LOCUS       NM_001370165            3998 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens synaptotagmin like 4 (SYTL4), transcript variant 9,
            mRNA.
ACCESSION   NM_001370165
VERSION     NM_001370165.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3998)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3998)
  AUTHORS   Alnaas,A.A., Watson-Siriboe,A., Tran,S., Negussie,M.,
            Henderson,J.A., Osterberg,J.R., Chon,N.L., Harrott,B.M., Oviedo,J.,
            Lyakhova,T., Michel,C., Reisdorph,N., Reisdorph,R., Shearn,C.T.,
            Lin,H. and Knight,J.D.
  TITLE     Multivalent lipid targeting by the calcium-independent C2A domain
            of synaptotagmin-like protein 4/granuphilin
  JOURNAL   J Biol Chem 296, 100159 (2021)
   PUBMED   33277360
  REMARK    GeneRIF: Multivalent lipid targeting by the calcium-independent C2A
            domain of synaptotagmin-like protein 4/granuphilin.
REFERENCE   3  (bases 1 to 3998)
  AUTHORS   Liu,X.Y., Jiang,W., Ma,D., Ge,L.P., Yang,Y.S., Gou,Z.C., Xu,X.E.,
            Shao,Z.M. and Jiang,Y.Z.
  TITLE     SYTL4 downregulates microtubule stability and confers paclitaxel
            resistance in triple-negative breast cancer
  JOURNAL   Theranostics 10 (24), 10940-10956 (2020)
   PUBMED   33042263
  REMARK    GeneRIF: SYTL4 downregulates microtubule stability and confers
            paclitaxel resistance in triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3998)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3998)
  AUTHORS   Liao,C., Zhou,Q., Zhang,Z., Wu,X., Zhou,Z., Li,B., Peng,J.,
            Shen,L., Li,D., Luo,X. and Yang,L.
  TITLE     Epstein-Barr virus-encoded latent membrane protein 1 promotes
            extracellular vesicle secretion through syndecan-2 and
            synaptotagmin-like-4 in nasopharyngeal carcinoma cells
  JOURNAL   Cancer Sci 111 (3), 857-868 (2020)
   PUBMED   31930596
  REMARK    GeneRIF: LMP1 upregulates SDC2 and SYTL4.
REFERENCE   6  (bases 1 to 3998)
  AUTHORS   Torii,S., Zhao,S., Yi,Z., Takeuchi,T. and Izumi,T.
  TITLE     Granuphilin modulates the exocytosis of secretory granules through
            interaction with syntaxin 1a
  JOURNAL   Mol Cell Biol 22 (15), 5518-5526 (2002)
   PUBMED   12101244
REFERENCE   7  (bases 1 to 3998)
  AUTHORS   Zhao,S., Torii,S., Yokota-Hashimoto,H., Takeuchi,T. and Izumi,T.
  TITLE     Involvement of Rab27b in the regulated secretion of pituitary
            hormones
  JOURNAL   Endocrinology 143 (5), 1817-1824 (2002)
   PUBMED   11956164
REFERENCE   8  (bases 1 to 3998)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains
            an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD
            of Slp4 specifically and directly binds the GTP-bound form of
            Rab3A, Rab8, and Rab27A.
REFERENCE   9  (bases 1 to 3998)
  AUTHORS   Yi,Z., Yokota,H., Torii,S., Aoki,T., Hosaka,M., Zhao,S., Takata,K.,
            Takeuchi,T. and Izumi,T.
  TITLE     The Rab27a/granuphilin complex regulates the exocytosis of
            insulin-containing dense-core granules
  JOURNAL   Mol Cell Biol 22 (6), 1858-1867 (2002)
   PUBMED   11865063
REFERENCE   10 (bases 1 to 3998)
  AUTHORS   Araki,W., Ohno,K., Matsunaga,K., Nakamura,H., Sugimoto,C. and
            Shimada,T.
  TITLE     [Two sisters with pseudoidiopathic hypoparathyroidism presenting
            extensive intracranial calcification]
  JOURNAL   Nihon Naika Gakkai Zasshi 78 (1), 81-82 (1989)
   PUBMED   2732579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390040.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the synaptotagmin like
            protein family. Members of this family are characterized by an
            N-terminal Rab27 binding domain and C-terminal tandem C2 domains.
