LOCUS       NM_001367656           14213 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens synaptotagmin 16 (SYT16), transcript variant 4, mRNA.
ACCESSION   NM_001367656
VERSION     NM_001367656.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14213)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 14213)
  AUTHORS   Chen,J., Wang,Z., Wang,W., Ren,S., Xue,J., Zhong,L., Jiang,T.,
            Wei,H. and Zhang,C.
  TITLE     SYT16 is a prognostic biomarker and correlated with immune
            infiltrates in glioma: A study based on TCGA data
  JOURNAL   Int Immunopharmacol 84, 106490 (2020)
   PUBMED   32289666
  REMARK    GeneRIF: SYT16 is a prognostic biomarker and correlated with immune
            infiltrates in glioma: A study based on TCGA data.
REFERENCE   3  (bases 1 to 14213)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 14213)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14213)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 14213)
  AUTHORS   Mosing,M.A., Verweij,K.J., Medland,S.E., Painter,J., Gordon,S.D.,
            Heath,A.C., Madden,P.A., Montgomery,G.W. and Martin,N.G.
  TITLE     A genome-wide association study of self-rated health
  JOURNAL   Twin Res Hum Genet 13 (4), 398-403 (2010)
   PUBMED   20707712
REFERENCE   7  (bases 1 to 14213)
  AUTHORS   Montes,M., Fuson,K.L., Sutton,R.B. and Robert,J.J.
  TITLE     Purification, crystallization and X-ray diffraction analysis of
            human synaptotagmin 1 C2A-C2B
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 62 (Pt 9), 926-929
            (2006)
   PUBMED   16946482
  REMARK    GeneRIF: Human synaptotagmin tandem C2 domains C2A-C2B have been
            expressed as a glutathione-S-transferase fusion protein in
            Escherichia coli, purified, and crystallized and the preliminary
            X-ray analysis reported.
REFERENCE   8  (bases 1 to 14213)
  AUTHORS   Craxton,M.
  TITLE     Synaptotagmin gene content of the sequenced genomes
  JOURNAL   BMC Genomics 5 (1), 43 (2004)
   PUBMED   15238157
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 14213)
  AUTHORS   Fukuda,M.
  TITLE     Molecular cloning, expression, and characterization of a novel
            class of synaptotagmin (Syt XIV) conserved from Drosophila to
            humans
  JOURNAL   J Biochem 133 (5), 641-649 (2003)
   PUBMED   12801916
REFERENCE   10 (bases 1 to 14213)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137918.4, AL356018.5 and AL390816.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.209153.1,
                                           SRR1660807.231984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683842.1/ ENSP00000508274.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AL137918.4         144367-144474       c
            109-288             AL356018.5         41688-41867
            289-955             AL356018.5         67432-68098
            956-1168            AL390816.4         33735-33947
