LOCUS       NM_001136504            7614 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens synaptotagmin 2 (SYT2), transcript variant 2, mRNA.
ACCESSION   NM_001136504
VERSION     NM_001136504.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7614)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7614)
  AUTHORS   Mironovich,O., Dadali,E., Malmberg,S., Markova,T., Ryzhkova,O. and
            Poliakov,A.
  TITLE     Identification of a Novel de Novo Variant in the SYT2 Gene Causing
            a Rare Type of Distal Hereditary Motor Neuropathy
  JOURNAL   Genes (Basel) 11 (11), 1238 (2020)
   PUBMED   33105646
  REMARK    GeneRIF: Identification of a Novel de Novo Variant in the SYT2 Gene
            Causing a Rare Type of Distal Hereditary Motor Neuropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7614)
  AUTHORS   Donkervoort,S., Mohassel,P., Laugwitz,L., Zaki,M.S., Kamsteeg,E.J.,
            Maroofian,R., Chao,K.R., Verschuuren-Bemelmans,C.C., Horber,V.,
            Fock,A.J.M., McCarty,R.M., Jain,M.S., Biancavilla,V., McMacken,G.,
            Nalls,M., Voermans,N.C., Elbendary,H.M., Snyder,M., Cai,C.,
            Lehky,T.J., Stanley,V., Iannaccone,S.T., Foley,A.R., Lochmuller,H.,
            Gleeson,J., Houlden,H., Haack,T.B., Horvath,R. and Bonnemann,C.G.
  TITLE     Biallelic loss of function variants in SYT2 cause a treatable
            congenital onset presynaptic myasthenic syndrome
  JOURNAL   Am J Med Genet A 182 (10), 2272-2283 (2020)
   PUBMED   32776697
  REMARK    GeneRIF: Biallelic loss of function variants in SYT2 cause a
            treatable congenital onset presynaptic myasthenic syndrome.
REFERENCE   4  (bases 1 to 7614)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7614)
  AUTHORS   Herrmann,D.N., Horvath,R., Sowden,J.E., Gonzalez,M.,
            Sanchez-Mejias,A., Guan,Z., Whittaker,R.G., Almodovar,J.L.,
            Lane,M., Bansagi,B., Pyle,A., Boczonadi,V., Lochmuller,H.,
            Griffin,H., Chinnery,P.F., Lloyd,T.E., Littleton,J.T. and
            Zuchner,S.
  TITLE     Synaptotagmin 2 mutations cause an autosomal-dominant form of
            lambert-eaton myasthenic syndrome and nonprogressive motor
            neuropathy
  JOURNAL   Am J Hum Genet 95 (3), 332-339 (2014)
   PUBMED   25192047
  REMARK    GeneRIF: Synaptotagmin 2 mutations cause an autosomal-dominant form
            of lambert-eaton myasthenic syndrome and nonprogressive motor
            neuropathy.
            Erratum:[Am J Hum Genet. 2014 Oct 2;95(4):472. Gonzales, Michael
            [corrected to Gonzalez, Michael]]
REFERENCE   6  (bases 1 to 7614)
  AUTHORS   Jones,J.M., Popma,S.J., Mizuta,M., Seino,S. and Meisler,M.H.
  TITLE     Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human
            chromosome 19
  JOURNAL   Mamm Genome 6 (3), 212-213 (1995)
   PUBMED   7749232
REFERENCE   7  (bases 1 to 7614)
  AUTHORS   Fukuda,M., Aruga,J., Niinobe,M., Aimoto,S. and Mikoshiba,K.
  TITLE     Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of
            IP4BP/synaptotagmin II
  JOURNAL   J Biol Chem 269 (46), 29206-29211 (1994)
   PUBMED   7961887
REFERENCE   8  (bases 1 to 7614)
  AUTHORS   Abicht,A., Muller,J.S. and Lochmuller,H.
  TITLE     Congenital Myasthenic Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301347
REFERENCE   9  (bases 1 to 7614)
  AUTHORS   Geppert,M., Archer,B.T. 3rd and Sudhof,T.C.
