LOCUS       NM_001177880            3528 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens synaptotagmin 12 (SYT12), transcript variant 2, mRNA.
ACCESSION   NM_001177880
VERSION     NM_001177880.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3528)
  AUTHORS   Liu,K., Luo,J., Shao,C., Ren,Z., Sun,S., Zhu,Y., Zhou,H., Jiang,Z.,
            Li,X., Gu,W., Xu,Y., Qiang,Y., Ren,B., Xu,L., Wu,H. and Shen,Y.
  TITLE     Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell
            Proliferation and Progression of Lung Adenocarcinoma and Involves
            the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of
            Rapamycin (mTOR) Pathway
  JOURNAL   Med Sci Monit 26, e920351 (2020)
   PUBMED   32108133
  REMARK    GeneRIF: Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell
            Proliferation and Progression of Lung Adenocarcinoma and Involves
            the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of
            Rapamycin (mTOR) Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3528)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Maximov,A., Shin,O.H., Liu,X. and Sudhof,T.C.
  TITLE     Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates
            spontaneous neurotransmitter release
  JOURNAL   J Cell Biol 176 (1), 113-124 (2007)
   PUBMED   17190793
  REMARK    GeneRIF: Studies of the orthologous gene in rat have shown that
            spontaneous synaptic-vesicle exocytosis is selectively modulated by
            synaptotagmin 12.
REFERENCE   4  (bases 1 to 3528)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315810.1, AP003176.2 and
            AL833834.1.
            
            On May 31, 2019 this sequence version replaced NM_001177880.1.
            
            Summary: This gene is a member of the synaptotagmin gene family and
            encodes a protein similar to other family members that mediate
            calcium-dependent regulation of membrane trafficking in synaptic
            transmission. Studies of the orthologous gene in rat have shown
            that the encoded protein selectively modulates spontaneous
            synaptic-vesicle exocytosis and may also be involved in regulating
            calcium independent secretion in nonneuronal cells. Alternative
            splicing results in multiple transcript variants. The gene has
            previously been referred to as synaptotagmin XI but has been
            renamed synaptotagmin XII to be standard with mouse and rat
            official nomenclature.[provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.57588.1,
                                           SRR7346977.1452956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMN02400288
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AK315810.1         76-424
            350-350             AP003176.2         178904-178904
            351-1559            AK315810.1         426-1634
            1560-3528           AL833834.1         1225-3193
FEATURES             Location/Qualifiers
     source          1..3528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..3528
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="synaptotagmin 12"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
     exon            1..133
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            134..190
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1422
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="isoform a is encoded by transcript variant 2;
                     synaptotagmin-XII"
                     /codon_start=1
                     /product="synaptotagmin-12 isoform a"
                     /protein_id="NP_001171351.1"
                     /db_xref="CCDS:CCDS8154.1"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
                     /translation="MAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWT
                     SGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNAQRASTRGPPSRKGSLSIED
                     TFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSM
                     EYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFD
                     EKFSIPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQD
                     QNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKM
                     SKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPS
                     ASGMGTTHWNQMLATLRRPVSMWHAVRRN"
     exon            191..384
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            385..777
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            778..993
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1114
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1248
