LOCUS       NM_001114133            4873 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens synaptopodin 2 like (SYNPO2L), transcript variant 1,
            mRNA.
ACCESSION   NM_001114133
VERSION     NM_001114133.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4873)
  AUTHORS   Wu,J., Ouyang,P., Huang,R., Cui,Y., Yang,Z., Xu,W., Ma,R.,
            Xiang,G., Zeng,W., Wu,W. and Li,J.
  TITLE     METTL16 Promotes Stability of SYNPO2L mRNA and leading to Cancer
            Cell Lung Metastasis by Secretion of COL10A1 and attract the
            Cancer-Associated Fibroblasts
  JOURNAL   Int J Biol Sci 20 (11), 4128-4145 (2024)
   PUBMED   39247832
  REMARK    GeneRIF: METTL16 Promotes Stability of SYNPO2L mRNA and leading to
            Cancer Cell Lung Metastasis by Secretion of COL10A1 and attract the
            Cancer-Associated Fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4873)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4873)
  AUTHORS   van Eldik,W., den Adel,B., Monshouwer-Kloots,J., Salvatori,D.,
            Maas,S., van der Made,I., Creemers,E.E., Frank,D., Frey,N.,
            Boontje,N., van der Velden,J., Steendijk,P., Mummery,C., Passier,R.
            and Beqqali,A.
  TITLE     Z-disc protein CHAPb induces cardiomyopathy and contractile
            dysfunction in the postnatal heart
  JOURNAL   PLoS One 12 (12), e0189139 (2017)
   PUBMED   29206857
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4873)
  AUTHORS   Lubitz,S.A., Brody,J.A., Bihlmeyer,N.A., Roselli,C., Weng,L.C.,
            Christophersen,I.E., Alonso,A., Boerwinkle,E., Gibbs,R.A.,
            Bis,J.C., Cupples,L.A., Mohler,P.J., Nickerson,D.A., Muzny,D.,
            Perez,M.V., Psaty,B.M., Soliman,E.Z., Sotoodehnia,N., Lunetta,K.L.,
            Benjamin,E.J., Heckbert,S.R., Arking,D.E., Ellinor,P.T. and Lin,H.
  CONSRTM   NHLBI GO Exome Sequencing Project
  TITLE     Whole Exome Sequencing in Atrial Fibrillation
  JOURNAL   PLoS Genet 12 (9), e1006284 (2016)
   PUBMED   27589061
  REMARK    GeneRIF: we did not observe associations between coding genetic
            variants and Atrial fibrillation (AF), suggesting that large-effect
            coding variation is not the predominant mechanism underlying AF. A
            coding variant in SYNPO2L requires further evaluation to determine
            whether it is causally related to AF
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4873)
  AUTHORS   Ellinor,P.T., Lunetta,K.L., Albert,C.M., Glazer,N.L., Ritchie,M.D.,
            Smith,A.V., Arking,D.E., Muller-Nurasyid,M., Krijthe,B.P.,
            Lubitz,S.A., Bis,J.C., Chung,M.K., Dorr,M., Ozaki,K., Roberts,J.D.,
            Smith,J.G., Pfeufer,A., Sinner,M.F., Lohman,K., Ding,J.,
            Smith,N.L., Smith,J.D., Rienstra,M., Rice,K.M., Van Wagoner,D.R.,
            Magnani,J.W., Wakili,R., Clauss,S., Rotter,J.I., Steinbeck,G.,
            Launer,L.J., Davies,R.W., Borkovich,M., Harris,T.B., Lin,H.,
            Volker,U., Volzke,H., Milan,D.J., Hofman,A., Boerwinkle,E.,
            Chen,L.Y., Soliman,E.Z., Voight,B.F., Li,G., Chakravarti,A.,
            Kubo,M., Tedrow,U.B., Rose,L.M., Ridker,P.M., Conen,D., Tsunoda,T.,
            Furukawa,T., Sotoodehnia,N., Xu,S., Kamatani,N., Levy,D.,
            Nakamura,Y., Parvez,B., Mahida,S., Furie,K.L., Rosand,J.,
            Muhammad,R., Psaty,B.M., Meitinger,T., Perz,S., Wichmann,H.E.,
            Witteman,J.C., Kao,W.H., Kathiresan,S., Roden,D.M.,
            Uitterlinden,A.G., Rivadeneira,F., McKnight,B., Sjogren,M.,
            Newman,A.B., Liu,Y., Gollob,M.H., Melander,O., Tanaka,T.,
            Stricker,B.H., Felix,S.B., Alonso,A., Darbar,D., Barnard,J.,
            Chasman,D.I., Heckbert,S.R., Benjamin,E.J., Gudnason,V. and Kaab,S.
