LOCUS       NM_001160329            2526 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens synaptotagmin 3 (SYT3), transcript variant 3, mRNA.
ACCESSION   NM_001160329
VERSION     NM_001160329.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2526)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2526)
  AUTHORS   Saheki,Y., Bian,X., Schauder,C.M., Sawaki,Y., Surma,M.A., Klose,C.,
            Pincet,F., Reinisch,K.M. and De Camilli,P.
  TITLE     Control of plasma membrane lipid homeostasis by the extended
            synaptotagmins
  JOURNAL   Nat Cell Biol 18 (5), 504-515 (2016)
   PUBMED   27065097
  REMARK    GeneRIF: the extended synaptotagmins (E-Syts), endoplasmic
            reticulum (ER) proteins that function as PtdIns(4,5)P2- and
            Ca(2+)-regulated tethers to the Pplasma membrane.
REFERENCE   4  (bases 1 to 2526)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   5  (bases 1 to 2526)
  AUTHORS   Shin,O.H., Rhee,J.S., Tang,J., Sugita,S., Rosenmund,C. and
            Sudhof,T.C.
  TITLE     Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B
            domain triggers fast exocytosis without stimulating SNARE
            interactions
  JOURNAL   Neuron 37 (1), 99-108 (2003)
   PUBMED   12526776
REFERENCE   6  (bases 1 to 2526)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
REFERENCE   7  (bases 1 to 2526)
  AUTHORS   Gerona,R.R., Larsen,E.C., Kowalchyk,J.A. and Martin,T.F.
  TITLE     The C terminus of SNAP25 is essential for Ca(2+)-dependent binding
            of synaptotagmin to SNARE complexes
  JOURNAL   J Biol Chem 275 (9), 6328-6336 (2000)
   PUBMED   10692432
REFERENCE   8  (bases 1 to 2526)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
REFERENCE   9  (bases 1 to 2526)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   10 (bases 1 to 2526)
  AUTHORS   Jones,J.M., Popma,S.J., Mizuta,M., Seino,S. and Meisler,M.H.
  TITLE     Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human
            chromosome 19
  JOURNAL   Mamm Genome 6 (3), 212-213 (1995)
   PUBMED   7749232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008743.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001160329.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031067.1, SRR1803613.74338.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000600079.6/ ENSP00000469398.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC008743.9         139436-139527       c
            93-230              AC008743.9         138671-138808       c
            231-393             AC008743.9         136910-137072       c
            394-919             AC008743.9         131932-132457       c
            920-1307            AC008743.9         129430-129817       c
            1308-1526           AC008743.9         128940-129158       c
            1527-1647           AC008743.9         125543-125663       c
            1648-1819           AC008743.9         125039-125210       c
            1820-1952           AC008743.9         124808-124940       c
            1953-2021           AC008743.9         122333-122401       c
            2022-2526           AC008743.9         121623-122127       c
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2526
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /note="synaptotagmin 3"
                     /db_xref="GeneID:84258"
                     /db_xref="HGNC:HGNC:11511"
                     /db_xref="MIM:600327"
     exon            1..92
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            93..230
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            231..393
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..2018
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /note="synaptotagmin III"
                     /codon_start=1
                     /product="synaptotagmin-3"
                     /protein_id="NP_001153801.1"
                     /db_xref="CCDS:CCDS12798.1"
                     /db_xref="GeneID:84258"
                     /db_xref="HGNC:HGNC:11511"
                     /db_xref="MIM:600327"
                     /translation="MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYP
                     RGPDADISVSLLSVIVTFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGP
                     GVGLAGLVGGGGHHLAAGLGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPS
                     YLDMDSYPEAAAAAVAAGVKPSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVT
                     SLAPTTRYPALPRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQ
                     GTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGF
                     SDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRF
                     SRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLTV
                     TIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAP
                     ESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQ
                     LVEEKTVTSFTKGSKGLSEKENSE"
     exon            394..919
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1307
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1526
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1647
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1819
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1952
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2021
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2526
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /note="hexamer: AATAAA"
     polyA_site      2526
                     /gene="SYT3"
                     /gene_synonym="SytIII"
                     /note="major polyA site"
ORIGIN      
        1 agtggcgagg ggaggagccg agccggcacc gcggctggcg cgcggggctg cggcggcggc
       61 ggcggcggca gcggcggcag cggcggctcc ggcccctaga tcagacattc tctctcatta
      121 cccggcgcgt gggaacgggt ccacagcccc ttgtccgccc tagaaccccc atgggctgcc
      181 gcccgccgcc gcctcggctg ccacccagga cacggcagag ataagcgcag gaccagacgg
      241 ccaccatgtc aggagactac gaggatgacc tctgccggcg ggcactcatc ctggtctcgg
      301 acctctgtgc gcgggtccga gatgctgaca ccaacgacag gtgccaggag ttcaatgacc
      361 gaatccgagg ctatccccgg ggtccagatg cagacatctc cgtgagcctg ctgtcggtca
      421 tcgtgacatt ctgtggcatt gtccttctgg gtgtctctct cttcgtgtcc tggaagttgt
      481 gctgggtgcc ctggcgggac aagggaggct cggcagtggg cggtggcccc ctgcgcaaag
      541 acctaggccc tggtgtcggg ctggcaggcc tggtaggcgg aggcgggcac cacctggcgg
      601 ctggcctggg tggccatcct ctgctgggcg gcccacacca ccatgcccat gccgcccacc
      661 atccaccctt tgctgagctg ctggagccag gcagcctggg gggttctgac acccctgagc
      721 cctcctactt ggacatggac tcgtatccag aggctgcagc agcagcagtg gccgctgggg
      781 tcaaaccgag ccaaacatcc cctgagctgc cctctgaggg gggagcaggc tctgggttgc
      841 tcctgctgcc ccccagtggt gggggcttgc ccagtgccca gtcacatcag caggtcacaa
      901 gcctggcacc cactaccagg tacccagccc tgccccgacc cctcacccag cagactctga
      961 cctcccagcc ggaccccagc agtgaggagc ggccacctgc cctgccctta cccctgcctg
     1021 gaggcgagga aaaagccaaa ctcattgggc agattaagcc agagctgtac caggggactg
     1081 gccctggtgg ccggcggagc ggtgggggcc caggctctgg agaggcaggc acaggggcac
     1141 cctgtggccg tatcagcttc gccctgcggt acctctatgg ctcggaccag ctggtggtga
     1201 ggatcctgca ggccctggac ctccctgcca aggactccaa cggcttctca gacccctacg
     1261 tcaagatcta cctgctgcct gaccgcaaga aaaagtttca gaccaaggtg cacaggaaga
     1321 ccctgaaccc cgtcttcaat gagacgtttc aattctcggt gcccctggcc gagctggccc
     1381 aacgcaaact gcacttcagc gtctatgact ttgaccgctt ctcgcggcac gacctcatcg
     1441 gccaggtggt gctggacaac ctcctggagc tggccgagca gccccctgac cgcccgctct
     1501 ggagggacat cgtggagggc ggctcggaaa aagcagatct tggggagctc aacttctcac
     1561 tctgctacct ccccacggcc gggcgcctca ccgtgaccat catcaaagcc tctaacctca
     1621 aagcgatgga cctcactggc ttctcagacc cctacgtgaa ggcctccctg atcagcgagg
     1681 ggcggcgtct gaagaagcgg aaaacctcca tcaagaagaa cacgctgaac cccacctata
     1741 atgaggcgct ggtgttcgac gtggcccccg agagcgtgga gaacgtgggg ctcagcatcg
     1801 ccgtggtaga ctacgactgc atcgggcaca acgaggtgat cggcgtgtgc cgtgtgggcc
     1861 ccgacgctgc cgacccgcac ggccgcgagc actgggcaga gatgctggcc aatccccgca
     1921 agcccgtgga gcactggcat cagctagtgg aggaaaagac tgtgaccagc ttcacaaaag
     1981 gcagcaaagg actatcagag aaagagaact ccgagtgagg ggtctggcct aggcccggga
     2041 tcggaccagg ctccctcagg accccatcct ttcctgcccg gaccgtgaat tcatctcctt
     2101 gaagccataa cgtccgagct gctggtgcgg ggcagccctg gccctaggct tcctaaccct
     2161 ggaagcgaga ggatgagagg aggccggccc agctccttct ttcagggtgg gggtcattca
     2221 gcctccactg tgtctgtctt ttcttccctg gggctccccc tcgaggcgag gggccatgca
     2281 tgtctggggg acccctgccc cccaaaaccc tctgtctgtc tctgtctctt tgctgtttgt
     2341 ccaagactca gtgtcccgac ccttgttctc gccgtgaatg tcaatgggcc aatcctctct
     2401 gtcctttcag acacacacac acctgtgtcc accccttctg ttcgccacac ccctgcgtct
     2461 ggccggtccc cccactgctg ctgctatcaa cgccagaata aacacactct gtgggtctca
     2521 ctccaa
//
