LOCUS       NM_177402               7635 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens synaptotagmin 2 (SYT2), transcript variant 1, mRNA.
ACCESSION   NM_177402 XM_001723461 XM_001725208 XM_001726797
VERSION     NM_177402.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7635)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7635)
  AUTHORS   Mironovich,O., Dadali,E., Malmberg,S., Markova,T., Ryzhkova,O. and
            Poliakov,A.
  TITLE     Identification of a Novel de Novo Variant in the SYT2 Gene Causing
            a Rare Type of Distal Hereditary Motor Neuropathy
  JOURNAL   Genes (Basel) 11 (11), 1238 (2020)
   PUBMED   33105646
  REMARK    GeneRIF: Identification of a Novel de Novo Variant in the SYT2 Gene
            Causing a Rare Type of Distal Hereditary Motor Neuropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7635)
  AUTHORS   Donkervoort,S., Mohassel,P., Laugwitz,L., Zaki,M.S., Kamsteeg,E.J.,
            Maroofian,R., Chao,K.R., Verschuuren-Bemelmans,C.C., Horber,V.,
            Fock,A.J.M., McCarty,R.M., Jain,M.S., Biancavilla,V., McMacken,G.,
            Nalls,M., Voermans,N.C., Elbendary,H.M., Snyder,M., Cai,C.,
            Lehky,T.J., Stanley,V., Iannaccone,S.T., Foley,A.R., Lochmuller,H.,
            Gleeson,J., Houlden,H., Haack,T.B., Horvath,R. and Bonnemann,C.G.
  TITLE     Biallelic loss of function variants in SYT2 cause a treatable
            congenital onset presynaptic myasthenic syndrome
  JOURNAL   Am J Med Genet A 182 (10), 2272-2283 (2020)
   PUBMED   32776697
  REMARK    GeneRIF: Biallelic loss of function variants in SYT2 cause a
            treatable congenital onset presynaptic myasthenic syndrome.
REFERENCE   4  (bases 1 to 7635)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7635)
  AUTHORS   Herrmann,D.N., Horvath,R., Sowden,J.E., Gonzalez,M.,
            Sanchez-Mejias,A., Guan,Z., Whittaker,R.G., Almodovar,J.L.,
            Lane,M., Bansagi,B., Pyle,A., Boczonadi,V., Lochmuller,H.,
            Griffin,H., Chinnery,P.F., Lloyd,T.E., Littleton,J.T. and
            Zuchner,S.
  TITLE     Synaptotagmin 2 mutations cause an autosomal-dominant form of
            lambert-eaton myasthenic syndrome and nonprogressive motor
            neuropathy
  JOURNAL   Am J Hum Genet 95 (3), 332-339 (2014)
   PUBMED   25192047
  REMARK    GeneRIF: Synaptotagmin 2 mutations cause an autosomal-dominant form
            of lambert-eaton myasthenic syndrome and nonprogressive motor
            neuropathy.
            Erratum:[Am J Hum Genet. 2014 Oct 2;95(4):472. Gonzales, Michael
            [corrected to Gonzalez, Michael]]
REFERENCE   6  (bases 1 to 7635)
  AUTHORS   Jones,J.M., Popma,S.J., Mizuta,M., Seino,S. and Meisler,M.H.
  TITLE     Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human
            chromosome 19
  JOURNAL   Mamm Genome 6 (3), 212-213 (1995)
   PUBMED   7749232
REFERENCE   7  (bases 1 to 7635)
  AUTHORS   Fukuda,M., Aruga,J., Niinobe,M., Aimoto,S. and Mikoshiba,K.
  TITLE     Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of
            IP4BP/synaptotagmin II
  JOURNAL   J Biol Chem 269 (46), 29206-29211 (1994)
   PUBMED   7961887
REFERENCE   8  (bases 1 to 7635)
  AUTHORS   Abicht,A., Muller,J.S. and Lochmuller,H.
  TITLE     Congenital Myasthenic Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301347
REFERENCE   9  (bases 1 to 7635)
  AUTHORS   Geppert,M., Archer,B.T. 3rd and Sudhof,T.C.
