LOCUS       NM_033542               2728 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SYS1 golgi trafficking protein (SYS1), transcript
            variant 1, mRNA.
ACCESSION   NM_033542
VERSION     NM_033542.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Behnia,R., Panic,B., Whyte,J.R. and Munro,S.
  TITLE     Targeting of the Arf-like GTPase Arl3p to the Golgi requires
            N-terminal acetylation and the membrane protein Sys1p
  JOURNAL   Nat Cell Biol 6 (5), 405-413 (2004)
   PUBMED   15077113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA526637.1 and AL591714.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033542.3.
            
            Summary: SYS1 forms a complex with ADP-ribosylation factor-related
            protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi
            apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by
            OMIM, Aug 2009].
            
            Transcript Variant: This variant encodes the longer isoform (a).
            Both variants 1 and 3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL591714.1, AK075264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243918.10/ ENSP00000243918.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                DA526637.1         57-105
            50-2728             AL591714.1         1-2679
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2728
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /note="SYS1 golgi trafficking protein"
                     /db_xref="GeneID:90196"
                     /db_xref="HGNC:HGNC:16162"
                     /db_xref="MIM:612979"
     exon            1..160
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..325
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..634
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /note="isoform a is encoded by transcript variant 1;
                     protein SYS1 homolog; SYS1 Golgi-localized integral
                     membrane protein homolog"
                     /codon_start=1
                     /product="protein SYS1 homolog isoform a"
                     /protein_id="NP_291020.1"
                     /db_xref="CCDS:CCDS13351.1"
                     /db_xref="GeneID:90196"
                     /db_xref="HGNC:HGNC:16162"
                     /db_xref="MIM:612979"
                     /translation="MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSS
                     PSLDQMFDAEILGFSTPPGRLSMMSFILNALTCALGLLYFIRRGKQCLDFTVTVHFFH
                     LLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLNSAPKSNV"
     exon            326..393
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..2728
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /note="hexamer: AATACA"
     polyA_site      1633
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /note="major polyA site"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /note="hexamer: AATAAA"
     polyA_site      2728
                     /gene="SYS1"
                     /gene_synonym="C20orf169; dJ453C12.4; dJ453C12.4.1"
                     /note="major polyA site"
ORIGIN      
        1 ctttcctacg cagccgctcc tgccgccgtg gtcgctggag ctttgcctct ctaggccggc
       61 agcgcctctc ctccatggtc ctgtctgtca gcgctgtttt gggagcccgc cggtgaggcc
      121 gggccacgct cagacacttc gatcgtcgag tctgtcactg ggcatggcgg gtcagttccg
      181 cagctacgtg tgggacccgc tgctgatcct gtcgcagatc gtcctcatgc agaccgtgta
      241 ttacggctcg ctgggcctgt ggctggcgct ggtggacggg ctagtgcgaa gcagcccctc
      301 gctggaccag atgttcgacg ccgagatcct gggcttttcc acccctccag gccggctctc
      361 catgatgtcc ttcatcctca acgccctcac ctgtgccctg ggcttgctgt acttcatccg
      421 gcgaggaaag cagtgtctgg atttcactgt cactgtccat ttctttcacc tcctgggctg
      481 ctggttctac agctcccgtt tcccctcggc gctgacctgg tggctggtcc aagccgtgtg
      541 cattgcactc atggctgtca tcggggagta cctgtgcatg cggacggagc tcaaggagat
      601 acccctcaac tcagccccta aatccaatgt ctagaatcag gccctttgga catcctgctg
      661 acacttgggc cccttaacac cttgggctgc tcagaccctc cagatgaggt ccagcccaga
      721 tctgagagga accctggaaa tgtgaagtct ctgttggttt gggagagata gtgagggcct
      781 gtcaaagaag gcaggtagca gtcagcatga cagctgcaag aatgacctct gtctgttgaa
      841 gccttggtat ctgagaggtc aggaagggga cctctttgag ggtaataaca gaattggaac
      901 catgccactc ttgagccaca atacctgtca ccagcctgtt gttttaagag agaaaaaaaa
      961 tcaaggatat ctgattggag caaaccactt ctttagtcat ctgtcttacc cccctgggac
     1021 agctgttacc tttgcagtgt tgccgaatca cagcagttac ctttgcagtg ttgccgaatc
     1081 acagcagttc tgttggagaa acgcttggtt tccggatcca gagccacaga aagaaatgta
     1141 ggtgtgaagt attaggctgc tgtcagggag aggatggcag atggaggcat caagcacaag
     1201 gaaaatgcac aacctgtgcc ctgttataca cacgttcatg tgcacccaag aacctatgac
     1261 tttcttccag ttccttctac caggtcccca tcctgctgcc agctctcaac atagcaggcc
     1321 ataggaccca gagaagaatc ccagcgttgc tcaaagtcta accatcataa agacactgcc
     1381 tgtcttctag gaatgaccag gcacccagct cccactggac tccaattttt tttcctgcct
     1441 tatttagaat tctttggcgg gaagggtatg atgggttccc agagacaaga agcccaacct
     1501 tctggcctgg gctgtgctga tagtgctgag ggagatagga atttgctgct aagatttttc
     1561 tttggggtgg agtttcctct gtgaggggct tgcagctatc cttcctgtgt atacaaatac
     1621 agtattttcc atggttctgc ctgcacttac tttgtaatgc cacggttgag attgagagag
     1681 atcagcgcag ccaggcaagg gaactttaaa gaattattag gccaccttct ccctttcctg
     1741 gaccccagag tcattcctcc atttggttaa aatactcagt gcagggaact cttacatcct
     1801 gtctccttca cttgcagcgt cccctgctat gcctcaggtg aaccacataa ttcttgggtt
     1861 tccgttccta cttgctagtg atttctgaac atgttcaatg gagcggcaca cagtctagac
     1921 ccacttccgc attgaaacct tcactgttcc tctttggttt cttcagagct ttcccaagag
     1981 agctgtcagt tttcagctgt cagtaacaca aatgagttta tggtaacaca aatgagtttt
     2041 gctatctctc tgagaagctc atctgacctc ctgactctca gccctacaga gtagggagtt
     2101 gatgctgaca ggatgaagat ttaggaataa atatgcctgg gaagagactg ggaaggttct
     2161 agggtgaggc acctcagtaa ctcatggtac cttggccaag ttggaaggaa gcagtttgtt
     2221 aatgaggcac agtaatcctg gctgcagggt ctaggaggta agaccagctg ggatgacctt
     2281 ccctgggtta atcaatttcc ctctagacaa cacaaactgc aggcatgtga ctaactttga
     2341 aagaacaccc atcatgtggc tgctgtcacc cttgaccagc cgtggtggtg gttactccat
     2401 ctgtggttgg agcgcctctt tgggattcac ttcaaggtct tgtgcctatt tttctgcata
     2461 tcttctgtga tgacaaatct ctgtcccctg agtgttaatt tgatttttag aaatggccaa
     2521 aagtcacgtg atccaaactt tttttcagta atatggagac tgagctgcat ggtagttggg
     2581 gatcaaaaat atgtgacctt aatgagattt ttatgatttc taaagtaaca ataaaagcag
     2641 tttttagagt tgagttccag agagggcagg gcaatggcag tgacatgttt gtcattttaa
     2701 taataaataa catctattga gtgcttaa
//
