LOCUS       NM_001242394            2851 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens synaptotagmin like 3 (SYTL3), transcript variant 2,
            mRNA.
ACCESSION   NM_001242394
VERSION     NM_001242394.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2851)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2851)
  AUTHORS   Dong,X., Yang,L., Liu,K., Ji,X., Tang,C., Li,W., Ma,L., Mei,Y.,
            Peng,T., Feng,B., Wu,Z., Tang,Q., Gao,Y., Yan,K., Zhou,W. and
            Xiong,M.
  TITLE     Transcriptional networks identify synaptotagmin-like 3 as a
            regulator of cortical neuronal migration during early
            neurodevelopment
  JOURNAL   Cell Rep 34 (9), 108802 (2021)
   PUBMED   33657377
  REMARK    GeneRIF: Transcriptional networks identify synaptotagmin-like 3 as
            a regulator of cortical neuronal migration during early
            neurodevelopment.
REFERENCE   3  (bases 1 to 2851)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2851)
  AUTHORS   Kurowska,M., Goudin,N., Nehme,N.T., Court,M., Garin,J., Fischer,A.,
            de Saint Basile,G. and Menasche,G.
  TITLE     Terminal transport of lytic granules to the immune synapse is
            mediated by the kinesin-1/Slp3/Rab27a complex
  JOURNAL   Blood 119 (17), 3879-3889 (2012)
   PUBMED   22308290
  REMARK    Erratum:[Blood. 2014 Feb 27;123(9):1432]
REFERENCE   5  (bases 1 to 2851)
  AUTHORS   Fukuda,M.
  TITLE     Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through
            interaction with the GDP-bound form of Rab27A in PC12 cells
  JOURNAL   J Biol Chem 278 (17), 15390-15396 (2003)
   PUBMED   12590134
REFERENCE   6  (bases 1 to 2851)
  AUTHORS   Fukuda,M.
  TITLE     The C2A domain of synaptotagmin-like protein 3 (Slp3) is an
            atypical calcium-dependent phospholipid-binding machine: comparison
            with the C2A domain of synaptotagmin I
  JOURNAL   Biochem J 366 (Pt 2), 681-687 (2002)
   PUBMED   12049610
REFERENCE   7  (bases 1 to 2851)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Synaptotagmin-like protein 3-a (Slp3-a) contains an
            N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of
            Slp3-a specifically and directly binds the GTP-bound form of
            Rab27A.
REFERENCE   8  (bases 1 to 2851)
  AUTHORS   Fukuda,M., Saegusa,C. and Mikoshiba,K.
  TITLE     Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
            identification of the Slp homology domain
  JOURNAL   Biochem Biophys Res Commun 283 (2), 513-519 (2001)
   PUBMED   11327731
REFERENCE   9  (bases 1 to 2851)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC394549.1, BC100829.1,
            AK304191.1, AL567177.3 and AI674404.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001242394.1.
            
            Summary: The protein encoded by this gene belongs to a family of
            peripheral membrane proteins that play a role in vesicular
            trafficking. This protein binds phospholipids in the presence of
            calcium ions. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) contains an alternate segment
            in the 5' UTR compared to variant 1. Variants 1 and 2 encode the
            same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2485883.1,
                                           SRR14038192.1645379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611299.5/ ENSP00000483936.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               DC394549.1         49-227
            180-1990            BC100829.1         1-1811
            1991-2394           AK304191.1         896-1299
            2395-2395           AL567177.3         423-423             c
            2396-2510           AK304191.1         1301-1415
            2511-2837           AI674404.1         18-344              c
            2838-2851           AK304191.1         1743-1756
FEATURES             Location/Qualifiers
     source          1..2851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..2851
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /note="synaptotagmin like 3"
                     /db_xref="GeneID:94120"
                     /db_xref="HGNC:HGNC:15587"
                     /db_xref="MIM:620973"
     exon            1..25
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            26..115
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            116..232
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            233..861
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             752..2584
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /note="isoform 1 is encoded by transcript variant 2;
                     exophilin-6; synaptotagmin-like protein 3"
                     /codon_start=1
                     /product="synaptotagmin-like protein 3 isoform 1"
                     /protein_id="NP_001229323.1"
                     /db_xref="CCDS:CCDS56458.1"
                     /db_xref="GeneID:94120"
                     /db_xref="HGNC:HGNC:15587"
                     /db_xref="MIM:620973"
                     /translation="MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQ
                     HLRWKGAKNTDWEHKEKCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWK
                     CTVCFEDRNVKIKTGEWFYEERAKKFPTGGKHETVGGQLLQSYQKLSKISVVPPTPPP