  TITLE     Synaptotagmin II. A novel differentially distributed form of
            synaptotagmin
  JOURNAL   J Biol Chem 266 (21), 13548-13552 (1991)
   PUBMED   1856191
REFERENCE   10 (bases 1 to 7635)
  AUTHORS   Blaustein,R.O., Germann,W.J., Finkelstein,A. and DasGupta,B.R.
  TITLE     The N-terminal half of the heavy chain of botulinum type A
            neurotoxin forms channels in planar phospholipid bilayers
  JOURNAL   FEBS Lett 226 (1), 115-120 (1987)
   PUBMED   2446925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104463.3, DA098279.1,
            BC100815.1 and AC118556.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_177402.4.
            
            Summary: This gene encodes a synaptic vesicle membrane protein. The
            encoded protein is thought to function as a calcium sensor in
            vesicular trafficking and exocytosis. Mutations in this gene are
            associated with myasthenic syndrome, presynaptic, congenital, with
            or without motor neuropathy. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the more prevalent
            variant. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.123156.1,
                                           SRR1660805.72270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162841, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367268.5/ ENSP00000356237.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC104463.3         112164-112194       c
            32-166              DA098279.1         4-138
            167-1922            BC100815.1         1-1756
            1923-7635           AC118556.2         2970-8682
FEATURES             Location/Qualifiers
     source          1..7635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..7635
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="synaptotagmin 2"
                     /db_xref="GeneID:127833"
                     /db_xref="HGNC:HGNC:11510"
                     /db_xref="MIM:600104"
     exon            1..197
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            198..392
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1474
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="synaptotagmin II"
                     /codon_start=1
                     /product="synaptotagmin-2"
                     /protein_id="NP_796376.2"
                     /db_xref="CCDS:CCDS1427.1"
                     /db_xref="GeneID:127833"
                     /db_xref="HGNC:HGNC:11510"
                     /db_xref="MIM:600104"
                     /translation="MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMF
                     AKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGM
                     KNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGV
                     LQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELG
                     GKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICT
                     SLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLN
                     PYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDML
                     ANPRRPIAQWHSLKPEEEVDALLGKNK"
     exon            393..559
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            560..679
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            680..847
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1015