            The encoded protein binds specific small Rab GTPases and is
            involved in intracellular membrane trafficking. This protein binds
            Rab27 and may be involved in inhibiting dense core vesicle
            exocytosis. Alternate splicing results in multiple transcript
            variants that encode the same protein. [provided by RefSeq, Mar
            2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.162032.1,
                                           SRR1803616.210428.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372989.6/ ENSP00000362080.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL390040.9         80074-80191         c
            119-206             AL390040.9         79488-79575         c
            207-282             AL390040.9         52881-52956         c
            283-375             AL390040.9         51163-51255         c
            376-555             AL390040.9         49998-50177         c
            556-771             AL390040.9         49528-49743         c
            772-881             AL390040.9         49290-49399         c
            882-984             AL390040.9         48967-49069         c
            985-1086            AL390040.9         39178-39279         c
            1087-1162           AL390040.9         38633-38708         c
            1163-1253           AL390040.9         38145-38235         c
            1254-1357           AL390040.9         37926-38029         c
            1358-1450           AL390040.9         36421-36513         c
            1451-1629           AL390040.9         35137-35315         c
            1630-1732           AL390040.9         34749-34851         c
            1733-1894           AL390040.9         34060-34221         c
            1895-2003           AL390040.9         29297-29405         c
            2004-2103           AL390040.9         27383-27482         c
            2104-2312           AL390040.9         26461-26669         c
            2313-3998           AL390040.9         22561-24246         c
FEATURES             Location/Qualifiers
     source          1..3998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3998
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /note="synaptotagmin like 4"
                     /db_xref="GeneID:94121"
                     /db_xref="HGNC:HGNC:15588"
                     /db_xref="MIM:300723"
     exon            1..118
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            119..206
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            207..282
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            283..375
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            376..555
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..2461
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /note="isoform 1 is encoded by transcript variant 9;
                     granuphilin-a; exophilin-2"
                     /codon_start=1
                     /product="synaptotagmin-like protein 4 isoform 1"
                     /protein_id="NP_001357094.1"
                     /db_xref="CCDS:CCDS14472.1"
                     /db_xref="GeneID:94121"
                     /db_xref="HGNC:HGNC:15588"
                     /db_xref="MIM:300723"
                     /translation="MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELL
                     EIKRKGAKRGSQHYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRC
                     KVCAKEIELKKATGDWFYDQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQT
                     QMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSL
                     DKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVI
                     DLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSS
                     MSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKR
                     SNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHG
                     RFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPA
                     SKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRK
                     TPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGI
                     SNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKLGL"
     exon            556..771
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            772..881
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            882..984
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1086
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1162
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1253
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1357
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1450
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1629
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1732
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1894
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2003
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2103
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2312
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..3998
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3975..3980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /note="hexamer: AATAAA"
