LOCUS       NM_182715               2130 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens synaptophysin like 1 (SYPL1), transcript variant 2,
            mRNA.
ACCESSION   NM_182715
VERSION     NM_182715.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2130)
  AUTHORS   Liu,J., Hermo,L., Ding,D., Wei,C., Mann,J.M., Yan,X., Melnick,A.F.,
            Wu,Y., Withrow,A., Cibelli,J., Hess,R.A. and Chen,C.
  TITLE     SYPL1 defines a vesicular pathway essential for sperm cytoplasmic
            droplet formation and male fertility
  JOURNAL   Nat Commun 14 (1), 5113 (2023)
   PUBMED   37607933
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2130)
  AUTHORS   Shu,T., Wu,K., Guo,Y., He,Q., Song,X., Shan,J., Wu,L., Liu,J.,
            Wang,Z., Liu,L. and Sun,X.
  TITLE     Evaluation of fecal SYPL1 as a diagnostic biomarker in colorectal
            cancer
  JOURNAL   Clin Biochem 103, 8-15 (2022)
   PUBMED   35218739
  REMARK    GeneRIF: Evaluation of fecal SYPL1 as a diagnostic biomarker in
            colorectal cancer.
REFERENCE   3  (bases 1 to 2130)
  AUTHORS   Liu,L., He,Q., Li,Y., Zhang,B., Sun,X., Shan,J., Pan,B., Zhang,T.,
            Zhao,Z., Song,X. and Guo,Y.
  TITLE     Serum SYPL1 is a promising diagnostic biomarker for colorectal
            cancer
  JOURNAL   Clin Chim Acta 509, 36-42 (2020)
   PUBMED   32502495
  REMARK    GeneRIF: Serum SYPL1 is a promising diagnostic biomarker for
            colorectal cancer.
REFERENCE   4  (bases 1 to 2130)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2130)
  AUTHORS   Hacker,B., Schultheiss,C., Doring,M. and Kurzik-Dumke,U.
  TITLE     Molecular partners of hNOT/ALG3, the human counterpart of the
            Drosophila NOT and yeast ALG3 gene, suggest its involvement in
            distinct cellular processes relevant to congenital disorders of
            glycosylation, cancer, neurodegeneration and a variety of further
            pathologies
  JOURNAL   Hum Mol Genet 27 (11), 1858-1878 (2018)
   PUBMED   29547901
REFERENCE   6  (bases 1 to 2130)
  AUTHORS   Brooks,C.C., Scherer,P.E., Cleveland,K., Whittemore,J.L.,
            Lodish,H.F. and Cheatham,B.
  TITLE     Pantophysin is a phosphoprotein component of adipocyte transport
            vesicles and associates with GLUT4-containing vesicles
  JOURNAL   J Biol Chem 275 (3), 2029-2036 (2000)
   PUBMED   10636906
REFERENCE   7  (bases 1 to 2130)
  AUTHORS   Windoffer,R., Borchert-Stuhltrager,M., Haass,N.K., Thomas,S.,
            Hergt,M., Bulitta,C.J. and Leube,R.E.
  TITLE     Tissue expression of the vesicle protein pantophysin
  JOURNAL   Cell Tissue Res 296 (3), 499-510 (1999)
   PUBMED   10370136
REFERENCE   8  (bases 1 to 2130)
  AUTHORS   Haass,N.K., Kartenbeck,M.A. and Leube,R.E.
  TITLE     Pantophysin is a ubiquitously expressed synaptophysin homologue and
            defines constitutive transport vesicles
  JOURNAL   J Cell Biol 134 (3), 731-746 (1996)
   PUBMED   8707851
REFERENCE   9  (bases 1 to 2130)
  AUTHORS   Leube,R.E.
  TITLE     Expression of the synaptophysin gene family is not restricted to
            neuronal and neuroendocrine differentiation in rat and human
  JOURNAL   Differentiation 56 (3), 163-171 (1994)
   PUBMED   8034131
REFERENCE   10 (bases 1 to 2130)
  AUTHORS   Zhong,C.Z., Hayzer,D.J. and Runge,M.S.
  TITLE     Molecular cloning of a cDNA encoding a novel protein related to the
            neuronal vesicle protein synaptophysin
  JOURNAL   Biochim Biophys Acta 1129 (2), 235-238 (1992)
   PUBMED   1730063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005095.2.
