LOCUS       NM_001405103            8513 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens synergin gamma (SYNRG), transcript variant 8, mRNA.
ACCESSION   NM_001405103 XM_017024076
VERSION     NM_001405103.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8513)
  AUTHORS   Ayaz,A., Uzunhan,T.A. and Aydin,K.
  TITLE     Interacting with AP1 complex mutated synergin gamma (SYNRG) reveals
            a novel coatopathy in the form of complicated hereditary spastic
            paraplegia
  JOURNAL   Brain Dev 44 (5), 329-335 (2022)
   PUBMED   35090779
  REMARK    GeneRIF: Interacting with AP1 complex mutated synergin gamma
            (SYNRG) reveals a novel coatopathy in the form of complicated
            hereditary spastic paraplegia.
REFERENCE   2  (bases 1 to 8513)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 8513)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8513)
  AUTHORS   Pharoah,P.D., Tsai,Y.Y., Ramus,S.J., Phelan,C.M., Goode,E.L.,
            Lawrenson,K., Buckley,M., Fridley,B.L., Tyrer,J.P., Shen,H.,
            Weber,R., Karevan,R., Larson,M.C., Song,H., Tessier,D.C., Bacot,F.,
            Vincent,D., Cunningham,J.M., Dennis,J., Dicks,E., Aben,K.K.,
            Anton-Culver,H., Antonenkova,N., Armasu,S.M., Baglietto,L.,
            Bandera,E.V., Beckmann,M.W., Birrer,M.J., Bloom,G., Bogdanova,N.,
            Brenton,J.D., Brinton,L.A., Brooks-Wilson,A., Brown,R., Butzow,R.,
            Campbell,I., Carney,M.E., Carvalho,R.S., Chang-Claude,J.,
            Chen,Y.A., Chen,Z., Chow,W.H., Cicek,M.S., Coetzee,G., Cook,L.S.,
            Cramer,D.W., Cybulski,C., Dansonka-Mieszkowska,A., Despierre,E.,
            Doherty,J.A., Dork,T., du Bois,A., Durst,M., Eccles,D., Edwards,R.,
            Ekici,A.B., Fasching,P.A., Fenstermacher,D., Flanagan,J., Gao,Y.T.,
            Garcia-Closas,M., Gentry-Maharaj,A., Giles,G., Gjyshi,A., Gore,M.,
            Gronwald,J., Guo,Q., Halle,M.K., Harter,P., Hein,A., Heitz,F.,
            Hillemanns,P., Hoatlin,M., Hogdall,E., Hogdall,C.K., Hosono,S.,
            Jakubowska,A., Jensen,A., Kalli,K.R., Karlan,B.Y., Kelemen,L.E.,
            Kiemeney,L.A., Kjaer,S.K., Konecny,G.E., Krakstad,C.,
            Kupryjanczyk,J., Lambrechts,D., Lambrechts,S., Le,N.D., Lee,N.,
            Lee,J., Leminen,A., Lim,B.K., Lissowska,J., Lubinski,J.,
            Lundvall,L., Lurie,G., Massuger,L.F., Matsuo,K., McGuire,V.,
            McLaughlin,J.R., Menon,U., Modugno,F., Moysich,K.B., Nakanishi,T.,
            Narod,S.A., Ness,R.B., Nevanlinna,H., Nickels,S., Noushmehr,H.,
            Odunsi,K., Olson,S., Orlow,I., Paul,J., Pejovic,T., Pelttari,L.M.,
            Permuth-Wey,J., Pike,M.C., Poole,E.M., Qu,X., Risch,H.A.,
            Rodriguez-Rodriguez,L., Rossing,M.A., Rudolph,A., Runnebaum,I.,
            Rzepecka,I.K., Salvesen,H.B., Schwaab,I., Severi,G., Shen,H.,
            Shridhar,V., Shu,X.O., Sieh,W., Southey,M.C., Spellman,P.,
            Tajima,K., Teo,S.H., Terry,K.L., Thompson,P.J., Timorek,A.,
            Tworoger,S.S., van Altena,A.M., van den Berg,D., Vergote,I.,
            Vierkant,R.A., Vitonis,A.F., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wik,E., Winterhoff,B., Woo,Y.L., Wu,A.H.,
            Yang,H.P., Zheng,W., Ziogas,A., Zulkifli,F., Goodman,M.T., Hall,P.,
            Easton,D.F., Pearce,C.L., Berchuck,A., Chenevix-Trench,G.,
            Iversen,E., Monteiro,A.N., Gayther,S.A., Schildkraut,J.M. and
            Sellers,T.A.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat Genet 45 (4), 362-370 (2013)
   PUBMED   23535730
REFERENCE   5  (bases 1 to 8513)
  AUTHORS   Turner,S.T., Bailey,K.R., Schwartz,G.L., Chapman,A.B., Chai,H.S.
