LOCUS       NM_001365809            7230 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens synaptotagmin 7 (SYT7), transcript variant 4, mRNA.
ACCESSION   NM_001365809 XM_005274383
VERSION     NM_001365809.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7230)
  AUTHORS   Ma,Y., Guo,J., Rao,H., Xin,J., Song,X., Liu,R., Shao,S., Hou,J.,
            Kong,L., Hu,Z., He,L., Pan,F. and Guo,Z.
  TITLE     The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases
            extracellular vesicle release and promotes tumour metastasis during
            oxidative stress
  JOURNAL   J Extracell Vesicles 13 (9), e12505 (2024)
   PUBMED   39235072
  REMARK    GeneRIF: The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway
            increases extracellular vesicle release and promotes tumour
            metastasis during oxidative stress.
REFERENCE   2  (bases 1 to 7230)
  AUTHORS   Liu,X., Li,R., Chen,X., Yao,J., Wang,Q., Zhang,J., Jiang,Y. and
            Qu,Y.
  TITLE     SYT7 is a key player in increasing exosome secretion and promoting
            angiogenesis in non-small-cell lung cancer
  JOURNAL   Cancer Lett 577, 216400 (2023)
   PUBMED   37774826
  REMARK    GeneRIF: SYT7 is a key player in increasing exosome secretion and
            promoting angiogenesis in non-small-cell lung cancer.
REFERENCE   3  (bases 1 to 7230)
  AUTHORS   Dong,S., Pan,J., Shen,Y.B., Zhu,L.X., Chen,L., Zhu,F., Li,H.,
            Shen,H.X., Xia,Q., Wu,Y.J. and Xie,X.J.
  TITLE     SYT7 plays a role in promoting thyroid cancer by mediating HMGB3
            ubiquitination
  JOURNAL   Endocr Relat Cancer 29 (4), 175-189 (2022)
   PUBMED   35073278
  REMARK    GeneRIF: SYT7 plays a role in promoting thyroid cancer by mediating
            HMGB3 ubiquitination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7230)
  AUTHORS   Wang,Q.W., Lu,S.Y., Liu,Y.N., Chen,Y., Wei,H., Shen,W., Chen,Y.F.,
            Fu,C.L., Wang,Y.H., Dai,A., Huang,X., Gage,F.H., Xu,Q. and Yao,J.
  TITLE     Synaptotagmin-7 deficiency induces mania-like behavioral
            abnormalities through attenuating GluN2B activity
  JOURNAL   Proc Natl Acad Sci U S A 117 (49), 31438-31447 (2020)
   PUBMED   33229564
  REMARK    GeneRIF: Synaptotagmin-7 deficiency induces mania-like behavioral
            abnormalities through attenuating GluN2B activity.
            Erratum:[Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2111933118.
            doi: 10.1073/pnas.2111933118.. PMID: 34341124]
REFERENCE   5  (bases 1 to 7230)
  AUTHORS   Fukuda,M., Ogata,Y., Saegusa,C., Kanno,E. and Mikoshiba,K.
  TITLE     Alternative splicing isoforms of synaptotagmin VII in the mouse,
            rat and human
  JOURNAL   Biochem J 365 (Pt 1), 173-180 (2002)
   PUBMED   12071850
  REMARK    GeneRIF: identified the conserved alternative splicing events in
            the spacer domain of Syt VII; also shown that Syt VIIa-GFP is
            mainly localized in the perinuclear region and tips of neurites
            (dense-core vesicles), and not in the plasma membrane
REFERENCE   6  (bases 1 to 7230)
  AUTHORS   Caler,E.V., Chakrabarti,S., Fowler,K.T., Rao,S. and Andrews,N.W.
  TITLE     The Exocytosis-regulatory protein synaptotagmin VII mediates cell
            invasion by Trypanosoma cruzi
  JOURNAL   J Exp Med 193 (9), 1097-1104 (2001)
   PUBMED   11342594
REFERENCE   7  (bases 1 to 7230)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
REFERENCE   8  (bases 1 to 7230)
  AUTHORS   Walker,M.G., Volkmuth,W., Sprinzak,E., Hodgson,D. and Klingler,T.
  TITLE     Prediction of gene function by genome-scale expression analysis:
            prostate cancer-associated genes
  JOURNAL   Genome Res 9 (12), 1198-1203 (1999)
   PUBMED   10613842
REFERENCE   9  (bases 1 to 7230)
  AUTHORS   Craxton,M. and Goedert,M.
