LOCUS       NM_138327               2871 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens trace amine associated receptor 1 (TAAR1), mRNA.
ACCESSION   NM_138327
VERSION     NM_138327.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Zilberg,G., Parpounas,A.K., Warren,A.L., Yang,S. and Wacker,D.
  TITLE     Molecular basis of human trace amine-associated receptor 1
            activation
  JOURNAL   Nat Commun 15 (1), 108 (2024)
   PUBMED   38168118
  REMARK    GeneRIF: Molecular basis of human trace amine-associated receptor 1
            activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2871)
  AUTHORS   Liu,H., Zheng,Y., Wang,Y., Wang,Y., He,X., Xu,P., Huang,S.,
            Yuan,Q., Zhang,X., Wang,L., Jiang,K., Chen,H., Li,Z., Liu,W.,
            Wang,S., Xu,H.E. and Xu,F.
  TITLE     Recognition of methamphetamine and other amines by trace amine
            receptor TAAR1
  JOURNAL   Nature 624 (7992), 663-671 (2023)
   PUBMED   37935377
REFERENCE   3  (bases 1 to 2871)
  AUTHORS   Xu,Z., Guo,L., Yu,J., Shen,S., Wu,C., Zhang,W., Zhao,C., Deng,Y.,
            Tian,X., Feng,Y., Hou,H., Su,L., Wang,H., Guo,S., Wang,H., Wang,K.,
            Chen,P., Zhao,J., Zhang,X., Yong,X., Cheng,L., Liu,L., Yang,S.,
            Yang,F., Wang,X., Yu,X., Xu,Y., Sun,J.P., Yan,W. and Shao,Z.
  TITLE     Ligand recognition and G-protein coupling of trace amine receptor
            TAAR1
  JOURNAL   Nature 624 (7992), 672-681 (2023)
   PUBMED   37935376
  REMARK    GeneRIF: Ligand recognition and G-protein coupling of trace amine
            receptor TAAR1.
REFERENCE   4  (bases 1 to 2871)
  AUTHORS   Shang,P., Rong,N., Jiang,J.J., Cheng,J., Zhang,M.H., Kang,D.,
            Qi,L., Guo,L., Yang,G.M., Liu,Q., Zhou,Z., Li,X.B., Zhu,K.K.,
            Meng,Q.B., Han,X., Yan,W., Kong,Y., Yang,L., Wang,X., Lei,D.,
            Feng,X., Liu,X., Yu,X., Wang,Y., Li,Q., Shao,Z.H., Yang,F. and
            Sun,J.P.
  TITLE     Structural and signaling mechanisms of TAAR1 enabled preferential
            agonist design
  JOURNAL   Cell 186 (24), 5347-5362 (2023)
   PUBMED   37963465
  REMARK    GeneRIF: Structural and signaling mechanisms of TAAR1 enabled
            preferential agonist design.
REFERENCE   5  (bases 1 to 2871)
  AUTHORS   Polini,B., Ricardi,C., Bertolini,A., Carnicelli,V., Rutigliano,G.,
            Saponaro,F., Zucchi,R. and Chiellini,G.
  TITLE     T1AM/TAAR1 System Reduces Inflammatory Response and beta-Amyloid
            Toxicity in Human Microglial HMC3 Cell Line
  JOURNAL   Int J Mol Sci 24 (14), 11569 (2023)
   PUBMED   37511328
  REMARK    GeneRIF: T1AM/TAAR1 System Reduces Inflammatory Response and
            beta-Amyloid Toxicity in Human Microglial HMC3 Cell Line.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2871)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 2871)
  AUTHORS   Freson,K., Jaeken,J., Van Helvoirt,M., de Zegher,F.,
            Wittevrongel,C., Thys,C., Hoylaerts,M.F., Vermylen,J. and Van
            Geet,C.
  TITLE     Functional polymorphisms in the paternally expressed XLalphas and
            its cofactor ALEX decrease their mutual interaction and enhance
            receptor-mediated cAMP formation
  JOURNAL   Hum Mol Genet 12 (10), 1121-1130 (2003)
   PUBMED   12719376
REFERENCE   8  (bases 1 to 2871)
  AUTHORS   Feldman,D.S., Zamah,A.M., Pierce,K.L., Miller,W.E., Kelly,F.,
            Rapacciuolo,A., Rockman,H.A., Koch,W.J. and Luttrell,L.M.