            and Boerwinkle,E.
  TITLE     Genomic association analysis identifies multiple loci influencing
            antihypertensive response to an angiotensin II receptor blocker
  JOURNAL   Hypertension 59 (6), 1204-1211 (2012)
   PUBMED   22566498
REFERENCE   6  (bases 1 to 8513)
  AUTHORS   Kent,H.M., McMahon,H.T., Evans,P.R., Benmerah,A. and Owen,D.J.
  TITLE     Gamma-adaptin appendage domain: structure and binding site for
            Eps15 and gamma-synergin
  JOURNAL   Structure 10 (8), 1139-1148 (2002)
   PUBMED   12176391
REFERENCE   7  (bases 1 to 8513)
  AUTHORS   Nogi,T., Shiba,Y., Kawasaki,M., Shiba,T., Matsugaki,N.,
            Igarashi,N., Suzuki,M., Kato,R., Takatsu,H., Nakayama,K. and
            Wakatsuki,S.
  TITLE     Structural basis for the accessory protein recruitment by the
            gamma-adaptin ear domain
  JOURNAL   Nat Struct Biol 9 (7), 527-531 (2002)
   PUBMED   12042876
REFERENCE   8  (bases 1 to 8513)
  AUTHORS   Takatsu,H., Yoshino,K. and Nakayama,K.
  TITLE     Adaptor gamma ear homology domain conserved in gamma-adaptin and
            GGA proteins that interact with gamma-synergin
  JOURNAL   Biochem Biophys Res Commun 271 (3), 719-725 (2000)
   PUBMED   10814529
REFERENCE   9  (bases 1 to 8513)
  AUTHORS   Page,L.J., Sowerby,P.J., Lui,W.W. and Robinson,M.S.
  TITLE     Gamma-synergin: an EH domain-containing protein that interacts with
            gamma-adaptin
  JOURNAL   J Cell Biol 146 (5), 993-1004 (1999)
   PUBMED   10477754
REFERENCE   10 (bases 1 to 8513)
  AUTHORS   Peyrard,M., Parveneh,S., Lagercrantz,S., Ekman,M., Fransson,I.,
            Sahlen,S. and Dumanski,J.P.
  TITLE     Cloning, expression pattern, and chromosomal assignment to 16q23 of
            the human gamma-adaptin gene (ADTG)
  JOURNAL   Genomics 50 (2), 275-280 (1998)
   PUBMED   9653655
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243585.2.
            
            On Apr 20, 2022 this sequence version replaced XM_017024076.2.
