LOCUS       NM_001114600            3480 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SUZ RNA binding domain containing 1 (SZRD1),
            transcript variant 1, mRNA.
ACCESSION   NM_001114600
VERSION     NM_001114600.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Deng,L., Gong,K. and Wang,G.
  TITLE     Hsa_circ_0008344 Promotes Glioma Tumor Progression and Angiogenesis
            Presumably by Regulating miR-638/SZRD1 Pathway
  JOURNAL   Neurotox Res 40 (3), 825-836 (2022)
   PUBMED   35394558
  REMARK    GeneRIF: Hsa_circ_0008344 Promotes Glioma Tumor Progression and
            Angiogenesis Presumably by Regulating miR-638/SZRD1 Pathway.
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Geng,Y.B., Pan,C.C., Xu,C., Zuo,P.C., Wang,Y., Li,X.O. and
            Zhang,L.W.
  TITLE     Long non-coding RNA LINC00346 regulates proliferation and apoptosis
            by targeting miR-128-3p/SZRD1 axis in glioma
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (18), 9581-9590 (2020)
   PUBMED   33015801
  REMARK    GeneRIF: Long non-coding RNA LINC00346 regulates proliferation and
            apoptosis by targeting miR-128-3p/SZRD1 axis in glioma.
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB501645.1, AB097046.1, BC010631.1 and AL358794.19.
            
            On Nov 22, 2018 this sequence version replaced NM_001114600.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.511386.1,
                                           SRR3476690.308028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401088.9/ ENSP00000383866.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB501645.1         155-155
            2-1703              AB097046.1         2-1703
            1704-3477           BC010631.1         1626-3399
            3478-3480           AL358794.19        83454-83456
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3480
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /note="SUZ RNA binding domain containing 1"
                     /db_xref="GeneID:26099"
                     /db_xref="HGNC:HGNC:30232"
                     /db_xref="MIM:620682"
     exon            1..67
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..475
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative MAPK activating protein PM20,PM21; SUZ
                     RNA-binding domain-containing; putative MAPK-activating
                     protein PM18/PM20/PM22; UPF0485 protein C1orf144; SUZ
                     domain-containing protein 1"
                     /codon_start=1
                     /product="SUZ RNA-binding domain-containing isoform 1"
                     /protein_id="NP_001108072.1"
                     /db_xref="CCDS:CCDS44065.1"
                     /db_xref="GeneID:26099"
                     /db_xref="HGNC:HGNC:30232"
                     /db_xref="MIM:620682"
                     /translation="MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVP
                     IVIQDDSLPAGPPPQIRILKRPTSNGVVSSPNSTSRPTLPVKSLAQREAEYAEARKRI
                     LGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR"
     exon            68..117
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /inference="alignment:Splign:2.1.0"
     exon            118..372
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /inference="alignment:Splign:2.1.0"
     exon            373..3480
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3443..3448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /note="hexamer: TATAAA"
     polyA_site      3480
                     /gene="SZRD1"
                     /gene_synonym="C1orf144"
                     /note="major polyA site"
ORIGIN      
        1 gaaagcggcg agtaagatgg aagatgagga ggtcgctgag agctgggaag aggcggcaga
       61 cagcggggaa atagacagac ggttggaaaa aaaactgaag atcacacaaa aagagagcag
      121 gaaatccaaa tctcctccca aagtgcccat tgtgattcag gacgatagcc ttcccgcggg
      181 gccccctcca cagatccgca tcctcaagag gcccaccagc aacggtgtgg tcagcagccc
      241 caactccacc agcaggccca cccttccagt caagtcccta gcacagcgag aggccgagta
