LOCUS       NM_175733               4002 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens synaptotagmin 9 (SYT9), mRNA.
ACCESSION   NM_175733
VERSION     NM_175733.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4002)
  AUTHORS   Leiva,S., Cantoia,A., Fabbri,C., Bugnon Valdano,M., Luppo,V.,
            Morales,M.A., Rosano,G. and Gardiol,D.
  TITLE     The Zika virus infection remodels the expression of the
            synaptotagmin-9 secretory protein
  JOURNAL   Biol Chem 405 (3), 189-201 (2023)
   PUBMED   37677740
  REMARK    GeneRIF: The Zika virus infection remodels the expression of the
            synaptotagmin-9 secretory protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4002)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4002)
  AUTHORS   Xie,H.H., Li,J., Li,P.Q., Zhang,A.A., Li,Y., Wang,Y.Z., Xie,D.X.
            and Xie,X.D.
  TITLE     A genetic variant in a homocysteine metabolic gene that increases
            the risk of congenital cardiac septal defects in Han Chinese
            populations
  JOURNAL   IUBMB Life 69 (9), 700-705 (2017)
   PUBMED   28834160
  REMARK    GeneRIF: The intronic SYT9 variant rs11041321, which exhibits a
            significant genome-wide association with circulating homocysteine,
            was associated with the occurrence of congenital cardiac septal
            defects (CCSDs). This finding helps to characterize the unexpected
            role of SYT9 in homocysteine metabolism and the development of
            CCSDs, which further highlighted the interplay of diet, genetics,
            and human birth defects
REFERENCE   4  (bases 1 to 4002)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: SYT9 expression is significantly downregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 4002)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4002)
  AUTHORS   Zhang,X., Kim-Miller,M.J., Fukuda,M., Kowalchyk,J.A. and
            Martin,T.F.
  TITLE     Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for
            Ca2+-triggered exocytosis
  JOURNAL   Neuron 34 (4), 599-611 (2002)
   PUBMED   12062043
REFERENCE   7  (bases 1 to 4002)
  AUTHORS   Fukuda,M., Kowalchyk,J.A., Zhang,X., Martin,T.F. and Mikoshiba,K.
  TITLE     Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells
  JOURNAL   J Biol Chem 277 (7), 4601-4604 (2002)
   PUBMED   11751925
REFERENCE   8  (bases 1 to 4002)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
REFERENCE   9  (bases 1 to 4002)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
REFERENCE   10 (bases 1 to 4002)
  AUTHORS   Perin,M.S.
  TITLE     Mirror image motifs mediate the interaction of the COOH terminus of
            multiple synaptotagmins with the neurexins and calmodulin
  JOURNAL   Biochemistry 35 (43), 13808-13816 (1996)
   PUBMED   8901523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027804.7, AC060799.6 and AC107884.15.
            
            On Nov 23, 2018 this sequence version replaced NM_175733.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.15052.1,
                                           SRR1803616.186340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318881.11/ ENSP00000324419.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AC027804.7         136323-136750
            429-780             AC060799.6         30964-31315
            781-1327            AC060799.6         41320-41866
            1328-1448           AC060799.6         143967-144087
            1449-1620           AC060799.6         145882-146053
            1621-1750           AC060799.6         148431-148560
            1751-4002           AC107884.15        119669-121920       c
FEATURES             Location/Qualifiers