  TITLE     Selective inhibition of heterotrimeric Gs signaling. Targeting the
            receptor-G protein interface using a peptide minigene encoding the
            Galpha(s) carboxyl terminus
  JOURNAL   J Biol Chem 277 (32), 28631-28640 (2002)
   PUBMED   12036966
REFERENCE   9  (bases 1 to 2871)
  AUTHORS   Bunzow,J.R., Sonders,M.S., Arttamangkul,S., Harrison,L.M.,
            Zhang,G., Quigley,D.I., Darland,T., Suchland,K.L., Pasumamula,S.,
            Kennedy,J.L., Olson,S.B., Magenis,R.E., Amara,S.G. and Grandy,D.K.
  TITLE     Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid
            diethylamide, and metabolites of the catecholamine
            neurotransmitters are agonists of a rat trace amine receptor
  JOURNAL   Mol Pharmacol 60 (6), 1181-1188 (2001)
   PUBMED   11723224
REFERENCE   10 (bases 1 to 2871)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL032821.2 and AL513524.8.
            
            On Feb 12, 2020 this sequence version replaced NM_138327.3.
            
            Summary: The protein encoded by this gene is a G-protein coupled
            receptor activated by trace amines. The encoded protein responds
            little or not at all to dopamine, serotonin, epinephrine, or
            histamine, but responds well to beta-phenylethylamine, p-tyramine,
            octopamine, and tryptamine. While primarily functioning in
            neurologic systems, there is evidence that this gene is involved in
            blood cell and immunologic functions as well. This gene is thought
            to be intronless. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138510.17884.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275216.3/ ENSP00000275216.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL032821.2         4368-4420           c
            54-2871             AL513524.8         129478-132295       c
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..2871
                     /gene="TAAR1"
                     /gene_synonym="TA1; TAR1; TRAR1"
                     /note="trace amine associated receptor 1"
                     /db_xref="GeneID:134864"
                     /db_xref="HGNC:HGNC:17734"
                     /db_xref="MIM:609333"
     exon            1..53
                     /gene="TAAR1"
                     /gene_synonym="TA1; TAR1; TRAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            54..2871
                     /gene="TAAR1"
                     /gene_synonym="TA1; TAR1; TRAR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1199
                     /gene="TAAR1"
                     /gene_synonym="TA1; TAR1; TRAR1"
                     /note="trace amine receptor 1"
                     /codon_start=1
                     /product="trace amine-associated receptor 1"
                     /protein_id="NP_612200.1"
                     /db_xref="CCDS:CCDS5158.1"
                     /db_xref="GeneID:134864"
                     /db_xref="HGNC:HGNC:17734"
                     /db_xref="MIM:609333"
                     /translation="MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIV
                     IVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTST
                     DIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIF
                     LELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAK
                     EQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPF
                     LHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLF
                     LELSS"
ORIGIN      
