LOCUS       NM_001318773            3653 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens synaptotagmin 12 (SYT12), transcript variant 3, mRNA.
ACCESSION   NM_001318773
VERSION     NM_001318773.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Liu,K., Luo,J., Shao,C., Ren,Z., Sun,S., Zhu,Y., Zhou,H., Jiang,Z.,
            Li,X., Gu,W., Xu,Y., Qiang,Y., Ren,B., Xu,L., Wu,H. and Shen,Y.
  TITLE     Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell
            Proliferation and Progression of Lung Adenocarcinoma and Involves
            the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of
            Rapamycin (mTOR) Pathway
  JOURNAL   Med Sci Monit 26, e920351 (2020)
   PUBMED   32108133
  REMARK    GeneRIF: Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell
            Proliferation and Progression of Lung Adenocarcinoma and Involves
            the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of
            Rapamycin (mTOR) Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3653)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Maximov,A., Shin,O.H., Liu,X. and Sudhof,T.C.
  TITLE     Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates
            spontaneous neurotransmitter release
  JOURNAL   J Cell Biol 176 (1), 113-124 (2007)
   PUBMED   17190793
  REMARK    GeneRIF: Studies of the orthologous gene in rat have shown that
            spontaneous synaptic-vesicle exocytosis is selectively modulated by
            synaptotagmin 12.
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY172636.1, DA187677.1 and
            AL833834.1.
            
            On May 31, 2019 this sequence version replaced NM_001318773.1.
            
            Summary: This gene is a member of the synaptotagmin gene family and
            encodes a protein similar to other family members that mediate
            calcium-dependent regulation of membrane trafficking in synaptic
            transmission. Studies of the orthologous gene in rat have shown
            that the encoded protein selectively modulates spontaneous
            synaptic-vesicle exocytosis and may also be involved in regulating
            calcium independent secretion in nonneuronal cells. Alternative
            splicing results in multiple transcript variants. The gene has
            previously been referred to as synaptotagmin XI but has been
            renamed synaptotagmin XII to be standard with mouse and rat
            official nomenclature.[provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (3) contains an alternate exon
            compared to variant 1. The resulting isoform (b) is shorter at the
            N-terminus compared to isoform a. Variants 3 and 4 both encode the
            same isoform (b).
            