            1169-1425           AL390816.4         39267-39523
            1426-1866           AL390816.4         44966-45406
            1867-2056           AL390816.4         48328-48517
            2057-14213          AL390816.4         64526-76682
FEATURES             Location/Qualifiers
     source          1..14213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.2"
     gene            1..14213
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /note="synaptotagmin 16"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
     exon            1..108
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            109..288
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            289..955
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..2370
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /note="isoform 4 is encoded by transcript variant 4; chr14
                     synaptotagmin; synaptotagmin 14-like protein;
                     synaptotagmin XIV-related protein; synaptotagmin XVI"
                     /codon_start=1
                     /product="synaptotagmin-16 isoform 4"
                     /protein_id="NP_001354585.1"
                     /db_xref="CCDS:CCDS45121.1"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
                     /translation="MVLAMASQDVQNFFQPFSSWISRVYEALQQAGDMLSASLVNISK
                     QDSKLSDKLDQDLDNIQIQETYFEDEEQDNDWSQEDANSLFLEVDHFSCCNSDLQDSA
                     QNSSPSLSQHAKDSCSTMSQWPNWASDDRKLPHVLSSIAEEEHHLEKQRSGLQHGFDS
                     QLPGTLETVNGKKQVNSFGDDEELSTSSDSDEEVIKQFEISVSRSQSFRSVTSEKGKQ
                     TGLEQKPKFSRSLLTHGEDGTEVSACEDLDGASQRRYSENLSYGEDDHIPAHSQSPCE
                     RGDAKHHGTSHQESSVVQSLRRQSTEGSLEMETAFNSRGFEDSYATDSSSMWSPEEQD
                     RTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHV
                     VLLPGKKHRGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMG
                     EKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPE
                     LLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRR
                     GQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDH
                     WEEMKETKGQQICRWHTLLES"
     exon            956..1168
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1425
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1866
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2056
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..14213
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14188..14193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /note="hexamer: AATAAA"
     polyA_site      14213
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcaccg ggcctgccga ggagcgcgcg cccggccggg ctcggcgccg gtttcccgaa
       61 cctgggcggc cgtcgggcag ccccctcgtc cgaccatggc gactgacatc actcctgaag
      121 ccattggctt cttgtctgct gttggggtct ttattgttct tctggccgtc ctcttcctct
