LOCUS       NM_206927               8263 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens synaptotagmin like 2 (SYTL2), transcript variant c,
            mRNA.
ACCESSION   NM_206927 XM_011545105
VERSION     NM_206927.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8263)
  AUTHORS   Xie,X., Yuan,Y., Huang,Y., Hong,X., Hong,S., Chen,G., Chen,Y.,
            Lin,Y., Lu,W., Fu,W. and Wang,L.
  TITLE     Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and
            poor extracellular matrix remodeling of the vascular wall in
            thoracic aortic aneurysm
  JOURNAL   Chin Med J (Engl) 137 (9), 1105-1114 (2024)
   PUBMED   37640670
  REMARK    GeneRIF: Effects of COL1A1 and SYTL2 on inflammatory cell
            infiltration and poor extracellular matrix remodeling of the
            vascular wall in thoracic aortic aneurysm.
REFERENCE   2  (bases 1 to 8263)
  AUTHORS   Li,Z., Tao,Y., Gao,Z., Peng,S., Lai,Y., Li,K., Chen,X. and Huang,H.
  TITLE     SYTL2 promotes metastasis of prostate cancer cells by enhancing
            FSCN1-mediated pseudopodia formation and invasion
  JOURNAL   J Transl Med 21 (1), 303 (2023)
   PUBMED   37147713
  REMARK    GeneRIF: SYTL2 promotes metastasis of prostate cancer cells by
            enhancing FSCN1-mediated pseudopodia formation and invasion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8263)
  AUTHORS   Francis,C.R., Claflin,S. and Kushner,E.J.
  TITLE     Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen Formation
            via Weibel-Palade Body Apical Secretion of Angiopoietin-2
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (6), 1972-1986 (2021)
   PUBMED   33853352
  REMARK    GeneRIF: Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen
            Formation via Weibel-Palade Body Apical Secretion of
            Angiopoietin-2.
REFERENCE   4  (bases 1 to 8263)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 8263)
  AUTHORS   Sung,H.Y., Han,J., Ju,W. and Ahn,J.H.
  TITLE     Synaptotagmin-like protein 2 gene promotes the metastatic potential
            in ovarian cancer
  JOURNAL   Oncol Rep 36 (1), 535-541 (2016)
   PUBMED   27220283
  REMARK    GeneRIF: Overexpression of SYTL2 promoted metastatic potential.
REFERENCE   6  (bases 1 to 8263)
  AUTHORS   Menasche,G., Menager,M.M., Lefebvre,J.M., Deutsch,E., Athman,R.,
            Lambert,N., Mahlaoui,N., Court,M., Garin,J., Fischer,A. and de
            Saint Basile,G.
  TITLE     A newly identified isoform of Slp2a associates with Rab27a in
            cytotoxic T cells and participates to cytotoxic granule secretion
  JOURNAL   Blood 112 (13), 5052-5062 (2008)
   PUBMED   18812475
  REMARK    GeneRIF: Rab27a recruits Slp2a-hem on vesicular structures in
            peripheral CTLs and following CTL-target cell conjugate formation,
            the Slp2a-hem/Rab27a complex colocalizes with perforin-containing
            granules at the immunologic synapse
REFERENCE   7  (bases 1 to 8263)
  AUTHORS   Fukuda,M., Saegusa,C. and Mikoshiba,K.
  TITLE     Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
            identification of the Slp homology domain
  JOURNAL   Biochem Biophys Res Commun 283 (2), 513-519 (2001)
   PUBMED   11327731
REFERENCE   8  (bases 1 to 8263)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
REFERENCE   9  (bases 1 to 8263)
  AUTHORS   Duncan,R.R., Shipston,M.J. and Chow,R.H.
  TITLE     Double C2 protein. A review
  JOURNAL   Biochimie 82 (5), 421-426 (2000)
   PUBMED   10865129
  REMARK    Review article
REFERENCE   10 (bases 1 to 8263)
  AUTHORS   Nalefski,E.A. and Falke,J.J.
  TITLE     The C2 domain calcium-binding motif: structural and functional
            diversity
  JOURNAL   Protein Sci 5 (12), 2375-2390 (1996)
   PUBMED   8976547
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000974.5 and AP000642.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_206927.3.