     source          1..4002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4002
                     /gene="SYT9"
                     /note="synaptotagmin 9"
                     /db_xref="GeneID:143425"
                     /db_xref="HGNC:HGNC:19265"
                     /db_xref="MIM:613528"
     exon            1..428
                     /gene="SYT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1759
                     /gene="SYT9"
                     /note="sytIX; synaptotagmin IX"
                     /codon_start=1
                     /product="synaptotagmin-9"
                     /protein_id="NP_783860.1"
                     /db_xref="CCDS:CCDS7778.1"
                     /db_xref="GeneID:143425"
                     /db_xref="HGNC:HGNC:19265"
                     /db_xref="MIM:613528"
                     /translation="MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPR
                     LRDPDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLPSGSKDNNQEPLNYM
                     DTETNEQENSEDFLDPPTPCPDSSMKISHTSPDIPLSTQTGIQENCAHGVRVQRQVTE
                     PTSSARHNSIRRQLNLSNPDFNIQQLQKQEQLTGIGRIKPELYKQRSLDNDDGRRSNS
                     KACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKV
                     HRKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFP
                     RECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYV
                     KVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHN
                     EIIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLVEKR"
     exon            429..780
                     /gene="SYT9"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1327
                     /gene="SYT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1448
                     /gene="SYT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1620
                     /gene="SYT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1750
                     /gene="SYT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..4002
                     /gene="SYT9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3980..3985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT9"
                     /note="hexamer: AGTAAA"
     polyA_site      4002
                     /gene="SYT9"
                     /note="major polyA site"
ORIGIN      
        1 gctctgggct gtgcggcacc gcctctcctc ggtgtctggg gagggacgga gggaccgggc
       61 gggagagaga gaaagcctga ccgaccggct ggcgaagagc tgcatgcaac cggtgggagg
      121 ccgggccggc tgggtctggg gctcgggctc aggctcgcac cgtttctcgg caggtccctg
      181 gcggtgagcg cggacggccc ggaggcggcg gctctgagct ggcaggcgga gggctgtctc
      241 ctgcgcccgc ctgcccggcg cggtccgagg atgcgggggg gcgatgcccg gggccaggga
      301 cgcgctctgt caccaggcgc tgcagctgct ggccgagctc tgtgcccgtg gggccctgga
      361 gcacgacagc tgccaggatt tcatttacca cctgcgggac cgtgccagac cccggctccg
      421 cgacccagat atctcagtga gcctgctgac ccttgtggtc actgcctgtg gtctcgctct
      481 ctttggcgtg tctctcttcg tatcttggaa actctgctgg gttccgtggc gagaacgagg
      541 cctgccctct ggtagcaaag acaacaacca ggagcccctt aactacatgg acacagagac
      601 caatgagcag gagaacagtg aggacttcct agatcctccc acgccctgcc ctgactcctc
      661 catgaagatc agccacacct cccctgacat tcccctctcc acccagacgg ggatccagga
      721 gaactgtgcc catggcgtcc gcgtgcagcg ccaagtcaca gagccaacct cgtcggcccg
      781 gcataattca atccgaagac aactcaactt gtcaaacccg gacttcaata tccagcagct
      841 tcaaaaacag gaacagttga ctggaattgg tagaattaaa ccagagttat ataagcagag
      901 gtcattggat aatgatgacg ggagacggag taacagcaag gcttgtggga aactgaactt
      961 cattttaaaa tatgactgtg acttagagca gctcatagtg aagattcaca aagctgtcaa
     1021 tttgcccgcc aaggactttt ctgggacttc agatccttat gtcaagatct atttgcttcc