      181 tcatcaacaa gaagctgtgt tttgaaacga taggaggcct tcctttcctg gagcatcgag
      241 ggaaaagaaa gcattctaaa gacaagactg ggattcacaa ggggctggct ggaagttttg
      301 agagtgaaat attcacagcc attaagagac ctccaaatta atttctcaac atgcttattc
      361 tatagttcac attcaatcca gagcactgaa ggaactgaac aactggacac tgtagacatc
      421 agatagctgg ccatggtgtt ggccatggcg tctcaggatg ttcagaactt cttccagcct
      481 ttctcttcct ggatatctcg ggtttatgaa gctctccagc aagcaggaga tatgttatct
      541 gcttcgctgg ttaacataag caaacaagac tctaaattga gtgacaaact agatcaggac
      601 ttagataata ttcagattca ggaaacgtac tttgaagatg aagaacaaga caatgattgg
      661 agtcaagagg atgcaaattc cttgtttctt gaagtggatc atttctcatg ttgtaatagt
      721 gatttgcagg actctgccca aaattcaagc ccaagcctta gccaacatgc aaaggactca
      781 tgttccacaa tgtcccagtg gcccaattgg gccagtgatg accgcaagtt accacatgtg
      841 ctttcttcta ttgcggagga agagcatcac cttgaaaagc aaagaagtgg ccttcaacat
      901 ggctttgaca gccagctccc tggtacttta gaaactgtta atggaaaaaa gcaagtcaac
      961 agctttgggg atgacgaaga gctgtccaca tcttctgaca gtgacgagga ggtgatcaaa
     1021 caatttgaga tttccgtgtc ccggtcccag agtttccgtt cagtgacatc tgagaaagga
     1081 aagcagacag gattggagca gaaaccaaaa ttcagccgtt cgttgttgac acacggagaa
     1141 gatggcacag aagtatctgc ctgcgaagat ttggatggag ccagccaacg gcgttattct
     1201 gagaatctct cctacggtga agatgaccac atccctgctc actcacagtc cccatgtgaa
     1261 agaggggatg ccaaacacca cggcacatct caccaagagt ccagtgtggt ccaaagcctc
     1321 aggcgccaat ccacagaggg cagcttggag atggagacag cttttaatag ccggggattt
     1381 gaagattcct atgccactga cagctcctcc atgtggagtc cagaggaaca ggacaggacc
     1441 aatttgcagg tgccatccgg ggtctcagag cccatctcaa agtgtggtga cctagatgtc
     1501 atctttgaat atagagccgc cagccagaag ctcacagtga ccattgtgag ggcacagggc
     1561 ctcccagata aggaccgaag tggtgtcaac tcctggcaag ttcatgtagt gctgctgcct
     1621 ggtaagaaac acaggggcag gacgaacata cagagagggc ccaaccccgt cttcagggag
     1681 aaggtcacct ttgccaagct ggagcccaga gatgtggctg cctgtgctgt ccgcttccgc
     1741 ctgtacgctg cccggaagat gacccgagag agaatgatgg gagagaaact attctatctc
     1801 agccacctgc acccagaagg ggaaatgaaa gtgactctgg ttctggagcc aagaagtaat
     1861 ataagcagtg gagggtctcc gctcagccca tctgcggttt ctcacagtga tagtacttca
     1921 tccacgcagt cgctgtctca tggaggggcg ccagagctgt tggtggggct ctcgtacaat
     1981 gccacaacgg ggcgattatc tgtggaaatg atcaaaggca gccatttccg aaacctcgct
     2041 gttaaccgag cacctgatac atatggaaaa ctctttctcc tcaattctgt gggtcaagag
     2101 atgtcccgtt gcaagacgtc cattcggcgt ggtcagccca atcctgtcta taaggagacc
     2161 tttgttttcc aggtggccct ctttcagctg tctgatgtca cgttgatgat ttccgtttat
     2221 aacaggcgta ctatgaagcg taaagagatg attggctgga ttgccctggg ccagaacagc
     2281 agtggagagg aggaacaaga tcactgggag gagatgaagg aaaccaaagg ccagcagatc
     2341 tgcagatggc acactttgct ggaatcctag gtttgctaac ctgcatttgt gtgctgtgtc
     2401 caccttggtt acctgtgttg ctgtctactg acactaagtg tcctggcaag ggtttcaggg
     2461 tttcaaaaac agattccact aacccctagg acattgtgag tgggagtttt gggtttctca