            
            Summary: The protein encoded by this gene is a synaptotagmin-like
            protein (SLP) that belongs to a C2 domain-containing protein
            family. The SLP homology domain (SHD) of this protein has been
            shown to specifically bind the GTP-bound form of Ras-related
            protein Rab-27A (RAB27A). This protein plays a role in
            RAB27A-dependent vesicle trafficking and controls melanosome
            distribution in the cell periphery. Alternative splicing results in
            multiple transcript variants encoding distinct isoforms.[provided
            by RefSeq, Jun 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4486657.1,
                                           SRR14038194.1629509.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359152.10/ ENSP00000352065.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AP000974.5         28246-28433         c
            189-678             AP000642.5         136343-136832       c
            679-830             AP000642.5         126990-127141       c
            831-966             AP000642.5         124355-124490       c
            967-1048            AP000642.5         116293-116374       c
            1049-1163           AP000642.5         115219-115333       c
            1164-1967           AP000642.5         112657-113460       c
            1968-5903           AP000642.5         102750-106685       c
            5904-6005           AP000642.5         99576-99677         c
            6006-6059           AP000642.5         97508-97561         c
            6060-6107           AP000642.5         96201-96248         c
            6108-6202           AP000642.5         93131-93225         c
            6203-6322           AP000642.5         89831-89950         c
            6323-6492           AP000642.5         88049-88218         c
            6493-6595           AP000642.5         86147-86249         c
            6596-6766           AP000642.5         83576-83746         c
            6767-6845           AP000642.5         79233-79311         c
            6846-6945           AP000642.5         76697-76796         c
            6946-7151           AP000642.5         74901-75106         c
            7152-8263           AP000642.5         72947-74058         c
FEATURES             Location/Qualifiers
     source          1..8263
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..8263
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /note="synaptotagmin like 2"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
     exon            1..188
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            189..678
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             578..7297
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /note="isoform c is encoded by transcript variant c;
                     chromosome 11 synaptotagmin; breast cancer-associated
                     antigen SGA-72M; exophilin-4; synaptotagmin-like protein
                     2; protein phosphatase 1, regulatory subunit 151"
                     /codon_start=1
                     /product="synaptotagmin-like protein 2 isoform c"
                     /protein_id="NP_996810.2"
                     /db_xref="CCDS:CCDS91569.1"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
                     /translation="MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQ
                     QLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNN
                     VNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKQRK
                     NPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKS
                     KQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKR
                     NSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVR
                     FSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSL
                     FHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSE
                     LTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGKPPPLPALKAKTSSRSGPYA
                     TEIKKSTDDSIFKVLDWFNRSSYSDDNKSFLQHPRGIESKEKTDSKSQVAVDLVTDDT
                     TLRENGSKTLSPSKIELKPVRSDSPFQAEGDMLVSESCQDNNVNIKSKFMNLSQKGTP
                     KEGPGILQPFESYGTPSQGSKNMDYSQDSKSPGKGNGASPSNSNYSYSVLKESDAENQ
                     VPCNTNNIGNLGEEEPKFHAHEENRGHSEVNFDSSTVVKEPGLKDNMNAERKSKVGNT
                     YILKASLEPENIKSTPGVANNGSPWKKPEVQFQQEAGEVPKNQVQREKYKRVSDRISF
                     WEGEKAGAKITHEKPTSSCSQEQPSAKAYQPVKKSQGVSSMDSLSTDQSEYNQAIPKR
                     VVLDEDDQASQLSNSYSSNKSKETKPQIAGPSRYYLSAEQSDKVSLFQNKKNEPIKRS
                     QVADSLPSRRNITLPALQPPSNVGSERHAPLEKDRPLVRESNANFKVMSLKERMDEPN
                     AEQVYNPSQFENLRKFWDLEANSNSKDNDKNITTTSQKNSAPFNRQKHKEFSDIKLSG
                     KNTHEAEVLLSPKKVMAREEMEKLNSKGILQVLPDEITFPLSPLRKYTYQLPGNESSK
                     ENVEKNTEGIVTPVFKEEKDYSEQEIQESIIKTNVLSKDCKDTFNDSLQKLLSETSTP
                     AIQPSGGKVHGKQVLEPSVSENRTWPQKTDFADTEEEVKGPEKIINEHVDKTVVHPKV
                     KRNSLTASLDKLLKEATGTSPSPLQAKLAPVITGTNSKLEEGRFFGKGIEQSHNTSAD
                     KREILAPFPVRDETFGNTALLKKAESGECQLSTQNLIQMAAEDSHPLDPTSQLSRKGS
                     FGDVASPPQDMLFPQDAHLVPQARVHPSQTEISETVEKVILPPRPVLNDVSAALQKLC
                     GEVWLSYPAGREVGPGEVNPEFPEAVQPVCSPLNPPGVISPWATMDTIVPDRKDFYSS
                     NVVPDKTHEVGSYLAAQMSPSDQTLSSFASIVAQYGKGLPQEVEEIVRETIVQPKSEF
                     LEFSAGLEKLLKEETETFPSKYESDTGNLSPSKLIGSTEEPRRATSECHPEELKETVE
                     KAEAPLITESAFDAGFEKLLKEITEAPPYQPQVSVREETHEKESSQSEQTRFLGTVPH
                     FYRAASQTSEMKDKSNGLESQVNQCDKMLGGDALVTDLLVDFCGSRSGVEIPRTPQLY
                     VAHEIGTIKTVTPPEDRDSESGVAGGQGTLQEPGFGEASEAISVSRNRQPIPLLMNKE
                     NSTKTSKVELTLASPYMKQEKEEEKEGFSESDFSDGNTSSNAESWRNPSSSEEEPSPV
                     LKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDDEKPDQKPVTNECVP
                     RISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSS
                     LTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCK
                     DLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKT
                     QKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENR
                     GEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRK
                     SRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFG
                     TGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK"
     exon            679..830
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            831..966
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1048
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1163
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1967
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..5903
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            5904..6005
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6006..6059
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6060..6107
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6108..6202
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6203..6322
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6323..6492
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6493..6595
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6596..6766
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6767..6845