     1081 tgatcggaaa acaaaacacc agactaaagt tcacagaaag accctgaacc ctgtgtttga
     1141 tgaagtgttt ttatttccgg ttccctacaa tgaccttgaa gcacggaagc ttcacttctc
     1201 tgtgtacgac tttgacaggt tctctcgtca tgacttaatc ggccaagtgg tggtggatca
     1261 cttcctagac ttggctgatt tccccaggga gtgcatcctt tggaaggata tcgaatatgt
     1321 caccaatgac aacgtggatc tgggagagct gatgttttcc ctgtgctatc ttccaacggc
     1381 tggcaggctg accattacca ttataaaagc aaggaattta aaggcaatgg acataacagg
     1441 agcatcagat ccctatgtga aagtctcgct gatgtgtgat ggcagacgac tgaagaagag
     1501 gaaaacatcc accaagagga acaccttgaa tcctgtttac aacgaagcca tagtctttga
     1561 tgtccctccc gagaacattg accaaatcca cttgtccata gcagtcatgg actatgaccg
     1621 tgtaggtcac aatgagatca tcggcgtgtg tcaagtaggc aacgaggctg agaggctggg
     1681 cagagaccac tggagtgaaa tgttgtcata tcctcggaag cccattgcac actggcattc
     1741 cctggtggag aaacgatgac catgggtaag aggactgctt gtgccaagga caaaatagga
     1801 caaccatctc acaaagatct taagtaactt tttccatcca gcaacatcca gacgatttca
     1861 gtgaccaaat gctcagctgt aaccacagca ctaactggcc ttctttccag attgggtttg
     1921 gtgaacctga atggtccagc caccttctgc aggtggccca aggtgatgtg ctgcagggaa
     1981 gcatgtctct catgccaaga accaagatcg gactatgaac aaaaacaaat gatagatata
     2041 gtgacagtac caagagtacc aggactcaat gtttcatatg aagcccttgg tgatgaggac
     2101 atagcatctg ccctggaaat cgttattcca acataatatt attttctaga atgccctgga
     2161 aggacagaat atttaaaaat atatccaggt gctaaatagg cagcagatct caattcacac
     2221 atgactacct ttgagctaat gactgtctcc agaaaataac tgtgccccaa gaagtgctcc
     2281 agatttgcaa ggaatagccc caagagaata ccaagacaag caggctgttc cctggaaaaa
     2341 atctaatgca aggagggcta gttcacagca aattcactgc ctcctcccat gcacgtggta
     2401 gagagtacca gtatcaacat ggccctgttt tctgctaaaa ccagattttg aggaatcaga
     2461 gacccccaac actactcact cagtagctag cagccccttc ctttcaactg ggagtgttat
     2521 tagaatgaaa agtaattagt tagaagggca tacatctcag tggcatgagc attgtggaat
     2581 atcctttcct aggcacattc gtccactaag ggaacagcct cagaaactgg tacagcaatg
     2641 ggtgagatga gatcatggag agagaacaca gccatcccct atagaaaggc acagcttttg
     2701 ggcttctctg gcctgaatgc cttctggggt atttccatat gcaacagccc agagtcatag
     2761 ccttgggcaa ccacacatag aggtttcctt ctcacttcag acacatacat cactttcaca
     2821 ccacttgggg atggaaatac ctacaagagt gaaggtcaag ggccctcccc aggcatctca
     2881 ttcattactc agcttccttc ctgaccaagt ctgccaacca atggccagct atgcgcctca
     2941 tcctcattgc ttctgcctcc acgtaaatga aaccaaaggc ctcagcatat cctgggagga
     3001 ctgggggctg ttacctaatg gtcctctctg tcccattata ggtgcaaggc accccatcca
     3061 cacatttgca ccactactcc aagatagtat ttttcttttc acacaatctc tttacagcag
     3121 aatccagagt tggattgtag tttaccttcc tggaaagctc attatctctg tttgaattaa
     3181 catttcagca tggaactaac tgggcggagg aaggatcgtt atacgtcttc agaaagttct
     3241 cattgcccca gctgcctagt actatacaag aagctctact ttgatggcag atctaagaag
     3301 gctataggcc tttgtttgta ggaagcagtg tcattacatt caagcttcac ttctctgatt
     3361 ggcttccaac cactgggatt caaagagaat ccaaggttct gcctatgtct gatgacataa
     3421 ggaaaacttg gcttcctctg ctcaaggttc ccctctgctc atccctcctc attcagacat
     3481 cctccaccat accagtgttt agaagcaaaa catgaagggc tagcgccacc aggatagtta
     3541 gcagaaatat tgtctgtaaa gctaggcaga tgagcccaga agaatggtcc cagagaaagc
     3601 agactggctc caatagatat caggcagcaa tcccaataaa ttctgacatg tccttggcaa
     3661 tggaagcctg ggttggagat cctgaggcag ctgtgcctac tgttccccac ctcagaagct
     3721 tcctgcccag agagccagca gccttgggat actaatgagg atgcaactgg cttattggta
     3781 tgaaatagaa ggtggctttg taggggcaag caggcaaaga gtactatcca catggcaggc
     3841 aggtggcttt gtgtctggaa agctttgcct agccagtaca gctgtgagca gaggctggtt
     3901 ataaatttga actccctcag cccatttgca actctgcctc tgttctcttg cattctgttt
     3961 ggttgccctt tagtttccta gtaaatgctc cttttgaaaa ac
//