     2521 atggtctgat ttggatttaa atattgtaat tttaaaaaca cacatacaca gtgaagtgtc
     2581 cgtatggaaa atattatacc acaattaaga ccactgatga gttaatttgt gccaatagat
     2641 cattgagttt tagttcaggg tatggggtga agcttcttct gctgtctctg tttgcttgaa
     2701 gagtaacctg agattgcaag ggagctgtta attgttacta tttgcaacca tttaggtgga
     2761 tgaatcagaa ttttcttaat atggtacaaa aaactccaaa atatagatat gaatcagatg
     2821 ctgagcctca taaaagaatc aaactctaat ccataaactc ttatttcaca tttttctctt
     2881 tatcaaagaa acctatttac ctaacgagta aatattataa acttgcactt ttaaaataaa
     2941 tttgtattaa ttaaatacct cttttatctt atattttgtg gtttctatga gatttggtta
     3001 gatgaatcat tttgaagcaa gaaaagagtt cagaaactac tgttttaaga caacttgtct
     3061 ccttttgaat atgtaagatt tcaaacttgt gactttcaag gtttttatgc tgtctttctc
     3121 acccaataag ttcttacaga ataagaaaac aaaaaacaag actactgcag tcatagattt
     3181 attgattttt tctgcttctg gtgttctttt ggattatcct ttttctatgt tcaattatat
     3241 atactcatat atgaatattt tgaatgtact gcatgtaaac catgctcttt ttaaactgag
     3301 tattttccat cactagagca tagtaaattg tacacagtga gtccttaata aatattgatt
     3361 tgattgactc ttcaaagtga acatgttata acacctgtga atggagaaat attttcagct
     3421 tgtgtggaat gacattaagt ttttctttga gcatttgaag tgcctataac tgtcattttt
     3481 ttatggcatt tgcagcaaca tatattagtc actacttgca atctgggcat gtgccattca
     3541 gaatactgat cttgtatggt tatgagcatg ggattttact tatgacttaa ttttacatat
     3601 ttatgcagtg catgtttact ttccttattc ataggtctgg gcccttaatt tcaattactt
     3661 taaattggca ttaataaaaa aatagggaaa gaatgtatgt acatttaatc cctgcgctca
     3721 atgtgcagct cttctgagca attgctcagt cacctatttt tagtttctat gtttcattgt
     3781 ggactttttc ctgtctgtgg gaagagtgat agctagtgat ggctgtatac agttaaaaac
     3841 acataactcc tcctcagctc cacgttttga cagattgtaa gcgtaggctg taacacttga
     3901 agaacatatt tattccttac agtgtgtaat ggttatcctg acaagaccag actagggcac
     3961 aggataactc tactatgctt tcagggttca gtctttgaat gaaatgattt catatggaag
     4021 aatgagaatt tgccaaataa attaatacct taattacttt tcaggtcatg ggagtttcat
     4081 atatatggct gctcagttat taggaatatg taataaaacc atgttcctct gggtttttac
     4141 cctacctttc tttgggagat ctcagagtgc ttttccagca ttatatccat taactgctga
     4201 gtggtctttg cagcgtggct aagtcattga gtagaactga gtgcgattga ttaagtagca
     4261 gcacaaagaa gtggcttttc acatctctta ctctttatgc cttgtgttta aagggaagta
     4321 gaacagcctc gctatgcttt cctttatgca gtaacataat agcagcattc attttaaaat
     4381 ttacatttga aaaaaatctg tatatattgt acagacagcc ctgaattttt ccctctcata
     4441 ttttcctgct gctgcatcct tgtttcttgg tacccaataa tcacctatac ttcattttct
     4501 gttcccaaga cccacccatt tttaaggttt tcggctggtg tagtgaagat atttgtgtgc
     4561 ttgatctgcc ttccaatggt ctgtttatga tacagtttac aggaatgcgc accattttaa
     4621 gggaaggaat gcctgaaaac attttttatt tttataattt tactatgttg gtgctactca
     4681 ccaaatagga tgcatgtaca tcttgaatat acagcaacat tcaccctcag ctgattgtat
     4741 acatttaagt gctgaagaca agatatataa caatatgtgg ctgatttttt ttacctttat
     4801 ttgaaattct agtttagtaa gatcttttga ttttgtgcac ttaaactccc ttattttctt
