LOCUS       NM_016524               3088 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens synaptotagmin 17 (SYT17), transcript variant 1, mRNA.
ACCESSION   NM_016524
VERSION     NM_016524.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3088)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3088)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3088)
  AUTHORS   Ruhl,D.A., Bomba-Warczak,E., Watson,E.T., Bradberry,M.M.,
            Peterson,T.A., Basu,T., Frelka,A., Evans,C.S., Briguglio,J.S.,
            Basta,T., Stowell,M.H.B., Savas,J.N., Roopra,A., Pearce,R.A.,
            Piper,R.C. and Chapman,E.R.
  TITLE     Synaptotagmin 17 controls neurite outgrowth and synaptic physiology
            via distinct cellular pathways
  JOURNAL   Nat Commun 10 (1), 3532 (2019)
   PUBMED   31387992
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3088)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3088)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   6  (bases 1 to 3088)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   7  (bases 1 to 3088)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 3088)
  AUTHORS   Chin,H., Choi,S.H., Jang,Y.S., Cho,S.M., Kim,H.S., Lee,J.H.,
            Jeong,S.W., Kim,I.K., Kim,G.J. and Kwon,O.J.
  TITLE     Protein kinase A-dependent phosphorylation of B/K protein
  JOURNAL   Exp Mol Med 38 (2), 144-152 (2006)
   PUBMED   16672768
  REMARK    GeneRIF: The results suggest that B/K proteins play a role as
            potential substrates for PKA in the area where they are expressed.
REFERENCE   9  (bases 1 to 3088)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3088)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010494.4, BC004518.2, AC003003.1 and AA705977.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016524.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.275771.1,
                                           SRR1803615.193796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355377.7/ ENSP00000347538.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               AC010494.4         49437-49833         c
            398-1018            BC004518.2         1-621
            1019-1019           AC010494.4         34265-34265         c
            1020-1879           BC004518.2         623-1482
            1880-3009           AC003003.1         83926-85055
            3010-3088           AA705977.1         14-92               c
FEATURES             Location/Qualifiers
     source          1..3088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..3088
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /note="synaptotagmin 17"
                     /db_xref="GeneID:51760"
                     /db_xref="HGNC:HGNC:24119"
     exon            1..422
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..1832
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /note="isoform 1 is encoded by transcript variant 1; B/K
                     protein; synaptotagmin XVII"
                     /codon_start=1
                     /product="synaptotagmin-17 isoform 1"
                     /protein_id="NP_057608.2"
                     /db_xref="CCDS:CCDS10575.1"
                     /db_xref="GeneID:51760"
                     /db_xref="HGNC:HGNC:24119"
                     /translation="MAYIQLEPLNEGFLSRISGLLLCRWTCRHCCQKCYESSCCQSSE
                     DEVEILGPFPAQTPPWLMASRSSDKDGDSVHTASEVPLTPRTNSPDGRRSSSDTSKST
                     YSLTRRISSLESRRPSSPLIDIKPIEFGVLSAKKEPIQPSVLRRTYNPDDYFRKFEPH
                     LYSLDSNSDDVDSLTDEEILSKYQLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHD
                     GSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLL
                     TVVDFDKFSRHCVIGKVSVPLCEVDLVKGGHWWKALIPSSQNEVELGELLLSLNYLPS
                     AGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESF
                     SFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSETNHWRRMLNTHRTA
                     VEQWHSLRSRAECDRVSPASLEVT"
     exon            423..440
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            441..589
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            590..738
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1358
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1479
