LOCUS       NM_031912               5724 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens synaptotagmin 15 (SYT15), transcript variant a, mRNA.
ACCESSION   NM_031912 XM_001720092
VERSION     NM_031912.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5724)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5724)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5724)
  AUTHORS   Fukuda,M.
  TITLE     Molecular cloning and characterization of human, rat, and mouse
            synaptotagmin XV
  JOURNAL   Biochem Biophys Res Commun 306 (1), 64-71 (2003)
   PUBMED   12788067
  REMARK    GeneRIF: molecular cloning and structure
REFERENCE   4  (bases 1 to 5724)
  AUTHORS   Sudhof,T.C.
  TITLE     Synaptotagmins: why so many?
  JOURNAL   J Biol Chem 277 (10), 7629-7632 (2002)
   PUBMED   11739399
  REMARK    Review article
REFERENCE   5  (bases 1 to 5724)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB158555.1, AB109022.1,
            AJ303363.1, AL356056.22 and AA878734.1.
            
            On May 17, 2019 this sequence version replaced NM_031912.4.
            
            Summary: This gene encodes a member of the Synaptotagmin (Syt)
            family of membrane trafficking proteins. Members of this family
            contain a transmembrane region and a C-terminal-type tandem C2
            domain. Unlike related family members, the encoded protein may be
            involved in membrane trafficking in non-neuronal tissues. Two
            trancript variants encoding distinct isoforms have been identified
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (a) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.177800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374321.9/ ENSP00000363441.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DB158555.1         113-160
            49-850              AB109022.1         8-809
            851-1164            AJ303363.1         180-493
            1165-5323           AL356056.22        145428-149586       c
            5324-5396           AA878734.1         4-76                c
            5397-5724           AL356056.22        145027-145354       c
FEATURES             Location/Qualifiers
     source          1..5724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..5724
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /note="synaptotagmin 15"
                     /db_xref="GeneID:83849"
                     /db_xref="HGNC:HGNC:17167"
                     /db_xref="MIM:608081"
     exon            1..48
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1307
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /note="isoform a is encoded by transcript variant a; chr10
                     synaptotagmin; synaptotagmin XV-a"
                     /codon_start=1
                     /product="synaptotagmin-15 isoform a"
                     /protein_id="NP_114118.2"
                     /db_xref="CCDS:CCDS73103.1"
                     /db_xref="GeneID:83849"
                     /db_xref="HGNC:HGNC:17167"
                     /db_xref="MIM:608081"
                     /translation="MAEQLALVIGGTIGGLLLLLLIGASCCLWRRFCATLTYEELPGT
                     PAMATTAASSGQRDRPCQPHARTQLSRPPAVPFVVPPTLQGRDWVPLHSGEWADAPWD
                     PCPASELLPHTSSGGLGDACMVGAINPELYKFPEDKSETDFPDGCLGRLWFSVEYEQE
                     AERLLVGLIKAQHLQAPSETCSPLVKLYLLPDERRFLQSKTKRKTSNPQFDEHFIFQV
                     SSKTITQRVLKFSVYHVDRQRKHQLLGQVLFPLKNETLVGDCRRVIWRDLEAESLEPP
                     SEFGDLQFCLSYNDYLSRLTVVVLRAKGLRLQEDRGIVSVFVKVSLMNHNKFVKCKKT
                     SAVLGSINPVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQLGRVVVGPYMYTRG
                     RELEHWDEMLSKPKELVKRWHALCRTTEP"
     exon            49..253
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     exon            254..396
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     exon            397..692