     4861 ggcaaagtct agacacaaat gcatttaaca tgtttttcac ttgagctttt acatttggtt
     4921 ttcaaaagag ttatgaaaga taattagttg gttctgcagt aaaaaactgc ttttgcctat
     4981 ttcttccagc taatgattaa tatctcatag ggagatttga cattgaagca gcactggttt
     5041 ttgttgcttg agtaggtctt tcagcgattt tgcctgaaga gcatgctttt aaaataatat
     5101 cgttaagagt aaatgatgcg ctgggtttat ggaaatctgc tttatagtgt gccttctttt
     5161 agggtgtgag tttacactga attgagaaat cctgatttca ccaattacgg tggtggctgt
     5221 tgtactctct actcccctct gactattgtt gaatttttaa atggaccatt caccaggcag
     5281 ccgaacacct gctctccgtt ccctctcctt cactggctcc cagtgtgatg cacagttgtt
     5341 ttggactctg tttttgctga tgctgcataa ctgttggagg tgggggtgtc ttgccttccc
     5401 taacataaga agaatttgta atgtctttgg atgtggcatt ccacctgcat gaaatcagga
     5461 aaagaatcat caccatgttt gtgagaggga aaagagtatg gcattgcata gtcattcgct
     5521 ttaggcacta ttaattctga catccttcat tgaaaattaa ctgacatcaa atgtcaatat
     5581 tctccatagt cctaggtgcc agtgagcctg aaacacagct tctgcctttt caatgtgtag
     5641 atttcatgat attttacaaa ttattgttac ctcttgtgca gttactgtgc tttagatgac
     5701 cttatctgag aaccaaaatt cttttctttc cagatgaagt actatttaag tagaaactag
     5761 cattaggtta aatcaaagtg cttctctgat agccaccaat ttgatttaat tgatgattcg
     5821 gtgtggacac cactgtgggt ttccaaaaaa actggttatc cttttgcagc agaggactta
     5881 gtattttaaa aacagaaaag taagtaggaa agtattattt gtaaatgtca taaaaccaga
     5941 tggaggcata ttctttactg ataaagaaac aggactagaa cacgcatgtg gtatctcctt
     6001 ttacttttga ggaaactgtg gttaaagaac attctattct atttgatcta agagcaaagc
     6061 aaatgatgga taatcctgaa atggtaaaag tatttttgtc ttaaaaatta ttcatttggg
     6121 caaagtcatt tacaacaaaa taaaaagtca tacagcacac ctatggaaga attaaagaat
     6181 acataaatgt gctggataca tttagcatcc tccagtgagt tgtatgtaag gagagtaaac
     6241 taataaacca aaatacatat cagatcaact agctatcact tttctaaaac ttgtagaatt
     6301 ctgaaaaata tttaaagatg ggagaaacga aactgtgcta agacaatgag attggcatag
     6361 cacagtgaag ttggcacaaa ctgtgatcct ggcctgggtt tacatgaaac tctgctgtgt
     6421 ggccttaaga aaattactta gccagcctgt atcctggttt cttcaactgg aaaatggaaa
     6481 taatacctac ctcattaggt gtcttaaaag atatcagtga aatcacagat gtaatgtgcc
     6541 tagcatagag ccgggcatgt agttagcatt ccgtagttcc tccttacagt catgcctgaa
     6601 aaagaaaata tttaagatgt gtcttctttt tctagcaaat gttattataa cactagagaa
     6661 aaacaaaaac caacgttcag atactgtaac aaggataggc tcatgaagcc aggctggatt
     6721 cgtaaataaa ggaggcttca tcaggacagc ctaatcagag ataagcctgg tatgtggagg
     6781 aaattgagcc ttaatagagt ccaactgtgg tagaaccaag tctttgcatt tatcccctta
     6841 gtttggaggg agtacaaatc cttgatggtt tgtgtgtacc tcttgatcga tcacaaacaa
     6901 ggcctctcct tgtctccagt tctcttattc ataaatggac aaggcatctt gtcgccttta
     6961 tcaaaagagt tggtgacaat ggcagtttga ctacatattt caactgtgat ccaaaaaagt
     7021 aaaataaatg atgtgatact atactgagac tgttttaaaa atggataaca ctttctttaa
     7081 aacctgcatt atatatccat tttatatcct gatagccaaa cattttaaaa tactctaata
     7141 acacagctct caaaacgtat ctgtttgact ggaatgtcct gctcagaaca aattatcact