            
            On Apr 20, 2020 this sequence version replaced NM_182715.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream, in-frame start codon, compared to variant 1. The
            encoded isoform (b) has a shorter N-terminus, compared to isoform
            a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016835.1, SRR11853563.30745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455385.7/ ENSP00000388336.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC005095.2         37533-37705         c
            174-298             AC005095.2         24551-24675         c
            299-506             AC005095.2         23083-23290         c
            507-695             AC005095.2         18342-18530         c
            696-2130            AC005095.2         15898-17332         c
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2130
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /note="synaptophysin like 1"
                     /db_xref="GeneID:6856"
                     /db_xref="HGNC:HGNC:11507"
                     /db_xref="MIM:616665"
     exon            1..173
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..830
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /note="isoform b is encoded by transcript variant 2;
                     pantophysin; synaptophysin-like protein 1"
                     /codon_start=1
                     /product="synaptophysin-like protein 1 isoform b"
                     /protein_id="NP_874384.1"
                     /db_xref="CCDS:CCDS47685.1"
                     /db_xref="GeneID:6856"
                     /db_xref="HGNC:HGNC:11507"
                     /db_xref="MIM:616665"
                     /translation="MSGFQINLNPLKEPLGFIKVLEWIASIFAFATCGGFKGQTEIQV
                     NCPPAVTENKTVTATFGYPFRLNEASFQPPPGVNICDVNWKDYVLIGDYSSSAQFYVT
                     FAVFVFLYCIAALLLYVGYTSLYLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDI
                     KIATGHNIIDELPPCKKKAVLCYFGSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKET
                     SLHSPSNTSAPHSQGGIPPPTGI"
     exon            174..298
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /inference="alignment:Splign:2.1.0"
     exon            299..506
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /inference="alignment:Splign:2.1.0"
     exon            507..695
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /inference="alignment:Splign:2.1.0"
     exon            696..2130
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /note="hexamer: AATAAA"
     polyA_site      2130
                     /gene="SYPL1"
                     /gene_synonym="H-SP1; SYPL"
                     /note="major polyA site"
ORIGIN      
        1 gcgccagccc cgcctgccct tcctcgccac cgggctgctc tggtctcgtc ggtcccctcc
       61 tccgccccgt cgtcctgact ctctctccct cctttcctca gaggatgtcc ggcttccaga
      121 tcaacctcaa cccgctcaag gagccactcg gcttcatcaa ggtcctcgag tggattgctt
      181 ctatctttgc ttttgccacc tgtggaggtt ttaagggcca aacagaaatt caagtgaatt
      241 gtcctcctgc agttactgag aataaaactg ttacagctac ttttggttat ccattcaggt
      301 tgaatgaggc atcatttcag ccacctccag gtgtaaacat atgtgatgta aattggaaag
      361 attacgtcct cataggcgat tactcttctt ctgcacaatt ctatgttacc tttgcagtct
      421 ttgtgttcct gtactgcatt gctgcccttc tgctttatgt tggctacacg agtctgtatc
      481 tggatagtcg taaacttcct atgatagact ttgttgttac acttgttgcc acttttttgt
      541 ggttggtgag cacttcagcc tgggctaaag ctctgacaga tattaaaata gctactggtc
      601 acaatattat tgatgaactt ccgccttgta agaagaaagc agtactgtgt tactttggct
      661 ctgtgaccag tatgggatcc ctaaatgtat ctgtgatatt tggctttcta aatatgatac
      721 tctggggagg aaatgcttgg tttgtgtaca aggagaccag cctacacagt ccatcaaata
      781 catctgcccc tcatagccaa ggaggtattc cacctcctac cggaatataa ttaaagggag
      841 aaatacactg tatgaagtat atgttgatac tatgacatgt tgccaacacc ttgagaagca
      901 ttatttgttt ctaataaaag taatggcttt gtcaatatat tggtgggttt aaaactttgc
      961 tgctttttta cataaagcct gtgcctttcc tagaaagtta agatgtaaat gtattctcac
     1021 atgtaaattt gaaagttcag gggtctatta tgaaatgata cacattttta aatgaaccat
     1081 aatttttttc actaagctgt ttgccttcca aagtgtttac accttaagcc ttaacatgta
     1141 tcttcattca gaaaacagtt atattgtcat accatagtag gaagaaaaac ctttatttgg
     1201 aatatacact actgtaagtt tgtacagatc atatacctac cacctgtctt tgcttaaaga
     1261 gccttgatta cataaatatg taggaaaaaa catattgagt tcaaaattta tatctaacat
     1321 tgtttatgtt atgatttttt tttaattgca aagactaggt gtatattttt ttctgttttt
     1381 ctaaatgacc cgtggtactt aataggtgta ctaaaattgt gttgggagca gggatttgga
     1441 aatttctgag agatgtgtag ttaatttagt aattctgttt catgagatat gatctgttat
     1501 gctagtggtt taataggctt gctatgtaag tagaacgtgg ctcaactaga tatctttata
     1561 tgtatgggca ttactcttag tgatatttgt ttcctgtcct ttgttgctca tgctgtttaa
     1621 gtgcaggctg agacccagcc tctttgtaag tacagtaaaa taatccaccg ttttttacag
     1681 accctagtca aagggttaaa aaaattaaga ttgctttcca tgtttgaaat ttaccattga
     1741 gagtcaatga agttgctatt ttgagtttag cattgatatt gtgaaaataa gtgcaatttg
     1801 gatttcatgt ttcttaatat tcattcttgt ttcacaaatg aatgattaag gaattatgca
     1861 tcataaagga acctaagtga ggtatatgat gagtgtattg tctttgcaca cacatatagg
     1921 tatattctga atacaagctt attcacattt tgcttcctaa tctttttgtt gtacagggat
     1981 tcaggtttct tattcttaca acatgattgt ttatatgtga agcacatctt gctgttgcct
     2041 tatttttgat gcttttattc atgacaagaa ttgtcaatat aagaatgtat atcttttttg
     2101 caaccaattt aataaaggag ttgaaagaaa
//