  TITLE     Synaptotagmin II. A novel differentially distributed form of
            synaptotagmin
  JOURNAL   J Biol Chem 266 (21), 13548-13552 (1991)
   PUBMED   1856191
REFERENCE   10 (bases 1 to 7614)
  AUTHORS   Blaustein,R.O., Germann,W.J., Finkelstein,A. and DasGupta,B.R.
  TITLE     The N-terminal half of the heavy chain of botulinum type A
            neurotoxin forms channels in planar phospholipid bilayers
  JOURNAL   FEBS Lett 226 (1), 115-120 (1987)
   PUBMED   2446925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK094430.1, BC100815.1 and
            AC118556.2.
            
            Summary: This gene encodes a synaptic vesicle membrane protein. The
            encoded protein is thought to function as a calcium sensor in
            vesicular trafficking and exocytosis. Mutations in this gene are
            associated with myasthenic syndrome, presynaptic, congenital, with
            or without motor neuropathy. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.166710.1,
                                           SRR1803616.82115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AK094430.1         1-309
            310-1901            BC100815.1         165-1756
            1902-7614           AC118556.2         2970-8682
FEATURES             Location/Qualifiers
     source          1..7614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..7614
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="synaptotagmin 2"
                     /db_xref="GeneID:127833"
                     /db_xref="HGNC:HGNC:11510"
                     /db_xref="MIM:600104"
     exon            1..176
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            177..371
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1453
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="synaptotagmin II"
                     /codon_start=1
                     /product="synaptotagmin-2"
                     /protein_id="NP_001129976.1"
                     /db_xref="CCDS:CCDS1427.1"
                     /db_xref="GeneID:127833"
                     /db_xref="HGNC:HGNC:11510"
                     /db_xref="MIM:600104"
                     /translation="MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMF
                     AKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGM
                     KNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGV
                     LQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELG
                     GKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICT
                     SLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLN
                     PYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDML
                     ANPRRPIAQWHSLKPEEEVDALLGKNK"
     exon            372..538
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            539..658
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            659..826
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            827..994
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1112
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1246
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..7614
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7595..7600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="hexamer: AAGAAA"
