LOCUS       NM_001193308            1936 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synaptotagmin like 1 (SYTL1), transcript variant 1,
            mRNA.
ACCESSION   NM_001193308
VERSION     NM_001193308.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1936)
  AUTHORS   Wang,J., Luo,J., Wu,X. and Li,Z.
  TITLE     WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in
            bladder cancer
  JOURNAL   Histol Histopathol 39 (5), 633-646 (2024)
   PUBMED   37933909
  REMARK    GeneRIF: WTAP enhances the instability of SYTL1 mRNA caused by
            YTHDF2 in bladder cancer.
REFERENCE   2  (bases 1 to 1936)
  AUTHORS   Wang,J., Luo,J., Wu,X. and Li,Z.
  TITLE     ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder
            cancer progression
  JOURNAL   Hum Cell 35 (6), 1961-1975 (2022)
   PUBMED   36107384
  REMARK    GeneRIF: ELK1 suppresses SYTL1 expression by recruiting HDAC2 in
            bladder cancer progression.
REFERENCE   3  (bases 1 to 1936)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1936)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1936)
  AUTHORS   Yokoyama,T., Nakatake,M., Kuwata,T., Couzinet,A., Goitsuka,R.,
            Tsutsumi,S., Aburatani,H., Valk,P.J., Delwel,R. and Nakamura,T.
  TITLE     MEIS1-mediated transactivation of synaptotagmin-like 1 promotes
            CXCL12/CXCR4 signaling and leukemogenesis
  JOURNAL   J Clin Invest 126 (5), 1664-1678 (2016)
   PUBMED   27018596
  REMARK    GeneRIF: results reveal that MEIS1, through induction of SYTL1,
            promotes leukemogenesis and supports leukemic cell homing and
            engraftment, facilitating interactions between leukemic cells and
            bone marrow stroma.
REFERENCE   6  (bases 1 to 1936)
  AUTHORS   Holt,O., Kanno,E., Bossi,G., Booth,S., Daniele,T., Santoro,A.,
            Arico,M., Saegusa,C., Fukuda,M. and Griffiths,G.M.
  TITLE     Slp1 and Slp2-a localize to the plasma membrane of CTL and
            contribute to secretion from the immunological synapse
  JOURNAL   Traffic 9 (4), 446-457 (2008)
   PUBMED   18266782
  REMARK    GeneRIF: These results suggest that both Slp1 and Slp2-a may form
            part of a docking complex, capturing secretory lysosomes at the
            immunological synapse.
REFERENCE   7  (bases 1 to 1936)
  AUTHORS   Johnson,J.L., Ellis,B.A., Noack,D., Seabra,M.C. and Catz,S.D.
  TITLE     The Rab27a-binding protein, JFC1, regulates androgen-dependent
            secretion of prostate-specific antigen and prostatic-specific acid
            phosphatase
  JOURNAL   Biochem J 391 (Pt 3), 699-710 (2005)
   PUBMED   16004602
  REMARK    GeneRIF: evidence that JFC1 differentially regulates the secretion
            of PSAP and PSA, and that Rab27a and PI3K play a central role in
            the exocytosis of prostate-specific markers
REFERENCE   8  (bases 1 to 1936)
  AUTHORS   Catz,S.D., Babior,B.M. and Johnson,J.L.
  TITLE     JFC1 is transcriptionally activated by nuclear factor-kappaB and
            up-regulated by tumour necrosis factor alpha in prostate carcinoma
            cells
  JOURNAL   Biochem J 367 (Pt 3), 791-799 (2002)
   PUBMED   12137562
  REMARK    GeneRIF: transcriptional activation of JFC1 by the
            TNFalpha/NF-kappaB pathway is significant in prostate carcinoma
            cell lines
REFERENCE   9  (bases 1 to 1936)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
  REMARK    GeneRIF: Jfc1/synaptotagmin-like protein 1 (Slp1) contains an
            N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of
            Slp1/Jfc1 specifically and directly binds the GTP-bound form of
            Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
REFERENCE   10 (bases 1 to 1936)
  AUTHORS   McAdara Berkowitz,J.K., Catz,S.D., Johnson,J.L., Ruedi,J.M.,
            Thon,V. and Babior,B.M.