     7201 gtttccctta tgagatccta atgaaagaaa ttcagttgat actacttttt aaaatgggtt
     7261 ttaagagtgg cttgttgata taatagcgca tccacttgtt ctcaagtgat tcaaaccttg
     7321 agtaaaaagg agagtttctg gagaatttag aagaatcttt gttgacattt aatctagaga
     7381 agtcttcagg agcaaaccac ttcaagttca gtgtaaccag gtgccatgag tcagtcatgt
     7441 gctacttgtg gttttaaacg aaacatgatt ctgggatgag aagtgcgagg ctacactcct
     7501 aatataatca aattgccaaa gcactgtttt gagtcctcgg tatcccaatt aaggagaaac
     7561 atgaagacat tggagaatca cttagcttag ggcttttagt agggaataat taaacatgta
     7621 gggaaggtga aggagttaga tgggaggtaa gaaggctgag gagatttcta gtaacaatga
     7681 tccaaaagtt ctaaccaggg ggatggtgca cactttctct tcttgaccac atggatagat
     7741 ttcagagcat ccctctaaat caagtctgga gaattatgtg aaggttgttt ctcattaatt
     7801 caaaatgtat tcattgtcta gtactatgct atctgggctg gcacagaact taaaatctct
     7861 ttggagtgct atgagtgcac attgaagcag ttggtcatca ttatacaatg atgcttacca
     7921 atatacaact gttaagttag tctaactatg tgccataaac agtagagttc cttgttacta
     7981 gtattggaag gtgaaacatt ggctgaattt attggggcaa gtgtctagga agccttggac
     8041 tggcagtgag tcttggttgc attatatggg aaattggtgg ggatgggggt gtcatagaat
     8101 catcatcttt ggaagttttt taaaatagaa aaatgtactt gaagtcttgg ttctgctaaa
     8161 gaagaatgag aggacaccca tgaatatacc ctttataaag ttccttctaa tatttaggtg
     8221 taacgttaaa aaagaatcaa caataacact ccaggcctgt cttcttccac tttggacatt
     8281 ttttccacat tgatttttct ctgcatcata gaaagttttc tctgaagagt tcctatttgg
     8341 gttttgttta gggctttggg gatgcctgca ggctcagggg gagtttcctc tcctatggtg
     8401 ctttgactgt ttttgtttcc cttgggtcac aaaaccatat cctagacaca cagacaataa
     8461 tcaccttatt tatatccact gtggaacctg tgaaacagct cgaggcttta cagaacaagc
     8521 tcataggcag tcatggagat ctgaggcctt tcttggaatg aagccgctaa cttgctaact
     8581 gctttccatt gctcactaat gctgccttaa ggtttcttca tgggaatttt tacttcatgc
     8641 ctttgagtga cagtgttacc agttttacct tgaggatgat gagaaggctg acttcctatt
     8701 gtattgccat atttatgcat tatttttgtt tacgtcattt cccccttgaa gtatctagtt
     8761 gctggggttt tgtttgtttt atacaaaatt tattcattca aaaagatctt tataggttgg
     8821 gcatggtggc tcacacctgt aatcccagaa ctttgggagg ccgaggtggg agaacagctt
     8881 gcgtccagga tttctagtcc agcctgggca acatagtgag atcttgtctc tacaaaatac
     8941 caaacattcg ctgggtatgg tggtgtgcgc ctatagtccc agctcctcag gaagctgagg
     9001 tgggaggatt gcttgaacct gtgaggtcaa ggctgcagtg agccgggatc atgccactgc
     9061 attcagcctg ggtagcagag tgagactctg tctcaaaaaa accaaaaaac aagacctttt
     9121 taagtgtaaa tgttccagac tcagggttag gggttggaga atggcagatg gataaaatag
     9181 tttaagttca acaatatttt tttgttgttt ctaaatattc tttttaaaaa ctagagtctg
     9241 ataagaaatc taggtaaata ataagatctt ttattaacct tgaatttttg gcttaatgta
     9301 tttctgtaat tgtctctttc cccctttgaa aggcagaaga tttagggaag gtgaaagtta
     9361 ttaccctgta tctaattaag aaataggtac acttgtttgt cagtctatgc tttcattcaa
     9421 aataaatgga tatgttttgt atctggggga ggaaatgcat cattccattc cagcagtgaa
     9481 aagaattata gcatcaaata ggatatttag tattcttgac ttttataatt aaatactgaa