     polyA_site      7614
                     /gene="SYT2"
                     /gene_synonym="CMS7; CMS7A; CMS7B; MYSPC; SytII"
                     /note="major polyA site"
ORIGIN      
        1 atagagagag ggagagactc gagagcgagc gagcgcggga gcgagggccg cagcggcagg
       61 gccggcgggg aagtgggaag agggacctgg acttcgggac cccagctgtc cccgcccccg
      121 cccccgcccc cgccctctcc accagctcag gctgaacgcg cccggaacgt cccaggctgt
      181 ttcctctgcc accatgagga acattttcaa gaggaaccag gagcctattg tggctcctgc
      241 caccaccacc gccacgatgc ccattggacc cgtggacaac tccactgaga gtgggggtgc
      301 tggggagagc caggaggaca tgtttgccaa actgaaggag aagttattca atgagataaa
      361 caagattccc ttaccaccct gggcactgat cgccattgct gtggttgctg ggctcctgct
      421 tctcacctgc tgcttctgca tctgcaagaa atgctgctgc aagaagaaga agaacaagaa
      481 ggagaagggc aaaggcatga agaatgccat gaacatgaag gacatgaaag ggggtcagga
      541 tgacgacgac gcagagacag gcctgactga gggggaaggt gaaggggagg aggagaaaga
      601 gccagagaac ctgggcaaac tgcagttttc cctggactat gattttcagg ctaatcagct
      661 tactgtgggc gttctgcagg ctgctgaact gcctgccctg gacatgggag gcacctcaga
      721 cccttatgtc aaggtcttcc tccttcctga caagaagaag aaatatgaga ccaaagtcca
      781 tcggaagaca ctgaaccctg ccttcaatga aaccttcacc ttcaaggtgc cataccagga
      841 gcttgggggc aaaactctgg tgatggccat ctatgacttt gaccgcttct ccaaacatga
      901 catcattgga gaggtaaagg tgcctatgaa cacagtggac ctcggccagc ccattgagga
      961 gtggagagac ctgcaaggcg gggaaaagga ggagccggag aagctgggcg acatctgcac
     1021 ctccctgcgc tatgtgccca cggccgggaa gctcactgtc tgcatcctgg aggctaagaa
     1081 cctcaagaag atggacgtgg gcggcctttc agacccgtac gtgaagatcc acctgatgca
     1141 gaatggcaag aggctcaaga agaagaagac aaccgtgaag aagaagaccc tgaacccata
     1201 cttcaacgag tccttcagct ttgagatccc cttcgagcag attcagaaag tccaggtagt
     1261 ggtcaccgtg ctggactatg acaagctggg caagaacgaa gccataggca agatcttcgt
     1321 gggcagcaat gccacgggca cagagctgcg gcactggtcc gacatgctgg ccaacccccg
     1381 gaggcccatc gcccagtggc actcgctcaa gcctgaggag gaggtggatg cactcctggg
     1441 caagaacaag tagacagcag cggctgggac cccacacctt tcacggacac tgacaagatc
     1501 cagagctatc aatacctcag ttatgcaacc ttagaggttt tcttttttct ttcatttgtt
     1561 gggtggttgt gtccttgttt ttccttgttt ttctcttttt aaagaccaac ttccctttga
     1621 tggctgtgtg aggagagtcc cctaagaggt gaaagagaag cctggctctg ttcacggtcc
     1681 caggagctgt ccttgctgca tgccctgtca cagttccctc gactctttca aagcttcaca
     1741 tctgcctcac cccaagcgag gctctctact ggcacaaact tgcagcagtt cctgtttttt
     1801 gagccttctg gaccaacaaa atggcagcac atcctgcttc ctgacaggga aggcatcaca
     1861 gtggccaatg atcgtgtgtg tgtgtgtgtg tgtgtgtgtg tatgtgtgtg tgtgtgtgtg
     1921 tgtgtgtgtg tgtgtgtgtg tctttgagca tttctcttca ttcctggaat gtgtgtgtgt
     1981 gtgtgtctct ttgagcatct ctcttcattc ctggaatgag ccatggacag taaagttgtg
     2041 tgggaaaaga aggctctttg gggaccctga catgaagaag tccactaagt gggagatctt
     2101 ctctcatcta tggcaaagtc tcaggatcct gttcagatat cggggctttc atactcctgt
     2161 tggtggctat ttgggaggca gcaagatgtg aagactggat gtgttcagaa ctaggaccaa
     2221 acgatgccat caaatacttc ctcctgccag tcatggtttc cccagaagtg tagttcctgg
     2281 gacattcatg gatatgagct attcactagt tgggtcagac taacagggac tctcagtccc
     2341 aaaatctcac tcttattgac aataaatatc aaactatgaa gaaacagaag tcccattacc
