LOCUS       NM_177963               3722 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens synaptotagmin 12 (SYT12), transcript variant 1, mRNA.
ACCESSION   NM_177963
VERSION     NM_177963.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3722)
  AUTHORS   Liu,K., Luo,J., Shao,C., Ren,Z., Sun,S., Zhu,Y., Zhou,H., Jiang,Z.,
            Li,X., Gu,W., Xu,Y., Qiang,Y., Ren,B., Xu,L., Wu,H. and Shen,Y.
  TITLE     Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell
            Proliferation and Progression of Lung Adenocarcinoma and Involves
            the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of
            Rapamycin (mTOR) Pathway
  JOURNAL   Med Sci Monit 26, e920351 (2020)
   PUBMED   32108133
  REMARK    GeneRIF: Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell
            Proliferation and Progression of Lung Adenocarcinoma and Involves
            the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of
            Rapamycin (mTOR) Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3722)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3722)
  AUTHORS   Maximov,A., Shin,O.H., Liu,X. and Sudhof,T.C.
  TITLE     Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates
            spontaneous neurotransmitter release
  JOURNAL   J Cell Biol 176 (1), 113-124 (2007)
   PUBMED   17190793
  REMARK    GeneRIF: Studies of the orthologous gene in rat have shown that
            spontaneous synaptic-vesicle exocytosis is selectively modulated by
            synaptotagmin 12.
REFERENCE   4  (bases 1 to 3722)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003176.2, DA239473.1,
            BC037406.1 and AL833834.1.
            
            On Nov 22, 2018 this sequence version replaced NM_177963.3.
            
            Summary: This gene is a member of the synaptotagmin gene family and
            encodes a protein similar to other family members that mediate
            calcium-dependent regulation of membrane trafficking in synaptic
            transmission. Studies of the orthologous gene in rat have shown
            that the encoded protein selectively modulates spontaneous
            synaptic-vesicle exocytosis and may also be involved in regulating
            calcium independent secretion in nonneuronal cells. Alternative
            splicing results in multiple transcript variants. The gene has
            previously been referred to as synaptotagmin XI but has been
            renamed synaptotagmin XII to be standard with mouse and rat
            official nomenclature.[provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.22200.1, BC037406.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527043.6/ ENSP00000435316.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AP003176.2         167234-167444
            212-286             DA239473.1         1-75
            287-3718            BC037406.1         1-3432
            3719-3722           AL833834.1         3190-3193
FEATURES             Location/Qualifiers
     source          1..3722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..3722
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="synaptotagmin 12"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
     exon            1..327
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            328..384
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1616
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="isoform a is encoded by transcript variant 1;
                     synaptotagmin-XII"
                     /codon_start=1
                     /product="synaptotagmin-12 isoform a"
                     /protein_id="NP_808878.1"
                     /db_xref="CCDS:CCDS8154.1"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
                     /translation="MAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWT
                     SGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNAQRASTRGPPSRKGSLSIED
                     TFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSM
                     EYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFD
                     EKFSIPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQD
                     QNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKM
                     SKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPS
                     ASGMGTTHWNQMLATLRRPVSMWHAVRRN"
     exon            385..578
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            579..971
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1187
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1308
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1442
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..3722
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3698
