LOCUS       NM_152280               5182 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens synaptotagmin 11 (SYT11), mRNA.
ACCESSION   NM_152280
VERSION     NM_152280.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5182)
  AUTHORS   Noh,K., Choi,H., Jo,E.H., Yoo,W. and Park,K.C.
  TITLE     Role of SYT11 in human pan-cancer using comprehensive approaches
  JOURNAL   Eur J Med Res 29 (1), 338 (2024)
   PUBMED   38890718
  REMARK    GeneRIF: Role of SYT11 in human pan-cancer using comprehensive
            approaches.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5182)
  AUTHORS   Ho,G.P.H., Wilkie,E.C., White,A.J. and Selkoe,D.J.
  TITLE     Palmitoylation of the Parkinson's disease-associated protein
            synaptotagmin-11 links its turnover to alpha-synuclein homeostasis
  JOURNAL   Sci Signal 16 (772), eadd7220 (2023)
   PUBMED   36787382
  REMARK    GeneRIF: Palmitoylation of the Parkinson's disease-associated
            protein synaptotagmin-11 links its turnover to alpha-synuclein
            homeostasis.
REFERENCE   3  (bases 1 to 5182)
  AUTHORS   Bajaj,R., Rodriguez,B.L., Russell,W.K., Warner,A.N., Diao,L.,
            Wang,J., Raso,M.G., Lu,W., Khan,K., Solis,L.S., Batra,H., Tang,X.,
            Fradette,J.F., Kundu,S.T. and Gibbons,D.L.
  TITLE     Impad1 and Syt11 work in an epistatic pathway that regulates
            EMT-mediated vesicular trafficking to drive lung cancer invasion
            and metastasis
  JOURNAL   Cell Rep 40 (13), 111429 (2022)
   PUBMED   36170810
  REMARK    GeneRIF: Impad1 and Syt11 work in an epistatic pathway that
            regulates EMT-mediated vesicular trafficking to drive lung cancer
            invasion and metastasis.
REFERENCE   4  (bases 1 to 5182)
  AUTHORS   Ofori,J.K., Karagiannopoulos,A., Barghouth,M., Nagao,M.,
            Andersson,M.E., Salunkhe,V.A., Zhang,E., Wendt,A. and Eliasson,L.
  TITLE     The highly expressed calcium-insensitive synaptotagmin-11 and
            synaptotagmin-13 modulate insulin secretion
  JOURNAL   Acta Physiol (Oxf) 236 (1), e13857 (2022)
   PUBMED   35753051
  REMARK    GeneRIF: The highly expressed calcium-insensitive synaptotagmin-11
            and synaptotagmin-13 modulate insulin secretion.
REFERENCE   5  (bases 1 to 5182)
  AUTHORS   Kim,B.K., Kim,D.M., Park,H., Kim,S.K., Hwang,M.A., Lee,J.,
            Kang,M.J., Byun,J.E., Im,J.Y., Kang,M., Park,K.C., Yeom,Y.I.,
            Kim,S.Y., Jung,H., Kweon,D.H., Cheong,J.H. and Won,M.
  TITLE     Synaptotagmin 11 scaffolds MKK7-JNK signaling process to promote
            stem-like molecular subtype gastric cancer oncogenesis
  JOURNAL   J Exp Clin Cancer Res 41 (1), 212 (2022)
   PUBMED   35768842
  REMARK    GeneRIF: Synaptotagmin 11 scaffolds MKK7-JNK signaling process to
            promote stem-like molecular subtype gastric cancer oncogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5182)
  AUTHORS   Inoue,S., Imamura,A., Okazaki,Y., Yokota,H., Arai,M., Hayashi,N.,
            Furukawa,A., Itokawa,M. and Oishi,M.
  TITLE     Synaptotagmin XI as a candidate gene for susceptibility to
            schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 144B (3), 332-340 (2007)
   PUBMED   17192956
  REMARK    GeneRIF: Excessive expression of Syt11 can be associated with
            schizophrenia.
REFERENCE   7  (bases 1 to 5182)
  AUTHORS   Glass,A.S., Huynh,D.P., Franck,T., Woitalla,D., Muller,T.,
            Pulst,S.M., Berg,D., Kruger,R. and Riess,O.
