LOCUS       NM_198992               4461 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens synaptotagmin 10 (SYT10), mRNA.
ACCESSION   NM_198992 XM_292025
VERSION     NM_198992.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4461)
  AUTHORS   den Hoed,M., Eijgelsheim,M., Esko,T., Brundel,B.J., Peal,D.S.,
            Evans,D.M., Nolte,I.M., Segre,A.V., Holm,H., Handsaker,R.E.,
            Westra,H.J., Johnson,T., Isaacs,A., Yang,J., Lundby,A., Zhao,J.H.,
            Kim,Y.J., Go,M.J., Almgren,P., Bochud,M., Boucher,G.,
            Cornelis,M.C., Gudbjartsson,D., Hadley,D., van der Harst,P.,
            Hayward,C., den Heijer,M., Igl,W., Jackson,A.U., Kutalik,Z.,
            Luan,J., Kemp,J.P., Kristiansson,K., Ladenvall,C., Lorentzon,M.,
            Montasser,M.E., Njajou,O.T., O'Reilly,P.F., Padmanabhan,S., St
            Pourcain,B., Rankinen,T., Salo,P., Tanaka,T., Timpson,N.J.,
            Vitart,V., Waite,L., Wheeler,W., Zhang,W., Draisma,H.H.,
            Feitosa,M.F., Kerr,K.F., Lind,P.A., Mihailov,E., Onland-Moret,N.C.,
            Song,C., Weedon,M.N., Xie,W., Yengo,L., Absher,D., Albert,C.M.,
            Alonso,A., Arking,D.E., de Bakker,P.I., Balkau,B., Barlassina,C.,
            Benaglio,P., Bis,J.C., Bouatia-Naji,N., Brage,S., Chanock,S.J.,
            Chines,P.S., Chung,M., Darbar,D., Dina,C., Dorr,M., Elliott,P.,
            Felix,S.B., Fischer,K., Fuchsberger,C., de Geus,E.J., Goyette,P.,
            Gudnason,V., Harris,T.B., Hartikainen,A.L., Havulinna,A.S.,
            Heckbert,S.R., Hicks,A.A., Hofman,A., Holewijn,S.,
            Hoogstra-Berends,F., Hottenga,J.J., Jensen,M.K., Johansson,A.,
            Junttila,J., Kaab,S., Kanon,B., Ketkar,S., Khaw,K.T., Knowles,J.W.,
            Kooner,A.S., Kors,J.A., Kumari,M., Milani,L., Laiho,P.,
            Lakatta,E.G., Langenberg,C., Leusink,M., Liu,Y., Luben,R.N.,
            Lunetta,K.L., Lynch,S.N., Markus,M.R., Marques-Vidal,P., Mateo
            Leach,I., McArdle,W.L., McCarroll,S.A., Medland,S.E., Miller,K.A.,
            Montgomery,G.W., Morrison,A.C., Muller-Nurasyid,M., Navarro,P.,
            Nelis,M., O'Connell,J.R., O'Donnell,C.J., Ong,K.K., Newman,A.B.,
            Peters,A., Polasek,O., Pouta,A., Pramstaller,P.P., Psaty,B.M.,
            Rao,D.C., Ring,S.M., Rossin,E.J., Rudan,D., Sanna,S., Scott,R.A.,
            Sehmi,J.S., Sharp,S., Shin,J.T., Singleton,A.B., Smith,A.V.,
            Soranzo,N., Spector,T.D., Stewart,C., Stringham,H.M., Tarasov,K.V.,
            Uitterlinden,A.G., Vandenput,L., Hwang,S.J., Whitfield,J.B.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilson,J.F., Witteman,J.C.,
            Wong,A., Wong,Q., Jamshidi,Y., Zitting,P., Boer,J.M., Boomsma,D.I.,
            Borecki,I.B., van Duijn,C.M., Ekelund,U., Forouhi,N.G., Froguel,P.,
            Hingorani,A., Ingelsson,E., Kivimaki,M., Kronmal,R.A., Kuh,D.,
            Lind,L., Martin,N.G., Oostra,B.A., Pedersen,N.L., Quertermous,T.,
            Rotter,J.I., van der Schouw,Y.T., Verschuren,W.M., Walker,M.,
            Albanes,D., Arnar,D.O., Assimes,T.L., Bandinelli,S., Boehnke,M., de
            Boer,R.A., Bouchard,C., Caulfield,W.L., Chambers,J.C., Curhan,G.,
            Cusi,D., Eriksson,J., Ferrucci,L., van Gilst,W.H., Glorioso,N., de
            Graaf,J., Groop,L., Gyllensten,U., Hsueh,W.C., Hu,F.B.,
            Huikuri,H.V., Hunter,D.J., Iribarren,C., Isomaa,B., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kiemeney,L.A., van der Klauw,M.M.,