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..3528
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3504
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /note="major polyA site"
     polyA_site      3528
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
ORIGIN      
        1 agagctgacc tacagctcaa tcgtggtggg agggagtaat tatccattca gaaaagggga
       61 aactttccgc tgcgcctcct gtcgctgttt tccttggctc ccggaggtgc gcagtatcgg
      121 gtccgttttt aagtcacagt cactgcagca gacatcatgg ctgtggatgt ggcagaatac
      181 catctgagcg tcatcaagag cccccctggc tgggaggtgg gtgtctatgc tgcaggggcc
      241 ctggccctgc tgggaatcgc agctgtgagc ctgtggaagc tctggacgtc ggggagcttc
      301 cccagcccct ctccgttccc caattacgac tacaggtacc ttcagcagaa gtacggcgag
      361 agctgcgcag aggccaggga gaagagagtg cctgcctgga atgcccagcg ggccagcacg
      421 cggggaccac ccagccgcaa aggcagtctc agcattgagg acacctttga gagcatcagt
      481 gaactggggc ctctggagct gatgggccgg gagttggacc tggcccccta tgggaccctc
      541 cggaagtccc agtcggccga ctccctgaac tccatctcct ccgtgagcaa cacctttggg
      601 caggacttca cactgggcca ggtggaggtg agcatggagt acgacactgc ctcccacacg
      661 ctgaacgtgg cggtgatgca gggcaaggac ctcctggagc gggaggaggc cagcttcgag
      721 tcctgcttca tgcgcgtcag cctgctgccg gacgagcaga tcgtgggcat ttctcggatc
      781 cagagaaatg cctactccat cttctttgat gagaagttct ccatccccct ggatcccaca
      841 gccctggagg agaagagcct gcggttttct gtatttggca tcgatgagga tgagcgcaac
      901 gtcagcacgg gggtggtgga gctgaagctt tctgtgcttg acctcccgct gcagcccttc
      961 agtggctggc tctatttaca ggaccagaac aaggccgccg atgctgtggg ggagatcctg
     1021 ctctccctca gctacctccc cacagccgag cgcctcaccg tggtcgtggt taaggccaag
     1081 aacctcatct ggaccaacga caagaccaca gcggacccct tcgtcaaggt gtacctgctg
     1141 caggatggga ggaagatgag caaaaagaag acagccgtga agagggatga ccccaacccg
     1201 gtgttcaacg aagccatgat cttctcggtg ccagccattg tgctccagga cctgtctctc
     1261 cgcgtgacgg tggctgagag cagcagcgac ggccgtgggg acaacgtggg ccatgtcatc
     1321 attgggccgt cagccagtgg catgggaacc acacattgga accagatgtt ggccacgctg
     1381 cgcaggcccg tgtccatgtg gcacgctgtc cggcgaaact agcaaccagg gcgggccagt
     1441 tgggcaatgg agctgctgga gcccggtacc cactcagctc tgtctgatgc cctctccata
     1501 gcccagctgg agccgtgaac actggggtcc cctggcagag tcctcatgac ccatcctggt
     1561 ctctctgtcc agattgcagc agaggagtgg gcgtggctct gtgtccaggg ccccagggtc
     1621 tgctcctgct gaggaccagc tgtggctggg ccaggacaga ggactcaacc ctgctcctcc
     1681 cggtaggcca gctgccgagc tgggctatgt tctggaaccc agtgaatctt gggggccagg
     1741 cactgtgcta ggcaccagca ggggtaacac gaagaagacc cggcccttag ggcatcagga
     1801 agactagctc ccctgccccg gaggatctgc tcagtgctga tggcagccca gctgtgtgga
     1861 ctcagggggc tctgagggct agggaaacag gaagggcctc tttgacaagg taggagctgt
     1921 gcttggaggg gcaggaaaag aactgagcat gtcgcaggca gcgggcccag cctgagcaat
     1981 ggcaggatgt gaacttcccc atcgcaaatg cagttctcag cccactgcag tggatacaag
     2041 gaagggcctt tctcggggcc ggagaagaga ccaagagacc aggcccgggc agcagcctac
     2101 cggccacgtg gaacactggc tccggagtta ttctctgtca aatctactcc ccggacctca
     2161 accatggcaa gaaccagagg tccaaagagg cccagaccca ggtccttgtg ctcagtcctg
     2221 cgcaaaccag gcccagaccc tgcaagcatt tgttgatgcc cttgcaggcc cactgggaga
     2281 aagatgcctc aggcaggtct cagcctgggg gtggcagggg tggggcagag agaatactga
     2341 cagcagaggt cttggtgggc tgcacgtgcc tgcgaagatg tggtggacaa ggaggctctc
     2401 gggctgggcc ttggaggggt ggcagcggaa ggacagccca ggtggctgag gcctgatggg
     2461 aagccgggga aggccagggt ggaagggcgg cttgagggac gccaggagaa gactgaatgc
     2521 caggctagga aggaggcggc tctcgatcac ggggtgggtg cccccgacac cgggtctcct
     2581 agcttgagtt ccctagaagc gaaatctgag agggggattc tggggcaagt agtttcttgc
     2641 gggtgagtgt tctcagagaa acttaccaga tcaagaaagg gagctcaggc tggatggagg
     2701 aagccacgca agtgtggctt caagatccat cgccttggcc tgatcgctgt gggggcaggg
     2761 gcctggagta cgaggggcac cctgggggct cccacccaga agcagagggg ctgggctgtt
     2821 gcacctctac tggcatcagt ctttggttac cccccagccc cagtaggagg agagcaggca
     2881 gagcttgtca tccccagcct ggtgtcccgc agtcccagga agccgcttct tgccttcatg
     2941 gctgagtgct gggaagggct gagctcaccc aggccagcag gtggggtatc atctgctcgg
     3001 tggggccacc cacaggtgac agcatggacc ctcaggctgg ctgcccctgt tccttggtcc
     3061 ataactggtg agctatggag acccaggcca acaaattatc cccagtgata tggggggagg
     3121 aggggctaga acaagggccc aggggactgg aggcaggatg gtggctttcc ctacctgaca
     3181 cagccatggc ccagccccaa ggccaggctg tctaccctat ggccacagca ggaggtcagc
     3241 ccagggccag gagacacatg gctggacaag gctttgcagc ctgggagacc ccgactttct
     3301 ctaacccagt ggctgtgcgg tgcaggccac tgactccccc cctgccctct cccctctctc
     3361 cctcccccta actgcatgac atgttaactg tgtgcccagg acagccgtgg tggggaccgg
     3421 gtatgccaac tggaatgatt ctagaaccaa aataaagttg gggcaggaag agggggcttc
     3481 cagggagccc tgctcggccc tgaatcacct tcgtctcttc tctaggaa
//