            
            Summary: This gene encodes a protein that interacts with the gamma
            subunit of AP1 clathrin-adaptor complex. The AP1 complex is located
            at the trans-Golgi network and associates specific proteins with
            clathrin-coated vesicles. This encoded protein may act to connect
            the AP1 complex to other proteins. Alternatively spliced transcript
            variants that encode different isoforms have been described for
            this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.969193.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC243585.2         140969-141108       c
            141-181             AC243585.2         132053-132093       c
            182-303             AC243585.2         127913-128034       c
            304-434             AC243585.2         118109-118239       c
            435-540             AC243585.2         117015-117120       c
            541-652             AC243585.2         116338-116449       c
            653-955             AC243585.2         110822-111124       c
            956-1189            AC243585.2         109070-109303       c
            1190-1267           AC243585.2         108031-108108       c
            1268-1464           AC243585.2         103481-103677       c
            1465-1713           AC243585.2         102327-102575       c
            1714-1847           AC243585.2         100481-100614       c
            1848-1966           AC243585.2         93161-93279         c
            1967-2029           AC243585.2         92885-92947         c
            2030-2974           AC243585.2         84805-85749         c
            2975-3568           AC243585.2         73662-74255         c
            3569-3732           AC243585.2         72070-72233         c
            3733-3786           AC243585.2         70882-70935         c
            3787-3883           AC243585.2         70014-70110         c
            3884-4032           AC243585.2         67669-67817         c
            4033-4101           AC243585.2         61473-61541         c
            4102-4212           AC243585.2         52228-52338         c
            4213-4248           AC243585.2         51869-51904         c
            4249-8513           AC243585.2         46497-50761         c
FEATURES             Location/Qualifiers
     source          1..8513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..8513
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="synergin gamma"
                     /db_xref="GeneID:11276"
                     /db_xref="HGNC:HGNC:557"
                     /db_xref="MIM:607291"
     exon            1..140
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..4380
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="isoform 8 is encoded by transcript variant 8;
                     gamma-synergin; AP1 gamma subunit binding protein 1;
                     adaptor-related protein complex 1 gamma subunit-binding
                     protein 1; AP1 subunit gamma-binding protein 1"
                     /codon_start=1
                     /product="synergin gamma isoform 8"
                     /protein_id="NP_001392032.1"
                     /db_xref="GeneID:11276"
                     /db_xref="HGNC:HGNC:557"
                     /db_xref="MIM:607291"
                     /translation="MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMP
                     MQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAAGMPYLGQAPFL
                     GMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKT
                     GEKSRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPDCPTSSHSTKTVSPSPAFLDEE