  TITLE     Alternative splicing of synaptotagmins involving transmembrane exon
            skipping
  JOURNAL   FEBS Lett 460 (3), 417-422 (1999)
   PUBMED   10556508
REFERENCE   10 (bases 1 to 7230)
  AUTHORS   Cooper,P.R., Nowak,N.J., Higgins,M.J., Church,D.M. and Shows,T.B.
  TITLE     Transcript mapping of the human chromosome 11q12-q13.1 gene-rich
            region identifies several newly described conserved genes
  JOURNAL   Genomics 49 (3), 419-429 (1998)
   PUBMED   9615227
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002754.5, AP003559.3 and
            AP003108.3.
            
            On Aug 31, 2019 this sequence version replaced NM_001365809.1.
            
            Summary: This gene is a member of the synaptotagmin gene family and
            encodes a protein similar to other family members that mediate
            calcium-dependent regulation of membrane trafficking in synaptic
            transmission. A similar protein in rodents mediates hormone
            secretion and lysosome exocytosis. In humans, expression of this
            gene has been associated with prostate cancer. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Oct 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000539008.6/ ENSP00000439694.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AP002754.5         4707-4993           c
            288-391             AP003559.3         149905-150008       c
            392-471             AP003559.3         145185-145264       c
            472-603             AP003559.3         140978-141109       c
            604-828             AP003559.3         139832-140056       c
            829-1197            AP003559.3         136012-136380       c
            1198-1320           AP003559.3         131945-132067       c
            1321-1456           AP003108.3         205177-205312       c
            1457-1727           AP003108.3         200103-200373       c
            1728-1897           AP003108.3         196551-196720       c
            1898-2012           AP003108.3         196015-196129       c
            2013-2212           AP003108.3         195263-195462       c
            2213-7230           AP003108.3         185902-190919       c
FEATURES             Location/Qualifiers
     source          1..7230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..7230
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /note="synaptotagmin 7"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
     exon            1..287
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2317
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /note="isoform 4 is encoded by transcript variant 4;
                     prostate cancer-associated protein 7; synaptotagmin VII"
                     /codon_start=1
                     /product="synaptotagmin-7 isoform 4"
                     /protein_id="NP_001352738.1"
                     /db_xref="CCDS:CCDS91487.1"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
                     /translation="MYRDPEAASPGAPSRDVLLVSAIITVSLSVTVVLCGLCHWCQRK
                     LGKRYKNSLETVGTPDSGRGRSEKKAINDLDRDFWNNNESTVQQKWSSYPPKEFILNI
                     SPYAPYGDPRLSLNGTLLSGAKVAAAAGLAVEREGRLGEKPAPVPPPGEDALRSGGAA
                     PSEPGSGGKAGRGRWRTVQSHLAAGKLNLSNFEDSTLSTATTLESIPSSTGEPKCQRP
                     RTLMRQQSLQQPLSQHQRGRQPSQPTTSQSLGQLQAHMASAPGPNPRAYGRGQARQGT
                     SAGSKYRAAGGRSRSNPGSWDHVVGQIRNRGLDMKSFLEGRMVVLSLVLGLSEQDDFA
                     NIPDLQNPGTQQNQNAQGDKRLPAGGKAVNTAPVPGQTPHDESDRRTEPRSSVSDLVN