            ##Evidence-Data-START##
            CDS exon combination :: AL833834.1, SRR1660809.274611.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN02400288, SAMN03465402 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                HY172636.1         76-155
            81-630              DA187677.1         1-550
            631-3653            AL833834.1         171-3193
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..3653
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="synaptotagmin 12"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
     exon            1..133
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            134..190
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            191..315
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            316..509
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            510..902
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..1547
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="isoform b is encoded by transcript variant 3;
                     synaptotagmin-XII"
                     /codon_start=1
                     /product="synaptotagmin-12 isoform b"
                     /protein_id="NP_001305702.1"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
                     /translation="MGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVS
                     MEYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFF
                     DEKFSIPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQ
                     DQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRK
                     MSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGP
                     SASGMGTTHWNQMLATLRRPVSMWHAVRRN"
     exon            903..1118
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1239
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1373
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..3653
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3629
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="major polyA site"
     polyA_site      3653
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
ORIGIN      
        1 agagctgacc tacagctcaa tcgtggtggg agggagtaat tatccattca gaaaagggga
       61 aactttccgc tgcgcctcct gtcgctgttt tccttggctc ccggaggtgc gcagtatcgg
      121 gtccgttttt aagtcacagt cactgcagca gacatcatgg ctgtggatgt ggcagaatac
      181 catctgagcg ggtccccggg gagaccctca tcctgctgca ccctggggat gagcctgtga
      241 ctcggaatcc actcaccgag gccttctgtg gagactgtca agtagccaag ggaaaataag
      301 cccaggaagg tcaagtcatc aagagccccc ctggctggga ggtgggtgtc tatgctgcag
      361 gggccctggc cctgctggga atcgcagctg tgagcctgtg gaagctctgg acgtcgggga
      421 gcttccccag cccctctccg ttccccaatt acgactacag gtaccttcag cagaagtacg
      481 gcgagagctg cgcagaggcc agggagaaga gagtgcctgc ctggaatgcc cagcgggcca
      541 gcacgcgggg accacccagc cgcaaaggca gtctcagcat tgaggacacc tttgagagca
      601 tcagtgaact ggggcctctg gagctgatgg gccgggagtt ggacctggcc ccctatggga
      661 ccctccggaa gtcccagtcg gccgactccc tgaactccat ctcctccgtg agcaacacct
      721 ttgggcagga cttcacactg ggccaggtgg aggtgagcat ggagtacgac actgcctccc
      781 acacgctgaa cgtggcggtg atgcagggca aggacctcct ggagcgggag gaggccagct
      841 tcgagtcctg cttcatgcgc gtcagcctgc tgccggacga gcagatcgtg ggcatttctc
      901 ggatccagag aaatgcctac tccatcttct ttgatgagaa gttctccatc cccctggatc
      961 ccacagccct ggaggagaag agcctgcggt tttctgtatt tggcatcgat gaggatgagc
     1021 gcaacgtcag cacgggggtg gtggagctga agctttctgt gcttgacctc ccgctgcagc
     1081 ccttcagtgg ctggctctat ttacaggacc agaacaaggc cgccgatgct gtgggggaga
     1141 tcctgctctc cctcagctac ctccccacag ccgagcgcct caccgtggtc gtggttaagg
     1201 ccaagaacct catctggacc aacgacaaga ccacagcgga ccccttcgtc aaggtgtacc
     1261 tgctgcagga tgggaggaag atgagcaaaa agaagacagc cgtgaagagg gatgacccca
     1321 acccggtgtt caacgaagcc atgatcttct cggtgccagc cattgtgctc caggacctgt
     1381 ctctccgcgt gacggtggct gagagcagca gcgacggccg tggggacaac gtgggccatg
     1441 tcatcattgg gccgtcagcc agtggcatgg gaaccacaca ttggaaccag atgttggcca
     1501 cgctgcgcag gcccgtgtcc atgtggcacg ctgtccggcg aaactagcaa ccagggcggg
     1561 ccagttgggc aatggagctg ctggagcccg gtacccactc agctctgtct gatgccctct
     1621 ccatagccca gctggagccg tgaacactgg ggtcccctgg cagagtcctc atgacccatc
     1681 ctggtctctc tgtccagatt gcagcagagg agtgggcgtg gctctgtgtc cagggcccca
     1741 gggtctgctc ctgctgagga ccagctgtgg ctgggccagg acagaggact caaccctgct
     1801 cctcccggta ggccagctgc cgagctgggc tatgttctgg aacccagtga atcttggggg
     1861 ccaggcactg tgctaggcac cagcaggggt aacacgaaga agacccggcc cttagggcat
     1921 caggaagact agctcccctg ccccggagga tctgctcagt gctgatggca gcccagctgt
     1981 gtggactcag ggggctctga gggctaggga aacaggaagg gcctctttga caaggtagga
     2041 gctgtgcttg gaggggcagg aaaagaactg agcatgtcgc aggcagcggg cccagcctga
     2101 gcaatggcag gatgtgaact tccccatcgc aaatgcagtt ctcagcccac tgcagtggat
     2161 acaaggaagg gcctttctcg gggccggaga agagaccaag agaccaggcc cgggcagcag
     2221 cctaccggcc acgtggaaca ctggctccgg agttattctc tgtcaaatct actccccgga
     2281 cctcaaccat ggcaagaacc agaggtccaa agaggcccag acccaggtcc ttgtgctcag
     2341 tcctgcgcaa accaggccca gaccctgcaa gcatttgttg atgcccttgc aggcccactg
     2401 ggagaaagat gcctcaggca ggtctcagcc tgggggtggc aggggtgggg cagagagaat
     2461 actgacagca gaggtcttgg tgggctgcac gtgcctgcga agatgtggtg gacaaggagg
     2521 ctctcgggct gggccttgga ggggtggcag cggaaggaca gcccaggtgg ctgaggcctg
     2581 atgggaagcc ggggaaggcc agggtggaag ggcggcttga gggacgccag gagaagactg
     2641 aatgccaggc taggaaggag gcggctctcg atcacggggt gggtgccccc gacaccgggt
     2701 ctcctagctt gagttcccta gaagcgaaat ctgagagggg gattctgggg caagtagttt
     2761 cttgcgggtg agtgttctca gagaaactta ccagatcaag aaagggagct caggctggat
     2821 ggaggaagcc acgcaagtgt ggcttcaaga tccatcgcct tggcctgatc gctgtggggg
     2881 caggggcctg gagtacgagg ggcaccctgg gggctcccac ccagaagcag aggggctggg
     2941 ctgttgcacc tctactggca tcagtctttg gttacccccc agccccagta ggaggagagc
     3001 aggcagagct tgtcatcccc agcctggtgt cccgcagtcc caggaagccg cttcttgcct
     3061 tcatggctga gtgctgggaa gggctgagct cacccaggcc agcaggtggg gtatcatctg
     3121 ctcggtgggg ccacccacag gtgacagcat ggaccctcag gctggctgcc cctgttcctt
     3181 ggtccataac tggtgagcta tggagaccca ggccaacaaa ttatccccag tgatatgggg
     3241 ggaggagggg ctagaacaag ggcccagggg actggaggca ggatggtggc tttccctacc
     3301 tgacacagcc atggcccagc cccaaggcca ggctgtctac cctatggcca cagcaggagg
     3361 tcagcccagg gccaggagac acatggctgg acaaggcttt gcagcctggg agaccccgac
     3421 tttctctaac ccagtggctg tgcggtgcag gccactgact ccccccctgc cctctcccct
     3481 ctctccctcc ccctaactgc atgacatgtt aactgtgtgc ccaggacagc cgtggtgggg
     3541 accgggtatg ccaactggaa tgattctaga accaaaataa agttggggca ggaagagggg
     3601 gcttccaggg agccctgctc ggccctgaat caccttcgtc tcttctctag gaa
//