      301 cgccgaggcc cggaagcgga tcctgggcag cgccagcccc gaggaggagc aggagaaacc
      361 catcctcgac aggccaacca ggatctccca acccgaagac agcaggcagc ccaataatgt
      421 gatcagacag cctttgggtc ctgatgggtc tcaaggcttc aaacagcgca gataaatgca
      481 ggcaagaaaa gatgccgccg ttgctgccgt caccgcctcc tgggtcgtcc gccacgggtt
      541 gcactgccgt ggcagacagc tggacttgag cagagggaac gacctgactt acttgcactg
      601 tgatccccct tgctccgccc actgtgacct tgaaccccat gcactgtgac ctcccccctt
      661 ctcccccttc ccactgtgat tggcacatcg acaagggctg tcccaagtca atggaaaggg
      721 aaagggtggg ggttagggga aggttggggg gacccagcaa ggactcagag agtcagacag
      781 tgccacttgg ccacttgggg taaagccagt gccagcaata acagtttatc atgctcatta
      841 atttgggatt tcaaaacaca aatgaaaact cacacccacc cacccccaag tgcatgtctc
      901 catcacttaa aaagtaagtt ccatttgaaa atatcctttc tttttttttt cttcctattt
      961 ttgtttgttt atacaaatat ctgatttgca agaaaaagtg catgggaggg gttttagtgg
     1021 tttaatgaat ttttaattaa gaaagggtag tttggtagtc tacttaaaaa tgtttctggg
     1081 aaattcacta gaaacattaa ccaataggat tttggtgagc ttagcttctg tattcctact
     1141 gccgcccaga aaaggggcag ggctctgcag ccgccaggac agacgagcac cccatgccta
     1201 tacctccctc cccgagctaa gtcccagggc atctgggcct tgcctggaga ctgggctagc
     1261 tctgtaggct cggagagcct ggggagggtg ccaaccccac ctctagtatt ttgggagata
     1321 gggaaagtga accgacttcc ccttcccata cccctcaggg tggttcccta ccagccaggc
     1381 ttactacttc tagaagaaag cagagtgcca gggagtgaga ttgcatccct gggcttagaa
     1441 gtgacggaga gaagacttgt ttagtatttt gccatcagca caaggaaaac caggagagag
     1501 tctgcctcca ggactctgag ccttctgcct cgtatgttca gaaggtggat aggtcttccc
     1561 actccagcat ggcttgaact cttaggggtc tgcagtgctc catctccatt ggtggcccca
     1621 gctcagtaac tatacctggt acatttcctg tgtgcaatca gtaccttgaa ggcagaacat
     1681 tctgaataaa gttggaaaaa gaacagcttt gctttgcaaa gattgatgac agactggttc
     1741 ctcagaggcc taggctaccc gtcacccctt tttccagagc gagggcctgg aatgaaggca
     1801 gtttatcctc tgtccctgga gcctggggtt tgctttggct ccttgaggtg gaagagacta
     1861 agagggcagc tgcccagagc agctgtgtgt acctggctcc tctcaggctt cctgatccct
     1921 tccgttgcac tgcgccttat ccctcagcca gccagacagc ctccctgctc ctgaccagca
     1981 gatacgtttc ggagtggttg gtgtggtttt tgtgatgagg gcagcacgtg gtggccaagg
     2041 tggcaagctg agtctcacag gctcactccc tcgttggttc cctgtgggaa tggtaggcca
     2101 ggcccagtaa gccatgcccc aacacgtcct ctcctccgga ggaagggcca gctgccagct
     2161 gagtcagcag ctagtccata gcacagcctt ataactgtaa agccaggcat tgcccatgag
     2221 cagagctgga accagagctt cagtcagtaa gagggaggat taccttcagg agaaggcaag
     2281 gaagaaaact ggctgctatc tttatagttc cactgcccta accaagtgtc cacattctaa
     2341 atgtgtagtg tccatccctt atgtaatagt ggtttcccgc ccaaagtgag actttccttt
     2401 taattggaga agggtataga ggtagtccag gtgggaacgc cagaagtgct gattgcccag
     2461 ccattgggac cacctgttct tgccccacta ccctctagtg ggaggccaaa gtaaaggctg
     2521 gctggtgggt gtctgtggat tgaggatgtg gcagggactg gtcctcccac ctccctctgg
     2581 ccaaagatgg gctttgcccg ctgtgtgcct gtcaccaccc accagcagtc atgccctggg
     2641 cttcccaaat ggagaggtag caggcaacgt ttttaaaaag aaagaaaaca ggaaactgta
     2701 ttgtgtcggg ggaggcggga gggagatgag gaaacggttt ggattttgtg tgtgggaggg
     2761 tattttttgg gggtagttgt ctgtaacttt cctaagtgct ttttttcctt ttctttttta
     2821 aagtaagttg caggctttgg cttggaaaac cccaggggga tggggggcag aaacctgagg
     2881 ctgctgcccc tttatctgcc ttcacggtac tgtccccttc ccccagctcc tccctgaccc
     2941 catgggccag gcctcagacc ttccagctaa ccgcttccca tgagccacta ctctgatgtc
     3001 agcctataac caaaggagct ggggggtcca ggcctggtga ccaacctttc tcagcccact
     3061 caatcagggt gctccccacc tgcaggcagg aggcaacacc ctatctgcta ccatcagccc
     3121 cttccagagc ccatctgccc cgcccagccc tgccctgccc agccataccc tgctctgccc
     3181 catctggggg tgccctgctc agggatgggc tggcagggct gtacccagcc tccctggtaa
     3241 gcagagactc aagaaacctc tggggtcctg ttttctggtc gtgtgatccc aggggtgcac
     3301 atgggcccct tgggtgtctg aacagaaggg catgggaggg agggctgcac ccctgcagtc
     3361 ttactctgct ggtgtagcgg gcagctgccc actcccaccc caccctgcac cgcgggctcc
     3421 tgagtcggca gattaagcat tttataaatt gtattttaaa tacatgtttt aaacttgtca
//