                     SLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDF
                     SGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLD
                     YDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSI
                     IVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDI
                     PTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWH
                     QLKA"
     exon            288..391
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            392..471
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            472..603
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            604..828
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1197
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1320
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1456
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1727
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1897
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2012
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2212
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..7230
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5610..5615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /note="hexamer: AATAAA"
     polyA_site      5631
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /note="major polyA site"
     regulatory      7205..7210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /note="hexamer: AATAAA"
     polyA_site      7230
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
ORIGIN      
        1 gcacacgcgg cgcgcaggcc ggagggaggc ggctcggcgc tgttcggcgg cggcggcagc
       61 gtgctccgcg ggcgggcggg agggctggcg ggcggccccc gctccccggc tccgcggcta
      121 ggtgcagccc gctcggcccc cgccctcgga cccgcccccg ggggtcgccc ggccccatgc
      181 ccagcggcgg cggcggagca gcgcgcggcc gcgggcggct ctgaggagcc cggagggaac
      241 cggcgacgag gggaccatgt accgggaccc ggaggcggcc agcccagggg cgccctcgcg
      301 cgacgtcctg ctggtctctg ccatcatcac cgtcagcctt agcgtcactg tcgtcctctg
      361 cggcctctgc cactggtgtc agcgcaaact gggcaaacgc tacaagaatt ccttggagac
      421 ggtgggcacg ccagactcag ggcgtgggcg cagtgagaag aaggctatca atgatctaga
      481 cagagacttt tggaataaca atgagagcac agtgcagcag aaatggagct cctaccctcc
      541 caaggagttt attctaaaca tttcacccta cgccccttat ggcgacccac gactgtccct
      601 caatggcacc ctcctgtcgg gcgccaaagt ggccgccgcg gcggggctgg cggtggagcg
      661 ggaaggccgg ctgggggaga agccggcacc ggtgccgcca cccggagagg acgccttgag
      721 aagcggcggg gctgccccca gcgagccggg cagcggtggc aaggcgggga gaggccgctg
      781 gcggacggtg cagagccacc tggccgcagg gaagctcaac ttgtccaatt tcgaggactc
      841 caccctgtcc acggccacta cccttgagtc tatccccagc tccacgggag agccgaaatg
      901 ccagcgaccc cgcaccctga tgcggcagca gagcctgcaa cagccgctga gccagcacca
      961 gcggggccgg cagcccagcc agcccaccac cagccagagc ctgggccagc tgcaggccca
     1021 catggcctcg gcaccaggcc ccaacccccg ggcctatggc cggggccagg ctcggcaggg
     1081 cacctcggcc ggctccaagt accgggcggc agggggccgc agccgctcca acccaggcag
     1141 ctgggaccac gtggtggggc agattcgaaa ccgaggcttg gacatgaaat ccttcctgga
     1201 aggccggatg gtggtgctat ccttggtctt agggctttcg gaacaggatg actttgccaa
     1261 tatccctgac ctgcaaaacc caggaaccca gcagaaccag aacgctcagg gggacaagag
     1321 gttgcctgca ggagggaagg cggtgaacac agcccccgtg ccaggccaga caccccacga
     1381 tgagtccgac cgccggaccg agccacgttc ctccgtctca gacctcgtca actccctcac
     1441 cagcgagatg ctcatgctct ccccaggctc cgaggaggat gaggcccacg agggttgcag
     1501 ccgagagaac ctgggccgga tccagttcag tgtcggctac aacttccagg agtccacgct
