LOCUS       NM_007247               8141 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synergin gamma (SYNRG), transcript variant 1, mRNA.
ACCESSION   NM_007247
VERSION     NM_007247.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8141)
  AUTHORS   Ayaz,A., Uzunhan,T.A. and Aydin,K.
  TITLE     Interacting with AP1 complex mutated synergin gamma (SYNRG) reveals
            a novel coatopathy in the form of complicated hereditary spastic
            paraplegia
  JOURNAL   Brain Dev 44 (5), 329-335 (2022)
   PUBMED   35090779
  REMARK    GeneRIF: Interacting with AP1 complex mutated synergin gamma
            (SYNRG) reveals a novel coatopathy in the form of complicated
            hereditary spastic paraplegia.
REFERENCE   2  (bases 1 to 8141)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 8141)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8141)
  AUTHORS   Pharoah,P.D., Tsai,Y.Y., Ramus,S.J., Phelan,C.M., Goode,E.L.,
            Lawrenson,K., Buckley,M., Fridley,B.L., Tyrer,J.P., Shen,H.,
            Weber,R., Karevan,R., Larson,M.C., Song,H., Tessier,D.C., Bacot,F.,
            Vincent,D., Cunningham,J.M., Dennis,J., Dicks,E., Aben,K.K.,
            Anton-Culver,H., Antonenkova,N., Armasu,S.M., Baglietto,L.,
            Bandera,E.V., Beckmann,M.W., Birrer,M.J., Bloom,G., Bogdanova,N.,
            Brenton,J.D., Brinton,L.A., Brooks-Wilson,A., Brown,R., Butzow,R.,
            Campbell,I., Carney,M.E., Carvalho,R.S., Chang-Claude,J.,
            Chen,Y.A., Chen,Z., Chow,W.H., Cicek,M.S., Coetzee,G., Cook,L.S.,
            Cramer,D.W., Cybulski,C., Dansonka-Mieszkowska,A., Despierre,E.,
            Doherty,J.A., Dork,T., du Bois,A., Durst,M., Eccles,D., Edwards,R.,
            Ekici,A.B., Fasching,P.A., Fenstermacher,D., Flanagan,J., Gao,Y.T.,
            Garcia-Closas,M., Gentry-Maharaj,A., Giles,G., Gjyshi,A., Gore,M.,
            Gronwald,J., Guo,Q., Halle,M.K., Harter,P., Hein,A., Heitz,F.,
            Hillemanns,P., Hoatlin,M., Hogdall,E., Hogdall,C.K., Hosono,S.,
            Jakubowska,A., Jensen,A., Kalli,K.R., Karlan,B.Y., Kelemen,L.E.,
            Kiemeney,L.A., Kjaer,S.K., Konecny,G.E., Krakstad,C.,
            Kupryjanczyk,J., Lambrechts,D., Lambrechts,S., Le,N.D., Lee,N.,
            Lee,J., Leminen,A., Lim,B.K., Lissowska,J., Lubinski,J.,
            Lundvall,L., Lurie,G., Massuger,L.F., Matsuo,K., McGuire,V.,
            McLaughlin,J.R., Menon,U., Modugno,F., Moysich,K.B., Nakanishi,T.,
            Narod,S.A., Ness,R.B., Nevanlinna,H., Nickels,S., Noushmehr,H.,
            Odunsi,K., Olson,S., Orlow,I., Paul,J., Pejovic,T., Pelttari,L.M.,
            Permuth-Wey,J., Pike,M.C., Poole,E.M., Qu,X., Risch,H.A.,
            Rodriguez-Rodriguez,L., Rossing,M.A., Rudolph,A., Runnebaum,I.,
            Rzepecka,I.K., Salvesen,H.B., Schwaab,I., Severi,G., Shen,H.,
            Shridhar,V., Shu,X.O., Sieh,W., Southey,M.C., Spellman,P.,
            Tajima,K., Teo,S.H., Terry,K.L., Thompson,P.J., Timorek,A.,
            Tworoger,S.S., van Altena,A.M., van den Berg,D., Vergote,I.,
            Vierkant,R.A., Vitonis,A.F., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wik,E., Winterhoff,B., Woo,Y.L., Wu,A.H.,
            Yang,H.P., Zheng,W., Ziogas,A., Zulkifli,F., Goodman,M.T., Hall,P.,
            Easton,D.F., Pearce,C.L., Berchuck,A., Chenevix-Trench,G.,
            Iversen,E., Monteiro,A.N., Gayther,S.A., Schildkraut,J.M. and
            Sellers,T.A.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat Genet 45 (4), 362-370 (2013)
   PUBMED   23535730
REFERENCE   5  (bases 1 to 8141)
  AUTHORS   Turner,S.T., Bailey,K.R., Schwartz,G.L., Chapman,A.B., Chai,H.S.
            and Boerwinkle,E.