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1133
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1267
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..7635
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7616..7621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="hexamer: AAGAAA"
     polyA_site      7635
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="major polyA site"
ORIGIN      
        1 gcagactgct aagctcagca agtcttgcgg caaaggcact tcggagccga gttggggcag
       61 cggtggagcg gggacttcgc gcccccaggg gaacgggcgc ccctgcgaaa ccgtcgccag
      121 ccacgcgtcc ttgccgtccg acgccccctc acattggaga ccccggatct ctcccgcctc
      181 cttcgggtcg ctctccgctg tttcctctgc caccatgagg aacattttca agaggaacca
      241 ggagcctatt gtggctcctg ccaccaccac cgccacgatg cccattggac ccgtggacaa
      301 ctccactgag agtgggggtg ctggggagag ccaggaggac atgtttgcca aactgaagga
      361 gaagttattc aatgagataa acaagattcc cttaccaccc tgggcactga tcgccattgc
      421 tgtggttgct gggctcctgc ttctcacctg ctgcttctgc atctgcaaga aatgctgctg
      481 caagaagaag aagaacaaga aggagaaggg caaaggcatg aagaatgcca tgaacatgaa
      541 ggacatgaaa gggggtcagg atgacgacga cgcagagaca ggcctgactg agggggaagg
      601 tgaaggggag gaggagaaag agccagagaa cctgggcaaa ctgcagtttt ccctggacta
      661 tgattttcag gctaatcagc ttactgtggg cgttctgcag gctgctgaac tgcctgccct
      721 ggacatggga ggcacctcag acccttatgt caaggtcttc ctccttcctg acaagaagaa
      781 gaaatatgag accaaagtcc atcggaagac actgaaccct gccttcaatg aaaccttcac
      841 cttcaaggtg ccataccagg agcttggggg caaaactctg gtgatggcca tctatgactt
      901 tgaccgcttc tccaaacatg acatcattgg agaggtaaag gtgcctatga acacagtgga
      961 cctcggccag cccattgagg agtggagaga cctgcaaggc ggggaaaagg aggagccgga
     1021 gaagctgggc gacatctgca cctccctgcg ctatgtgccc acggccggga agctcactgt
     1081 ctgcatcctg gaggctaaga acctcaagaa gatggacgtg ggcggccttt cagacccgta
     1141 cgtgaagatc cacctgatgc agaatggcaa gaggctcaag aagaagaaga caaccgtgaa
     1201 gaagaagacc ctgaacccat acttcaacga gtccttcagc tttgagatcc ccttcgagca
     1261 gattcagaaa gtccaggtag tggtcaccgt gctggactat gacaagctgg gcaagaacga
     1321 agccataggc aagatcttcg tgggcagcaa tgccacgggc acagagctgc ggcactggtc
     1381 cgacatgctg gccaaccccc ggaggcccat cgcccagtgg cactcgctca agcctgagga
     1441 ggaggtggat gcactcctgg gcaagaacaa gtagacagca gcggctggga ccccacacct
     1501 ttcacggaca ctgacaagat ccagagctat caatacctca gttatgcaac cttagaggtt
     1561 ttcttttttc tttcatttgt tgggtggttg tgtccttgtt tttccttgtt tttctctttt
     1621 taaagaccaa cttccctttg atggctgtgt gaggagagtc ccctaagagg tgaaagagaa
     1681 gcctggctct gttcacggtc ccaggagctg tccttgctgc atgccctgtc acagttccct
     1741 cgactctttc aaagcttcac atctgcctca ccccaagcga ggctctctac tggcacaaac
     1801 ttgcagcagt tcctgttttt tgagccttct ggaccaacaa aatggcagca catcctgctt
     1861 cctgacaggg aaggcatcac agtggccaat gatcgtgtgt gtgtgtgtgt gtgtgtgtgt
     1921 gtatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtctttgagc atttctcttc
     1981 attcctggaa tgtgtgtgtg tgtgtgtctc tttgagcatc tctcttcatt cctggaatga
     2041 gccatggaca gtaaagttgt gtgggaaaag aaggctcttt ggggaccctg acatgaagaa
     2101 gtccactaag tgggagatct tctctcatct atggcaaagt ctcaggatcc tgttcagata
     2161 tcggggcttt catactcctg ttggtggcta tttgggaggc agcaagatgt gaagactgga
     2221 tgtgttcaga actaggacca aacgatgcca tcaaatactt cctcctgcca gtcatggttt
     2281 ccccagaagt gtagttcctg ggacattcat ggatatgagc tattcactag ttgggtcaga