     9541 tgccctttgc aagacagtaa gttagatcct ggaatgctag gtctgtacaa acttgacaca
     9601 tttcttacaa gctctgtgtt ttaatagtca aaggcattgc taccctttgc tttttgaaag
     9661 agtgaactgg taacagtagc cgccagagaa agaggtgaca atctaaacaa agagccctgc
     9721 ttacctttct gtgactaaaa ctagtcttaa aaactgaata catttggggc atccttatga
     9781 aataggtaaa ggtcaacatt gggagtgtcc ctaccttggc agatagacca atactttttt
     9841 cctagactca acccattttt aaagcaggag tttttccaat ggatttattg tttataattc
     9901 tactaaacat gtcttagtcc acgcaaatta actcaaaatc tttggtggcc tgaaaattct
     9961 gactgaaagc aagtttttcg tgttgcccag ttgatagtcc ataataaaaa atgtacatat
    10021 cttgtttaaa aaagaccttg atgtttgaga agaaatatcg gaagtctgcc agtaaaaact
    10081 ctgattaagt gaggaacatg tacattaaaa gatattttca tgtaagttat tttaagatag
    10141 ttgcattcta ggaccatgtt tcttttttga gagtgtttct ttgtcaagtt ccttatagcc
    10201 aatgccttga ccaaagctta ctaattttgc cacatttcct tgtgggttat gataatcttt
    10261 attaattcac aactctacca aattataata cagtctttta ttatgccacc atatgaatgc
    10321 agctgcaaat tcaattttgt gaaatacaaa gtcctttcca gaattttaaa acttaatttc
    10381 agtatagatt ttaagtttgt gaataagaaa ttagtatttg tataccttat tatgacagag
    10441 gtttctgtta caatattttc tcttatagtg ttgggatagg atttgacctg tattttcagg
    10501 ttaaagctgg tctttgagat ctacttttta agaaattaat aaattttatt ttttagagtt
    10561 ttaggttcac agcaaaattg atcctaaaat atagagttct catatactcc aaacacaacc
    10621 ttcttccccg tgaacatttt gaacaccaca gtgctatatt tgttacaact gatgaacctt
    10681 cattgacata acattatcac ccaaagtgca tagttcatat taaggttcac tcttggtgtt
    10741 gtgtatttta tgggttttga ccaatgcaca atgacgtgtg tccactattg tagtatcata
    10801 cagaagattt tcactgccct aaaaatcctc tgtgctctgc ctattcattc ctccctccca
    10861 cctaagccct ggcatccact ggtccttgta ctgtccccag agttttgcct tttccagaat
    10921 gtcatacagt atgtagcctt ttcagattgg cttttttttt tttcacttag ggatagtcat
    10981 gtaagttttc atgtcttttt atggcttgat agttcattta ttttaagtgc tgaataatat
    11041 ttcattgtct ggttgtatca ccatttatga cctatttgct cttatttcta gttccagttg
    11101 ctatggcaaa ttttattaaa gtgcgtgctc tcaggaaaag ctgcatatat tttatatgat
    11161 ccatcaaata aaatgtagca acttccagtc tagaataaat ttcacctata tgatattgag
    11221 cttgttttac attgggggag gagatttatg aaaaaatata ataatttcat aatttatatt
    11281 accctatcta tgagtttttc cctccattgg aatctaaaca gaaagttctg aaggttatga
    11341 agacgtgatc ccaaatttag tgactctgta gtgtcttttg ttgagcaatg agttaaatac
    11401 ctgtcgataa aaagtgttaa ttatgttatt actgattcat gatagaaaat caccttctgt
    11461 cgctagttta tatgacttta catttaccac tcctgccaag agaaaggaag ctttgtgatt
    11521 gtgccccgtc atagttaatt gtacaaatca attaaaaatg gtatgtaagc atctggctca
    11581 cacagcagct ctgaattctg aatgaaaaga taacccatgc taatgtatat gttgcatgaa
    11641 caagtagatg ggtgttggaa agaaaacact gatagtcact ctgggtgaag ggggaggcct
    11701 ggccaatgat ttgtatctga gaaacatttt gagattattt atatgtcttc tgactgccct
    11761 ttgctttgta gctacagcaa cttgcagaac ctggcattat tgcagagatg aaggtatagt
    11821 tgtataaaga atattggatt aaagttgatg aggcctgtgt tctgatatca aatcttccac