  TITLE     Screening for mutations in synaptotagmin XI in Parkinson's disease
  JOURNAL   J Neural Transm Suppl (68), 21-28 (2004)
   PUBMED   15354386
  REMARK    GeneRIF: Lack of disease-causing mutations in a detailed analysis
            of a large sample of familial and sporadic Parkinson's disease
            patients argues against a major role of mutations in the
            synaptotagmin XI gene in PD.
REFERENCE   8  (bases 1 to 5182)
  AUTHORS   Huynh,D.P., Scoles,D.R., Nguyen,D. and Pulst,S.M.
  TITLE     The autosomal recessive juvenile Parkinson disease gene product,
            parkin, interacts with and ubiquitinates synaptotagmin XI
  JOURNAL   Hum Mol Genet 12 (20), 2587-2597 (2003)
   PUBMED   12925569
  REMARK    GeneRIF: parkin interacts with and ubiquitinates synaptotagmin XI
REFERENCE   9  (bases 1 to 5182)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
REFERENCE   10 (bases 1 to 5182)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA239014.1, AL139128.24,
            BC004291.1 and AA824539.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152280.4.
            
            Summary: This gene is a member of the synaptotagmin gene family and
            encodes a protein similar to other family members that are known
            calcium sensors and mediate calcium-dependent regulation of
            membrane trafficking in synaptic transmission. The encoded protein
            is also a substrate for ubiquitin-E3-ligase parkin. The gene has
            previously been referred to as synaptotagmin XII but has been
            renamed synaptotagmin XI to be consistent with mouse and rat
            official nomenclature. [provided by RefSeq, Apr 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.199022.1,
                                           SRR1803612.220490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368324.5/ ENSP00000357307.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA239014.1         99-100
            3-154               AL139128.24        96082-96233
            155-338             BC004291.1         143-326
            339-339             AL139128.24        104587-104587
            340-740             BC004291.1         328-728
            741-741             AL139128.24        104989-104989
            742-2951            BC004291.1         730-2939
            2952-4779           AL139128.24        119482-121309
            4780-5182           AA824539.1         19-421              c
FEATURES             Location/Qualifiers
     source          1..5182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5182
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /note="synaptotagmin 11"
                     /db_xref="GeneID:23208"
                     /db_xref="HGNC:HGNC:19239"
                     /db_xref="MIM:608741"
     exon            1..229
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1491
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /note="synaptotagmin 12; synaptotagmin XI"
                     /codon_start=1
                     /product="synaptotagmin-11"
                     /protein_id="NP_689493.3"
                     /db_xref="CCDS:CCDS1122.1"
                     /db_xref="GeneID:23208"
                     /db_xref="HGNC:HGNC:19239"
                     /db_xref="MIM:608741"
                     /translation="MAEITNIRPSFDVSPVVAGLIGASVLVVCVSVTVFVWSCCHQQA
                     EKKQKNPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGPGREGGRRNLLVDAAEAG
                     LLSRDKDPRGPSSGSCIDQLPIKMDYGEELRSPITSLTPGESKTTSPSSPEEDVMLGS
                     LTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRHRVKTRVLRKT
                     LDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQ
                     LTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKV
                     NVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEV
                     VGRLILGAHSVTASGAEHWREVCESPRKPVAKWHSLSEY"
     exon            230..1056
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1180
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..5182
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2927..2932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /note="hexamer: AATAAA"
     polyA_site      2951
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /note="hexamer: AATAAA"
     polyA_site      5182
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /note="major polyA site"
ORIGIN      
        1 agcgcatccc cggagcatct taagagctga gcgcagctga caactagggg ccggaccgtc
       61 gcaggaggcg tccgctggat accttccccc ttccctgacc tagagctcta cagctgctgc
      121 ctcggtactg accgagggtt cccagagctg tctcaccatt gcaaaaacgt tatagcaaca
      181 gcctctgatt acgacatggc tgagatcacc aatatccgac ctagctttga tgtgtcaccg
      241 gtggtggccg gcctcatcgg ggcctctgtg ctggtggtgt gtgtctcggt gaccgtcttt
      301 gtctggtcat gctgccacca gcaggcagag aagaagcaga agaacccacc atacaagttt
      361 attcacatgc tcaaaggcat cagcatatac ccagagaccc tcagcaacaa gaagaaaatc
      421 atcaaagtgc ggagagacaa agatggtcct gggagggaag gtggacgtag gaacctgttg
      481 gtggacgcag cagaggctgg cctgctaagc cgagacaaag atcccagggg gcctagctct
      541 ggatcttgta tagaccaatt acccatcaaa atggactatg gggaagaact aaggagccct
      601 attacaagcc tgacccctgg ggagagcaaa accacctctc catcatctcc agaggaggat
      661 gtcatgctag gatccctcac cttctcagtg gactataact tcccgaaaaa agccctggtg
      721 gtgacaatcc aggaggccca tgggctgcca gtgatggatg accagaccca gggatctgac
      781 ccctacatca aaatgaccat ccttcctgac aaacggcatc gggtgaagac cagagtgctg
      841 cggaagaccc tggaccctgt gtttgacgag accttcacct tctatggcat cccctacagc
      901 cagctgcagg acctggtgct gcacttcctt gtcctcagct ttgaccgctt ctctcgggat
      961 gatgtcattg gcgaggtcat ggtgccactg gcaggggtgg accccagcac aggcaaggta
     1021 caactgacca gggacatcat caaaaggaat atccagaagt gcatcagcag aggggagctc
     1081 caggtgtctc tgtcatatca gcctgtggca cagagaatga cagtggtggt cctcaaagcc
     1141 agacacttgc cgaagatgga tatcaccggt ctctcaggta atccttatgt caaggtgaac
     1201 gtctactacg gcagaaagcg cattgccaag aagaaaaccc atgtgaagaa gtgcactttg
     1261 aaccccatct tcaatgaatc tttcatctac gacatcccca ctgacctcct gcctgatatc
     1321 agcatcgagt tcctcgttat cgacttcgat cgcaccacca agaatgaggt ggtggggagg
     1381 ctgatcctgg gggcacacag tgtcacagcc agtggtgctg aacactggag agaggtctgc
     1441 gagagccccc gcaagcctgt ggccaagtgg cacagtctga gcgagtacta atcctgttct
     1501 tctctcctct aatccccggg ggccaagctg gggagggatg tggaggggaa aaagatgaca
     1561 gagaagtgga ctccaaacct cattttagtt gtagaagaaa atttcttaca aaacaaattc
     1621 cacaaagaac accctatatg accacagctg cagatcagtt cttagcaatg atgttttttt
     1681 ttctgctttg caaggcgcta gaatctttta ttttacttta ttttttttga ggtggagttt
     1741 cgctcttgtt gcccgggctg gagtgcaatg gtgagatctc aactcactgc aacctctgcc
     1801 ctccaggttc aagtgattct cctccctcag cctcccaagt agctgggatt acaggcaccc
     1861 acgagcatgc ccggctaatt ttttgtattt tcagtagaga tgggtttcac catgttggcc
     1921 aggctggtct cgaattccag acctcaggtg atccacccgc ctcggcctcc caaagtgctg
     1981 ggattacagg tgcgagccac cgtgcccggc ctctggtttt gttttgtttt ttttttttaa
     2041 tgggggacaa aagagaggga aagaccccta taaatctata tataacaatg taaccatata
     2101 cttgcatgtc taatacaaac tgaagaaatt agcctaactg ccaatatcaa gttgcagatt
     2161 ttaatccatg gaaattgtgt tttgtgctga attgtatttg ctgattacct gaaattggct
     2221 tctttttatt gggcttctct ggagaatttc tcccactccc cacctctgca gaagaaaatt