     2341 ctaacaggga ctctcagtcc caaaatctca ctcttattga caataaatat caaactatga
     2401 agaaacagaa gtcccattac cagaaagacc aaaattaaac tcctggatct tcaccccatc
     2461 cagtgggaaa cacagatgct ttctcccttt ccagaatata agcagccaag ttcatttgca
     2521 tttattcccc attgtgcttt tgcttctgtt tctcttttaa gtggagcaac actgtctgaa
     2581 gacacgttat ctgtgcagag ccagagaact ttaaaaggaa agtttaaatg ttcttagttc
     2641 tcctgaggtc caggtaagaa gggggtggta agaagaggat gggggacaga tggctgagat
     2701 cccttgggag gagatatagg ggagcactgg aattcccccg actcccactc cttgctccct
     2761 tggccctctg ccctccatgc tggagagctg ataggtagct ggagtggccc agggagacct
     2821 atgggaagga cccgtcctac cattaggggg cttctctcta tgaatgctaa gaaacaaagg
     2881 gcatccattc caaatgagta gcagaggtga ccttctaggg tttctaccca tgctcagttg
     2941 tatcccattc cctgttcacc ttttgtcccc agcactgata taaaagccat atatatgtta
     3001 gtcaggtttg cactgagtct tcttccaatc cttcagcctg gacaacagag tgaggtcccc
     3061 ttgtggccag aggccagccc tccttgcctg ccttcctttg acctctcttt tccatccatg
     3121 aagccctcag gcccttgcca ttttttcacc acagaaaact catggcttct ccagaagcct
     3181 gagtatctct ctttcccagc acaaatggca gcatctctat cctgccccat ctgggccact
     3241 tcagcttcct gtagacaccc aagacagatg gacagtgttg gagggaatca ggctttgagg
     3301 atccagtgtg aagaagttgc agagtgtctt tttattttat tttaaaaagg gggaaggggc
     3361 ttttggtttt gctttgtttt ttggatgaag gagtgaggga aatgagggaa tacccccacc
     3421 agaaacagac tggaaagcct gcctgtctct tggagatcct tctttgtctt gttagtggta
     3481 catgggaagt tatgttttta ctggtgtgtg tgtgtgtgtg tgtgtgtgta cttaatgatg
     3541 ggaaggtaag actctgatca ggattatgaa ctgcggtcct tgggaccaaa ggtgtggtca
     3601 tggtagagag ttgtaggaca atagggtgtt ttcagaatct gggtggccac agagtgggat
     3661 ttcctggtat ggacatcaga agtcactgga ctcttctccc aaccccagag ttatgggatt
     3721 ttggtgcttt ctcagggtct ctccccagac tcactcttct cacccatatc ccacagactc
     3781 actcatggag acccccttgt caatatcccc tctaccttta ctcctttgcc ctttcccaat
     3841 tcatcttcta ccacctggat tcttttccat tcatgaactt cattcagccc ttccaaagcc
     3901 caagatttgc attcccttga cagggaggaa aggcaatggt aggaacctct ggtggtctgg
     3961 gtgtctatgt gcctggtgac cagggctgga tttttattac tctgagccca ctgctagtga
     4021 ggagccttga ggggtgggga caggttgctg agtgattttg aacgttgaca ccagtgtgga
     4081 gccagtgtgg gtgtggggag cagtgccttc ctcaggtccc agctggtcct gatatgccac
     4141 gtagtggatg gcatctgtct tggtccatgg gcttggtggg aacatgcttc tgcttgtgtg
     4201 ttttccatac ctgagggctg acgtagctta aaccacaggg catcatgcca aacactcact
     4261 gctgggcagg tttatttctg gggatgtcag ggtactgggg tgtaggcact aagcaggata
     4321 gagttagggt gtctggctag taaggggttc tggacgcctc tggggctgtg agttttcatc
     4381 tcaaagtctg ttccagagaa aggaaagtag tatagaggtg atttttagag aagctgagac
     4441 catgaaaaca agcctaatcc catccagaaa ctggggtaaa gtctgaaagt tcgttttctt
     4501 cttcctccct gaataattgt tccagaaggg atgctaactc tgccagagct acaggcagat
     4561 ttttgggctt tggaagtgga agctgaggcc tggggaaggc tgggtaagga atgctggggc
     4621 aatctcagac agtaggcagg tgcttggcat gaatgagaag tgactttcct ggagtccctc
     4681 agtagaggat gagatagcag ggattaggcc acagtctcag atcctgatct tttttcttcc
     4741 taggaaagca tacataactt gtgtctgcag aatcagtgtg ggatgatttt gctggcccaa
     4801 ggcttcagcg agagggagaa gagaggtcac tacagccctc ctgtgggtaa aagcagctct
     4861 cttataaacc tgcctccatg cagtggggtg ggggtaaggg tgggtgacag caaagaggtt
     4921 gaggaacctc cctgggtttg gggagtgaga gcttccatgt tcccttaatg tcctaggtta