  TITLE     Genomic association analysis identifies multiple loci influencing
            antihypertensive response to an angiotensin II receptor blocker
  JOURNAL   Hypertension 59 (6), 1204-1211 (2012)
   PUBMED   22566498
REFERENCE   6  (bases 1 to 8141)
  AUTHORS   Kent,H.M., McMahon,H.T., Evans,P.R., Benmerah,A. and Owen,D.J.
  TITLE     Gamma-adaptin appendage domain: structure and binding site for
            Eps15 and gamma-synergin
  JOURNAL   Structure 10 (8), 1139-1148 (2002)
   PUBMED   12176391
REFERENCE   7  (bases 1 to 8141)
  AUTHORS   Nogi,T., Shiba,Y., Kawasaki,M., Shiba,T., Matsugaki,N.,
            Igarashi,N., Suzuki,M., Kato,R., Takatsu,H., Nakayama,K. and
            Wakatsuki,S.
  TITLE     Structural basis for the accessory protein recruitment by the
            gamma-adaptin ear domain
  JOURNAL   Nat Struct Biol 9 (7), 527-531 (2002)
   PUBMED   12042876
REFERENCE   8  (bases 1 to 8141)
  AUTHORS   Takatsu,H., Yoshino,K. and Nakayama,K.
  TITLE     Adaptor gamma ear homology domain conserved in gamma-adaptin and
            GGA proteins that interact with gamma-synergin
  JOURNAL   Biochem Biophys Res Commun 271 (3), 719-725 (2000)
   PUBMED   10814529
REFERENCE   9  (bases 1 to 8141)
  AUTHORS   Page,L.J., Sowerby,P.J., Lui,W.W. and Robinson,M.S.
  TITLE     Gamma-synergin: an EH domain-containing protein that interacts with
            gamma-adaptin
  JOURNAL   J Cell Biol 146 (5), 993-1004 (1999)
   PUBMED   10477754
REFERENCE   10 (bases 1 to 8141)
  AUTHORS   Peyrard,M., Parveneh,S., Lagercrantz,S., Ekman,M., Fransson,I.,
            Sahlen,S. and Dumanski,J.P.
  TITLE     Cloning, expression pattern, and chromosomal assignment to 16q23 of
            the human gamma-adaptin gene (ADTG)
  JOURNAL   Genomics 50 (2), 275-280 (1998)
   PUBMED   9653655
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB085203.1, AF169548.1,
            BC090930.1, AC243585.2 and N93929.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007247.5.
            
            Summary: This gene encodes a protein that interacts with the gamma
            subunit of AP1 clathrin-adaptor complex. The AP1 complex is located
            at the trans-Golgi network and associates specific proteins with
            clathrin-coated vesicles. This encoded protein may act to connect
            the AP1 complex to other proteins. Alternatively spliced transcript
            variants that encode different isoforms have been described for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169548.1, SRR14038197.2331445.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612223.5/ ENSP00000483453.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB085203.1         23-42
            21-3429             AF169548.1         1-3409
            3430-3687           BC090930.1         3167-3424
            3688-4042           AF169548.1         3668-4022
            4043-8062           AC243585.2         46576-50595         c
            8063-8141           N93929.1           21-99               c
FEATURES             Location/Qualifiers
     source          1..8141
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..8141
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="synergin gamma"
                     /db_xref="GeneID:11276"
                     /db_xref="HGNC:HGNC:557"
                     /db_xref="MIM:607291"
     exon            1..140
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..4008
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma-synergin; AP1 gamma subunit binding protein 1;
                     adaptor-related protein complex 1 gamma subunit-binding