     polyA_site      3998
                     /gene="SYTL4"
                     /gene_synonym="SLP4"
                     /note="major polyA site"
ORIGIN      
        1 gagggtgaga agggccggct gccggagctg ggttgcgatc ttcccggagc cggagaccct
       61 cccttgaaac cggcactggg acttctcgat ctctggaggc acctgttgca agtgacagcg
      121 ctcggccgtc gagcggggtc gctaacccgc actctcttcg gacctacgac atcgcggctt
      181 ctctggcgtt ggccagtcag ccacagggaa ctagtaaaaa aagaaaaaga aaaaataaag
      241 tgaaagaggc gtgttgtcta gtttcaaagg agaggagaga agagactgag tcgccctgtg
      301 ttgcccaggc tggtcttgaa ctcctaggct caagagatcc tcctgcctca gcctcccaaa
      361 gtgctgggat tacaggcaac tctggtagct ctccttgtct ggttgttttg aagaaagaag
      421 agtagaagaa aaagttgagt aaatcatgtc ggagttactg gacctttctt ttctgtctga
      481 ggaggaaaag gatttgattc tcagtgttct acagcgagat gaagaggtcc ggaaagcaga
      541 tgagaaaagg attaggcgac taaagaatga gttactggag ataaaaagga aaggggccaa
      601 gaggggcagc caacactaca gtgatcggac ctgtgcccgg tgccaggaga gcctgggccg
      661 tttgagtccc aaaaccaata cttgtcgggg ttgtaatcac ctggtgtgtc gggactgccg
      721 catacaggaa agcaatggta cctggaggtg caaggtgtgc gccaaggaaa tagagttgaa
      781 gaaagcaact ggggactggt tttatgacca gaaagtgaat cgctttgctt accgcacagg
      841 tagtgagata atcaggatgt ccctgcgcca caaacctgca gtgagtaaaa gagagacagt
      901 gggacagtcc ctccttcatc agacacagat gggtgacatc tggccaggaa gaaagatcat
      961 tcaggagcgg cagaaggagc ccagtgtgct atttgaagtg ccaaagctga aaagtggaaa
     1021 gagtgcattg gaagctgaga gtgagagtct ggatagcttc acagctgact cggatagcac
     1081 ctccaggaga gactctctgg ataaatctgg cctctttcca gaatggaaga agatgtctgc
     1141 tcccaaatct caagtagaaa aggaaactca gcctggaggt caaaatgtgg tatttgtgga
     1201 tgagggtgag atgatattta agaagaacac cagaaaaatc ctcaggcctt cagagtacac
     1261 taaatctgtg atagatcttc gcccagaaga tgtggtacat gaaagtggct ccttgggaga
     1321 cagaagcaaa tccgtcccag gcctcaatgt ggatatggaa gaggaagaag aagaagaaga
     1381 cattgaccac ctagtgaagt tacatcgcca gaagctagcc agaagcagca tgcaaagtgg
     1441 ctcctccatg agtacgatcg gcagcatgat gagcatctac agtgaagctg gtgatttcgg
     1501 gaacatcttt gtgactggca ggattgcctt ttccctgaag tatgagcagc aaacccagag
     1561 tctggttgtc catgtgaagg agtgccatca gctggcctat gctgatgaag ccaagaagcg
     1621 ctctaaccca tatgtgaaga cttaccttct gcctgacaag tcccgccaag gaaaaagaaa
     1681 aaccagcatc aagcgggaca ctattaatcc actatatgat gagacgctga ggtatgagat
     1741 cccagaatct ctcctggccc agaggaccct gcagttctca gtttggcatc atggtcgttt
     1801 tggcagaaac actttccttg gagaggcaga gatccagatg gattcctgga agcttgataa
     1861 gaaactggat cattgcctcc ctttacatgg aaagatcagt gctgagtccc cgactggctt
     1921 gccatcacac aaaggcgagt tggtggtttc attgaaatac atcccagcct ccaaaacccc
     1981 tgttggaggt gaccggaaaa agagtaaagg tggggaaggg ggagagctcc aggtgtggat
     2041 caaagaagcc aagaacttga cggctgccaa agcaggaggg acttcagaca gctttgtcaa
     2101 gggatacctc cttcccatga ggaacaaggc cagtaaacgt aaaactcctg tgatgaagaa
     2161 gaccctgaat cctcactaca accatacatt tgtctacaat ggtgtgaggc tggaagatct
     2221 acagcatatg tgcctggaac tgactgtgtg ggaccgggag cccctggcca gcaatgactt
     2281 cctgggaggg gtcaggctgg gtgttggcac tgggatcagt aatggggaag tggtggactg
     2341 gatggactcg actggggaag aagtgagcct gtggcagaag atgcgacagt acccagggtc
     2401 ttgggcagaa gggactctgc agctccgttc ctcaatggcc aagcagaagc tgggtttatg
     2461 agtccctgtc ctcttctgca ggtccagccc tggcgagggc aggtcagagg aagtgaagaa
     2521 atcaagagca aagatttata atttaatgtg tatgtgtgta tgtgtgtatg tgtgtgtgtg
     2581 tgtgtgtgtg tgtatgtgta caaacatgta ttttctgcaa atctcattat gctggctaga
     2641 gtgatgcaga cttgttcttc tttttaaagc agtctcaaga ataagcattt ctttaaaatg
     2701 tttctgtgta taatctagtt tattttcaga gtccattttt tcttatgtct ttataaggtt
     2761 cacttaactt aaaaacagct tttaaaacaa ctttttatct tctgtcttgc tatcattgtt
     2821 cctacttccc taggaagccc tggctacctt tcgcattagg accagtctgg gttttaaggc
     2881 tctgggaagc agggttggtt agtaaagaca ggaatgttgg ggagaggtga gtagttcctt
     2941 cctctttctc ctctccaatt tatgctttta acttattttc tacctggata aacttctgga
     3001 acttggcttt taaatttaac ttttctagtt tttaagcagt ttccaccttg ctttggtcta
     3061 atgcttttct ttgaaatgct aacagaattc ccaagctttt tccagttcta gatatcttta
     3121 ctagaccttt gggggactct tataatggag ctgcttttga aaagcacttt aattagataa
     3181 tgtattttga ctaaatcacg aggatgccca gtgagagctt ctagctgatc tcagaggacc
     3241 agagtgactg agggtaaagt gtctcacagc ccatgctgaa ttttctgcat tttaaactga
     3301 tactgcagtc attggagaga gagctcctca tttctcgaat gaaagatgag atatattcat
     3361 cctcatgtac cacatctgtc ttagtgtttg cgtctggggt gtgttatcaa acagagcatg
     3421 gtctacatcc cactgtgtca accagaagag ccaagtgtta tctcaattgg cccagtgttt
     3481 ctccaggctg gggactgtta agggctctaa gggaatgtag acagagtctc cctgttattc
     3541 tgacttcctg cttgatgagc tttcagttcc tgtttttgct attgtttcct aaatttgacc
     3601 tacatattac atgggtgtag tgtgttgagg cttttcaaag aagggtctag tgagctaagt
     3661 ttcatcttct ggtactcatt gatcaaactg acctttctat tctcataagc gtttctaccc
     3721 aaagttgtgt gtggaaggag tgtatagcag agaggaaatc cctttcaaca gagtcagctg
     3781 ctaactgatt tcctataagc acactggatt aagggcagcc acagtggttt ctactgtatg
     3841 tatgaaccga atggaggaat gttttcaaag attgatttgg tgtggattgc aattgtaatg
     3901 gaaggcataa cttgggatcc cgggctgtaa cttgctcttt tgtttcccac ccccctgaca
     3961 tgtatgtgtg ctttaataaa gctttctcac ttgtcaaa
//