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="major polyA site"
     polyA_site      3722
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
ORIGIN      
        1 atctccggct cggaccccag gagcagagac agcgctcgag cttgtcactt taaattcaag
       61 agggagcggg cgggcaagcg ggcgagcgcg agggagcgcg cggcgggctc ctgggagcgt
      121 gcccggactg cggcgcagct ccggtccgcc gccccggccc ggccgagccc ccggcccgcg
      181 ccgcgctcct cggaggcggg agcccggcga cactgcaggg gtggcgttgc cgccggcggc
      241 cgggctaggc gcaggtgcgt gcgcgctgcg ggaggcgggc cggcagctgg agcccagccg
      301 gagcggcggc ccctccgcgg agcccggtca cagtcactgc agcagacatc atggctgtgg
      361 atgtggcaga ataccatctg agcgtcatca agagcccccc tggctgggag gtgggtgtct
      421 atgctgcagg ggccctggcc ctgctgggaa tcgcagctgt gagcctgtgg aagctctgga
      481 cgtcggggag cttccccagc ccctctccgt tccccaatta cgactacagg taccttcagc
      541 agaagtacgg cgagagctgc gcagaggcca gggagaagag agtgcctgcc tggaatgccc
      601 agcgggccag cacgcgggga ccacccagcc gcaaaggcag tctcagcatt gaggacacct
      661 ttgagagcat cagtgaactg gggcctctgg agctgatggg ccgggagttg gacctggccc
      721 cctatgggac cctccggaag tcccagtcgg ccgactccct gaactccatc tcctccgtga
      781 gcaacacctt tgggcaggac ttcacactgg gccaggtgga ggtgagcatg gagtacgaca
      841 ctgcctccca cacgctgaac gtggcggtga tgcagggcaa ggacctcctg gagcgggagg
      901 aggccagctt cgagtcctgc ttcatgcgcg tcagcctgct gccggacgag cagatcgtgg
      961 gcatttctcg gatccagaga aatgcctact ccatcttctt tgatgagaag ttctccatcc
     1021 ccctggatcc cacagccctg gaggagaaga gcctgcggtt ttctgtattt ggcatcgatg
     1081 aggatgagcg caacgtcagc acgggggtgg tggagctgaa gctttctgtg cttgacctcc
     1141 cgctgcagcc cttcagtggc tggctctatt tacaggacca gaacaaggcc gccgatgctg
     1201 tgggggagat cctgctctcc ctcagctacc tccccacagc cgagcgcctc accgtggtcg
     1261 tggttaaggc caagaacctc atctggacca acgacaagac cacagcggac cccttcgtca
     1321 aggtgtacct gctgcaggat gggaggaaga tgagcaaaaa gaagacagcc gtgaagaggg
     1381 atgaccccaa cccggtgttc aacgaagcca tgatcttctc ggtgccagcc attgtgctcc
     1441 aggacctgtc tctccgcgtg acggtggctg agagcagcag cgacggccgt ggggacaacg
     1501 tgggccatgt catcattggg ccgtcagcca gtggcatggg aaccacacat tggaaccaga
     1561 tgttggccac gctgcgcagg cccgtgtcca tgtggcacgc tgtccggcga aactagcaac
     1621 cagggcgggc cagttgggca atggagctgc tggagcccgg tacccactca gctctgtctg
     1681 atgccctctc catagcccag ctggagccgt gaacactggg gtcccctggc agagtcctca
     1741 tgacccatcc tggtctctct gtccagattg cagcagagga gtgggcgtgg ctctgtgtcc
     1801 agggccccag ggtctgctcc tgctgaggac cagctgtggc tgggccagga cagaggactc
     1861 aaccctgctc ctcccggtag gccagctgcc gagctgggct atgttctgga acccagtgaa
     1921 tcttgggggc caggcactgt gctaggcacc agcaggggta acacgaagaa gacccggccc
     1981 ttagggcatc aggaagacta gctcccctgc cccggaggat ctgctcagtg ctgatggcag
     2041 cccagctgtg tggactcagg gggctctgag ggctagggaa acaggaaggg cctctttgac
     2101 aaggtaggag ctgtgcttgg aggggcagga aaagaactga gcatgtcgca ggcagcgggc
     2161 ccagcctgag caatggcagg atgtgaactt ccccatcgca aatgcagttc tcagcccact
     2221 gcagtggata caaggaaggg cctttctcgg ggccggagaa gagaccaaga gaccaggccc
     2281 gggcagcagc ctaccggcca cgtggaacac tggctccgga gttattctct gtcaaatcta
     2341 ctccccggac ctcaaccatg gcaagaacca gaggtccaaa gaggcccaga cccaggtcct
     2401 tgtgctcagt cctgcgcaaa ccaggcccag accctgcaag catttgttga tgcccttgca
     2461 ggcccactgg gagaaagatg cctcaggcag gtctcagcct gggggtggca ggggtggggc
     2521 agagagaata ctgacagcag aggtcttggt gggctgcacg tgcctgcgaa gatgtggtgg
     2581 acaaggaggc tctcgggctg ggccttggag gggtggcagc ggaaggacag cccaggtggc
     2641 tgaggcctga tgggaagccg gggaaggcca gggtggaagg gcggcttgag ggacgccagg
     2701 agaagactga atgccaggct aggaaggagg cggctctcga tcacggggtg ggtgcccccg
     2761 acaccgggtc tcctagcttg agttccctag aagcgaaatc tgagaggggg attctggggc
     2821 aagtagtttc ttgcgggtga gtgttctcag agaaacttac cagatcaaga aagggagctc
     2881 aggctggatg gaggaagcca cgcaagtgtg gcttcaagat ccatcgcctt ggcctgatcg
     2941 ctgtgggggc aggggcctgg agtacgaggg gcaccctggg ggctcccacc cagaagcaga
     3001 ggggctgggc tgttgcacct ctactggcat cagtctttgg ttacccccca gccccagtag
     3061 gaggagagca ggcagagctt gtcatcccca gcctggtgtc ccgcagtccc aggaagccgc
     3121 ttcttgcctt catggctgag tgctgggaag ggctgagctc acccaggcca gcaggtgggg
     3181 tatcatctgc tcggtggggc cacccacagg tgacagcatg gaccctcagg ctggctgccc
     3241 ctgttccttg gtccataact ggtgagctat ggagacccag gccaacaaat tatccccagt
     3301 gatatggggg gaggaggggc tagaacaagg gcccagggga ctggaggcag gatggtggct
     3361 ttccctacct gacacagcca tggcccagcc ccaaggccag gctgtctacc ctatggccac
     3421 agcaggaggt cagcccaggg ccaggagaca catggctgga caaggctttg cagcctggga
     3481 gaccccgact ttctctaacc cagtggctgt gcggtgcagg ccactgactc cccccctgcc
     3541 ctctcccctc tctccctccc cctaactgca tgacatgtta actgtgtgcc caggacagcc
     3601 gtggtgggga ccgggtatgc caactggaat gattctagaa ccaaaataaa gttggggcag
     3661 gaagaggggg cttccaggga gccctgctcg gccctgaatc accttcgtct cttctctagg
     3721 aa
//