     4981 attcataagg catctgagtc ctgggtctca cccagcctca cagagagaaa aactgtccct
     5041 gagggtgtcc cctcccactc aaaggtagaa agagattgag ccaggaactg ccctcatatc
     5101 ctctgctctg ccccttccct tccctttcct ctgcccctcc cacctaaagc tgtttggggc
     5161 cctttctcag agccctgggt ggtggcaggc agggaggagt cccaagatcc tggtggccct
     5221 gagccccatg ctatggttgc cagatttggc aaataaaaat acaggatgtc cagttacatt
     5281 tgaatttcag ttcaacaaca aacaattatt aagtgtaaat atgtcctagg caaatagttg
     5341 ggacatatac taaaaaataa tttgttgttt atctgaaatt caaatgtaac tggtcatcct
     5401 gcattgtgtc tgggaaccct accctatgac ttttccccct ctccctttgg tcccaagggg
     5461 ccaggaaccc caaggatttg acttaaccag ttttttgaac tgcaatattg agaaggggac
     5521 actgtgactt gaagacacat gaattacttt attttttaag caacaacaaa ataagaacct
     5581 tctgaagcca tttgagcctc atctgccccc atccgtgtat atttaattat atataaaaga
     5641 agataattac ctagaaacat atgaacagaa tcttgtttaa tcaagatgca tgtctataac
     5701 tttctgtaaa tagccgcatg gcaatgctga gagtcccctt gatccccaac ctcaaaccca
     5761 ttttacagaa ctggttgagg ctgctccttt gattttatgt cgtgtaaagt ctttgttccc
     5821 cagccccacc cctgcctcct cccatcggga aaccccccat gggagtcatc agtgggcggg
     5881 agtcggtgcc tgctccagtc cagccctgcc ttgggagatg ctggaggacc ctgtcgccct
     5941 gaaggcctgt ttgctgcaca tctgcctgca gagccaaacc tcagggcccg gtgcagtgtc
     6001 cagcctggta tctggcatcc cagtagcttc catgttctgt gtatgtgtgt ggtgtgcccc
     6061 ttcctcccac tgtttgaatt cactgaaaag ccataaaggg ggcctcctgc tggagatttg
     6121 gcctcccttg gctcctccca ggagccccca tgtctctcca actggctccc cacagaccac
     6181 ttctgaaggg ctcacctgtt gtcactccct cctgctccct cagtcccgtg tcatgagaat
     6241 ggacggtgtc cagggcttcc ggtggggtct caggagatgc ccatgctggc cctgcccgag
     6301 ctggctttct cggcctgggt tcacagttca gctccatctc tacgctgggc gaggagcaga
     6361 cagcagtggg actccatggt tctggatacc tttcctgggg tccctgtgga ggcaaccagg
     6421 attttcagga gcagccagtc agcagctcag ccagggatga cagaaccatc cctgcttact
     6481 cacctctgta gtgtgagggt ctgtgggtgg tgatggagga gggactcagg gagaggccgg
     6541 tgaatacagg ggctgacgct cttccctcgt gcatcctcct gcagtctgac agaaagcagc
     6601 ccaatagcgg ggcaacctca gggctaccag cgatcccctg agagtggggt gggcaggttc
     6661 agctgtgaga gaggctcagg cagagcaggt gtggactaag tcccctgacc ttcacacctg
     6721 ctccccagag aagccccagc cagttgcacc aagtagcaga ggtgagtaga ggggcctggg
     6781 ggcttccaag gccccaggtc atcctgttga actgagaggg acaggtagcc cccctgcctg
     6841 cggcccctgg ccccatgggc acctgagggc agtactgcat gggaagagcc caggatgcct
     6901 caggcctggc aactgtgaca agtatgagga aggagagaga acgggaaggg aatcaggcag
     6961 ggcgcattcg aggaggccag aggtggcgag gcaggcttgc cctgcacaaa ccacaacaga
     7021 agttgcacac agaagtccca gggacctttg tgctgggaac tgaaagagtg gggaaggtgg
     7081 aggggaccat ttcagagcag gctggaatca ggtgcttgga ccagtgaaga catgtcttgc
     7141 ttcctccagc tctctctggg gccctcccac tctccacacc cacagcagag acaaattgag
     7201 gcaagagttg agagagcatc tgtctggtga ggtgatggga gcagtgtgca tggggcacca
     7261 ggagttcctc catcccacct gccttagcga tcaggacttt aggggggcct cttcaaagat
     7321 agtgaccctt ctgccctgac tcctgcccat ctaaggactt gatttgctgc tttctgaaaa
     7381 ccctggggct gaaaacttca aaatcagggc ctggcagagc ctagcttcgc caaggtcagc
     7441 ccaccaggag ccctgccttc gtctccatag gaaggacaca tgtacagccc ttgcccccgg
     7501 ccctctcatt cccacttctg cttggcaatg ctctccatct cccttatgtg gactcttgtt
     7561 cttgtctgat ctcttgtcaa attgttattt tgtaatgaac tgcgtctcct tattaaagaa
     7621 atgagctgaa agaaa
//