     1561 caccgtgaag atcatgaagg cccaggagct gccggccaag gacttcagcg gcaccagcga
     1621 ccccttcgtc aagatctacc tgctgcccga caagaagcac aagctggaga ccaaggtgaa
     1681 gcggaagaac ctgaaccccc actggaacga gaccttcctc tttgaaggtt ttccctatga
     1741 gaaggtggtg cagaggatcc tctacctcca agtcctggac tatgaccgct tcagccgcaa
     1801 cgaccccatt ggggaggtgt ccatccccct taacaaggtg gacctgaccc agatgcagac
     1861 cttctggaag gatctgaagc catgcagcga tgggagtggg agccgagggg agctgctctt
     1921 gtctctctgc tacaacccct ctgccaactc catcatcgtg aacatcatca aagcccggaa
     1981 cctcaaagcc atggacatcg ggggcacatc agacccctac gtgaaggtat ggctgatgta
     2041 caaggacaag cgggtggaga agaagaagac ggtgacgatg aagaggaacc tgaaccccat
     2101 cttcaatgag tccttcgcct tcgatatccc cacggagaag ctgagggaga cgaccatcat
     2161 catcactgtc atggacaagg acaagctcag ccgcaatgac gtcatcggca agatctacct
     2221 gtcctggaag agcgggccag gggaggtgaa gcactggaag gacatgattg cccgtccccg
     2281 gcagcccgtg gcccagtggc accagctgaa ggcctgagtg gggccaaggg aggcccaggg
     2341 ggccgagggc ccaggtcccc atcatgccct caccacttta tgcacaacgc ccggcctgag
     2401 ccccctgcca tagggagggg aggaccctga gggctcagcc agggaggggt cccaggactc
     2461 aactgggccc cgtttctagg aagtaccagc cccatccccc acagtccagc tccggggaag
     2521 gggctctggg aggcattttc ctgctttgcc ccttttcttc ctgacttact aatactaaag
     2581 aagttggggg agctcgagag ccagacggcc agacaggcag acccctccag aggcccgcca
     2641 ggtgggcatg gtcccccatt ttctttaagg cagcacctgg agtggagaga ggccactccc
     2701 tctccagccc ccgatgtgga cccggggagg ggaggctgag gcgtttggcc ccggcctggc
     2761 caggagaggc ccatccccag ggcagtttca ggtgccggct gggccctgaa tgtcgaggat
     2821 agtatatagc ccgctcctgg gtcctggagc tgtggccctt tgtactcgtg ttgtgtccat
     2881 tgtgtgtgtg cgtggggaca gaggcctgga aatgcggagg actatacaga gaaggcaggt
     2941 tttgtgaagg ccaggcaggg ttggaggccg ggggtgtgag aggagaggcc catagggctg
     3001 agtggggtcg ggtgaggcag aggtcagaaa cagaagagct gcagttgctg gagctgggct
     3061 gagaactggg ctgcctcctg ccatcccccc gtctcctccc cttctcccct tggtgccccc
     3121 ctctgctcag aatctgaagt agttccctcc tcagcaattt catctcttga acactgactc
     3181 acacctttta ggcacctact gtgtgcatag cattccacca ggactcatct cccttccttc
     3241 tcagggggtc ccgagccccg actagctttg ccctaactcc ttcatcaaaa gaccccccgc
     3301 cagcttccca cacctcatac gcagccacat ctgccctatt ctccatgctt tccagcttgc
     3361 ctgcccttcc tcatctctcc ctgcctgtgc agacctccac ccttctttcc tccacccctc
     3421 catcccccaa tgcttgtaga ccttccattc attccgtctc atcgtgcgtg gtctctgatc
     3481 gtccatcacc tgaccttctc caggactgtc ttctcaccct tccccactcc ctggtccccg
     3541 ggagcagctc cttctgcccg actcactcac agtgcaggga aaggaggcag ggaaaagacc
     3601 aggattctgt gagttctgag gttgccacac acaaagaagc tgtggtttct ctgcctcggc
     3661 cactgatgag actaaaactg gcttcccctt ggagacggca gatttcaggc tgatccctgc
     3721 ttaagccctc tcatccccac gctggtcctg gtattgatac aagacccagc tggtgacaaa
     3781 gcctccaatc ctgggggtcc acgagcctgg gcctgacatt cccagaacta ccgccaggtg
     3841 gcgccaggcc cccacagtct gtggccgtgg tcttagcccc cagttccact ctggatgggc
     3901 ctgtgacacc ccaaagagaa gaaggggact ctggataggg tccccacatc cagggcgtgg
     3961 ggagaccatt ggcatttggg aaccattttc cttcgaacgg cttccccttg agctgagcat
     4021 tctgcttgct gcagtagacg ggtcgccttt tgcccatacc gaaattttct gaaattaaat
     4081 cgcacacccc caccatttcc tctccctggg atctggagga acatcataca tagtaggtga
     4141 atcgttttgt agagtgaaga atgctaatgt aaagcaaata gtcacccacg ttccttgtaa
     4201 atccaaatgt ttctatattg tagctttgct taaaatgggg tcggccccaa ctgcatcctc
     4261 ctctttggcg ggctggggag cggcccccag ccgggacggg agggcagcga ccccgaggcc
     4321 tcgtggacgt gggagagagt gtggtgggaa gtcttgagcg gaggagggga tctgcccttc