                     EFSDFMQGPVEVPPCGPSSTSQPFQSFHPSTPLGQLHTQKAGTQPLPPSQSPVPFALH
                     GVPGQIPYFSTASASHSVPEAGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPG
                     SSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPP
                     WIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGK
                     LTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPS
                     GPAGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTYPANQVVKPEEDDFQDFQDAS
                     KSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAAD
                     KSSENTVPPGDPGDKYSAFRELEQTAENKPLGESFAEFRSAGTDDGFTDFKTADSVSP
                     LEPPTKDKTFPPSFPSGTIQQKQQTQVKNPLNLADLDMFSSVNCSSEKPLSFSAVFST
                     SKSVSTPQSTGSAATMTALAATKTSSLADDFGEFSLFGEYSGLAPVGEQDDFADFMAF
                     SNSSISSEQKPDDKYDALKEEASPVPLTSNVGSTVKGGQNSTAASTKYDVFRQLSLEG
                     SGLGVEDLKDNTPSGKSDDDFADFHSSKFSSINSDKSLGEKAVAFRHTKEDSASVKSL
                     DLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAADI
                     EDLKYAAFGSYSSNFAVSTLTSYDWSDRDDATQGRKLSPFVLSAGSGSPSATSILQKK
                     ETSFGSSENITMTSLSKVTTFVSEDALPETTFPALASFKDTIPQTSEQKEYENRDYKD
                     FTKQDLPTAERSQEATCPSPASSGASQETPNECSDDFGEFQSEKPKISKFDFLVATSQ
                     SKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLNE
                     KPALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALNVIKKANDTLNGISSSSVCTEV
                     IQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLA
                     TLTCCWEKMTVITKHLSPYHELLEEKPDENSLDFSSCMLRPGIKNAQELACGVCLLNV
                     DSRSRKEEKPAEEHPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLVLPD
                     LL"
     exon            141..181
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            182..303
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            304..434
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            435..540
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            541..652
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            653..955
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1189
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1267
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1464
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1713
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1847
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1966
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2029
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2974
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3568
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3732
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3786
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3883
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..4032
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4101
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4212
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4248
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..8513
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4834..4839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: AATAAA"
     polyA_site      4859
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="major polyA site"
     regulatory      8389..8394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: AATAAA"
     polyA_site      8410
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="major polyA site"
     regulatory      8424..8429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: TATAAA"
