LOCUS       NM_001040709            3703 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synaptophysin like 2 (SYPL2), mRNA.
ACCESSION   NM_001040709 XM_001134408 XM_001134453
VERSION     NM_001040709.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3703)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3703)
  AUTHORS   Jiao,H., Arner,P., Gerdhem,P., Strawbridge,R.J., Naslund,E.,
            Thorell,A., Hamsten,A., Kere,J. and Dahlman,I.
  TITLE     Exome sequencing followed by genotyping suggests SYPL2 as a
            susceptibility gene for morbid obesity
  JOURNAL   Eur J Hum Genet 23 (9), 1216-1222 (2015)
   PUBMED   25406998
  REMARK    GeneRIF: SYPL2 is a susceptibility gene for morbid obesity.
REFERENCE   3  (bases 1 to 3703)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   4  (bases 1 to 3703)
  AUTHORS   Satoh,K., Akatsu,H., Yamamoto,T., Kosaka,K., Yokota,H. and
            Yamada,T.
  TITLE     Mitsugumin 29 is transcriptionally induced in senile
            plaque-associated astrocytes
  JOURNAL   Brain Res 1441, 9-16 (2012)
   PUBMED   22290180
  REMARK    GeneRIF: Mitsugumin (MG)29 is expressed in astrocytes of Alzheimer
            disease brains associated with senile plaques, but is is not
            expressed in neurons around lesions.
REFERENCE   5  (bases 1 to 3703)
  AUTHORS   Shi,J., Potash,J.B., Knowles,J.A., Weissman,M.M., Coryell,W.,
            Scheftner,W.A., Lawson,W.B., DePaulo,J.R. Jr., Gejman,P.V.,
            Sanders,A.R., Johnson,J.K., Adams,P., Chaudhury,S., Jancic,D.,
            Evgrafov,O., Zvinyatskovskiy,A., Ertman,N., Gladis,M., Neimanas,K.,
            Goodell,M., Hale,N., Ney,N., Verma,R., Mirel,D., Holmans,P. and
            Levinson,D.F.
  TITLE     Genome-wide association study of recurrent early-onset major
            depressive disorder
  JOURNAL   Mol Psychiatry 16 (2), 193-201 (2011)
   PUBMED   20125088
REFERENCE   6  (bases 1 to 3703)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   7  (bases 1 to 3703)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB071160.1, DA097637.1, DB291596.1, AI983207.1, DN831287.1 and
            AL355145.31.
            
            On Nov 22, 2018 this sequence version replaced NM_001040709.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293082.1, AB158472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369872.4/ ENSP00000358888.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB071160.1         69-72
            5-12                DA097637.1         7-14
            13-593              DB291596.1         1-581
            594-672             AI983207.1         515-593
            673-990             DN831287.1         133-450
            991-3703            AL355145.31        7479-10191
FEATURES             Location/Qualifiers
     source          1..3703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3703
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /note="synaptophysin like 2"
                     /db_xref="GeneID:284612"
                     /db_xref="HGNC:HGNC:27638"
     exon            1..352