            Kooner,J.S., Kraft,P., Iacoviello,L., Lehtimaki,T., Lokki,M.L.,
            Mitchell,B.D., Navis,G., Nieminen,M.S., Ohlsson,C., Poulter,N.R.,
            Qi,L., Raitakari,O.T., Rimm,E.B., Rioux,J.D., Rizzi,F., Rudan,I.,
            Salomaa,V., Sever,P.S., Shields,D.C., Shuldiner,A.R., Sinisalo,J.,
            Stanton,A.V., Stolk,R.P., Strachan,D.P., Tardif,J.C.,
            Thorsteinsdottir,U., Tuomilehto,J., van Veldhuisen,D.J.,
            Virtamo,J., Viikari,J., Vollenweider,P., Waeber,G., Widen,E.,
            Cho,Y.S., Olsen,J.V., Visscher,P.M., Willer,C., Franke,L.,
            Erdmann,J., Thompson,J.R., Pfeufer,A., Sotoodehnia,N.,
            Newton-Cheh,C., Ellinor,P.T., Stricker,B.H., Metspalu,A.,
            Perola,M., Beckmann,J.S., Smith,G.D., Stefansson,K., Wareham,N.J.,
            Munroe,P.B., Sibon,O.C., Milan,D.J., Snieder,H., Samani,N.J. and
            Loos,R.J.
  CONSRTM   Global BPgen Consortium; CARDIoGRAM Consortium; PR GWAS Consortium;
            QRS GWAS Consortium; QT-IGC Consortium; CHARGE-AF Consortium
  TITLE     Identification of heart rate-associated loci and their effects on
            cardiac conduction and rhythm disorders
  JOURNAL   Nat Genet 45 (6), 621-631 (2013)
   PUBMED   23583979
REFERENCE   2  (bases 1 to 4461)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zeng,L., Zeng,H., Jin,W., Chen,J., Yin,G.,
            Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.
  TITLE     Cloning and characterization of human synaptotagmin 10 gene
  JOURNAL   DNA Seq 14 (5), 393-398 (2003)
   PUBMED   14756426
  REMARK    GeneRIF: This cDNA clone is 3287 bp and contains an open reading
            frame from 299 to 1870 encoding a putative protein of 523 amino
            acids. It shares 94.6 and 94.8% homology to rat Syt 10 and mouse
            Syt 10 at protein level, respectively.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016956.20, BC101024.2 and AC023158.28.
            
            On May 17, 2019 this sequence version replaced NM_198992.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY198413.1, BC101024.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228567.7/ ENSP00000228567.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC016956.20        76427-76599
            174-2345            BC101024.2         1-2172
            2346-4461           AC023158.28        59266-61381
FEATURES             Location/Qualifiers
     source          1..4461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.1"
     gene            1..4461
                     /gene="SYT10"
                     /note="synaptotagmin 10"
                     /db_xref="GeneID:341359"
                     /db_xref="HGNC:HGNC:19266"
     exon            1..448
                     /gene="SYT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1869
                     /gene="SYT10"
                     /note="synaptotagmin X; sytX"
                     /codon_start=1
                     /product="synaptotagmin-10"
                     /protein_id="NP_945343.1"
                     /db_xref="CCDS:CCDS8732.1"
                     /db_xref="GeneID:341359"
                     /db_xref="HGNC:HGNC:19266"
                     /translation="MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGS
                     QGGSSTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISS
                     APTEVFETEEKKEIKENEKPAVKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQR
                     QITEPTSSTRHSSFRRHLPRQMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKS
                     VDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLL
                     PDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVI
                     LDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKA
                     MDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSI
                     AVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSF
                     DSQGSCPSPKPPSTP"
     exon            449..806
                     /gene="SYT10"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1374
                     /gene="SYT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1495
                     /gene="SYT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1667
                     /gene="SYT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1797
                     /gene="SYT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..4461
                     /gene="SYT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1961..1966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYT10"
                     /note="hexamer: AATATA"
     polyA_site      1984
                     /gene="SYT10"
                     /note="major polyA site"
ORIGIN      
        1 actccatgcc gggtctctag ttccagcgcg cctcggctcg ctcgcgcggc gggagagttg
       61 gcgcaaacct cgcggcagcc gcagcctcct cgcgcgcctc tccttcccct acgccctccg
      121 ctcccgccat ggggccaacg tggggctcct aagagttgcc ggctctcagc ggcgcaatct
      181 ccagccaaag tcaccgcggg cggactatgg cttagggcgc cagaggggtt agaggtacgg
      241 gaagaggaaa agacggctaa ctgggaaaaa aagagaaaac gaaagaaaag ccaaacgatg
      301 agtttccaca aggaggacgg agtgaacagt ctgtgccaga aggctctgca catcgtcacc
      361 gagctgtgct tcgccggcca ggtggagtgg gagaagtgct cgggcatctt ccctcgggac
      421 aggggcagcc agggcggaag cagcacagat atttcagtca gcctgttagc tgtcgttgtc
      481 agcttttgtg gactggcctt gttggttgtc tcactttttg tcttctggaa gctgtgttgg
      541 ccatgctgga aaagcaaacc tgtgacttcc aacatcacta cgcttccaca gagcatttca
      601 agtgctccta ctgaagtttt tgagactgaa gagaaaaaag aaattaagga aaatgaaaag
      661 ccagccgtaa aagctattga gcctgcaata aaaatcagcc acacttcccc tgacatccca
      721 gcagaagtcc aaactgcttt aaaagaacat ttaattaaac atgcacgtgt gcaaagacaa
      781 attactgagc ctacgtcatc aacccgccac agttccttcc gaagacacct gccgaggcaa
      841 atgcaggttt ccagtgttga ttttagcatg ggcacagaac ctgttttaca acgaggagaa
      901 acaacaacca gcattgggag gataaagcca gaactctaca aacagaaatc agttgactct
      961 gagggcaacc aaaacgaaga tgtcaaaatc tgtgggaaac ttaactttac cctccagtat
     1021 gattatgaaa atgaacttct agttgttaaa attatcaaag ctttagatct ccctgctaaa
     1081 gacttcacag gaacttctga cccttatgtg aagatgtatc ttcttccaga taggaaaaag
     1141 aaatttcaga cccgcgtgca cagaaagact ttaaatcctc tatttgatga aacttttcaa
     1201 tttcctgtag catatgatca actaagcaac cgaaaactac atttcagtgt gtatgatttt
     1261 gacagatttt ctagacatga catgattggg gaagtgattc ttgataattt gtttgaagtc
     1321 tctgatctct ccagggaagc cacagtatgg aaagatattc actgtgctac cacagaaagt
     1381 atagacctgg gtgaaatcat gttttccctt tgttacctac cgacggctgg gcgtatgaca
     1441 ttgacagtca ttaagtgcag aaatctgaag gcgatggata ttactggctc atcagatcct
     1501 tatgtcaaag tgtccctgat gtgtgaaggt cgaagattaa aaaagaggaa aacaactaca
     1561 aagaaaaaca ctctaaaccc tgtgtacaat gaggccatta tttttgacat ccctccagag
     1621 aacgtggacc aggtcagcct ctccattgcg gtcatggatt acgatagggt aggacacaat
     1681 gaggtcatag gagtgtgcag aacaggactg gatgctgagg gtcttgggcg agaccactgg
