LOCUS       NM_020783               3936 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens synaptotagmin 4 (SYT4), mRNA.
ACCESSION   NM_020783
VERSION     NM_020783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3936)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3936)
  AUTHORS   Huang,C., Walker,E.M., Dadi,P.K., Hu,R., Xu,Y., Zhang,W.,
            Sanavia,T., Mun,J., Liu,J., Nair,G.G., Tan,H.Y.A., Wang,S.,
            Magnuson,M.A., Stoeckert,C.J. Jr., Hebrok,M., Gannon,M., Han,W.,
            Stein,R., Jacobson,D.A. and Gu,G.
  TITLE     Synaptotagmin 4 Regulates Pancreatic beta Cell Maturation by
            Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles
  JOURNAL   Dev Cell 45 (3), 347-361 (2018)
   PUBMED   29656931
  REMARK    GeneRIF: Syt4 Overexpression Represses Basal Insulin Secretion and
            Impairs Islet Morphogenesis.
REFERENCE   3  (bases 1 to 3936)
  AUTHORS   Tratnjek,L., Glavan,G., Visnjar,T. and Zivin,M.
  TITLE     Upregulation and axonal transport of synaptotagmin-IV in the
            direct-pathway medium spiny neurons in hemi-parkinsonian rats
            induced by dopamine D1 receptor stimulation
  JOURNAL   Eur J Neurosci 43 (7), 885-898 (2016)
   PUBMED   26750488
REFERENCE   4  (bases 1 to 3936)
  AUTHORS   Rahimi,M., Vinciguerra,M., Daghighi,M., Ozcan,B.,
            Akbarkhanzadeh,V., Sheedfar,F., Amini,M., Mazza,T., Pazienza,V.,
            Motazacker,M.M., Mahmoudi,M., De Rooij,F.W., Sijbrands,E.,
            Peppelenbosch,M.P. and Rezaee,F.
  TITLE     Age-related obesity and type 2 diabetes dysregulate neuronal
            associated genes and proteins in humans
  JOURNAL   Oncotarget 6 (30), 29818-29832 (2015)
   PUBMED   26337083
  REMARK    GeneRIF: Data show although no any significant differences between
            patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and
            VAV3, except for VGF protein, there was a trend between the
            expression of these four genes and their protein levels.
REFERENCE   5  (bases 1 to 3936)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   6  (bases 1 to 3936)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
REFERENCE   7  (bases 1 to 3936)
  AUTHORS   Thomas,D.M., Ferguson,G.D., Herschman,H.R. and Elferink,L.A.
  TITLE     Functional and biochemical analysis of the C2 domains of
            synaptotagmin IV
  JOURNAL   Mol Biol Cell 10 (7), 2285-2295 (1999)
   PUBMED   10397765
REFERENCE   8  (bases 1 to 3936)
  AUTHORS   Perin,M.S.
  TITLE     Mirror image motifs mediate the interaction of the COOH terminus of
            multiple synaptotagmins with the neurexins and calmodulin
  JOURNAL   Biochemistry 35 (43), 13808-13816 (1996)
   PUBMED   8901523
REFERENCE   9  (bases 1 to 3936)
  AUTHORS   Ullrich,B., Li,C., Zhang,J.Z., McMahon,H., Anderson,R.G.,
            Geppert,M. and Sudhof,T.C.
  TITLE     Functional properties of multiple synaptotagmins in brain
  JOURNAL   Neuron 13 (6), 1281-1291 (1994)
   PUBMED   7993622
REFERENCE   10 (bases 1 to 3936)
  AUTHORS   Hilbush,B.S. and Morgan,J.I.