     2281 ttgctcttat aaaacctcat gttttcatca ttcccatctt ttctttttat tgcctcttat
     2341 atctctgctc tttgacctca aggtctagag gtctgcagta agccaagaaa caaaggtggg
     2401 gtggatgagg caaggtttgc aggagaaaga ggaattgaga aatggggtat ttttgctatc
     2461 agctcttctg ctatgaagta gtaaaaggca gtctataatt aactgacaga cctaactgaa
     2521 gcacagagaa tacatcagac ttatgcatcc aagacatcag aacttggatt ttatcaaact
     2581 tgatgacttc tctaaaagga gctttggaaa cttcaaattc agctatagga tagtaccaat
     2641 gaacacatcc agctgatccc aaaagctgtt ttcaggtata aggacaagga gaggagacaa
     2701 gtgacgacag ccattcccct ttgcagctat ctactgtagt gacagccatt tcttggttga
     2761 tgggttggaa gtcatcagag gtttgaagaa ttacactggc ctttgttttt ctggaaatgc
     2821 cgaccatgga gatgctttag agtcttctca aatagcttag atgttgtaat gaggttagct
     2881 ttgcttcata aaacaggggc cctcagaagt tctccttaaa tttttcaata aaaatttagc
     2941 tcttaaaaaa ataacagtgt gactgagtga atgaagataa gttggattct ttcagagcat
     3001 tcttttcctc aaaacgagct gcataattct tggaatttat gtcttaccac atggtggagg
     3061 gatggaggaa ctacaggatg caattcttct tctaccaatg ggcaatagag gttgagagag
     3121 attcagcatc tttctgggat tagaattcaa gtctctttac tcctacagca gctgtgtctc
     3181 caacgttgag actttgcaga tggcacagac tccatggata ataggtaaac ttggggccgg
     3241 gcgcagtggc tcacgcctgt aatcccagta ttttgggagg ccgaggtgga aagatcgctt
     3301 gagcccagga gttcaagacc agcctgggct acatgacgaa actccatctc tatcaaaaat
     3361 acaaaaaatt aactaggtgt ggtgctgcac gcctgtggtc ccagctattc aggaggctga
     3421 ggtgggagga tcatttgagc ccagaggtag aggctgcagt gagccatgat catgccactg
     3481 cactctgggc tgggtaacag agtgagatcc tgtctcaaaa attaattaat taattaatta
     3541 aaataaacta ggtaaacttg gataggcagt agatattttt gcccacctga ggaggaactc
     3601 agtcaagctg ttgcttaaca gcttgatcca gggcgtgaaa ggttagttga gactgaagtg
     3661 ttcacttcca tagaagaaca tcacttttaa ccttgctttg gcgaagggag tcggaaagct
     3721 gagtctctat ggacgggggg gtgatcttgc tttcagtgtt ccctcagctt ttgtggattt
     3781 aaaaccattc tgctccccct aaaccttttg tttgatttca gcccatgttc ttgacaatgc
     3841 agagcaattc tgagcagtca caaagcctac tctctgttct tgtccctgcc aacccccacc
     3901 ccccataatc tgactcacaa cttcaccatc agttggggtc ataccactag tctctgtcct
     3961 ataccccatg aaatgtaaat actgtatcat aagtagaaga aaataatttt tgttttctaa
     4021 aaatgcattt tgagatagtt taatgtaaat ctgacaggag cattctgaag ccccattagg
     4081 aaaaaattta aatggttcct cttcatcgcc ttaatgtcta aagatcagaa atcgctgagc
     4141 aaacccgctt ttgtttcctt cccagaaaca atgcaaaaca acaggtggag atagtctggt
     4201 ctttgccctg ctgtgtgtgc ctctgtagct cctcctgaca aacgtctggg aaaacagcct
     4261 caccccactc tcctctctct tccccatttc cttgtagctt tattccttgc atctttgggt
     4321 ctactgagca gtgggtgctg aggtgacagg ggaggaacca gttgttctgt agcctaggaa
     4381 ctgcctcagt gtctttgcca gaaaaaggca aagaggcgga cagtgcaggg ctcctccctc
     4441 ctacctcagg cctgatccat cgtgcccttg actttgccgt ctcaaagttt cttagctgac
     4501 tttggctttc acatttgttc tttccagagc taactgataa gagtggagga ggaatgcctt
     4561 ctcctaagag tcagttgaaa gaaagacaag agagtcacat cttagctttt gcacaaggca
     4621 ttcgtggtca ggaataggtt agggaatggt cacttctgat tttccaacag ttgctccttc
     4681 tctgaagaga tcttgattcc tttgggaaga caagaatttt tcttaataac aaaggtccct
     4741 ttatgagtta ttccttcttt cagttcatct cactggagca cagccaagat ggacatgttt
     4801 atggacagtg ctctagatgt gaaaacagat agaactggtt tgtgggacag gggcagcttg
     4861 ctcaggagag ggaataacgc aggtcccttt tcttggaagg cttgtactat ggccatgaca
     4921 gtgacattgc cctcaccatg atccctctcc aaagtggttg tctttcttta ccttgtgtct
     4981 tctcttgtaa aaatgaaact caaaaataaa ataaatgtgt caaattttga aaaaaaaaga
     5041 aaactgaaaa agctaacatg aattgtgtga aattgcataa tgctgtaatg ctaatctaca
     5101 atatgtaatg ctatcttgta tgttgaattt gttaatgcac cacacaagtg caaaataaag
     5161 actgattcac attacatagg ca
//