     2401 agaaagacca aaattaaact cctggatctt caccccatcc agtgggaaac acagatgctt
     2461 tctccctttc cagaatataa gcagccaagt tcatttgcat ttattcccca ttgtgctttt
     2521 gcttctgttt ctcttttaag tggagcaaca ctgtctgaag acacgttatc tgtgcagagc
     2581 cagagaactt taaaaggaaa gtttaaatgt tcttagttct cctgaggtcc aggtaagaag
     2641 ggggtggtaa gaagaggatg ggggacagat ggctgagatc ccttgggagg agatataggg
     2701 gagcactgga attcccccga ctcccactcc ttgctccctt ggccctctgc cctccatgct
     2761 ggagagctga taggtagctg gagtggccca gggagaccta tgggaaggac ccgtcctacc
     2821 attagggggc ttctctctat gaatgctaag aaacaaaggg catccattcc aaatgagtag
     2881 cagaggtgac cttctagggt ttctacccat gctcagttgt atcccattcc ctgttcacct
     2941 tttgtcccca gcactgatat aaaagccata tatatgttag tcaggtttgc actgagtctt
     3001 cttccaatcc ttcagcctgg acaacagagt gaggtcccct tgtggccaga ggccagccct
     3061 ccttgcctgc cttcctttga cctctctttt ccatccatga agccctcagg cccttgccat
     3121 tttttcacca cagaaaactc atggcttctc cagaagcctg agtatctctc tttcccagca
     3181 caaatggcag catctctatc ctgccccatc tgggccactt cagcttcctg tagacaccca
     3241 agacagatgg acagtgttgg agggaatcag gctttgagga tccagtgtga agaagttgca
     3301 gagtgtcttt ttattttatt ttaaaaaggg ggaaggggct tttggttttg ctttgttttt
     3361 tggatgaagg agtgagggaa atgagggaat acccccacca gaaacagact ggaaagcctg
     3421 cctgtctctt ggagatcctt ctttgtcttg ttagtggtac atgggaagtt atgtttttac
     3481 tggtgtgtgt gtgtgtgtgt gtgtgtgtac ttaatgatgg gaaggtaaga ctctgatcag
     3541 gattatgaac tgcggtcctt gggaccaaag gtgtggtcat ggtagagagt tgtaggacaa
     3601 tagggtgttt tcagaatctg ggtggccaca gagtgggatt tcctggtatg gacatcagaa
     3661 gtcactggac tcttctccca accccagagt tatgggattt tggtgctttc tcagggtctc
     3721 tccccagact cactcttctc acccatatcc cacagactca ctcatggaga cccccttgtc
     3781 aatatcccct ctacctttac tcctttgccc tttcccaatt catcttctac cacctggatt
     3841 cttttccatt catgaacttc attcagccct tccaaagccc aagatttgca ttcccttgac
     3901 agggaggaaa ggcaatggta ggaacctctg gtggtctggg tgtctatgtg cctggtgacc
     3961 agggctggat ttttattact ctgagcccac tgctagtgag gagccttgag gggtggggac
     4021 aggttgctga gtgattttga acgttgacac cagtgtggag ccagtgtggg tgtggggagc
     4081 agtgccttcc tcaggtccca gctggtcctg atatgccacg tagtggatgg catctgtctt
     4141 ggtccatggg cttggtggga acatgcttct gcttgtgtgt tttccatacc tgagggctga
     4201 cgtagcttaa accacagggc atcatgccaa acactcactg ctgggcaggt ttatttctgg
     4261 ggatgtcagg gtactggggt gtaggcacta agcaggatag agttagggtg tctggctagt
     4321 aaggggttct ggacgcctct ggggctgtga gttttcatct caaagtctgt tccagagaaa
     4381 ggaaagtagt atagaggtga tttttagaga agctgagacc atgaaaacaa gcctaatccc
     4441 atccagaaac tggggtaaag tctgaaagtt cgttttcttc ttcctccctg aataattgtt
     4501 ccagaaggga tgctaactct gccagagcta caggcagatt tttgggcttt ggaagtggaa
     4561 gctgaggcct ggggaaggct gggtaaggaa tgctggggca atctcagaca gtaggcaggt
     4621 gcttggcatg aatgagaagt gactttcctg gagtccctca gtagaggatg agatagcagg
     4681 gattaggcca cagtctcaga tcctgatctt ttttcttcct aggaaagcat acataacttg
     4741 tgtctgcaga atcagtgtgg gatgattttg ctggcccaag gcttcagcga gagggagaag
     4801 agaggtcact acagccctcc tgtgggtaaa agcagctctc ttataaacct gcctccatgc
     4861 agtggggtgg gggtaagggt gggtgacagc aaagaggttg aggaacctcc ctgggtttgg
     4921 ggagtgagag cttccatgtt cccttaatgt cctaggttaa ttcataaggc atctgagtcc
     4981 tgggtctcac ccagcctcac agagagaaaa actgtccctg agggtgtccc ctcccactca