  TITLE     A third synaptotagmin gene, Syt3, in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 91 (17), 8195-8199 (1994)
   PUBMED   8058779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB483932.1, AB037763.1, BC036538.2, BM311221.1 and AI912792.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020783.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036538.2, AB037763.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255224.8/ ENSP00000255224.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DB483932.1         161-183
            24-2599             AB037763.1         1-2576
            2600-3414           BC036538.2         2489-3303
            3415-3415           AB037763.1         3392-3392
            3416-3805           BM311221.1         177-566
            3806-3934           AB037763.1         3782-3910
            3935-3936           AI912792.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..3936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..3936
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /note="synaptotagmin 4"
                     /db_xref="GeneID:6860"
                     /db_xref="HGNC:HGNC:11512"
                     /db_xref="MIM:600103"
     exon            1..243
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1487
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /note="sytIV; synaptotagmin IV"
                     /codon_start=1
                     /product="synaptotagmin-4"
                     /protein_id="NP_065834.1"
                     /db_xref="CCDS:CCDS11922.1"
                     /db_xref="GeneID:6860"
                     /db_xref="HGNC:HGNC:11512"
                     /db_xref="MIM:600103"
                     /translation="MAPITTSREEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRKSSK
                     SNKTPPYKFVHVLKGVDIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLN
                     GNFPKTNLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFS
                     LEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPA
                     FDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIELSEGKMLMNRE
                     IIKRNVRKSSGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHA
                     KKRISKKKTHVKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEVIGQLV
                     LGAAAEGTGGEHWKEICDYPRRQIAKWHVLCDG"
     exon            244..1058
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1179
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..3936
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3914..3919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /note="hexamer: AATAAA"
     polyA_site      3936
                     /gene="SYT4"
                     /gene_synonym="HsT1192"
                     /note="major polyA site"
ORIGIN      
        1 agaagagcca aaacaggaac cgaggtggca aatcactgtg cgagggcgag tggacctccc
       61 tctttgcctc ctccctgttc caggagctgg tgccctgggc tctgcgctgt tgttttcagc
      121 gctccgaaag ccggcgcttg agatccaggc aagtgaatcc agccaggcag ttttcccttc
      181 agcacctcgg acagaacacg cagtaaaaaa tggctccgat caccaccagc cgggaagaat
      241 ttgatgaaat ccccacagtg gtggggatct tcagtgcatt tggcctggtc ttcacagtct
      301 ctctctttgc atggatctgc tgtcagagaa aatcatccaa gtctaacaag actcctccat
      361 acaagtttgt gcatgtgctt aagggagttg atatttaccc tgaaaaccta aatagcaaaa
      421 agaagtttgg agcagatgat aaaaatgaag taaagaataa gccagctgtg ccaaagaatt
      481 cattgcatct ggatcttgaa aagagagatc tcaatggcaa ttttcccaaa accaacctca
      541 aacctggcag tccttctgat ctggagaatg caaccccgaa gctcttttta gaaggggaaa
      601 aagagtcagt ttcccctgag agtttaaagt ccagcacttc ccttacttca gaagagaaac
      661 aagagaagct gggaactctc ttcttctcct tagaatacaa cttcgagaga aaagcatttg
      721 tggtcaatat caaggaagcc cgtggcttgc cagccatgga tgagcagtcg atgacctctg
      781 acccatatat caaaatgacg atcctcccag agaagaagca taaagtgaaa actagagtgc