     polyA_site      8446
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
     regulatory      8496..8501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
                     /note="hexamer: AATACA"
     polyA_site      8513
                     /gene="SYNRG"
                     /gene_synonym="AP1GBP1; SYNG"
ORIGIN      
        1 gtgttcagct gacagctgct gataaggtgg cggcggcgaa ggcagcggca ggtcgggagc
       61 aagatggcgc tgcggccagg agctggttct ggtggcggcg gggccgcggg agctggcgcg
      121 gggtccgccg ggggaggcgg cttcatgttt cctgttgcag gtgggataag accccctcaa
      181 gcaggcctga tgccgatgca gcaacaagga tttcctatgg tctctgtcat gcagcctaat
      241 atgcaaggca ttatgggaat gaattacagc tctcagatgt cccaaggacc tattgctatg
      301 caggcaggaa taccaatggg accaatgcca gcagcgggaa tgccttacct aggacaagca
      361 cccttcctgg gcatgcgtcc tccaggccca cagtacactc cagacatgca gaagcagttt
      421 gccgaagagc agcagaaacg atttgaacag cagcaaaaac tcttagaaga agaaagaaaa
      481 agacgccagt ttgaagagca gaagcaaaag ctcagacttt tgagcagtgt gaaacccaag
      541 acaggagaga agagtagaga tgatgctttg gaagccataa aaggaaattt agatgggttt
      601 tccagagatg caaaaatgca ccctactcca gcatcgcacc ccaagaaacc agattgcccc
      661 acatcatctc attctactaa aactgtctcc ccatcacctg cctttcttga tgaagaagaa
      721 ttcagtgact ttatgcaggg gcctgttgaa gttcccccat gtgggccttc ttccacgtcc
      781 cagccctttc agtctttcca cccctccacc ccacttggcc agttgcatac acagaaggct
      841 gggacacagc ctctccctcc aagtcagagt ccagtgcctt ttgccttaca tggcgtccct
      901 gggcaaattc cttacttctc tactgcttca gcctcacaca gtgtaccaga agcaggccct
      961 tccttggagg agaagttcct agtatcttgt gatataagta catctgggca ggaacaaatt
     1021 aaattaaata cttctgaagt tggccacaaa gccctaggcc caggttccag taagaagtat
     1081 cccagtttaa tggccagtaa cggggttgct gtagatggat gtgtaagtgg taccaccact
     1141 gcagaggcag aaaatacttc agatcaaaac ctgtcaattg aagagagtgg tgtgggagta
     1201 tttccctcac aggatcctgc tcagcccaga atgcctcctt ggatttacaa tgagagtttg
     1261 gttccagatg cctataagaa aatcttagaa accacaatga ctccaactgg aatagatact
     1321 gccaaactgt atcccattct gatgtcatct gggcttccca gggaaactct tggacagata
     1381 tgggccttag ctaatcgaac tacacctggc aaacttacaa aagaagaact ttataccgtt
     1441 ctagccatga tagcggtaac acagaggggc gttcctgcaa tgagtcctga tgctttaaac
     1501 cagttcccag cagctcctat tccaacttta agtggctttt ctatgactct gcctacaccg
     1561 gtgagtcagc caactgtgat accttcaggt cctgcgggct ccatgcccct cagccttgga
     1621 cagccagtca tgggcattaa ccttgttgga ccagtgggtg gagctgcagc ccaggcttct
     1681 agtggtttca taccaaccta ccctgcaaat caggtagtaa agccagaaga agatgacttc
     1741 caggattttc aagatgcttc taagtcagga tcccttgatg actcattcag tgatttccaa
     1801 gagttgcctg cttcttcaaa aacaagtaac tcccagcatg gaaacagtgc cccttctttg
     1861 ttgatgccac ttcctggaac taaagcattg ccttcaatgg acaaatatgc tgtgtttaaa
     1921 ggaattgcag ctgacaagtc ctctgaaaat actgttccac ctggagatcc tggtgataaa
     1981 tatagtgctt tcagagaact tgaacagaca gcagagaata aacctttagg agaaagcttt
     2041 gcagaattca gatctgcagg aactgatgat ggtttcaccg attttaaaac agccgatagt
     2101 gtatcaccac tagagccacc aacaaaagac aaaacttttc caccatcctt cccctcagga
     2161 actatacaac agaaacaaca aacacaagtg aaaaaccctc tgaacttagc agacctagat
     2221 atgttttcct cagttaattg cagcagcgag aaaccattgt ctttttcagc tgtgtttagc
     2281 acatcaaaat cagtttctac accacagtca acaggttctg ctgctactat gacagcattg
     2341 gcagcaacaa aaacttctag tttggctgat gattttggag aattcagcct ttttggggaa
     2401 tattctggtc tagcacctgt tggggagcag gatgactttg cagattttat ggctttcagt
     2461 aatagctcta tttcatctga gcaaaagccg gatgacaaat atgatgccct taaagaggaa
     2521 gccagtcctg ttcctctaac cagcaacgtg ggcagcacag tgaagggtgg acaaaactcg
     2581 actgctgcgt ctaccaagta cgatgtcttc agacaacttt ctctggaagg gtctggacta