                     protein 1; AP1 subunit gamma-binding protein 1"
                     /codon_start=1
                     /product="synergin gamma isoform 1"
                     /protein_id="NP_009178.3"
                     /db_xref="CCDS:CCDS11321.1"
                     /db_xref="GeneID:11276"
                     /db_xref="HGNC:HGNC:557"
                     /db_xref="MIM:607291"
                     /translation="MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMP
                     MQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAAGMPYLGQAPFL
                     GMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKT
                     GEKSRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQI
                     KLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGV
                     GVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRET
                     LGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFS
                     MTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTYPANQV
                     VKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKAL
                     PSMDKYAVFKGIAADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGESFAEFRSAGT
                     DDGFTDFKTADSVSPLEPPTKDKTFPPSFPSGTIQQKQQTQVKNPLNLADLDMFSSVN
                     CSSEKPLSFSAVFSTSKSVSTPQSTGSAATMTALAATKTSSLADDFGEFSLFGEYSGL
                     APVGEQDDFADFMAFSNSSISSEQKPDDKYDALKEEASPVPLTSNVGSTVKGGQNSTA
                     ASTKYDVFRQLSLEGSGLGVEDLKDNTPSGKSDDDFADFHSSKFSSINSDKSLGEKAV
                     AFRHTKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSL
                     DLPTVSGQHPPAADIEDLKYAAFGSYSSNFAVSTLTSYDWSDRDDATQGRKLSPFVLS
                     AGSGSPSATSILQKKETSFGSSENITMTSLSKVTTFVSEDALPETTFPALASFKDTIP
                     QTSEQKEYENRDYKDFTKQDLPTAERSQEATCPSPASSGASQETPNECSDDFGEFQSE
                     KPKISKFDFLVATSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSP
                     ALEQPFRDRSNTLNEKPALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALNVIKKAN
                     DTLNGISSSSVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKD
                     IDKVWNNLIGFMSLATLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEE
                     KPAEEHPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLVLPDLL"
     exon            141..181
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            182..303
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            304..434
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            435..540
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            541..652
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            653..886
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            887..964
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1161
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1410
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1544
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1663
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1726
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2671
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..3265
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3429
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3483
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3580
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3729
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3840
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..3876
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..8141
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4462..4467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: AATAAA"