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6846..6945
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            6946..7151
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            7152..8263
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8182..8187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /note="hexamer: AATAAA"
     polyA_site      8217
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /note="major polyA site"
     regulatory      8239..8244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /note="hexamer: AATAAA"
     polyA_site      8263
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /note="major polyA site"
ORIGIN      
        1 agtgccgggc gacacccggg ccgtgccgcc agcgtccgtc gggagagtga aggctcgcaa
       61 cgccttgccc gggggaaggt aacgcgccgc gcccggggct gcgcggtttg caccgccagg
      121 ccgagggctg ggggccagaa gacaagagag acggcgaggc gcgctccctg cccggcagcg
      181 actcggaggt aggtgatgct ctgatgctgc tgcctcttat gaattgacga caggtgcaga
      241 gagagaataa actgtgtcta agactggacc agagagtgag tgtgctggaa gccaccatag
      301 gaacaagcga cctgtttggc aaggaataca gcatccttct gagagcctct tctcgacact
      361 atcccacaga ccaggacttc ctcatgggaa agagcactta ggatcttgct atcagctgcc
      421 ctaaactttt gctgagccaa aataagactt tgatgcagaa ctgaacaaga tatttcattt
      481 ttgtgtgttt taatcttcct ggttgcagtc ttagttgttc agccctgaga attttgagcc
      541 acatttgttg ctattatttt tgcatgcact tttcaaaatg attgacttaa gcttcctgac
      601 tgaagaggaa caagaggcca tcatgaaggt tttgcagcgg gatgctgctc tgaagagggc
      661 cgaagaagag agagtcagac atttgcctga aaaaattaag gatgaccagc agctgaagaa
      721 tatgagtggc caatggtttt atgaagccaa ggcaaaaagg cacagggaca aaatccatgg
      781 cgcagatatc atcagagcat ctatgagaaa gaagaggccc cagatagcag ctgagcagag
      841 taaagacaga gaaaatgggg caaaggaaag ctgggtgaat aatgtcaaca aagatgcttt
      901 ccttcctcca gagctggctg gcgttgtaga agagccagaa gaagatgcag caccagcaag
      961 cccgagttcc agtgtggtaa atccagcttc cagtgtgatt gatatgtccc aggaaaacac
     1021 aaggaaacca aatgtgtctc cagagaagca gaggaagaat ccgtttaata gctccaagtt
     1081 gccagaaggt cactcatcac aacaaactaa aaatgaacag tcaaaaaatg gaagaactgg
     1141 tttatttcag acttcaaaag aggatgaatt gtcagagtca aaagaaaagt caactgtcgc
     1201 agatacttca atccaaaagt tagagaaatc aaagcagact ttgccaggcc tttcaaatgg
     1261 gtcccaaatc aaggctccaa tccccaaagc caggaagatg atctacaaat caactgattt
     1321 aaacaaagat gataaccagt cttttcctag acaaaggaca gactccctga aagcgagagg
     1381 ggctccgaga gggatcctca agcgcaactc cagttccagt agcacagact cagaaaccct
     1441 tcgttataat cacaactttg aacccaaaag caaaattgtg tcacctggcc taaccatcca
     1501 tgagagaatt tctgagaagg agcattcttt agaagacaac tcttccccaa actccctgga
     1561 gccattaaag catgtgagat tctctgcagt gaaggatgag cttccacaga gtcctgggct
     1621 aatccatggt cgggaagtag gagaatttag tgttttagaa tctgacagat tgaaaaatgg
     1681 aatggaagat gcaggggaca cagaagagtt tcagagtgac cctaagcctt ctcaatacag
     1741 aaagccttcg ctttttcatc aatcaacctc aagcccatat gtatcaaaaa gtgaaacaca
     1801 tcagccaatg acttctggtt cttttccaat taatgggctg cattctcatt cagaagtttt
     1861 aactgcaaga ccacagtcta tggagaattc accaaccatc aatgaaccca aagataaatc
     1921 atcagaatta acaaggcttg aatctgtatt acccagaagc cctgctgatg aactgtctca
     1981 ttgtgttgag cctgagccat ctcaggtgcc aggtggcagt tctagagacc gtcagcaagg
     2041 taagccccct cctctcccgg ctctaaaagc taagacatct tcacgttctg gtccatatgc
     2101 cactgagata aagaagtcaa ctgatgattc catatttaaa gttctagact ggtttaaccg
     2161 aagttcttat tcagatgaca ataagtcatt cctccaacat ccccgaggaa tagagtccaa
     2221 agaaaaaaca gactcaaaat cacaggttgc tgttgacttg gtgacagatg acactacttt
     2281 aagagaaaat ggctcaaaga ccctatcacc cagcaaaatt gaattgaagc ctgtgagatc
     2341 tgactcacca ttccaagcag agggagatat gctggtttct gaaagttgcc aagataataa