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     exon            693..863
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     exon            864..984
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1164
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..5724
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5610..5615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /note="hexamer: AATAGA"
     polyA_site      5639
                     /gene="SYT15"
                     /gene_synonym="CHR10SYT; SYT15B; sytXV"
                     /note="major polyA site"
ORIGIN      
        1 agccgcccag accggcgaga ccagcctgcg ggagcagccc catggcggag cagctggccc
       61 tggtgattgg gggcaccatc ggggggctgc tgctgctgct gttgatcggg gcaagctgct
      121 gtctgtggag aaggttctgt gccaccctca cctatgagga gctgcctggg acaccagcca
      181 tggccaccac agctgcctcc agtgggcagc gggacaggcc ctgccagccg catgctagga
      241 cccaactgag caggccacca gctgtgccat tcgtggtgcc cccaaccctt caaggccgag
      301 attgggtgcc cctgcacagt ggagagtggg ccgatgcccc atgggacccc tgcccggcat
      361 cagagctgct gcctcacacc tccagcggcg gccttggaga tgcatgtatg gtgggggcca
      421 tcaacccaga gctgtacaag ttcccggagg acaaaagtga gaccgacttc cccgacggct
      481 gcctggggcg gctgtggttc tcggtggaat atgagcagga ggctgagcgg ctgctggtgg
      541 gcttgatcaa ggcacagcac ctgcaagccc cctcggagac ctgcagcccc ctggtgaagc
      601 tctacctgct gcccgatgag cggcgcttcc tccaatccaa gaccaaacgc aaaacctcca
      661 acccgcagtt tgacgagcac ttcatctttc aggtgtccag caagaccatc acccagaggg
      721 tgctgaagtt ctccgtctac cacgtggaca ggcagaggaa gcaccagctc ctgggccagg
      781 tgctcttccc cttgaagaat gagaccctag tgggggactg ccggcgtgtc atctggagag
      841 acctggaggc cgagagcctg gagcccccct cggagtttgg cgacctccag ttctgcctca
      901 gctacaacga ctacctgagc cgcctgacgg tggttgtgct gcgtgccaag ggcctccggc
      961 tccaggagga cagaggcatt gtcagtgtgt ttgtcaaagt gtctctgatg aaccacaaca
     1021 agtttgtcaa gtgcaagaag acttcagctg tgctgggctc catcaaccct gtgtacaatg
     1081 agaccttcag cttcaaggcc gatgccaccg agctggatac cgctagcctc agcctgactg
     1141 tggtgcagaa catggaaggg gacaagagcc agcagctggg ccgagtggtg gtgggcccct
     1201 acatgtacac ccgcggcaga gagctggagc actgggacga gatgctcagc aagcccaagg
     1261 agctggtgaa gcgctggcat gcgctctgcc gcaccacgga gccctgaccc ttcgcccagc
     1321 accgcggttc cgctttggga gccgaccatc ctcgcagttg catgtgacag ccacagccac
     1381 acgcatggac gtttcatcca acagctcccc gagctgccag ccagcccgag ccaggaggac
     1441 gtgagtgctg atatgcagga gagaagaggg gacaaagaag ccctggcccg gtcagcggct
     1501 ctggccatac agccttccga cacactccct cctccttatc tgcggggctg cctgggctcg
     1561 gaatcccggc tcctggtcct cacagccctg atttggacca gaatctcaga tgctcagaag
     1621 aaagatcctg tttagtgatg acccagctct acctgctgaa tggacctgca gggtaaactt
     1681 gggtgcctcc atctgggaaa gctgatgatg tgttcatgca gtcgatgacc ctcactgctt
     1741 tttcagccag ggtttctctg ccttctgcct ggcagagaaa acacactgct atggggaaaa
     1801 tcacagggag ggcgctgtga ccagcgcact caggcaccaa gtgtcggcat ggctcactgt
     1861 gctgggtgaa ggcctccccg agcattaggt cctccacggg gctgtgtcaa atgccctccc
     1921 acattgtgtc aagtctgccc atggcccacc ctccccacag tccaaaacca cacagccctg
     1981 gttctccagc tgttctgctg ctgtttctgt gctctccctg attaagagca ttcagttcct
     2041 gggctctccc tttgagcagg aaatggtgaa agcatgtggc tatggtatag cccacagggc
     2101 tgagattgct gtgttgcagt attgatgtaa aatttgttaa gaaggaagta cccacagatc
     2161 actgccatca actccccaga agttgcactc aagctagtga gcagcccttg tgcttgtcac
     2221 agttactgta acaggtagtg tgtatttgca cctggcatcg tgcagcctgc acgtcaacac
     2281 gttgttttgt gtaactagaa cagcacatgg aaccactatc tctttctctt ttttccttct
     2341 ttttcttttt ttttttttta ttttaatttt ttgagacgga gtttccctct tgtcacccag
     2401 gctggagtgc aatggcgtga tctcggctca ctgcaccctc cacctcccag gttcaagcga
     2461 ttctcctgcc tcagcctccc aagtagctgg gattactggc gcccgccacc atgcctggct
     2521 aatttttttt atttttagta gagacggaat tttaccatgt tggctaggct ggtctcaaat
     2581 tcctggcctc aggtgatcca cctgcctcag cctcccaaag tgctgggatt acaggcatga