     2641 ggtgttgaag acctgaaaga taacactcct tcaggaaaaa gtgatgatga ttttgctgac
     2701 ttccactcca gtaaattttc ttccataaac tcggacaaat ccctgggaga gaaagcagtg
     2761 gctttcagac acaccaaaga agactctgca tcagtgaagt ccttagatct cccttccatt
     2821 ggtggcagca gtgttggcaa ggaggactct gaagatgcac tctctgttca gtttgacatg
     2881 aaattggctg atgtgggagg agatcttaag catgtcatgt ctgatagctc tttggattta
     2941 ccaacagtta gtggccagca tcctcctgct gcagatatag aggacttaaa atatgctgct
     3001 tttggaagct acagtagcaa ttttgcagtg agcacactta caagctatga ctggtcagac
     3061 agggatgatg caactcaggg cagaaaactc tctccatttg tcctctcagc aggaagtgga
     3121 tccccctcag ccacctcaat tcttcaaaag aaagagactt catttggcag ttctgaaaac
     3181 atcaccatga catctctctc caaagtaacg acctttgtaa gtgaagatgc tcttccagag
     3241 accaccttcc cagctcttgc cagttttaaa gacacgattc ctcagaccag tgagcaaaag
     3301 gaatatgaaa acagagacta taaagatttc acaaaacagg acctgcctac ggctgaacgg
     3361 agccaggagg ccacgtgtcc cagcccagcg tccagtggtg cctctcaaga aaccccgaac
     3421 gaatgttcgg atgactttgg agagtttcaa agtgaaaagc ccaaaatcag caaatttgac
     3481 ttcttagtag ccacttcaca aagcaaaatg aaatccagtg aagaaatgat caaaagtgag
     3541 ctggcaacct ttgacctttc tgttcaagga tcacacaaga ggagtttgag ccttggtgat
     3601 aaagaaataa gccgttcttc tccttctcca gctttggagc agcctttcag agaccgttcc
     3661 aatactctga atgagaagcc cgccctgccc gtcatccgag acaagtacaa agacctgacg
     3721 ggagaggtgg aggaaaatga gagatatgca tatgaatggc agagatgcct ggggagtgcc
     3781 ctgaatgtca ttaagaaggc aaatgatacc ttaaatggaa tcagtagtag ttctgtttgc
     3841 acagaagtaa ttcagtcagc tcaaggcatg gaatatttat taggtgttgt tgaagtgtac
     3901 agggtaacca agcgtgtgga gctggggata aaagccactg cagtgtgcag tgagaaactc
     3961 cagcagttgc tgaaggacat cgataaagta tggaataacc taatcggctt catgtcactc
     4021 gccacactca catgctgctg ggaaaagatg actgtgatta caaagcatct ctctccttac
     4081 catgagctct tagaagaaaa gccagatgaa aactcgctgg atttttcctc ctgtatgtta
     4141 cggcctggga ttaaaaatgc tcaggagctt gcctgtggag tgtgcctctt gaatgtggac
     4201 tcgaggagcc ggaaagaaga gaagcctgca gaagaacatc ctaaaaaagc attcaactca
     4261 gaaacagaca gtttcaagct ggcctatgga gggcaccagt atcacgccag ctgtgccaac
     4321 ttctggatca actgtgtcga accaaagcct cctggcctcg tcctgcctga cctgctctga
     4381 acaactcctc tgtgaagcat tgactttttt ttttctgtga caccccacgg ggtgacaggg
     4441 accaataaat agaatgcgag cactgcacag ttcgcttccc tgaatcgata tgaagaacac
     4501 cgcaagggac ggggcccccg tcatccccac ggccagtctg caggacttca ggtaaaattg
     4561 tcccacccaa actgcacgtg gcaccagaag cttgctcact tatctctact taagattttc
     4621 tgaaatacgg accacggctt tcttgatcta aggaagaact tgctgctgca gtattgaaac
     4681 tgtgaagaac tgacatttga agaaaaatag attaccgttg cgggactaga atgggcgact
     4741 gcttggagcc agtgcttgtt tttatctagg acacttactg tcctgtgaag tagaatacat
     4801 ttatctgcat ttagtttgtt aatgtctgaa atgaataaaa agaggaaatt gcgattaaac
     4861 tgatgttctg ctttttatgg agaagattct gcccatctcc cctggacagt agcaggcagg
     4921 tgagggcaga ttttacccac ttggttgtca caactgaacc agttctctac tccttccctt
     4981 cacttctgtc cactctcaag actttttccc aaaacatgcc tgggcactct gcagccgtga
     5041 agaatgctca ttttgacaga ggcccaaatc ctgtgtatta ggataatatc cttccccccg
     5101 ggagccttcg ctgcaaacct gttctgccgc atgcaaagac tgtgaccatg gagttttctc
     5161 agacaagatt tggaaaggca gtggaatgaa atctctttgc agtggcctct ctccaaattt
     5221 ccaaagatga ctgcataggg accaacactg cctgactttg cagtatctgt gagaaaaacc
     5281 tgaaaattaa ttcagggtga aaatgtggag ctctcggcct agtgtaaagt atcaagatgt
     5341 atatttatgg gatagataca tgacttagaa gaagtagaag aaaattgtcc agaaacagta
     5401 ctgaatttta gatagaaaag gctcatgctt cctggagtag ggaattgtct ttgccattta
     5461 atgtgaatgc ataaaattag gggaaaaacc caagtggcta agagctgtgt tattcctggg
     5521 aagaactacc aatctagggc acacgtctct ctgaattgtt gattatgcgc tttatgaaga