  TITLE     JFC1, a novel tandem C2 domain-containing protein associated with
            the leukocyte NADPH oxidase
  JOURNAL   J Biol Chem 276 (22), 18855-18862 (2001)
   PUBMED   11278853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA948740.1 and BC035725.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001193308.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035725.1, SRR3476690.279672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616558.5/ ENSP00000481032.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                DA948740.1         8-70
            64-1936             BC035725.1         1-1873
FEATURES             Location/Qualifiers
     source          1..1936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1936
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /note="synaptotagmin like 1"
                     /db_xref="GeneID:84958"
                     /db_xref="HGNC:HGNC:15584"
                     /db_xref="MIM:608042"
     exon            1..129
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            130..358
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1856
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /note="isoform 1 is encoded by transcript variant 1; NADPH
                     oxidase-related, C2 domain-containing protein;
                     exophilin-7; synaptotagmin-like protein 1"
                     /codon_start=1
                     /product="synaptotagmin-like protein 1 isoform 1"
                     /protein_id="NP_001180237.1"
                     /db_xref="CCDS:CCDS53286.1"
                     /db_xref="GeneID:84958"
                     /db_xref="HGNC:HGNC:15584"
                     /db_xref="MIM:608042"
                     /translation="MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEA
                     IAGVLQRDARLRQLEEGRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLV
                     RASMRRKKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAPQERLRETEGPDFPSP
                     SVPLKASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQI
                     LENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHY
                     EPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTAVKKRNLNPVFNETL
                     RYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPTWLPLQPRVPPS
                     PDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFV
                     LPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLG
                     GTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRTNLAPRT"
     exon            359..507
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..580
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..626
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..699
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..800
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..914
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1075
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1172
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1331
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1410
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1510
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1716
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1936
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1914..1919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /note="hexamer: AATAAA"
     polyA_site      1936
                     /gene="SYTL1"
                     /gene_synonym="JFC1; SLP1"
                     /note="major polyA site"
ORIGIN      
        1 agctgctggc tgggctgcct gttgagtcag ccttcttccc tcacggctct tctcccggtc
       61 cctgaaactc ggctgccagg ggagctggag ccacctgcga aggtgtcctc ccatactgga
      121 cccctacagg aagctccgtg tgcccagctg gggcacagcc ccagctgatg ccccagaggg
      181 gccacccatc gcaagagggg ctttgggctc tgccctccct ccccatggcg catgggccaa
      241 agcctgagac tgaaggactg ttggacctca gcttcctgac agaggaggag caggaggcca
      301 ttgctggcgt cctccaacga gatgcccgcc tgcgccagct ggaggagggg cgggtcagca
      361 agctccgggc ctcagtggca gaccctgggc agctgaagat cctgacaggg gactggttcc
      421 aggaagcacg ctcccagcgg caccacaatg cccacttcgg ctctgacctt gtccgagcgt
      481 ctatgcgcag gaagaagagc accaggggag accaggctcc aggccacgac agggaggctg
      541 aggctgctgt gaaagagaag gaagaggggc cagagcccag gctcaccatt gatgaggccc
      601 ctcaggagag gctcagggag actgagggac ctgatttccc atcgccttct gtccccctaa
      661 aggcttcaga tcctgaggag gcgtcccagg cccaggaaga tcctggccaa ggagaccaac
      721 aggtctgtgc cgaggaggct gacccggagc tggagcccgc gtcgggggga gagcaggagc
      781 cgcggcccca gcaagcccag accaaggccg cgtcccagat cctggagaat ggggaggagg
      841 ccccggggcc cgacccctct ctcgaccgca tgctcagcag cagctcctcg gtgtccagcc
      901 ttaactcctc cacgctgagc ggcagccaga tgagcctgtc aggcgacgcg gaggcggtgc
      961 aggtccgcgg ctccgtgcac ttcgcgctgc actacgagcc gggcgccgcc gagctgcgcg
     1021 tgcacgtgat ccagtgccag ggcctggccg ccgcccggcg ccgccgctcg gacccctacg
     1081 tcaaaagcta cctcctcccg gataagcaga gcaagcgcaa gacggcggtg aagaaacgga
     1141 atctgaatcc ggttttcaac gagactctcc ggtactccgt cccgcaggcc gagcttcagg
     1201 gccgcgtgct gagcctgtct gtgtggcacc gcgaaagcct gggtcgcaac atctttctgg
     1261 gcgaagttga agtgcccctg gacacgtggg actggggctc tgagcccacc tggctccccc
     1321 tgcagccccg ggtcccaccc tctcccgacg accttccgag ccgcgggtta ctcgccctgt
     1381 ccctcaagta cgtccccgcc ggctccgagg gcgcaggact gcccccgagc ggggagctgc
     1441 acttctgggt gaaggaggct cgggacctcc tgccgctgcg ggcaggatcc ctggacactt
     1501 acgtacaatg cttcgtgctg cctgatgaca gccaggccag ccgccagcgt acaagggttg
     1561 tgcgacgcag cctcagccct gtgttcaatc acaccatggt gtacgatggc tttgggcctg
     1621 ctgacctgcg ccaggcttgt gccgagctct ccctctggga ccatggggcc ctggccaacc
     1681 gccagctggg gggcacacgc ctcagcctgg gcaccggcag cagctatggg ctgcaggtgc
     1741 cctggatgga ttccacacct gaggagaagc agctgtggca agccctcctg gagcagccgt
     1801 gcgaatgggt ggatggcctt ctacccctca gaaccaacct ggcccccagg acgtagcccc
     1861 accaagcctc tctctctgga cccccatctc agggcctgcc cttggctaaa gtcaataaag
     1921 tctattctaa gagcaa
//