     2641 gtcaccgcac ccagcccgac cagtatcttt ttcttatgca gtgaaacaac tttagcaaaa
     2701 gaggcaatga atgttatact gagtttctac ctctttaact ccacctccaa tttctgtcaa
     2761 tctacaaaca caagtgtcgc ctcgcagtgt ttcgtatgaa cagaatatct tgtgtttgct
     2821 ttttgtcact tatttcactt gcacattttt tgtttgtttg tttgtttgtt tgtttgtttt
     2881 ttgagatgga gtcttgctct gtcgcccagg ctggagtgcg gtggcgcgat ctaggcttac
     2941 tgcaagctcc gcctcccggg tttacttaca ccactgtcct gcctcagcct ccggagtagc
     3001 tgggactaca gacacctgcc accacgccct gctaattttt tgtattttca agtagagacg
     3061 gggtttcact gtgttagcca ggatggtctc gatctcctga cctcatgatc tacccgcctc
     3121 ggcctcccaa agtgctggga ttacaggcgt gagccaccac gcccggccca cttgcacatt
     3181 ttcaaagtag tccgcaaagc tgtagtttct aatagcttca tagctcacat gtaatagggg
     3241 ttctctgtgt gtttatagag caggctacta cagtggaact gtttctgttt catctgacat
     3301 ccggatagat gccagccacc cccacattcc aaggtgagat ttctgactag cagtgacttt
     3361 tctagggccg cttggaaaag ttgataagta tccttttctg caggacagag tagactggta
     3421 tctctgactc atccctgaaa aatctaaatg gcaagagact agctggctct ctgctctgat
     3481 ggggaggagg ttgttgtttg ggctgttctc tacagacata gtcagggcaa aaagcatacg
     3541 catgcttccc atggaccaga gaaacctggc ctgggttgtc tcaaatcctg tccacaaggc
     3601 aactccagaa gaaagaagcc ctttacattt ccataaaaca ctttagaatc agctagtcaa
     3661 tttccacaaa ataaagtgct agaatttgat tggatttaat tgattatgta gaacaatttg
     3721 ggggccattt gacatcatta aaatattcaa tcttcctatt cattaacatg gtatatctct
     3781 tcactttaag tcttttgtat gtttctcaga actatttttg tggttttcag taaagtgttc
     3841 ttgcacatcc ttcaatagat ttattcttag acgttttata tttgtttatg gctagtatat
     3901 acagattctg ttgctacaaa actatgttga ccttgttatc cagtgagagg ctttgtgaca
     3961 ttcatttaaa ttgtaataat ttgcagatta tttttgtata atcatgtcct ctgtgaatga
     4021 cagttttatt tcttcctttc ttaatcttta tgccttattt agctcttgcc aaactgcagt
     4081 ggctgagcaa ttggacaaga taaagaaata aaagtgatcc agatcataaa gaaagaagta
     4141 aaactatatc tgcacatgac ataatcttgt ctatggaaaa tcctaaggaa tccacacaca
     4201 aaaaaactac tagagctaat aagtttggca aggttgcaag atataaaatt ggtatacaaa
     4261 ttgcagtggc taggacctcc agcagaatgc tgactataag tagtgatagt gggtattctt
     4321 gtctcatcct caatctcagg ggtggtgggt gtggcatgtg gagagttgtc aatattcacc
     4381 atgaagtttg atggttgtta taggattttt aatgtactca ttaacatata ttctcaagct
     4441 gttaaaaaga tttttttaat tacaaataag gttaaatttc tctcaaatac ttactctgca
     4501 ccttttgaaa taattttatt tttctccttt attctttgga tgtgatgact tatactaatt
     4561 gactgttgaa tgtcaaacca aacttaacat tcttgtaata gaaaccagca gggtgtgtac
     4621 acttttgtgt gtgtgcgcag gtttatacac ataaacacaa caatacttgg acttatttat
     4681 ttaaaattta gatttattag agggagcatg gccataaaat aaaataaaat aaaatttaga
     4741 tttaagtcga gctcagtggc tcacatctat tatccccgca ctttggaagg ccaaggcagg
     4801 tagattgtct aagctcagga atttgagacc aacgtggtga aactcggtct ctacaaaaac
     4861 cacaaaaatt agccaggtat ggtgtcacat gcctgttgtc ccagctactt ggagggctgg
     4921 ggcaggagta ttgcgtgagc ccgggaggtt aaggctgaag tgagtcatgt tcacgccact
     4981 gcactacagc ttggataaca aagcgagact ctgtctccaa aaataaaata agtaaataaa
     5041 taaataaata aaatttagat caatttgctg ttatattttt atataaacta tgtttatgac
     5101 ataagtataa acaaaaaaat aaaataagta aataaataaa taaaatttag attaatttgc
     5161 tgttatattt ttatataagc tatgtttatg acagactttc ctataatatt cttatcataa
     5221 tgttcttgca cttgaaagaa tgtgcattct gcagttgtgt gcaggtgtta tgtgtatttc
     5281 aactgggtca agtttgttaa tcaggttggt caaattatct acatctttac tgatattttt
     5341 gtctgttttt ctataaatta ctgagagagg ataaagcctg ccactgttat tatgaatttg
     5401 tttatttctc ctttgagttt tgttagtttt tgttttatgc atttagaggt tgtgttatta
     5461 ggctcatacc catttaaaat tgacgttttc tggtagagtg aacctttatt atgtgaaatg
     5521 gctttctcta ccactcacaa tggtattttt ttcactttcc cccttatttt tgaattttca
     5581 atgttcttat aatgatgtca tgtctcttga atagagttgt tttaatcaag tctgtcaaat
     5641 tttgtctttt gtgtatttcg tgaatttaca tttattgtaa ttactgatat agttgtgttc
     5701 ataaatacca tcttactact tgtt
//