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1635
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..3088
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /note="hexamer: ATTAAA"
     polyA_site      3088
                     /gene="SYT17"
                     /gene_synonym="Syt-17; sytXVII"
                     /note="major polyA site"
ORIGIN      
        1 gcgctccggc cccggcgtct ccggccccgc ctgcgctggg gtcgctgcag tccccgcagc
       61 tgccccgggc tgcttgccca ggcgccccgg ccttattcca gcctggggag cgcctcggtg
      121 gggagcacgg gacagcgagg gaggccgagg cgggggccct gggcgcccga tatctccgaa
      181 ccggggaggc ggccccgatt ccgagagccg gaacgcaggg aaaggcaagg acggggcggc
      241 cggcggaggg gcgggcgccg ctcatcagcc acgccagtca cgtctggggc caccggctgc
      301 ctttttcttc ctttccccct ttgctttctt ccccctccgc tgttggcgag ggcaaagtgg
      361 ccgtggcggc gccatgcccg ggccggagtg agtgcgcgcg ggcgaaaatg gcgtacatcc
      421 agttggaacc attaaacgag ggttttcttt ctagaatctc tggtctgctg ctgtgcagat
      481 ggacctgccg gcactgctgt cagaagtgct acgagtccag ctgttgccag tcaagtgagg
      541 atgaagttga aattctggga cctttccctg ctcagacccc tccctggctg atggccagcc
      601 ggagcagtga caaggatggt gactctgtcc acacggccag cgaagtcccg ctgaccccac
      661 ggaccaattc cccggatgga agacgctcgt cctcagacac atccaagtct acatacagcc
      721 tgacgcggag gatttcgagt cttgagtcaa gacgtcccag ctctccactc atcgatatta
      781 aacccatcga gtttggcgtt ctcagcgcca agaaggagcc catccaacct tcggtgctca
      841 gacggaccta taaccccgac gactatttca ggaagttcga accccacctg tactccctcg
      901 actccaacag cgacgatgtg gactctctga cagacgagga gatcctgtcc aagtaccagc
      961 tgggcatgct gcacttcagc actcagtacg acctgctgca caaccacctc accgtgcgcg
     1021 tgatcgaggc cagggacctg ccacctccca tctcccacga tggctcgcgc caggacatgg
     1081 cgcactccaa cccctacgtc aagatctgtc tcctgccaga ccagaagaac tcaaagcaga
     1141 ccggggtcaa acgcaagacc cagaagcccg tgtttgagga gcgctacacc ttcgagatcc
     1201 ccttcctgga ggcccagagg aggaccctgc tcctgaccgt ggtggatttt gataagttct
     1261 cccgccactg tgtcattggg aaagtttctg tgcctttgtg tgaagttgac ctggtcaagg
     1321 gcgggcactg gtggaaggcg ctgattccca gttctcagaa tgaagtggag ctgggggagc
     1381 tgcttctgtc actgaattat ctcccaagtg ctggcagact gaatgttgat gtcattcgag
     1441 ccaagcaact tcttcagaca gatgtgagcc aaggttcaga cccctttgtg aaaatccagc
     1501 tggtgcatgg actcaaactt gtgaaaacca agaagacgtc cttcttaagg ggcacaattg
     1561 atcctttcta caatgaatcc ttcagcttca aagttcccca agaagaactg gaaaatgcca
     1621 gcctagtgtt tacagttttc ggccacaaca tgaagagcag caatgacttc atcgggagga
     1681 tcgtcattgg ccagtactct tcaggcccct ctgagaccaa ccactggagg cgcatgctca
     1741 acacgcaccg cacagccgtg gagcagtggc atagcctgag gtcccgagct gagtgtgacc
     1801 gcgtgtctcc tgcctccctg gaggtgacct gagggctgca gggaaggcag ctttcatttg
     1861 tttaaaaaaa aaaaaaaaag acggaaaaaa atgtgtcaca tactattaca tccacacctg
     1921 catacacact cgcaacatgt ctacacacgt ccacacacac agacacacag ataccccaaa
     1981 tcctctcaga actgagagga agctgactat tgatcacaaa atggccgccc tcagttgagt
     2041 gaggcctagg aactttccgg aagccccatc catagatcac aagctcagtg ggctctgccg
     2101 tgggacttat tggcagtgcc tgctcttgtc aatactcctg ccccaaaatg cactttcaac
     2161 cctcaggcca gagaaaggac ctcccaaagg gtgccaagct ccatcaagac taaatttacc
     2221 aagagtttgg ccagtgtgtg ggagacttga acacccccca cttccgaaac acacacctac
     2281 tgggtaactt ctgaacaggc tgctgttccc tggggttctt caaacctgat acctttctcc
     2341 aaaggtgtaa gtatctttgt cttctccgta gtaaatgtga taactagatt atgggccatt
     2401 tggagaaacc aaatggcaac caaaactatt ccagtgtcag aagcctttcc tggcttaaca
     2461 gaattgttct tgtgttagct catcccaggg aacgccctgt gggtatgtat gtgtatgtcc
     2521 tcgtgcatgt gccctcacag gcgaacacgt gtgtgcctat gtgtcctctt ggagagcatg
     2581 gcgatgggcc aggacctcag ccctgagcac tgccttctct ctgcctctcc tgtccagtga
     2641 gagtccaacc agtgtcctcc tgtctgtcag agatcccact ttggataaaa gtagtgtgtg
     2701 tgtgtgtgtg tgtgtgtgtg tgtgtgtgta aagtaaatag gatatgatag agcaaaagta
     2761 acattttttg accgaatcat ggtgattgtg acccacgaaa gacatacaaa gacttgatat
     2821 atggattaaa atggctatca caccccatcc atgatgatct tcttccttaa tcatactctg
     2881 aggatctttc tgtgtttttc tgtgaacgaa tgtcacgtct ctcgtgctaa ggaattagtg
     2941 tagttagaat agatctctct ctctctctct ttctctctct ctctttcctc tctctctgtt
     3001 ggatgcttct gtatcttttt ccacagcata atgtctggtg tgatggggag ctatttattg
     3061 aaattaaaga ttatttattt gtgccatg
//