     polyA_site      4487
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="major polyA site"
     regulatory      8017..8022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: AATAAA"
     polyA_site      8038
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="major polyA site"
     regulatory      8052..8057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: TATAAA"
     polyA_site      8074
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
     regulatory      8124..8129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: AATACA"
     polyA_site      8141
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
ORIGIN      
        1 gtgttcagct gacagctgct gataaggtgg cggcggcgaa ggcagcggca ggtcgggagc
       61 aagatggcgc tgcggccagg agctggttct ggtggcggcg gggccgcggg agctggcgcg
      121 gggtccgccg ggggaggcgg cttcatgttt cctgttgcag gtgggataag accccctcaa
      181 gcaggcctga tgccgatgca gcaacaagga tttcctatgg tctctgtcat gcagcctaat
      241 atgcaaggca ttatgggaat gaattacagc tctcagatgt cccaaggacc tattgctatg
      301 caggcaggaa taccaatggg accaatgcca gcagcgggaa tgccttacct aggacaagca
      361 cccttcctgg gcatgcgtcc tccaggccca cagtacactc cagacatgca gaagcagttt
      421 gccgaagagc agcagaaacg atttgaacag cagcaaaaac tcttagaaga agaaagaaaa
      481 agacgccagt ttgaagagca gaagcaaaag ctcagacttt tgagcagtgt gaaacccaag
      541 acaggagaga agagtagaga tgatgctttg gaagccataa aaggaaattt agatgggttt
      601 tccagagatg caaaaatgca ccctactcca gcatcgcacc ccaagaaacc aggcccttcc
      661 ttggaggaga agttcctagt atcttgtgat ataagtacat ctgggcagga acaaattaaa
      721 ttaaatactt ctgaagttgg ccacaaagcc ctaggcccag gttccagtaa gaagtatccc
      781 agtttaatgg ccagtaacgg ggttgctgta gatggatgtg taagtggtac caccactgca
      841 gaggcagaaa atacttcaga tcaaaacctg tcaattgaag agagtggtgt gggagtattt
      901 ccctcacagg atcctgctca gcccagaatg cctccttgga tttacaatga gagtttggtt
      961 ccagatgcct ataagaaaat cttagaaacc acaatgactc caactggaat agatactgcc
     1021 aaactgtatc ccattctgat gtcatctggg cttcccaggg aaactcttgg acagatatgg
     1081 gccttagcta atcgaactac acctggcaaa cttacaaaag aagaacttta taccgttcta
     1141 gccatgatag cggtaacaca gaggggcgtt cctgcaatga gtcctgatgc tttaaaccag
     1201 ttcccagcag ctcctattcc aactttaagt ggcttttcta tgactctgcc tacaccggtg
     1261 agtcagccaa ctgtgatacc ttcaggtcct gcgggctcca tgcccctcag ccttggacag
     1321 ccagtcatgg gcattaacct tgttggacca gtgggtggag ctgcagccca ggcttctagt
     1381 ggtttcatac caacctaccc tgcaaatcag gtagtaaagc cagaagaaga tgacttccag
     1441 gattttcaag atgcttctaa gtcaggatcc cttgatgact cattcagtga tttccaagag
     1501 ttgcctgctt cttcaaaaac aagtaactcc cagcatggaa acagtgcccc ttctttgttg
     1561 atgccacttc ctggaactaa agcattgcct tcaatggaca aatatgctgt gtttaaagga
     1621 attgcagctg acaagtcctc tgaaaatact gttccacctg gagatcctgg tgataaatat
     1681 agtgctttca gagaacttga acagacagca gagaataaac ctttaggaga aagctttgca
     1741 gaattcagat ctgcaggaac tgatgatggt ttcaccgatt ttaaaacagc cgatagtgta
     1801 tcaccactag agccaccaac aaaagacaaa acttttccac catccttccc ctcaggaact
     1861 atacaacaga aacaacaaac acaagtgaaa aaccctctga acttagcaga cctagatatg
     1921 ttttcctcag ttaattgcag cagcgagaaa ccattgtctt tttcagctgt gtttagcaca
     1981 tcaaaatcag tttctacacc acagtcaaca ggttctgctg ctactatgac agcattggca
     2041 gcaacaaaaa cttctagttt ggctgatgat tttggagaat tcagcctttt tggggaatat
     2101 tctggtctag cacctgttgg ggagcaggat gactttgcag attttatggc tttcagtaat
     2161 agctctattt catctgagca aaagccggat gacaaatatg atgcccttaa agaggaagcc
     2221 agtcctgttc ctctaaccag caacgtgggc agcacagtga agggtggaca aaactcgact
     2281 gctgcgtcta ccaagtacga tgtcttcaga caactttctc tggaagggtc tggactaggt