                     VSESQCSRSPGRLQEFGQFRGFNKSVENLFLSLATHVKKLSKSQNDMTSEKHLLATGP
                     RQCVGQTERRSQSDTAVNVTTRKVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAPS
                     TIFSGGFRHGSLISIDSTCTEMGNFDNANVTGEIEFAIHYCFKTHSLEICIKACKNLA
                     YGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQL
                     QVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLRAKAEKYEDSVPQSNGE
                     LTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKNLPVRPDGTLNSFVKGCL
                     TLPDQQKLRLKSPVLRKQACPQWKHSFVFSGVTPAQLRQSSLELTVWDQALFGMNDRL
                     LGGTRLGSKGDTAVGGDACSLSKLQWQKVLSSPNLWTDMTLVLH"
     exon            862..1080
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1145
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1197
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1267
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1346
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1471
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1606
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1785
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1888
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2059
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2165
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2268
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2474
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2851
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /note="hexamer: AATAAA"
     polyA_site      2851
                     /gene="SYTL3"
                     /gene_synonym="SLP3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctctt gaagcagatg cgaaggctcc ccgaatgaga aagaatactc ggaatcagcg
       61 gtgaattgca gtgatctttc agagaaagcg cctgttcaac tttgtcctct ctcagagact
      121 cagagccttg gggcactgag ggatgccagt tctgcctgtt catctggaac ctggatctaa
      181 ggagggaaga ggcgttgccc ctgctggcat agtcaggtac cagcccagcc aggtattgaa
      241 cgggctgagc ttttcatgat ggttcctgct gacctggaaa catcttaaat ggaaggttag
      301 cttctatgag tcactgatac tctttttatt gctatttcta aatttccttg gcttgaaaat
      361 tacttctgct ttgcagaaat tatctgcttg cagctgtgga taatttataa caatctctgg
      421 tgaaacctca gaaaagagat atgcttttgt cttagatgga tgtcagcagc tgctgcagaa
      481 cccggtgaaa acaccccccg ggtagcacga ggctctgcga gccgtaactc cgacaaacgc
      541 agaacttctt gaggctttct tcttctaagg agtatgacac agttaaaaag gaaaaaagaa
      601 ccacaagcaa aacagttgcc agtgaaatag gagagggagc tctttaaaca aggctggctg
      661 cagctggcct ccgccgctca tctgcagggc gtgagcgctt ggtccatgca gtgaagctct
      721 tccaacctgg gtcaacgaaa acggagaaga aatggcccaa gaaatagatc tgagtgctct
      781 caaggagtta gaacgcgagg ccattctcca ggtcctgtac cgagaccagg cggttcaaaa
      841 cacagaggag gagaggacac ggaaactgaa aacacacctg cagcatctcc ggtggaaagg
      901 agcgaagaac acggactggg agcacaaaga gaagtgctgt gcgcgctgcc agcaggtgct
      961 ggggttcctg ctgcaccggg gcgccgtgtg ccggggctgc agccaccgcg tgtgtgccca
     1021 gtgccgagtg ttcctgaggg ggacccatgc ctggaagtgc acggtgtgct tcgaggacag
     1081 gaatgtcaaa ataaaaactg gagaatggtt ctatgaggaa cgagccaaga aatttccaac
     1141 tggaggcaaa catgagacag ttggagggca gctcttgcaa tcttatcaga agctgagcaa
     1201 aatttctgtg gttcctccta ctccacctcc tgtcagcgag agccagtgca gccgcagtcc
     1261 tggcaggtta caggaatttg gtcagtttag aggatttaat aagtccgtgg aaaatttgtt
     1321 tctgtctctt gctacccacg tgaaaaagct ctccaaatcc cagaatgata tgacttctga
     1381 gaagcatctt ctcgccacgg gccccaggca gtgtgtggga cagacagaga gacggagcca
     1441 gtctgacact gcggtcaacg tcaccaccag gaaggtcagt gcaccagata ttctgaaacc
     1501 tctcaatcaa gaggatccca aatgctctac taaccctatt ttgaagcaac agaatctccc
     1561 atccagtccg gcacccagta ccatattctc tggaggtttt agacacggaa gtttaattag
     1621 cattgacagc acctgtacag agatgggcaa ttttgacaat gctaatgtca ctggagaaat
     1681 agaatttgcc attcattatt gcttcaaaac ccattcttta gaaatatgca tcaaggcctg
     1741 taagaacctt gcctatggag aagaaaagaa gaaaaagtgc aatccgtatg tgaagaccta
     1801 cctgttgccc gacagatcct cccagggaaa gcgcaagact ggagtccaaa ggaacaccgt
     1861 ggacccgacc tttcaggaga ccttgaagta tcaggtggcc cctgcccagc tggtgacccg
     1921 gcagctgcag gtctcggtgt ggcatctggg cacgctggcc cggagagtgt ttcttggaga
     1981 agtgatcatt cctctggcca cgtgggactt tgaagacagc acaacacagt ccttccgctg
     2041 gcatccgctc cgggccaagg cggagaaata cgaagacagc gttcctcaga gtaatggaga
     2101 gctcacagtc cgggctaagc tggttctccc ttcacggccc agaaaactcc aagaggctca
     2161 agaagggaca gatcagccat cacttcatgg tcaactttgt ttggtagtgc taggagccaa
     2221 gaatttacct gtgcggccag atggcacctt gaactcattt gttaagggct gtctcactct
     2281 gccagaccaa caaaaactga gactgaagtc gccagtcctg aggaagcagg cttgccccca
     2341 gtggaaacac tcatttgtct tcagtggcgt aaccccagct cagctgaggc agtcaagctt
     2401 ggagttaact gtctgggatc aggccctctt tggaatgaac gaccgcttgc ttggaggaac
     2461 cagacttggt tcaaagggag acacagctgt tggcggggat gcatgctcac tatcgaagct
     2521 ccagtggcag aaagtccttt ccagccccaa tctatggaca gacatgactc ttgtcctgca
     2581 ctgacatgaa ggcctcaagg ttccaggttg cagcaggcgt gaggcactgt gcgtctgcag
     2641 aggggctacg aaccaggtgc agggtcccag ctggagaccc ctttgacctt gagcagtctc
     2701 catctgcggc cctgtcccat ggcttaaccg cctattggta tctgtgtata tttacgttaa
     2761 acacaattat gttacctaag cctctggtgg gttatctcct ctttgagatg tagaaaatgg
     2821 ccagatttta ataaacgttg ttacccatgt c
//
