LOCUS       NP_689493                431 aa            linear   PRI 01-JUL-2024
DEFINITION  synaptotagmin-11 [Homo sapiens].
ACCESSION   NP_689493
VERSION     NP_689493.3
DBSOURCE    REFSEQ: accession NM_152280.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 431)
  AUTHORS   Noh,K., Choi,H., Jo,E.H., Yoo,W. and Park,K.C.
  TITLE     Role of SYT11 in human pan-cancer using comprehensive approaches
  JOURNAL   Eur J Med Res 29 (1), 338 (2024)
   PUBMED   38890718
  REMARK    GeneRIF: Role of SYT11 in human pan-cancer using comprehensive
            approaches.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 431)
  AUTHORS   Ho,G.P.H., Wilkie,E.C., White,A.J. and Selkoe,D.J.
  TITLE     Palmitoylation of the Parkinson's disease-associated protein
            synaptotagmin-11 links its turnover to alpha-synuclein homeostasis
  JOURNAL   Sci Signal 16 (772), eadd7220 (2023)
   PUBMED   36787382
  REMARK    GeneRIF: Palmitoylation of the Parkinson's disease-associated
            protein synaptotagmin-11 links its turnover to alpha-synuclein
            homeostasis.
REFERENCE   3  (residues 1 to 431)
  AUTHORS   Bajaj,R., Rodriguez,B.L., Russell,W.K., Warner,A.N., Diao,L.,
            Wang,J., Raso,M.G., Lu,W., Khan,K., Solis,L.S., Batra,H., Tang,X.,
            Fradette,J.F., Kundu,S.T. and Gibbons,D.L.
  TITLE     Impad1 and Syt11 work in an epistatic pathway that regulates
            EMT-mediated vesicular trafficking to drive lung cancer invasion
            and metastasis
  JOURNAL   Cell Rep 40 (13), 111429 (2022)
   PUBMED   36170810
  REMARK    GeneRIF: Impad1 and Syt11 work in an epistatic pathway that
            regulates EMT-mediated vesicular trafficking to drive lung cancer
            invasion and metastasis.
REFERENCE   4  (residues 1 to 431)
  AUTHORS   Ofori,J.K., Karagiannopoulos,A., Barghouth,M., Nagao,M.,
            Andersson,M.E., Salunkhe,V.A., Zhang,E., Wendt,A. and Eliasson,L.
  TITLE     The highly expressed calcium-insensitive synaptotagmin-11 and
            synaptotagmin-13 modulate insulin secretion
  JOURNAL   Acta Physiol (Oxf) 236 (1), e13857 (2022)
   PUBMED   35753051
  REMARK    GeneRIF: The highly expressed calcium-insensitive synaptotagmin-11
            and synaptotagmin-13 modulate insulin secretion.
REFERENCE   5  (residues 1 to 431)
  AUTHORS   Kim,B.K., Kim,D.M., Park,H., Kim,S.K., Hwang,M.A., Lee,J.,
            Kang,M.J., Byun,J.E., Im,J.Y., Kang,M., Park,K.C., Yeom,Y.I.,
            Kim,S.Y., Jung,H., Kweon,D.H., Cheong,J.H. and Won,M.
  TITLE     Synaptotagmin 11 scaffolds MKK7-JNK signaling process to promote
            stem-like molecular subtype gastric cancer oncogenesis
  JOURNAL   J Exp Clin Cancer Res 41 (1), 212 (2022)
   PUBMED   35768842
  REMARK    GeneRIF: Synaptotagmin 11 scaffolds MKK7-JNK signaling process to
            promote stem-like molecular subtype gastric cancer oncogenesis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 431)
  AUTHORS   Inoue,S., Imamura,A., Okazaki,Y., Yokota,H., Arai,M., Hayashi,N.,
            Furukawa,A., Itokawa,M. and Oishi,M.
  TITLE     Synaptotagmin XI as a candidate gene for susceptibility to
            schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 144B (3), 332-340 (2007)
   PUBMED   17192956
  REMARK    GeneRIF: Excessive expression of Syt11 can be associated with
            schizophrenia.