     1741 aatgaaatgc tggcctatca tcgaaaacca ataacgcact ggcacccatt gctggagtta
     1801 cctggccggg cgaccagttt tgatagtcaa ggatcctgcc cttctcctaa accaccttcc
     1861 acaccataat gcctccaaaa tgagaccatg atattaagca tctaggatca cgtgctcatt
     1921 gaatcagaaa aaaagtggaa ggtttggttt cctcatttga aatatatccg tactaatgaa
     1981 caaacttgat gtgcactttt ttatttgctt ttattgttga ttttttaact ttgaacatca
     2041 atacatttta cttgaataca tatagtcctt agttgcataa ggcattttat ccttcgtatc
     2101 aaatgcctgt tagcacaaag agtgttttac tatgttgtaa ttctttgcat atgaaatgtt
     2161 tttttaaaca gttcatactt acctaaaatt aaatatagtt tatgctgcta ttgtataaag
     2221 tagcacatgt catatatgta tgggtttgat tttgttatac tgtgttcatt tctagttgtg
     2281 caggtggttc tgtataaact taaaaggaga ttttgaactt aacttacaca acattaaatc
     2341 cttgcacaat caaattaatg ttacttatct gataatactt ttctttcatt ctcagaaaat
     2401 tactttcttg gtgaggtttg gctctgctaa actcaaaact tgtctctcaa gcttgttctt
     2461 taaaatacat agacaaagct gtaaatttaa agaatcattt tgaatataaa tttaagaagt
     2521 aatacttatt ggctgaaaaa cggaggctga gccattgtgg ctaccatttt acactgtttt
     2581 actgtaacat tagctcaaat atctgttgca ctgttcaact gatattttta aaattctaat
     2641 aatcttcatc tcaaatgtag cattagtatt tctaagtgaa cagaatcaga agttaatttt
     2701 taagtgtttg taaggttctc aagtactgtg acatgtattt ttttgtgacg tgtatttttt
     2761 gtgacttgaa gctatcatat agatcctgta tttctgatag accatactaa cagacaccaa
     2821 aggaacaaca acactgtctg tgttcatcac cgtttagatt gtacacagta atggtgactc
     2881 ttaaacccag tcagaagctc atcattggaa ttcagtattt tcttaaagaa aggatgattt
     2941 attttcagca acatatagaa atatactata aatattaata atacaacttc aatgcttaat
     3001 aataataaac aaattaattc taaaggccca ggcctccagt ccttgcatga aaggcatttg
     3061 ccttcataag gatcaaggtt caggccacta catgtaaaaa ctatgcaagt gtttttacaa
     3121 gacagaactt tcttttaagt caggtcaaca tattttgtcc cattttcagg ccctgttgga
     3181 aggtatctat actgaattac cccaacctta cttttaagat gtgtggtata gatagtatat
     3241 atttcaagct tatttcaaaa ttggtggttt ttttaaaaaa agaggcaaga aaataaaaac
     3301 atatttacct ggatgagaaa attttatcag cggttatgaa atttttattt ttgtaaaatc
     3361 ccattatttc taaatattaa aaaaaagttt taaaagcctt gaaattttgt tgacatctct
     3421 tatagtgatg gcattactgt taattaagag gtaaatattt tgcacattac cattttaaag
     3481 gcaaacacag ttctgcctca gatttttcaa aaatgcttat accaccctaa ggaaaacagg
     3541 tactcctagc taacattttc tcattgaaaa taatagaaga aagctgtttg gaaacatttg
     3601 gctaccttgt cgagcctaaa agaattattt gctataggta aaatgaaaga tgacacttgc
     3661 attttgaaat tatttgtttt attgggaaat aaaacttttc aaataggaag acaaaaagtt
     3721 atactattaa tagaatgaca tttttggaga cagttgtttt attagtagat ataactgcag
     3781 cttaaagtaa attagcaatt acgtttccta agtgagtata attattttca cccaaaaaca
     3841 catttttaag gactttttgt tgattcttag aaactcgctt ttctttactc cctaaggaga
     3901 aaaagccaat gcttgtgatg aaaaaatgtg aaccattggc caatcagaag actctaatat
     3961 gggaattgta gattaaaata agttttaaaa gaatttttta aatgtttcct tgaagttaga
     4021 ataaactcat catgcaagga tatgtgttaa tcctgagaaa gagatcagcg agaggaaatt
     4081 caccacaact catctttcat gtaattcagg aggtaggttt atgctcagat taataaggca
     4141 tgattgttaa aaatgacagt tcatattatt aaaatgtaat cctaacaatt ttaatacaac
     4201 acaccctcac tctacacagc ccacacattc atatacacat aacttaccat ctttctgctt
     4261 gtaattgaag atgaaatatt ttcagtttca gtatttaaaa taagatttga tattacaaat
     4321 ccccttattt gtgtgggaca tcacatttta atgacagtac tgacacatta tgaagctgca
     4381 gttcaggtat ataatgaaca tctaatttca gggacttctt cagggactta ccaaatatca
     4441 gtctaggaaa aaaaagagta a
//