     2401 tgtgaatatc aaatccaaat tcatgaattt gtcccaaaaa ggcaccccaa aggaaggccc
     2461 aggtatattg caaccatttg aaagctatgg caccccaagt caagggagta aaaatatgga
     2521 ctatagccaa gattcaaaaa gcccaggaaa agggaatggg gcatctcctt caaatagtaa
     2581 ctattcctac agtgttctca aggaatctga tgcagaaaac caagttccat gcaacactaa
     2641 taatattggc aacttgggtg aagaagaacc caagtttcat gctcatgaag aaaatagagg
     2701 acactcagaa gtgaattttg actcttcaac agttgtcaaa gaaccaggtt tgaaagataa
     2761 catgaatgca gagagaaaga gcaaagtagg aaatacctat atcctgaaag cctccttaga
     2821 gccagagaat attaagtcaa cacctggggt tgccaacaat ggctctcctt ggaagaagcc
     2881 tgaggtccaa ttccagcaag aagctggtga ggttcccaag aaccaagtgc agagagagaa
     2941 atacaaaaga gtgagtgaca gaatatcctt ttgggaagga gagaaagctg gtgctaagat
     3001 aactcatgaa aaacccacat cttcatgtag ccaggaacaa ccttctgcta aagcatatca
     3061 gcctgtgaag aagtcacagg gtgtatcatc catggacagt ttatctacag accagagtga
     3121 atataatcag gccattccca aacgagtggt cttagatgag gatgatcaag catcccagct
     3181 ctccaattct tattcctcaa ataaatctaa agagaccaag ccacaaatag caggtccatc
     3241 cagatactat ctttcagctg agcaatcaga taaagtgtct ctgtttcaga ataagaaaaa
     3301 tgagcctata aaaagatcac aagtggcaga cagtttgcct tctagaagaa acattacttt
     3361 accagcactg caacctccct caaatgtcgg gagtgaacga catgctccat tggagaaaga
     3421 cagacctcta gttcgtgaat caaatgccaa ctttaaagtt atgtccctaa aagaaagaat
     3481 ggatgaaccc aatgcagaac aggtctataa tccctctcag tttgagaatt tgagaaagtt
     3541 ttgggactta gaagctaatt caaacagtaa ggataatgac aagaatatta ccaccacaag
     3601 ccaaaaaaat tctgcacctt ttaataggca gaaacacaag gaattcagcg acattaaatt
     3661 atcaggtaaa aatacccatg aagcagaggt gcttctaagc ccaaaaaaag ttatggcaag
     3721 agaggaaatg gagaaattaa attcaaaggg catactccag gtgctaccag atgaaatcac
     3781 atttcctttg agtccactta gaaagtatac ttatcagttg ccaggaaatg agtcatcaaa
     3841 ggaaaatgtg gaaaagaata cggaagggat tgttactcca gtgtttaagg aagaaaagga
     3901 ttactcagaa caagagattc aagaatccat aataaaaacc aatgttttgt ctaaagactg
     3961 caaagacact tttaatgaca gcttgcagaa actgctttca gaaacctcaa caccagcaat
     4021 tcaaccctct ggtggaaaag ttcatggaaa acaagtgctt gaaccaagtg tttctgaaaa
     4081 taggacatgg cctcaaaaaa cagattttgc tgatactgag gaagaagtca aaggacctga
     4141 gaagatcatt aatgagcatg ttgacaaaac agtagttcat ccaaaggtta aacggaactc
     4201 tttgactgct agtctagaca aactcctgaa ggaagcaact ggaacttcac cctctccctt
     4261 gcaagccaag ttggcgcctg ttatcactgg aaccaactct aagctggaag aggggagatt
     4321 ttttggaaaa gggatagaac agagtcacaa tacttcagct gataagagag aaatactagc
     4381 tccttttcca gtgagagatg aaacttttgg aaatacagct ctcctcaaga aagctgaaag
     4441 tggtgagtgc cagctaagca cacagaattt gattcagatg gctgcagaag attctcatcc
     4501 attggatcca acttcccagc tttccagaaa gggttctttt ggggatgtgg ccagccctcc
     4561 ccaagatatg ctttttcccc aggatgctca tcttgttccc caggctaggg tacacccttc
     4621 tcaaacggaa atttcggaga ctgtagagaa agtcattctt ccacccagac ctgtattgaa
     4681 tgatgtaagt gctgcattac agaagctgtg tggagaagta tggttaagtt atccagctgg
     4741 aagggaagta ggtcctggag aagtgaaccc agaatttcct gaagcagtac agccagtatg
     4801 tagcccccta aatcctccag gagtgatatc accatgggct acgatggaca ccatagttcc
     4861 agacaggaag gatttttatt cctccaatgt agttcctgat aaaactcatg aagttggatc
     4921 ttatttagct gcccaaatgt ctccatcaga ccagacgctt agctcatttg cttccattgt
     4981 tgctcaatat ggcaaaggcc tccctcagga agtggaagaa attgtgaggg aaacaattgt
     5041 tcaacccaaa tcagagttcc tcgaattcag tgctggctta gaaaaactac tgaaggaaga
     5101 aactgaaacc ttcccctcaa aatatgaaag tgatacaggg aatctttctc catcaaagtt
     5161 aataggtagt acagaggagc ccaggcgagc cacttctgaa tgccatcctg aggaattaaa
     5221 agaaacagta gaaaaggccg aggctccgtt aataactgag agtgcttttg atgctggttt
     5281 tgagaaactt cttaaagaaa taactgaagc tcctccttat cagccccagg tgtcagtgag