     5041 aaggtagaaa gagattgagc caggaactgc cctcatatcc tctgctctgc cccttccctt
     5101 ccctttcctc tgcccctccc acctaaagct gtttggggcc ctttctcaga gccctgggtg
     5161 gtggcaggca gggaggagtc ccaagatcct ggtggccctg agccccatgc tatggttgcc
     5221 agatttggca aataaaaata caggatgtcc agttacattt gaatttcagt tcaacaacaa
     5281 acaattatta agtgtaaata tgtcctaggc aaatagttgg gacatatact aaaaaataat
     5341 ttgttgttta tctgaaattc aaatgtaact ggtcatcctg cattgtgtct gggaacccta
     5401 ccctatgact tttccccctc tccctttggt cccaaggggc caggaacccc aaggatttga
     5461 cttaaccagt tttttgaact gcaatattga gaaggggaca ctgtgacttg aagacacatg
     5521 aattacttta ttttttaagc aacaacaaaa taagaacctt ctgaagccat ttgagcctca
     5581 tctgccccca tccgtgtata tttaattata tataaaagaa gataattacc tagaaacata
     5641 tgaacagaat cttgtttaat caagatgcat gtctataact ttctgtaaat agccgcatgg
     5701 caatgctgag agtccccttg atccccaacc tcaaacccat tttacagaac tggttgaggc
     5761 tgctcctttg attttatgtc gtgtaaagtc tttgttcccc agccccaccc ctgcctcctc
     5821 ccatcgggaa accccccatg ggagtcatca gtgggcggga gtcggtgcct gctccagtcc
     5881 agccctgcct tgggagatgc tggaggaccc tgtcgccctg aaggcctgtt tgctgcacat
     5941 ctgcctgcag agccaaacct cagggcccgg tgcagtgtcc agcctggtat ctggcatccc
     6001 agtagcttcc atgttctgtg tatgtgtgtg gtgtgcccct tcctcccact gtttgaattc
     6061 actgaaaagc cataaagggg gcctcctgct ggagatttgg cctcccttgg ctcctcccag
     6121 gagcccccat gtctctccaa ctggctcccc acagaccact tctgaagggc tcacctgttg
     6181 tcactccctc ctgctccctc agtcccgtgt catgagaatg gacggtgtcc agggcttccg
     6241 gtggggtctc aggagatgcc catgctggcc ctgcccgagc tggctttctc ggcctgggtt
     6301 cacagttcag ctccatctct acgctgggcg aggagcagac agcagtggga ctccatggtt
     6361 ctggatacct ttcctggggt ccctgtggag gcaaccagga ttttcaggag cagccagtca
     6421 gcagctcagc cagggatgac agaaccatcc ctgcttactc acctctgtag tgtgagggtc
     6481 tgtgggtggt gatggaggag ggactcaggg agaggccggt gaatacaggg gctgacgctc
     6541 ttccctcgtg catcctcctg cagtctgaca gaaagcagcc caatagcggg gcaacctcag
     6601 ggctaccagc gatcccctga gagtggggtg ggcaggttca gctgtgagag aggctcaggc
     6661 agagcaggtg tggactaagt cccctgacct tcacacctgc tccccagaga agccccagcc
     6721 agttgcacca agtagcagag gtgagtagag gggcctgggg gcttccaagg ccccaggtca
     6781 tcctgttgaa ctgagaggga caggtagccc ccctgcctgc ggcccctggc cccatgggca
     6841 cctgagggca gtactgcatg ggaagagccc aggatgcctc aggcctggca actgtgacaa
     6901 gtatgaggaa ggagagagaa cgggaaggga atcaggcagg gcgcattcga ggaggccaga
     6961 ggtggcgagg caggcttgcc ctgcacaaac cacaacagaa gttgcacaca gaagtcccag
     7021 ggacctttgt gctgggaact gaaagagtgg ggaaggtgga ggggaccatt tcagagcagg
     7081 ctggaatcag gtgcttggac cagtgaagac atgtcttgct tcctccagct ctctctgggg
     7141 ccctcccact ctccacaccc acagcagaga caaattgagg caagagttga gagagcatct
     7201 gtctggtgag gtgatgggag cagtgtgcat ggggcaccag gagttcctcc atcccacctg
     7261 ccttagcgat caggacttta ggggggcctc ttcaaagata gtgacccttc tgccctgact
     7321 cctgcccatc taaggacttg atttgctgct ttctgaaaac cctggggctg aaaacttcaa
     7381 aatcagggcc tggcagagcc tagcttcgcc aaggtcagcc caccaggagc cctgccttcg
     7441 tctccatagg aaggacacat gtacagccct tgcccccggc cctctcattc ccacttctgc
     7501 ttggcaatgc tctccatctc ccttatgtgg actcttgttc ttgtctgatc tcttgtcaaa
     7561 ttgttatttt gtaatgaact gcgtctcctt attaaagaaa tgagctgaaa gaaa
//