     5581 gatttttcaa tctcgtgtgc tttactttgt gtggtttaga ccctctgacc tagactttta
     5641 tttttaaact gaaaaagttg gtcttgtcta tataattgct gcttttacat aatttatttt
     5701 cccctctcag gacaaattct gtcttgctcc atcttacagc ttttccatgt tctccaagaa
     5761 aggtgtggaa cattttcatt aaacagctgt tgctgaggct tctgcttgac cttctgcgtg
     5821 cccgaatgca cagagaggca ccgaggagag aaaggctttt ctcactcgct cccgatgata
     5881 ccgtctctgg ccattcctga ctgaggcagc tcactctgaa tgggcacctt tggagctttt
     5941 gcccaccaca aggctagtgg ggtgtttcta acaacacaag tgggacagct tttggcaggc
     6001 ttttcctgag gcctcggcgc ttccatcctg gacagcacca cttccacatg gagctggaat
     6061 gcaagcaggc tgctaattgg ccttaaaaat tctttgtttt tttttgagat ggagtttcac
     6121 tcttgttgcc caggcttgag tgcaatggca caatctcagc tcagtgcaac ctccgcctcc
     6181 cgggttcaag cgattctcct gcctcagcct cgtgagtagc tgggattaca ggcgtgcacc
     6241 accacgccca gctaattttg tatttttagt agaggcaagg tttctccatg ttggccaggc
     6301 ttgaactccg gacctcaggc gatccgcccg cctcagcctc ccaaagtacc gggattacag
     6361 gcgtgagcca ctgcgcctgg cctaaatttc ataacagaac catgacagca gaatctacct
     6421 ttgcaataag aatgtttccc aggagttaga gaccagccct gggcatgatg gtaaagaccc
     6481 cagctaatta tacaaaaaat aattagccgg gtaggtggag tgcatctgtg gacattcgtg
     6541 gtcccagcta ctaggtaagc tgaggcggga gatcacaagt ccaggagttt gaggctgcac
     6601 gtgacagcgt aggtgatgac agagcgagac actgtctctt aaaaaaaaaa aaaaaaaagt
     6661 ttcccagttt gaatttgtat tgctgaagca tttttttgaa atgctatata gatgcctgtc
     6721 atgtcacagt ggcccagtat caacatttta aaaagctcac ttggtagctg ggctggtttc
     6781 tattcctgag aaattccaga atgcctcaga taaaattcct tagtataatc cccattttcc
     6841 ttaccaagga tggtaggctt agtcactcct tgggaggtgc cacaggaaaa ttcagcagat
     6901 gtcaacagaa aaaaagcctt tgctatgaaa agtattcact acctttcata tctcttgaat
     6961 acttgaaatg tttaattaga tgccaccaat agggatccaa ggagtgtggg acacggttgc
     7021 gctgcttttc tttataaacg tttattaaaa tggctcaacg ctgcattcag cttcacctca
     7081 gctcttcttg tcagccagga gccccgtgtc cttggaaact gtagccaagg ttacttattt
     7141 ccatactgtg cattgtgtca gcccgcttca ccccactgct tgaatggcca ttaataagca
     7201 cttttctttt tttggtggga tgttttgcct ttaaaatttt tatggcttag tgtgtaattt
     7261 aatttttgtc tggacatgct tgagatagaa gaggtactgg atatatgagg atattttcca
     7321 tgctttattt ttcctgtggc tactagttag cattccatag gggttgtgaa tttttaatta
     7381 tttgaatatt ttgtgtacat atacatattt gaagggtttt gggggggtct tatttgttta
     7441 aaggtgtctt ctgtttgcct atttcaagtg tacttcagct ttgcaaagat tatagggctg
     7501 tatgttacag aaataggaaa tgctggccct gtactgggga ccactacaaa aattcccttt
     7561 agccgggcgt ggtggctcac gcctgtaatc cccagcactt tgggaggccg agccgggtgg
     7621 atcacccgag gtcaggagtt caagaccagc ctggccaaca tggcgagacc ctgtctctac
     7681 taaaaataca aaaattagct gggcatggtg gcaggtgcct gtaatccgag ctactcggga
     7741 ggctgaggca ggagaattgc ttgaaccaga gaggcggagg ttgcagtgag ccgagatcgc
     7801 gccactgcac tccagcctgg gcaacaagag cgaaactctg tctcaaaaat aaaaaattcc
     7861 ctttaacacc ttcaaggtca aatgcctgcc tttgtgaaca gttaataaac tgacattttc
     7921 agacatttgc cattcagaag ggagcattgt agcctgctgt agaccattcc agcaaatgtc
     7981 agaatgcagg gcaagatgtg tgtcgactat gttttttatg tttaagttac ttacttattt
     8041 cttcaggtaa gtgtgtacca aataacaata ctgaaaagcc ctccccttgc caggccgagg
     8101 aaataaagct taagtgaaac agctcttggg ggaaaaatgc cactttacaa atacttttct
     8161 aacaaaatag cattataatg aagtttttac ttaattccat tatttatatg ttgacgtgaa
     8221 tgtaagtggt taaaaagtat tcatgtggga catctcatta ctttgtagct gtggctttat
     8281 taaccagtga atgctgtggc ccttagcgaa atgcgttgtc ttctgcgtga tgtggaattc
     8341 gcgcctgtat tttaaaagat ggtgtggttt ctcccttgtt tgtattttaa taaacaactg
     8401 ctctaattga tgtgtttaga cattataaag ctttaccttt aaaatatttt cagggtctgt
     8461 tctgaaatca ccccttgtta aacttctcta accaaaatac aagtgtagaa gaa
//