REFERENCE   7  (residues 1 to 431)
  AUTHORS   Glass,A.S., Huynh,D.P., Franck,T., Woitalla,D., Muller,T.,
            Pulst,S.M., Berg,D., Kruger,R. and Riess,O.
  TITLE     Screening for mutations in synaptotagmin XI in Parkinson's disease
  JOURNAL   J Neural Transm Suppl (68), 21-28 (2004)
   PUBMED   15354386
  REMARK    GeneRIF: Lack of disease-causing mutations in a detailed analysis
            of a large sample of familial and sporadic Parkinson's disease
            patients argues against a major role of mutations in the
            synaptotagmin XI gene in PD.
REFERENCE   8  (residues 1 to 431)
  AUTHORS   Huynh,D.P., Scoles,D.R., Nguyen,D. and Pulst,S.M.
  TITLE     The autosomal recessive juvenile Parkinson disease gene product,
            parkin, interacts with and ubiquitinates synaptotagmin XI
  JOURNAL   Hum Mol Genet 12 (20), 2587-2597 (2003)
   PUBMED   12925569
  REMARK    GeneRIF: parkin interacts with and ubiquitinates synaptotagmin XI
REFERENCE   9  (residues 1 to 431)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
REFERENCE   10 (residues 1 to 431)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA239014.1, AL139128.24,
            BC004291.1 and AA824539.1.
            
            On Dec 9, 2008 this sequence version replaced NP_689493.2.
            
            Summary: This gene is a member of the synaptotagmin gene family and
            encodes a protein similar to other family members that are known
            calcium sensors and mediate calcium-dependent regulation of
            membrane trafficking in synaptic transmission. The encoded protein
            is also a substrate for ubiquitin-E3-ligase parkin. The gene has
            previously been referred to as synaptotagmin XII but has been
            renamed synaptotagmin XI to be consistent with mouse and rat
            official nomenclature. [provided by RefSeq, Apr 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.199022.1,
                                           SRR1803612.220490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368324.5/ ENSP00000357307.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     Protein         1..431
                     /product="synaptotagmin-11"
                     /note="synaptotagmin 12; synaptotagmin XI"
                     /calculated_mol_wt=48166
     Site            16..36
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BT88.2)"
     Region          134..154
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BT88.2)"
     Site            134
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9R0N3; propagated from
                     UniProtKB/Swiss-Prot (Q9BT88.2)"
     Region          158..283
                     /region_name="C2A_Synaptotagmin-4-11"
                     /note="C2A domain first repeat present in Synaptotagmins 4
                     and 11; cd08388"
                     /db_xref="CDD:176034"
     Region          292..429
                     /region_name="C2B_Synaptotagmin-4"
                     /note="C2 domain second repeat present in Synaptotagmin 4;
                     cd08404"
                     /db_xref="CDD:176049"
     Site            order(322,329,383,385,390)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176049"
     CDS             1..431
                     /gene="SYT11"
                     /gene_synonym="SYT12; sytXI"
                     /coded_by="NM_152280.5:196..1491"
                     /db_xref="CCDS:CCDS1122.1"
                     /db_xref="GeneID:23208"
                     /db_xref="HGNC:HGNC:19239"
                     /db_xref="MIM:608741"
ORIGIN      
        1 maeitnirps fdvspvvagl igasvlvvcv svtvfvwscc hqqaekkqkn ppykfihmlk
       61 gisiypetls nkkkiikvrr dkdgpgregg rrnllvdaae agllsrdkdp rgpssgscid
      121 qlpikmdyge elrspitslt pgeskttsps speedvmlgs ltfsvdynfp kkalvvtiqe
      181 ahglpvmddq tqgsdpyikm tilpdkrhrv ktrvlrktld pvfdetftfy gipysqlqdl
      241 vlhflvlsfd rfsrddvige vmvplagvdp stgkvqltrd iikrniqkci srgelqvsls
      301 yqpvaqrmtv vvlkarhlpk mditglsgnp yvkvnvyygr kriakkkthv kkctlnpifn
      361 esfiydiptd llpdisiefl vidfdrttkn evvgrlilga hsvtasgaeh wrevcesprk
      421 pvakwhslse y
//
