LOCUS       NM_001033080            1056 bp    mRNA    linear   PRI 01-FEB-2024
DEFINITION  Homo sapiens trace amine associated receptor 2 (TAAR2), transcript
            variant 1, mRNA.
ACCESSION   NM_001033080
VERSION     NM_001033080.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Babusyte,A., Kotthoff,M., Fiedler,J. and Krautwurst,D.
  TITLE     Biogenic amines activate blood leukocytes via trace
            amine-associated receptors TAAR1 and TAAR2
  JOURNAL   J Leukoc Biol 93 (3), 387-394 (2013)
   PUBMED   23315425
  REMARK    GeneRIF: biogenic amines potently regulate blood cell functions via
            TAAR1 and TAAR2 and open the perspective of their specific
            pharmacological modulation.
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Liberles,S.D. and Buck,L.B.
  TITLE     A second class of chemosensory receptors in the olfactory
            epithelium
  JOURNAL   Nature 442 (7103), 645-650 (2006)
   PUBMED   16878137
  REMARK    GeneRIF: Previous studies reported TAAR expression in brain. This
            paper found TAAR expression only in olfactory epithelial cells and
            that each TAAR detects a unique set of amine ligands. TAARs seem to
            function as a family of chemosensory receptors for amines.
REFERENCE   4  (bases 1 to 1056)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   5  (bases 1 to 1056)
  AUTHORS   Lee,D.K., Lynch,K.R., Nguyen,T., Im,D.S., Cheng,R., Saldivia,V.R.,
            Liu,Y., Liu,I.S., Heng,H.H., Seeman,P., George,S.R., O'Dowd,B.F.
            and Marchese,A.
  TITLE     Cloning and characterization of additional members of the G
            protein-coupled receptor family
  JOURNAL   Biochim Biophys Acta 1490 (3), 311-323 (2000)
   PUBMED   10684976
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY703480.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY703480.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367931.1/ ENSP00000356908.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..1056
                     /gene="TAAR2"
                     /gene_synonym="GPR58; taR-2"
                     /note="trace amine associated receptor 2"
                     /db_xref="GeneID:9287"
                     /db_xref="HGNC:HGNC:4514"
                     /db_xref="MIM:604849"
     CDS             1..1056
                     /gene="TAAR2"
                     /gene_synonym="GPR58; taR-2"
                     /note="isoform 1 is encoded by transcript variant 1; G
                     protein-coupled receptor 58"
                     /codon_start=1
                     /product="trace amine-associated receptor 2 isoform 1"
                     /protein_id="NP_001028252.1"
                     /db_xref="CCDS:CCDS34541.1"
                     /db_xref="GeneID:9287"
                     /db_xref="HGNC:HGNC:4514"
                     /db_xref="MIM:604849"
                     /translation="MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRV
                     AMYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMI
                     RSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVI
                     KRLLLLCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGF
                     FTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQVKKDKKAAKTLGIVIGVFLLCWF
                     PCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKI
                     FSSCFHNTILCMQKESE"
     exon            1..60
                     /gene="TAAR2"
                     /gene_synonym="GPR58; taR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            61..1056
                     /gene="TAAR2"
                     /gene_synonym="GPR58; taR-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctgtct catcagagca acatgaactt tcacatttca aaagaacaca gacaaaaaag
       61 gaaaaattca attgctctga atatggaaat agatcttgcc cagaaaatga aagatctctg
      121 ggtgtccgag tggctatgta ttcatttatg gcaggatcca tattcatcac aatatttggc
      181 aatcttgcca tgataatttc catttcctac ttcaagcagc ttcacacacc aaccaacttc
      241 ctcatcctct ccatggccat cactgatttc ctcctgggat tcaccatcat gccatatagt
      301 atgatcagat cggtggagaa ctgctggtat tttgggctta cattttgcaa gatttattat
      361 agttttgacc tgatgcttag cataacatcc atttttcatc tttgctcagt ggccattgat
      421 agattttatg ctatatgtta cccattactt tattccacca aaataactat tccagtcatt
      481 aaaagattgc tacttctatg ttggtcggtc cctggagcat ttgccttcgg ggtggtcttc
      541 tcagaggcct atgcagatgg aatagagggc tatgacatct tggttgcttg ttccagttcc
      601 tgcccagtga tgttcaacaa gctatggggg accaccttgt ttatggcagg tttcttcact
      661 cctgggtcta tgatggtggg gatttatggc aaaatttttg cagtatccag aaaacatgct
      721 catgccatca ataacttgcg agaaaatcaa aataatcaag tgaagaaaga caaaaaagct
      781 gccaaaactt taggaatagt gataggagtt ttcttattat gttggtttcc ttgtttcttc
      841 acaattttat tggatccctt tttgaacttc tctactcctg tagttttgtt tgatgccttg
      901 acatggtttg gctattttaa ctccacatgt aatccgttaa tatatggttt cttctatccc
      961 tggtttcgca gagcactgaa gtacattttg ctaggtaaaa ttttcagctc atgtttccat
     1021 aatactattt tgtgtatgca aaaagaaagt gagtag
//
