactt
      241 caaagcgctt cacacgccca ccaacttcct gctgctctcc ctggccctgg ctgacatgtt
      301 tctgggtctg ctggtgctgc ccctcagcac cattcgctca gtggagagct gctggttctt
      361 cggggacttc ctctgccgcc tgcacaccta cctggacacc ctcttctgcc tcacctccat
      421 cttccatctc tgtttcattt ccattgaccg ccactgtgcc atctgtgacc ccctgctcta
      481 tccctccaag ttcacagtga gggtggctct caggtacatc ctggcaggat ggggggtgcc
      541 cgcagcatac acttcgttat tcctctacac agatgtggta gagacaaggc tcagccagtg
      601 gctggaagag atgccttgtg tgggcagttg ccagctgctg ctcaataaat tttggggctg
      661 gttaaacttc cctttgttct ttgtcccctg cctcattatg atcagcttgt atgtgaagat
      721 ctttgtggtt gctaccagac aggctcagca gattaccaca ttgagcaaaa gcctggctgg
      781 ggctgccaag catgagagaa aagctgccaa gaccctgggc attgctgtgg gcatatacct
      841 cttgtgctgg ctgcccttca ccatagacac gatggtcgac agcctccttc actttatcac
      901 acccccactg gtctttgaca tctttatctg gtttgcttac ttcaactcag cctgcaaccc
      961 catcatctat gtcttttcct accagtggtt tcggaaggca ctgaaactca cactgagcca
     1021 gaaggtcttc tcaccgcaga cacgcactgt tgatttgtac caagaatgat tccttctact
     1081 aaatgcaggc aaggagtagg acctcacagg aaagataagt ggcactgtga ccgtgggctg
     1141 tgtggtgttg
//
