LOCUS       NM_001366225            4451 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synaptotagmin 6 (SYT6), transcript variant 6, mRNA.
ACCESSION   NM_001366225
VERSION     NM_001366225.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   McGue,M., Zhang,Y., Miller,M.B., Basu,S., Vrieze,S., Hicks,B.,
            Malone,S., Oetting,W.S. and Iacono,W.G.
  TITLE     A genome-wide association study of behavioral disinhibition
  JOURNAL   Behav Genet 43 (5), 363-373 (2013)
   PUBMED   23942779
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Rafiq,S., Tapper,W., Collins,A., Khan,S., Politopoulos,I.,
            Gerty,S., Blomqvist,C., Couch,F.J., Nevanlinna,H., Liu,J. and
            Eccles,D.
  TITLE     Identification of inherited genetic variations influencing
            prognosis in early-onset breast cancer
  JOURNAL   Cancer Res 73 (6), 1883-1891 (2013)
   PUBMED   23319801
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Dalgin,G.S., Drever,M., Williams,T., King,T., DeLisi,C. and
            Liou,L.S.
  TITLE     Identification of novel epigenetic markers for clear cell renal
            cell carcinoma
  JOURNAL   J Urol 180 (3), 1126-1130 (2008)
   PUBMED   18639284
  REMARK    GeneRIF: SYT6 is hypermethylated in renal cell carcinoma.
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Roggero,C.M., Tomes,C.N., De Blas,G.A., Castillo,J., Michaut,M.A.,
            Fukuda,M. and Mayorga,L.S.
  TITLE     Protein kinase C-mediated phosphorylation of the two polybasic
            regions of synaptotagmin VI regulates their function in acrosomal
            exocytosis
  JOURNAL   Dev Biol 285 (2), 422-435 (2005)
   PUBMED   16111671
  REMARK    GeneRIF: Acrosomal exocytosis is regulated through the PKC-mediated
            phosphorylation of conserved threonines in the polybasic regions of
            synaptotagmin VI.
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Michaut,M., De Blas,G., Tomes,C.N., Yunes,R., Fukuda,M. and
            Mayorga,L.S.
  TITLE     Synaptotagmin VI participates in the acrosome reaction of human
            spermatozoa
  JOURNAL   Dev Biol 235 (2), 521-529 (2001)
   PUBMED   11437455
REFERENCE   9  (bases 1 to 4451)
  AUTHORS   Perin,M.S.
  TITLE     Mirror image motifs mediate the interaction of the COOH terminus of
            multiple synaptotagmins with the neurexins and calmodulin
  JOURNAL   Biochemistry 35 (43), 13808-13816 (1996)
   PUBMED   8901523
REFERENCE   10 (bases 1 to 4451)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162594.13.
            
            Summary: The protein encoded by this gene belongs to the
            synaptotagmin family. Synaptotagmins share a common domain
            structure that includes a transmembrane domain and a cytoplasmic
            region composed of 2 C2 domains, and are involved in
            calcium-dependent exocytosis of synaptic vesicles. This protein has
            been shown to be a key component of the secretory machinery
            involved in acrosomal exocytosis. Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.169014.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: PMID: 11437455, 16111671
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AL162594.13        88777-89036         c
            261-609             AL162594.13        74782-75130         c
            610-1168            AL162594.13        72662-73220         c
            1169-1289           AL162594.13        38768-38888         c
            1290-1461           AL162594.13        34261-34432         c
            1462-1591           AL162594.13        32915-33044         c
            1592-1660           AL162594.13        28902-28970         c
            1661-4451           AL162594.13        24459-27249         c
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..4451
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /note="synaptotagmin 6"