     5341 agaagaaact cacgagaagg agtcctcaca gtcagagcag accaggttct tggggacagt
     5401 gccccatttt tacagggcag cctcacagac ctctgaaatg aaggataaaa gtaatggttt
     5461 ggaatctcaa gtcaaccaat gtgataaaat gttgggagga gacgcacttg tgactgattt
     5521 attggtagat ttttgtggtt ccagaagtgg agttgagatc cctagaaccc cacaacttta
     5581 tgtggctcat gaaataggga ccattaaaac tgtaaccccc ccagaggaca gggacagtga
     5641 aagtggggtt gcagggggac aagggactct tcaggaacct ggctttggag aggcttctga
     5701 agcaattagt gtgtccagaa ataggcaacc cattcctctc ctgatgaaca aagaaaactc
     5761 tacaaaaaca agtaaagttg aattgactct agcatcgcca tatatgaaac aagagaaaga
     5821 ggaagaaaaa gaaggtttct ctgagtctga tttttcagat ggaaacacca gttctaatgc
     5881 agagagctgg agaaatcctt ccagttcaga agaagaaccc agtcctgttt tgaaaacttt
     5941 ggaaaggagt gccgctagga aaatgccttc caaaagtcta gaagacattt catcagattc
     6001 atcaaatcaa gcaaaagtag ataatcagcc agaagaatta gtgcgtagtg ctgaagatga
     6061 tgagaaacca gatcagaagc cagttacaaa tgaatgcgta ccaagaattt ccacagtgcc
     6121 tacacaacct gataatccat tttctcaccc tgacaaactc aaaaggatga gcaagtctgt
     6181 tccagcattt ctccaagatg agagtgatga cagagaaaca gatacagcat cagaaagcag
     6241 ttaccagctc agcagacaca agaagagccc gagctcttta accaatctta gcagctcctc
     6301 tggcatgacg tccttgtctt ctgtgagtgg cagtgtgatg agtgtttata gtggagactt
     6361 tggcaatctg gaagttaaag gaaatattca gtttgcaatt gaatatgtgg agtcactgaa
     6421 ggagttgcat gtttttgtgg cccagtgtaa ggacttagca gcagcggatg taaaaaaaca
     6481 gcgttcagac ccatatgtaa aggcctattt gctaccagac aaaggcaaaa tgggcaagaa
     6541 gaaaacactc gtagtgaaga aaaccttgaa tcctgtgtat aacgaaatac tgcggtataa
     6601 aattgaaaaa caaatcttaa agacacagaa attgaacctg tccatttggc atcgggatac
     6661 atttaagcgc aatagtttcc taggggaggt ggaacttgat ttggaaacat gggactggga
     6721 taacaaacag aataaacaat tgagatggta ccctctgaag cggaagacag caccagttgc
     6781 ccttgaagca gaaaacagag gtgaaatgaa actagctctc cagtatgtcc cagagccagt
     6841 ccctggtaaa aagcttccta caactggaga agtgcacatc tgggtgaagg aatgccttga
     6901 tctaccactg ctaaggggaa gtcatctaaa ttcttttgtt aaatgtacca tccttccaga
     6961 tacaagtagg aaaagtcgcc agaagacaag agctgtaggg aaaaccacca accctatctt
     7021 caaccacact atggtgtatg atgggttcag gcctgaagat ctgatggaag cctgtgtaga
     7081 gcttactgtc tgggaccatt acaaattaac caaccaattt ttgggaggtc ttcgtattgg
     7141 ctttggaaca ggtaaaagtt atgggactga agtggactgg atggactcta cttcagagga
     7201 agttgctctc tgggagaaga tggtaaactc ccccaatact tggattgaag caacactgcc
     7261 tctcagaatg cttttgattg ccaagatttc caaatgagcc caaattccac tggctcctcc
     7321 actgaaaact actaaaccgg tggaatctga tcttgaaaat ctgagtaggt ggacaaatat
     7381 cctcactttc tatctattgc acctaaggaa tactacacag catgtaaaag tcaatctgca
     7441 tgtgcttctt tgattacaag gcccaaggga tttaaatata acaaaatgtg taatttgtga
     7501 ctctaatatt aaataagata tttgaacaag ctaggaaaat tgaatttctg ctgctgcttc
     7561 aaagaaaaag ctgccccaga gcattaaaca tggggtattg ttaagaagca aaatgttctt
     7621 gtttgccatc atgtgtttca caccacaatt ctgtgccaca gttaagaggg tctggtaccc
     7681 ttgcaggacc tttgtaggtt gtgggaaaaa gtcgcagaaa gatactcaaa gtggagcagg
     7741 gaatggagac agacatcagt gatgataaaa aaaaaaatgg accttaagaa actatttact
     7801 ctgtaatctc taataaaata tggaattcca tattagggca atgagactga aactactggt
     7861 gtttttctgc cttgagaaaa caaacagtta aaacaagcct caaatgtatt ttagtgccac
     7921 ccactggcca taggtacaat tcagttgttg gcttgttttg acttaattct aaaataggtc
     7981 tcaagcctgt atttttatga gtttattttt ttaaaaccct gcatatatat gattgttttt
     8041 cttataactt tactatatga aagcagcata agagtagtca caaacatgtt ttgcaacaaa
     8101 gttttaatta gaatgtaagt tgctcagtta tactgttctt cttatgtatg taaaattttc
     8161 gtattttgta aaaaccctta gaataaatta tcatttgatt taaattgtat tagaaaatta
     8221 gcgtgacttc tcattttaaa taaaatattt taggaattct aaa
//