      841 tgagaaaaac cttggatcca gcttttgatg agacctttac attctatggg ataccctaca
      901 cccaaatcca agaattggcc ttgcacttca caattttgag ttttgacagg ttttcaagag
      961 atgatatcat tggggaagtt ctaattcctc tctcgggaat tgaattatct gaaggaaaaa
     1021 tgttaatgaa tagagagatc atcaagagaa atgttaggaa gtcttcagga cggggtgagt
     1081 tactgatctc tctctgctat cagtccacca caaacactct aactgtggtt gtcttaaaag
     1141 ctcgacatct gcctaaatct gatgtgtccg gactttcaga tccctatgtc aaagtgaacc
     1201 tgtaccatgc caaaaagaga atctccaaga agaagactca tgtgaagaaa tgcaccccca
     1261 atgcagtgtt caatgagctg tttgtctttg atattccttg tgagggcctt gaagatataa
     1321 gtgttgaatt tttggttttg gattctgaaa gggggtcccg aaatgaggta atcgggcagt
     1381 tagtcttggg tgcagcagca gaaggaactg gtggagagca ctggaaagag atctgtgact
     1441 accccaggag acaaattgcc aagtggcacg tgctctgtga tggttagcat cctagccgtg
     1501 agttggaact taaaggtttt tactaggcaa ggagaaattt tctttctttc tatattggat
     1561 tgcaagcttg ggaaatcaag ctaccttttt gttgttgttg ttgttgctag aaatggattg
     1621 aattagtaga ccagaaagta acttcaaatg tgtattatga taatttccct atttattaga
     1681 agagttggat aaattttcat aagatattca atatctcctt cagattacca gtgatataac
     1741 taggaatagt cagacatttt atgaatactg tgccagaatc ccaaattata aatgtgacaa
     1801 tctcattgga acatgtcaca aaaagttaat gtgattaaga tttaaaaacg aaaagtatgc
     1861 cttgccttgt gaaaatttat ccatttatct tcaggttggg gaaatcaatt tttctttaaa
     1921 tccaaagata ctaaaaaaat gtcctccagt ttgtatttat taattctgtc atgtgcaaat
     1981 ggttgtcctg catataaaag tatctggtca tttcagtttg gtttgtaatt atttgatgca
     2041 attttatcat aagagtaact cagattcatt tcaaaaggac agtgaacaag ctgagaaatt
     2101 attttatcaa agggctgagt tgagaacact gtggctgaaa tataattttt ctccccccta
     2161 aggttacatg tgagtcaaaa ttttgtaaaa tataacctca cataagaacc atggccttgg
     2221 attattcact gcctgtcaca agcctcagtg tggcctgaga aatccctatg tacctttgtg
     2281 aaattgttga attagttagt gaataaagaa ataaacttca actagaaatc cagttagaag
     2341 tgcaattttc ttataggaaa taggtatagt gtgcaagtgt acttttaagg ccatcgtttg
     2401 tacccagagt cggcatggcc acctaagtct tcatttaatt tattgtcccc cagaaaagat
     2461 taagatgcta cttgaaaaga ctgtgaagat tttttacatt gccagataaa aagtgttact
     2521 taaccaacaa acaaatgtaa gactacaaaa tcgttcaaga gcaattctaa tataatttac
     2581 atatgttcac gcaaaatatg cttaggctgt caaattagca caacaaagaa tgtgtttcac
     2641 tatcttttct aggctaattt gtcttgagct gttgtctata gagcagttta cagacttgtg
     2701 tcttgtatca ttttccagtg ccagggttct gaaattcatt cagaacctgt tagattaaag
     2761 ctgcaccctg tgattatttg aaaagaatta gcttgagagt aatgtcacta tatttgagtt
     2821 cttagagaag tatgagtgga acttgagtac agttgaatta ttaaatatgc aagttagaaa
     2881 ttaagtctac tgaaaaattt acattttgag tcaggttttg tgtcagtact ttagcagttt
     2941 ttgagaatgt gtttgatatc acagtgtttg taaattctat gaaaaatgca ttttccaaac
     3001 aacttataca tgctttttat gactatgcct aatgtaaaga aaatgtatta cattctgtat
     3061 gtacaaagat taaaaatcaa cctctttttt gtgctttaaa atgactttgg gattaaaaaa
     3121 gcatatttcc caatcattgt cttcattcca ctacaaagtc acctcacagc atcttgctcc
     3181 actcggcatc tctgtgaaag caacatgaaa tgaactgtag taggtgtgta gtttggggaa
     3241 gtcaaatggc cattttatgt atgtgcattt ggtatcatgg gccgtggaac agaatatatg
     3301 ttggacctct gaaaagttgt aaggggccaa ttctaagtat tcttcacggc agccagaagt
     3361 taatggtggt agcagctgag gtatggttgt tggacgaggc cgattttttt ttttttaaca
     3421 tggaacaatg aaaccaacaa caaacatttt taaaattaaa atggataatt tgtaaatagt
     3481 ttttagcttt taaaatttaa agtgtttttg agtgtgaaaa gttgagtaaa actatttgca
     3541 actggttttc agaaaagaga aaagaaacaa caaaggaatt gaaacaggca gggagatctt
     3601 aatacctaat ttcatcattt ctgaaaatgt actgttttag aatgtattac aatatcaatg
     3661 tgaatatctt gaatcctgtt acaaatcctg cactgtatta aacatgtaaa ttaattgttt
     3721 gtctgattag ccaatctcac cacccaaatg gggaggtata catgtttgaa gaactgtgta
     3781 actcagtaat tgatttgttc tgatgttgta actcaataga agtgttttgg aaggaagcat
     3841 ggtgtgtgag acagtgtctg ttcttttgtg ccagctctgt atgatgtttg taagaccatg
     3901 tttgtaagac atgaataaat tgctgctttt gcccaa
//