     2341 gttgaagacc tgaaagataa cactccttca ggaaaaagtg atgatgattt tgctgacttc
     2401 cactccagta aattttcttc cataaactcg gacaaatccc tgggagagaa agcagtggct
     2461 ttcagacaca ccaaagaaga ctctgcatca gtgaagtcct tagatctccc ttccattggt
     2521 ggcagcagtg ttggcaagga ggactctgaa gatgcactct ctgttcagtt tgacatgaaa
     2581 ttggctgatg tgggaggaga tcttaagcat gtcatgtctg atagctcttt ggatttacca
     2641 acagttagtg gccagcatcc tcctgctgca gatatagagg acttaaaata tgctgctttt
     2701 ggaagctaca gtagcaattt tgcagtgagc acacttacaa gctatgactg gtcagacagg
     2761 gatgatgcaa ctcagggcag aaaactctct ccatttgtcc tctcagcagg aagtggatcc
     2821 ccctcagcca cctcaattct tcaaaagaaa gagacttcat ttggcagttc tgaaaacatc
     2881 accatgacat ctctctccaa agtaacgacc tttgtaagtg aagatgctct tccagagacc
     2941 accttcccag ctcttgccag ttttaaagac acgattcctc agaccagtga gcaaaaggaa
     3001 tatgaaaaca gagactataa agatttcaca aaacaggacc tgcctacggc tgaacggagc
     3061 caggaggcca cgtgtcccag cccagcgtcc agtggtgcct ctcaagaaac cccgaacgaa
     3121 tgttcggatg actttggaga gtttcaaagt gaaaagccca aaatcagcaa atttgacttc
     3181 ttagtagcca cttcacaaag caaaatgaaa tccagtgaag aaatgatcaa aagtgagctg
     3241 gcaacctttg acctttctgt tcaaggatca cacaagagga gtttgagcct tggtgataaa
     3301 gaaataagcc gttcttctcc ttctccagct ttggagcagc ctttcagaga ccgttccaat
     3361 actctgaatg agaagcccgc cctgcccgtc atccgagaca agtacaaaga cctgacggga
     3421 gaggtggagg aaaatgagag atatgcatat gaatggcaga gatgcctggg gagtgccctg
     3481 aatgtcatta agaaggcaaa tgatacctta aatggaatca gtagtagttc tgtttgcaca
     3541 gaagtaattc agtcagctca aggcatggaa tatttattag gtgttgttga agtgtacagg
     3601 gtaaccaagc gtgtggagct ggggataaaa gccactgcag tgtgcagtga gaaactccag
     3661 cagttgctga aggacatcga taaagtatgg aataacctaa tcggcttcat gtcactcgcc
     3721 acactcacac cagatgaaaa ctcgctggat ttttcctcct gtatgttacg gcctgggatt
     3781 aaaaatgctc aggagcttgc ctgtggagtg tgcctcttga atgtggactc gaggagccgg
     3841 aaagaagaga agcctgcaga agaacatcct aaaaaagcat tcaactcaga aacagacagt
     3901 ttcaagctgg cctatggagg gcaccagtat cacgccagct gtgccaactt ctggatcaac
     3961 tgtgtcgaac caaagcctcc tggcctcgtc ctgcctgacc tgctctgaac aactcctctg
     4021 tgaagcattg actttttttt ttctgtgaca ccccacgggg tgacagggac caataaatag
     4081 aatgcgagca ctgcacagtt cgcttccctg aatcgatatg aagaacaccg caagggacgg
     4141 ggcccccgtc atccccacgg ccagtctgca ggacttcagg taaaattgtc ccacccaaac
     4201 tgcacgtggc accagaagct tgctcactta tctctactta agattttctg aaatacggac
     4261 cacggctttc ttgatctaag gaagaacttg ctgctgcagt attgaaactg tgaagaactg
     4321 acatttgaag aaaaatagat taccgttgcg ggactagaat gggcgactgc ttggagccag
     4381 tgcttgtttt tatctaggac acttactgtc ctgtgaagta gaatacattt atctgcattt
     4441 agtttgttaa tgtctgaaat gaataaaaag aggaaattgc gattaaactg atgttctgct
     4501 ttttatggag aagattctgc ccatctcccc tggacagtag caggcaggtg agggcagatt
     4561 ttacccactt ggttgtcaca actgaaccag ttctctactc cttcccttca cttctgtcca
     4621 ctctcaagac tttttcccaa aacatgcctg ggcactctgc agccgtgaag aatgctcatt
     4681 ttgacagagg cccaaatcct gtgtattagg ataatatcct tccccccggg agccttcgct
     4741 gcaaacctgt tctgccgcat gcaaagactg tgaccatgga gttttctcag acaagatttg
     4801 gaaaggcagt ggaatgaaat ctctttgcag tggcctctct ccaaatttcc aaagatgact
     4861 gcatagggac caacactgcc tgactttgca gtatctgtga gaaaaacctg aaaattaatt
     4921 cagggtgaaa atgtggagct ctcggcctag tgtaaagtat caagatgtat atttatggga
     4981 tagatacatg acttagaaga agtagaagaa aattgtccag aaacagtact gaattttaga
     5041 tagaaaaggc tcatgcttcc tggagtaggg aattgtcttt gccatttaat gtgaatgcat
     5101 aaaattaggg gaaaaaccca agtggctaag agctgtgtta ttcctgggaa gaactaccaa
     5161 tctagggcac acgtctctct gaattgttga ttatgcgctt tatgaagaga tttttcaatc