     4381 tccactcctc tcttggatcc gcctcggttt cctgtccccc caccacccgc ctgccccgcg
     4441 gaagaccgcc cagtgagcca gcccccacct tccaggcgcc ttcgccctgg ggatccaacc
     4501 aacttgtatc gagtgggcgg ggcaacggct ccccattttt cccgagcccc gcccacagag
     4561 ctcttagcca atcctatgca gagagcatct cctggcaggg gtctcttccc aaccagaccc
     4621 cacccaggca cattagcgac caggcttggg cttccccagc gccccaccac caccacgtgc
     4681 aggtggagct ctgggatgct atgttggggc ggcaagcggt gggccgaggg ccgggtaggc
     4741 tagcacggga ggtaagggtg gtatgggatg gggcgggggc ggtctagggc aataggagag
     4801 cagagaatgg gggaacttga gggtgggggg agggcaccgg agccttgcca ccatcccagg
     4861 actttgggca agtcacccgc actccctggg cctcggtttc cccatctgta aaatgatggt
     4921 aataatactt cacctacctc ataggggagg ttgtgaggcc accatcacct gacctggggg
     4981 tcaaggcagg aggactccga aggtgctacc cgtgagcaaa gtgtaattac cgaatcctga
     5041 ctgcaaggcc cacctgcccc tcccccacag agcctccaga gctagctgag gccaacgcag
     5101 gcccatccgt ctcttcactc tgtcgcaggc cctttcatgg gcttcgtctg ccatctttgt
     5161 gggtgcccta gacttagtcc ttatcttgtc ctggtttcct ttcttgtgac catctcccca
     5221 tgaaagtgct gtacaaattc cacccgcccc aggacccccg cacctgccct ctggcaccag
     5281 atgccaggga agggacagag gaaaacagcc acaaacaagc caggggggct ccccggagcc
     5341 ccaggggtgg ggattggtgg ccactgtttg tatgttcttg agtgcaagtg ttttataaaa
     5401 aataaaacaa aaacccacca tcacaaaaaa aaaaattttg cagcgaagag aaatgaagaa
     5461 aaactgaaga aaaaaaaaaa acaggaaaaa aagaaccata caaaattttt ccaccacaca
     5521 taccctctaa gccagcaaga tttcctcttt gcaaaatcat atttttgtgg gaatgggccc
     5581 tgctttttgt ggcaaggcct gttctgatta ataaaggatc gtgaaaaagt agggccttgg
     5641 ctgtttcctc cgtgggtccc agccctccct cacctccctg ggggcagagg cagtggggtg
     5701 aaggggatgg gggccccggg gctgagcctc ccctcagtgt gtcacctttg ggatttgact
     5761 tcactggtga ccaggccctt cccgagtgtc cagccatcct cagatctcta tagaatatga
     5821 tcccactggc ttcccagaaa gcagagaggc agctacatct cccagatcag gcctgacaca
     5881 aggctttttg ggagtagagt cctctctagg cctcaggggt gccctccagg gtcacccagc
     5941 ctgacgtccc ctccctcagt tcccagagga cacttgccac cctccaaggc agctcagaca
     6001 aaccaaaggg ggacgctcca gctttcccac caccatccat ggggccactg tagtttcagg
     6061 ccagcgcctc cttcctggtc cctgaggtgg gaaaaggaaa gacaatgagc tctgtgtctg
     6121 ttggctggac ctgcggcttc tctcagccct cttctagttt cattctttag gattagaaaa
     6181 gtctcttcca ctcaatagaa caggttccag cctgaggtgt gggaagctgg gttgtaatcc
     6241 cttctgcagc ctctgtggcc ctgggcaagc tctttccttc cacctgtttc ttctggccac
     6301 aacaaagcaa taaccatccc catcccctgc cctttcttcc ccacccagcc caggggaagc
     6361 tgagcccccg cagctctcag ggtacttcag aaggaaggtg ctacatctgg ttcagacaca
     6421 ggcacaaaag gaacgagcac atccccattg tcatgtgtcc acctgctggc ccctgccccc
     6481 accaggagtg aagcgggcca tcccatccgc cctctgctcc cagcacttgg ggccagcagc
     6541 tgcctcccgg agctgcacta agtaccccat ccaaagctgt ctgtccctca tttcccacaa
     6601 cctggtttag atatcacttc tgatctctgt tccagagatc agaggaagcc ccggggtcag
     6661 gtaagtagcc tcaggggctc ccttggccag agcttctgtt caggcgctct ccatgaaagc
     6721 agccctggaa aactgagcct gaagtcagag acagctcagg cccagcacag ggggcagtcc
     6781 cttgccactg gctcgggccc ttccctggac tttttgcctt cctccatttt tgcttctctg
     6841 ggtctgtctt cgtccatgcc tgctctgaga tgctccccca cccctccctg tacctgggac
     6901 caccgccctc tggtgttttc tttctcctgt gagtcccccc ctggatactg ctgctttctg
     6961 gaaggctgtc ctgggttacg tcctgcgctc ctctccctcc cacgcaaaga caaccagaag
     7021 gacaagcctt gagcacgccg atgccccagc tcgtggctcc ccagaccatc tgtttcccgt
     7081 gaagacgccc cgctccccgt gtctgtgtcc tgcgtgtatg tgtcgtgtct tgtgtagatt
     7141 gtgagccccc tgggcaggga tccctgtctg catacatgtt ccatgtggca cgcccaggtg
     7201 tgctaataaa cgttcatctt cagaacaaga
//