        1 agtgttcctg ctgtctgctc atccgctgac tgtgttcact cttacctgag caggtttctg
       61 ggataagtat gtgcaaataa aaaataaaca tgagaaggaa ctgtaacctg attatggatt
      121 tgggaaaaag ataaatcaac acacaaaggg aaaagtaaac tgattgacag ccctcaggaa
      181 tgatgccctt ttgccacaat ataattaata tttcctgtgt gaaaaacaac tggtcaaatg
      241 atgtccgtgc ttccctgtac agtttaatgg tgctcataat tctgaccaca ctcgttggca
      301 atctgatagt tattgtttct atatcacact tcaaacaact tcatacccca acaaattggc
      361 tcattcattc catggccact gtggactttc ttctggggtg tctggtcatg ccttacagta
      421 tggtgagatc tgctgagcac tgttggtatt ttggagaagt cttctgtaaa attcacacaa
      481 gcaccgacat tatgctgagc tcagcctcca ttttccattt gtctttcatc tccattgacc
      541 gctactatgc tgtgtgtgat ccactgagat ataaagccaa gatgaatatc ttggttattt
      601 gtgtgatgat cttcattagt tggagtgtcc ctgctgtttt tgcatttgga atgatctttc
      661 tggagctaaa cttcaaaggc gctgaagaga tatattacaa acatgttcac tgcagaggag
      721 gttgctctgt cttctttagc aaaatatctg gggtactgac ctttatgact tctttttata
      781 tacctggatc tattatgtta tgtgtctatt acagaatata tcttatcgct aaagaacagg
      841 caagattaat tagtgatgcc aatcagaagc tccaaattgg attggaaatg aaaaatggaa
      901 tttcacaaag caaagaaagg aaagctgtga agacattggg gattgtgatg ggagttttcc
      961 taatatgctg gtgccctttc tttatctgta cagtcatgga cccttttctt cactacatta
     1021 ttccacctac tttgaatgat gtattgattt ggtttggcta cttgaactct acatttaatc
     1081 caatggttta tgcatttttc tatccttggt ttagaaaagc actgaagatg atgctgtttg
     1141 gtaaaatttt ccaaaaagat tcatccaggt gtaaattatt tttggaattg agttcataga
     1201 attattatat tttactgttt tgcaaatcgg ttgatgatca tatttatgaa cacaacataa
     1261 cgaaccacat gcaccaacca catggatttt tttttaaatc agttacttga gtcaaagtat
     1321 gtatggtgag ttaaattatg atgcttatag gtaatttcct atttgggaca tagtaggtat
     1381 acgcttttcc attcttacca cacataatgg aactttgcaa atccagtatt taaaggccta
     1441 cattttatat aacttttcct gcccttagaa gaactgccat gagtttactg tggtacctta
     1501 gtcagctgtt cagtggtgga aactataggg ctgaatttga ggatgcaaat cagaatgatt
     1561 ttgtcatata cgtatacatg tcctggtcac atatgtgtat aagtctttta gtaaaatcaa
     1621 ctaaaagtac acacattaaa tgttaccgct aaataattgt tgacacataa tttatttgta
     1681 ttgttaatat atattccaat ccttaaatat cttgatcttc acatttttaa attatgtttt
     1741 tctgattctc atgcttctaa gaaatttgaa aaataaagga aaatataaaa ataaaatata
     1801 tacaaaccaa atgaaattaa aaaaatgtta ttcatagtat acttcctggt aaggattata
     1861 tcatctaaaa ttctttattt tatattaata tttctctttt tcaactttta ttttggagtc
     1921 ggggcatatg tgcacatatt aactaaatat aatgcatgat gctgaggttt gagctatgag
     1981 taatcccttt ttgtggctgt ataacgtgac tgcacagatg tacaaatata tttttaacca
     2041 ttccctattg ttaattccag ttgtttctaa cttttctaaa aataatataa attaaatgaa
     2101 attcctgctt tttacctgcc actgaagtca tgaaaatgtc tagaaggatt ttaccatgtc
     2161 ttaaggtcat atctggcatg atagggttca aaacacaggc tacctggtat taaacaaatt
     2221 cactttgctg ggctccacaa tacacagaag gagaagcagt catccatcaa agtagctaaa
     2281 catgagggcc aacaagaagt ataatcagac tagatgtacc atggctattt agatggcata
     2341 tataaaaata caaaagagga acaaataatg gtttcaaata agattctcta aaggaagtgg
     2401 gcaaacattc taaattacaa gcattcatca gcaattgagc tgatgaatac aaacttcaca
     2461 tggtctgttt cagattgagt atcactgggg atttggattt accttctgct catgaataag
     2521 ttagggtaag gcaaatgatt ttaaacgtaa ctaaatgcac actgctgcgt ataaatttct
     2581 gtttacaaat ctgaggatct ccggaggata tgtgaaatcc ttccagaaat tatagtctgt
     2641 ttctggagta tatattttgt ttcaatgatc tgtatcaatt tttgctctag tacttttaaa
     2701 aacattatgt tttatgtttt taatttagta cacacaagac taaataagta gtgtccctaa
     2761 tcactctcag tttcaaaaga gtttttttca cctgtgagac cagtttgact tttttcacct
     2821 gtgagtccag tctgtcaaat tttaaaaagg aaacaagcat ttagtgagtt t
//