                     /db_xref="GeneID:148281"
                     /db_xref="HGNC:HGNC:18638"
                     /db_xref="MIM:607718"
     exon            1..260
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1609
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /note="isoform d is encoded by transcript variant 6;
                     synaptotagmin VI"
                     /codon_start=1
                     /product="synaptotagmin-6 isoform d"
                     /protein_id="NP_001353154.1"
                     /db_xref="GeneID:148281"
                     /db_xref="HGNC:HGNC:18638"
                     /db_xref="MIM:607718"
                     /translation="MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQP
                     PERSPSAAGAGTSVSLLAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSPSSANPP
                     LEALQSPSFRGNMADKLKDPSTLGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTRLQ
                     RQTTEPASSTRHTSFKRHLPRQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVD
                     GEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPD
                     RKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVILD
                     NLFEASDLSRETSIWKDIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMD
                     ITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISV
                     MDYDRVGHNEIIGVCRVGITAEGLGRDHWNEMLAYPRKPIAHWHSLVEGNPRL"
     exon            261..609
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            610..1168
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1289
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1461
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1591
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1660
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..4451
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4429..4434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /note="hexamer: ATTAAA"
     polyA_site      4451
                     /gene="SYT6"
                     /gene_synonym="sytVI"
                     /note="major polyA site"
ORIGIN      
        1 gctgcaggga gggtcttctt ggggccgtcg tgccccgccc cagtgcggcc ggggcgcggg
       61 ttcgagctgc tgctcggcaa gcctgggtgt ctagggcatg agcggagtgt ggggggccgg
      121 cgggcctcgg tgccaggagg cgctcgcggt cctcgcctcg ctgtgccggg cccggccgcc
      181 ccctctcggg ctggacgtgg agacttgtcg gagcttcgag ctgcagcccc cagagcggag
      241 tcccagcgcg gcaggcgcag gcacctctgt cagcctcctc gcagttgtag ttattgtgtg
      301 tggcgtggcc ctggtggcag tttttctctt tctcttttgg aagctgtgct ggatgccctg
      361 gaggaacaag gaggcctcca gtccctcttc tgctaatccc cccttggaag ccctccagag
      421 ccccagcttc agaggcaaca tggcggacaa gctgaaggac cccagcaccc tgggcttcct
      481 ggaggcggcc gtgaagatca gccacacgtc cccagatatc ccagctgagg tgcagatgtc
      541 ggtcaaggag cacatcatgc gtcacacccg gctgcagcgg caaactacag agccagcgtc
      601 atccaccagg cacacgtcct tcaagcgcca cctgccaagg cagatgcatg tctccagtgt
      661 agactatggc aatgagcttc caccagcagc agagcagccc accagcattg gccgcatcaa
      721 gcctgagctc tacaagcaga agtcggtgga tggggaggat gccaagtctg aggccaccaa
      781 gagctgcggg aagatcaact tcagcctacg ctacgattac gagaccgaga ccctgattgt
      841 gcgtatcctg aaggcttttg acctccctgc caaggacttt tgtggaagct ctgaccctta
      901 tgtcaagatc tacctcctgc ctgaccgcaa atgcaagctg cagacccggg tgcaccgcaa
      961 gaccctgaac cccacctttg atgagaactt ccacttccct gtgccctatg aggagctggc
     1021 tgaccgcaag ctgcatctca gtgtcttcga ctttgaccgc ttctcccgcc atgacatgat
     1081 tggcgaggtc atcctggaca acctctttga ggcctctgac ctgtctcggg aaacctccat
     1141 ctggaaggat atccaatatg ccacaagtga aagcgtggac ttgggagaga tcatgttctc
     1201 cctttgctac ctgcccactg caggcaggct caccctcaca gtgattaagt gtcggaacct
     1261 caaggcgatg gacatcacag gctattcaga tccctatgtg aaagtgtcct tgctctgtga
     1321 tgggcggagg ctgaagaaga agaaaacaac cataaagaaa aacactctca atcctgtcta