    11881 taatgagctc taaaatgaat atcaagtcac aattttttca agccttcatt gttgcatcta
    11941 tcagatggga atagtaatac tcattttacc tatttttacc aggtggttgt aggaacagga
    12001 ttcattcatt ccttcattaa tataatgaac actttgagac cccactatat aacagggcca
    12061 tacatatgac aaggtgatag atggaaagac gttttgcaga atttttgaag acttgcaatg
    12121 tttttgaaga ctacaggata gtttgtgatt tttatattaa ggtcgtatca actctttatg
    12181 tcaatatatc aaagtaattg acacttttag agctctgcca atcagtgggc catattcata
    12241 gaatgtcagt aatctgtctg aatacaagtt atagttggtc tttagctgtt ctgtctctga
    12301 ggagctagaa ataaaatatt aggttctaat ttttttttgt tcaaacactg atcatgtaac
    12361 aaactgcaaa tccatgtttt cagcaggttc gccaaccttt gagttgaatg cagacctttc
    12421 tttagaacaa cctaactttg agtacaggca aagtattaaa tggaatagct tttcctcccc
    12481 tacaaagtgg atttgaatac agtccttaga aaaattcttc ccctgccaaa aaaggtcctt
    12541 caatctcctt tattattttt cttttgaaga atcaaacttg tccatctctc ccctcccaag
    12601 tgactttcct cactcatgta atcattttct tcataaatgc ccttttacta tcccacagaa
    12661 aaagtaaaga tttaaaaaat catttttaag gtacatccaa gatttcatag caatatttta
    12721 tttgtgttca cagtgcaaga taaatctgac tttctcaata tttttggtct tcatatggca
    12781 tctgaaacag ttgttcacat tcacacattt atgtttcacc atatgcatac tgtgtacagc
    12841 tctgttgttc taaaatattt tattggtttt cctttatatc tcaacttttg atgggtgtcc
    12901 ttgaagaact ttcatgaaaa aaatgtaaat gtgaatgatt cattcatttt gaacatatgt
    12961 aactatttta ggagattttc aggagatttt accctacatg gagtacactg ttcttagcag
    13021 ggaatgtgct ttatattact attctactca cagctggatg ctgcagatgt attaacattg
    13081 taaacatgta ctttttctat tctatgctta ctttaataca ttatttatat gtgctagact
    13141 gtgctgagtt ttggtggttg tcaaaggcag tcagtaattt tataaatttc acttttgtgg
    13201 atagttaagt ataacatggt ttagtataaa atctggtctt cctctagatt tctaagtcac
    13261 tagaagaatt tcttggcaaa ttgattgttc aaggccagtt ttgttagttg taaggtggaa
    13321 gccaccccaa tcctctccca gtgtttcata ggcattttca gacctggatg ctattatagt
    13381 tcctcctcta gttttccagt agagaattcg tatgtggtcc agaggttcaa gagagagaga
    13441 gaaaaaattt ctcctcaaaa gaattgaacc cttactttag aaacttctga caatcttcag
    13501 aacattccat gtgggtgtcc ttgtgtttct catagtatga cttattgatt catggtgtct
    13561 cttattaaag aagcatgaat gtatcactag ctgttaccag aacaaacagc tgtagaatgt
    13621 aatgacccat cctatttcta aatttacttc tatcagtgga taatttgtgt ataggaaaag
    13681 gtgtggaaat tttttaattg ttaaaaactg gaataccttt ctaccttttg tagtctttaa
    13741 gatttcataa tgatggtttt aatgtattac tatcttacta ttatgtattg tgtttaaaca
    13801 agaccaatca gtgaaatatt gaatgtcaat actttttgtt agaaatgccc tctgaaaatg
    13861 ttagaaaatg taaaacttta cctgtgacaa ggaataaatt catgattaga agaattatac
    13921 tgtttttctt gtgcaaataa tacttaaggc agatgttcag tctcacagtg atgttggaaa
    13981 gcatatttta tgcagtctaa acactatttc tgtattagat atttaaatgc atgaggataa
    14041 attctaattg ctttttgttt aaaacagaaa catagaagaa gcattagccc cagtttgtat
    14101 aaaatgtctg ctgcaactga attcatgata gttcatgaaa actgaaaatc attccaattt
    14161 tgtaaaactg ctgctactgg ttttatcaat aaagttttag cagatggctt ata
//