     5221 tcgtgtgctt tactttgtgt ggtttagacc ctctgaccta gacttttatt tttaaactga
     5281 aaaagttggt cttgtctata taattgctgc ttttacataa tttattttcc cctctcagga
     5341 caaattctgt cttgctccat cttacagctt ttccatgttc tccaagaaag gtgtggaaca
     5401 ttttcattaa acagctgttg ctgaggcttc tgcttgacct tctgcgtgcc cgaatgcaca
     5461 gagaggcacc gaggagagaa aggcttttct cactcgctcc cgatgatacc gtctctggcc
     5521 attcctgact gaggcagctc actctgaatg ggcacctttg gagcttttgc ccaccacaag
     5581 gctagtgggg tgtttctaac aacacaagtg ggacagcttt tggcaggctt ttcctgaggc
     5641 ctcggcgctt ccatcctgga cagcaccact tccacatgga gctggaatgc aagcaggctg
     5701 ctaattggcc ttaaaaattc tttgtttttt tttgagatgg agtttcactc ttgttgccca
     5761 ggcttgagtg caatggcaca atctcagctc agtgcaacct ccgcctcccg ggttcaagcg
     5821 attctcctgc ctcagcctcg tgagtagctg ggattacagg cgtgcaccac cacgcccagc
     5881 taattttgta tttttagtag aggcaaggtt tctccatgtt ggccaggctt gaactccgga
     5941 cctcaggcga tccgcccgcc tcagcctccc aaagtaccgg gattacaggc gtgagccact
     6001 gcgcctggcc taaatttcat aacagaacca tgacagcaga atctaccttt gcaataagaa
     6061 tgtttcccag gagttagaga ccagccctgg gcatgatggt aaagacccca gctaattata
     6121 caaaaaataa ttagccgggt aggtggagtg catctgtgga cattcgtggt cccagctact
     6181 aggtaagctg aggcgggaga tcacaagtcc aggagtttga ggctgcacgt gacagcgtag
     6241 gtgatgacag agcgagacac tgtctcttaa aaaaaaaaaa aaaaaagttt cccagtttga
     6301 atttgtattg ctgaagcatt tttttgaaat gctatataga tgcctgtcat gtcacagtgg
     6361 cccagtatca acattttaaa aagctcactt ggtagctggg ctggtttcta ttcctgagaa
     6421 attccagaat gcctcagata aaattcctta gtataatccc cattttcctt accaaggatg
     6481 gtaggcttag tcactccttg ggaggtgcca caggaaaatt cagcagatgt caacagaaaa
     6541 aaagcctttg ctatgaaaag tattcactac ctttcatatc tcttgaatac ttgaaatgtt
     6601 taattagatg ccaccaatag ggatccaagg agtgtgggac acggttgcgc tgcttttctt
     6661 tataaacgtt tattaaaatg gctcaacgct gcattcagct tcacctcagc tcttcttgtc
     6721 agccaggagc cccgtgtcct tggaaactgt agccaaggtt acttatttcc atactgtgca
     6781 ttgtgtcagc ccgcttcacc ccactgcttg aatggccatt aataagcact tttctttttt
     6841 tggtgggatg ttttgccttt aaaattttta tggcttagtg tgtaatttaa tttttgtctg
     6901 gacatgcttg agatagaaga ggtactggat atatgaggat attttccatg ctttattttt
     6961 cctgtggcta ctagttagca ttccataggg gttgtgaatt tttaattatt tgaatatttt
     7021 gtgtacatat acatatttga agggttttgg gggggtctta tttgtttaaa ggtgtcttct
     7081 gtttgcctat ttcaagtgta cttcagcttt gcaaagatta tagggctgta tgttacagaa
     7141 ataggaaatg ctggccctgt actggggacc actacaaaaa ttccctttag ccgggcgtgg
     7201 tggctcacgc ctgtaatccc cagcactttg ggaggccgag ccgggtggat cacccgaggt
     7261 caggagttca agaccagcct ggccaacatg gcgagaccct gtctctacta aaaatacaaa
     7321 aattagctgg gcatggtggc aggtgcctgt aatccgagct actcgggagg ctgaggcagg
     7381 agaattgctt gaaccagaga ggcggaggtt gcagtgagcc gagatcgcgc cactgcactc
     7441 cagcctgggc aacaagagcg aaactctgtc tcaaaaataa aaaattccct ttaacacctt
     7501 caaggtcaaa tgcctgcctt tgtgaacagt taataaactg acattttcag acatttgcca
     7561 ttcagaaggg agcattgtag cctgctgtag accattccag caaatgtcag aatgcagggc
     7621 aagatgtgtg tcgactatgt tttttatgtt taagttactt acttatttct tcaggtaagt
     7681 gtgtaccaaa taacaatact gaaaagccct ccccttgcca ggccgaggaa ataaagctta
     7741 agtgaaacag ctcttggggg aaaaatgcca ctttacaaat acttttctaa caaaatagca
     7801 ttataatgaa gtttttactt aattccatta tttatatgtt gacgtgaatg taagtggtta
     7861 aaaagtattc atgtgggaca tctcattact ttgtagctgt ggctttatta accagtgaat
     7921 gctgtggccc ttagcgaaat gcgttgtctt ctgcgtgatg tggaattcgc gcctgtattt
     7981 taaaagatgg tgtggtttct cccttgtttg tattttaata aacaactgct ctaattgatg
     8041 tgtttagaca ttataaagct ttacctttaa aatattttca gggtctgttc tgaaatcacc
     8101 ccttgttaaa cttctctaac caaaatacaa gtgtagaaga a
//