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1117
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /note="mitsugumin 29"
                     /codon_start=1
                     /product="synaptophysin-like protein 2"
                     /protein_id="NP_001035799.1"
                     /db_xref="CCDS:CCDS41365.1"
                     /db_xref="GeneID:284612"
                     /db_xref="HGNC:HGNC:27638"
                     /translation="MSSTESAGRTADKSPRQQVDRLLVGLRWRRLEEPLGFIKVLQWL
                     FAIFAFGSCGSYSGETGAMVRCNNEAKDVSSIIVAFGYPFRLHRIQYEMPLCDEESSS
                     KTMHLMGDFSAPAEFFVTLGIFSFFYTMAALVIYLRFHNLYTENKRFPLVDFCVTVSF
                     TFFWLVAAAAWGKGLTDVKGATRPSSLTAAMSVCHGEEAVCSAGATPSMGLANISVLF
                     GFINFFLWAGNCWFVFKETPWHGQGQGQDQDQDQDQGQGPSQESAAEQGAVEKQ"
     exon            353..427
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /inference="alignment:Splign:2.1.0"
     exon            428..552
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /inference="alignment:Splign:2.1.0"
     exon            553..754
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /inference="alignment:Splign:2.1.0"
     exon            755..946
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /inference="alignment:Splign:2.1.0"
     exon            947..3703
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /note="hexamer: AATAAA"
     polyA_site      3703
                     /gene="SYPL2"
                     /gene_synonym="MG29"
                     /note="major polyA site"
ORIGIN      
        1 gacccggcgg ccaagttcgc tgcgagtttg acagaagttt gaatccgagt cgggggcttt
       61 ctgctgccgg cggggcaccg cggcggccgc agcctctgag agcacgaaca gcagcgcccc
      121 cgcgtcccag ccagccagcc agccagactg gactccggcc caccgacggc cgctcgcgct
      181 ccggccccgc tcgcctgctc tgccccggac ctgcagctcc ccgctccccc gccgtgtccg
      241 ccgcctcccg gccagagagc caagccacca cgccgcgccc agcgctcgcc gcgccagcat
      301 gtcctcgacc gagagcgccg gccgcacggc ggacaagtcg ccgcgccagc aggtggaccg
      361 cctactcgtg gggctgcgct ggcggcggct ggaggagccg ctgggcttca tcaaagttct
      421 ccagtggctc tttgctattt tcgccttcgg gtcctgtggc tcctacagcg gggagacagg
      481 agcaatggtt cgctgcaaca acgaagccaa ggacgtgagc tccatcatcg ttgcatttgg
      541 ctatcccttc aggttgcacc ggatccaata tgagatgccc ctctgcgatg aagagtccag
      601 ctccaagacc atgcacctca tgggggactt ctctgcaccc gccgagttct tcgtgaccct
      661 tggcatcttt tccttcttct ataccatggc tgccctagtt atctacctgc gcttccacaa
      721 cctctacaca gagaacaaac gcttcccgct ggtggacttc tgtgtgactg tctccttcac
      781 cttcttctgg ctggtagctg cagctgcctg gggcaagggc ctgaccgatg tcaagggggc
      841 cacacgacca tccagcttga cagcagccat gtcagtgtgc catggagagg aagcagtgtg
      901 cagtgccggg gccacgccct ctatgggcct ggccaacatc tccgtgctct ttggctttat
      961 caacttcttc ctgtgggccg ggaactgttg gtttgtgttc aaggagaccc cgtggcatgg
     1021 acagggccag ggccaggacc aggaccagga ccaggaccag ggccagggtc ccagccagga
     1081 gagtgcagct gagcagggag cagtggagaa gcagtaagca gccccccacc tggctattcc
     1141 cgaactggac agcacctctt caaccacctc cggcttccag gacctttctc ttcctcctcc
     1201 tccaattccc ctcccccatc attctggtct ttgagctttg agacgatggg caggcatcag