     1381 caatgaggcc atcatctttg acattccccc ggaaaacatg gatcaagtca gcctgctcat
     1441 ctcagtcatg gactatgatc gagtgggcca caatgagatc ataggagtct gtcgtgtggg
     1501 gatcactgct gaaggcctgg gcagggacca ctggaacgag atgctggcat acccccggaa
     1561 gcccatcgca cactggcact ccttggtgga gggaaaccct cggttgtgat ttcattcacg
     1621 tggatgctgc aagcagagag actgccacct ggagttagga tggcagggcc gagctgctag
     1681 cttcgacagt gagagctcgt gcccatctcc gaaaccacct ccaacaccat gagatgtgca
     1741 gccaaataac acaaatggga ctcagcaatg ttctctttgc acttgttcaa ccgtctaaac
     1801 agtgttgtgc agtcgcagtg gcggcagcag cggcagccgt ccgtcactcc agagtcttac
     1861 ctgctcctgt gtaggtcaaa gctgagacac ttgtcatgtg gtcagatctg tcttagtctt
     1921 ttgtgtctcc caaggtgatg tttttgtggt ttttcacttt ttatgggtct gctggtaaga
     1981 aaagggaaaa aaaaaaagag taggaaaaga caaagggtgg aaagcccaga agttggttct
     2041 agaaaataca aggtacagtt ttttggaaag aggtggattg agtttctgaa atgctgcgtc
     2101 tccagcaagc tccacaaccc tggaaaagga ggaggcgtgg tgggactgcg gctgcatttt
     2161 cagtgccctg caggaatggg gtgaatccat ggaagagcct ttgtgaggtg aattactagt
     2221 ctttgaagct cttcgctggc aggacataaa ccacgctggg accctcagtc ccgtgttgaa
     2281 atcacaagac ctctgaggcg cttgtgagcc ttcagctgat gtgcagggtt cctcgctccc
     2341 cttcctcgct ggctttcccc atgaattgaa aacgtcttga ttcctcatgg gaacttagtc
     2401 actttcttta ggaatgattc agttcagccg aaactaaaca cgccatatgt tttctgatgc
     2461 gccacagtta atgatcacat ttgtttgaaa acaggatctt tgtcctcaga aataatcttg
     2521 attgtaaagt aagagagaaa catatgttct ggaatgattt ctgcattata catagcttta
     2581 taattccatg aagtatcaag ctgctgttta aaatgcctaa acagattaaa gaaaaaccta
     2641 gattaaatgt tcttttccaa atggggagtt ttgaaatcca aatagcagtt tgagtccatc
     2701 tttctatgaa gagtatgttt ttgattgaaa ccgagtcagc gtaagcctat ttcagcccct
     2761 ttggctcttt gacaatattc atcttaaact ttagttctat aaattactaa gtacttcagt
     2821 gttgtttgtt tcagtggttg tgagggtttc ttgtttcctt tagatcttta ccttaggcca
     2881 aactcagttt aggaaaaaaa aaattgtttg aactattctg tgttgtaata gcacatttct
     2941 gttgagttaa tagtggtctt cccaccaacc cctaaaacca ggttgatttg ctcaatctca
     3001 gtttgtataa ccccagtaag cgcatggagg tgagtttcta cttcgacttg tggcgacaca
     3061 gtgccagttt cctgagctgt gtgtactact tgcaagaggc aagtctgctg aagaacccct
     3121 tcttttaaca gtggaaaatc aagaacagaa aatctgttca cacacctgtg tcttattctt
     3181 tatatatgct acatggtaga ggagcagcga ccaataaagt atccctcatt ttaaaccaag
     3241 ttgtcagatt tctctgctga tagaacgctg catagtatct tctagcccta aaaatgacca
     3301 ggttgggcat gagttaacag gatattgtgg caaaaggaat tttctgctta gaaaagtaaa
     3361 tgtagataaa cctaaactcc accctgtact gagccttagg ctagggactc atgtgtaaag
     3421 atgacttttc tccccagata tcttgtcatt gacaggcctt cctagtctgg tagtcctaca
     3481 tttgggtgtt ctcctgagag tgagaaaaaa cccaaggtca tgacaagatt cctggcaggt
     3541 gacagacttc attatgattc tgactctaga ctgaccccat caagatagtc gtttccgtca
     3601 gtgaacagat gctgaaggcc ttgccattac aaaggagaca actgagttcc ctgggtcata
     3661 aggagtccag aaattagtgt gagaaggtcc ttctggaagt gaactcaaaa ttcatgtcca
     3721 gctgtcatcg ttaaaccctt aggcaggtga gtataaccca ttctaacctc ttggagaagg
     3781 gagtgtgatc aatgtgaatc acaatagtat tgctcatctg agacattcct cttatatcca
     3841 agcagctatc tcccatgagt gaacatccca gtggtttcag aaaatcatgt cctgaacaga
     3901 ttctagccag ccccacacca ccctggccaa ctgcaaccgc tgctgctcta gcagtctggg
     3961 tcaattccta caggcttggg agcccacccc agggaggctt ttatctcctg cagcctcatc
     4021 cccagcaccc tcaaggtaga ctactcctca gcctgaatca tgaatgaaac ctgaacatct
     4081 gccaacttca ttatctagcc cagtatctct tccctcacag agaagaagaa aatgaaatac
     4141 aaagttgatc catttgttgg ctttctctgg ccggagaaac ctctcgggtt gttgctgtga
     4201 gctttgatga agttgtgata accagggcca tttgcacata ggttttttta aaaaacatga
     4261 aaagttccct tctcctttat ttagcagtgt ttccgggctg aaagacgccc tcctccccct
     4321 ctgcgcttac ccaggacgtt aattaattgc actgtcattt aaaatattat gttgttaatt
     4381 actcgtttgt gtcttcccac ccgtgtcaca gcctggagtt tttattcaat taaatctctg
     4441 tctcttgccc a
//