     1261 ctgttggaaa cctgggcagc cctctcagtg gcttcctatc ctccttcttg ctggagccat
     1321 gaatggcagg agctcagtgc ttcttgtgca gtgcctggac ccaggtatct tacttggggt
     1381 cttacttgta cccttacagt ctctgagaac cagcctctgc tgcaggtgag ggttgggggc
     1441 aggaaaccag tgctctgaga ctggttccta gcagccacct ttctgtcaac ctgtccggct
     1501 tcaacaatat tagggggaag ggaaatcagc tagtagcctt cccctctggt cccttgtgtg
     1561 gaggccccaa tagtggtttg gcgacccctc ctcagtggct gtcatctagt ccctgcgtct
     1621 gatctccagt catcccatga ctcagtgtgc cttccactgt cttctctggc ctctgcctgc
     1681 ccacagaatc caccatgtgt gaaccagaga ggtccaccag cctagaaaac agcccttcag
     1741 agggtcctga tgaggccttc ctggactcag ctgggagcaa gataaattgc aactgagttg
     1801 cagcttcaag aaagtaaagc cagtaagctt gctggcagaa tcaatttctt ctatcccctc
     1861 aatcctccca cccaccaggc tggggcactt tccaccaaca ctctaaactc tactttagaa
     1921 acgccctatc ttcctccctg tcctccttct tggtctcaca cttgggactc aaaaatgtgg
     1981 agtcaggacc tgcctcctaa tccccttact tctctgtcca tctcccttcc ccagcatcgt
     2041 gcatctgagg catttgagat cctttttgaa gtctgtccag gccttccttt tattcctgtg
     2101 gggccagaca ggggcttagg aagggccaaa ggaccatcat gaggctaagt tgccccagag
     2161 ccccaggatg gatgggccca ttttttcctt attccctgct cagttttttc ccctgctcct
     2221 tctctagtcc ttctttcata tttctccttc tcatcttgaa aacaggatgt tccctcttcc
     2281 cttgctgtcc catttctccc ctgtgtcctt atttctccca gtctctatcc cctctcaagt
     2341 ccagggcagg ccgatgctat tggtgcttct tcactttggg acccagttcc atatttgtct
     2401 ttagtgtata tcctcttcct gatacctcct tcagtccctc tctgggcccc aaggctgaga
     2461 atcagtgtta actgggtaag gatcatttgc ttcctaccca gctcaatctg ccctggccat
     2521 agggcttccc agggaaggaa gaagagggaa gaatccgacc actttccaat ccagtgccaa
     2581 ttggcccact aagcatccta aaggtgaatg tgccctgtgc caatctctcc tcaggactga
     2641 gtcaaccccc ttcaacctcc tcacctctct aaacaccatc catagtaaca tgtgcattac
     2701 tggggtacct aggagtcagg acttttgact tcaggccagt catttcctcc cgatggggaa
     2761 agggtgagat ttacatcccc aaatgcttga gtccctcagt gaaagaatta gtttttgttt
     2821 gtttgtttaa gattttgggg aagagatttg aggaggaaag aaaggagatg gggtgagagg
     2881 gtttttaagt ctgaaactct ctgtcatgag ctgtccccat ggttactcaa ggacaagggg
     2941 ggacagtttt gcctacagct ccagagacac agagaacaaa ggggtgacct tcatttttct
     3001 tcaagccggc ctctgtgggg gtctgtgagc agcttctact ggatctttgt ttggattctg
     3061 tgtctgtatt tataatttat ttgaaatgtg ctgggtagtg ttctcatttg ggggctgaag
     3121 ttagcaactg ggccttcagc tagggaaagc agttgcgggc agggggtggg gggagattat
     3181 attcactcct gccaaggact cccagcccag gactctcttt agagcaagga agcctcgttc
     3241 tctttcttct caagaggctc tcttgttctc catcaggaga gccttgattt aggctacggc
     3301 ctcactctct atggccaccc taagaggaaa ggctacttca cctcattacc tccagagggc
     3361 tgggcagggc caagtgcctc ataggactca tgttctctcc aaccagggct ggcatcactg
     3421 ctttgcaaag tggggcctga ggtagaagaa ggtgtctggt ttctccagct gctgtaggag
     3481 gctaatgggc agggtacttg ccctttgtcc cactagactc taacccagca ccagggtgcc
     3541 cacctaggac ctttcctgga catgagtttc cttcactatc atagtcatga gcctcctact
     3601 tctgggattg cagatcaggg gtggggggag aatgttgcat gttgttttct ggtgcttgtt
     3661 attatatatt tgaataaaca gtgctgcaag tacttgccat gaa
//