  TITLE     Meta-analysis identifies six new susceptibility loci for atrial
            fibrillation
  JOURNAL   Nat Genet 44 (6), 670-675 (2012)
   PUBMED   22544366
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4873)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4873)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB188489.1 and AK022983.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001114133.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB188489.1, AK295873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142363 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394810.3/ ENSP00000378289.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3578              AB188489.1         46-3623
            3579-3580           AK022983.1         2822-2823
            3581-4873           AB188489.1         3624-4916
FEATURES             Location/Qualifiers
     source          1..4873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..4873
                     /gene="SYNPO2L"
                     /note="synaptopodin 2 like"
                     /db_xref="GeneID:79933"
                     /db_xref="HGNC:HGNC:23532"
     exon            1..212
                     /gene="SYNPO2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..3041
                     /gene="SYNPO2L"
                     /note="isoform a is encoded by transcript variant 1;
                     synaptopodin 2-like protein"
                     /codon_start=1
                     /product="synaptopodin 2-like protein isoform a"
                     /protein_id="NP_001107605.1"
                     /db_xref="CCDS:CCDS44438.1"
                     /db_xref="GeneID:79933"
                     /db_xref="HGNC:HGNC:23532"
                     /translation="MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGR
                     AGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQ
                     VLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRR
                     GPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEAL
                     LLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTK
                     CRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESE
                     LDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFE
                     QQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPF
                     QPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPP
                     FLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPE
                     PPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGIL
                     QEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAE
                     ACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVN
                     GAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPS
                     WKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQ
                     LKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATT
                     LDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRP
                     GAGHQ"
     exon            213..364
                     /gene="SYNPO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            365..879
                     /gene="SYNPO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            880..4873
                     /gene="SYNPO2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4855..4860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNPO2L"
                     /note="hexamer: AATAAA"
     polyA_site      4873
                     /gene="SYNPO2L"
                     /note="major polyA site"
ORIGIN      
        1 agcaggagca ggacagccgg acaggaagcc cagacggggt tcgagcacct caacttctct
       61 cctggggaca ctgttcaaac tccgggggcc ataggccaag ctgagcgatg ggtgctgagg
      121 aggaggtgct ggtcacacta tcagggggag ccccctgggg cttccgactt catggggggg
      181 ccgagcagag gaaaccgtta caggtgtcta agattcgaag acggagccag gctggcagag
      241 caggactccg agagagggac cagctcttgg caatcaatgg ggtctcttgc accaacctct
      301 cccatgccag tgccatgagc ctcatcgatg cctcaggaaa tcagcttgtc ctcactgtgc
      361 agcggttagc agacgagggt cctgtgcaat ctccatctcc ccatgagctt caggtgctgt
      421 cacccttatc tccactaagt cctgagcccc ctggtgctcc agttcctcag cctcttcagc
      481 ctgggagcct tcgttcacct cctgatagtg aggcttacta cggagagact gacagtgatg
      541 ctgatggccc tgccacccag gagaagcccc gtcgacctcg ccgccgaggc cccacaaggc
      601 ccacccctcc gggtgcccca cctgatgagg tctacctgtc tgacagccct gcagagccag
      661 cacctactat ccctggccct cccagccagg gtgacagccg tgtgagctcc ccgtcttggg
      721 aggatggggc agcccttcag ccacccccag ctgaggctct gctgttaccc catggccccc
      781 tccgacctgg tcctcatctc atccctatgg tggggcctgt tccccaccca gtggcagaag
      841 atcttactac cacctacacc cagaaggcca agcaagccaa actgcaacgt gcagagagcc
      901 tccaagagaa gagcataaaa gaggccaaga ccaaatgcag gacaattgca tccctgctca
      961 ctgcagcccc caacccccac tccaaagggg tacttatgtt taagaaacgg cggcagagag
     1021 ccaagaagta caccctggtg agcttcgggg ctgctgctgg gacaggcgct gaggaggagg
     1081 acggcgttcc ccccacgagt gagtccgagc tggacgaaga agccttctct gacgcccgca
     1141 gcctcaccaa tcaatctgac tgggacagtc cctatctgga catggagctt gccagggcgg
     1201 gctcaagagc atcagagggc cagggctctg ggctgggagg gcagctgagt gaggtctctg
     1261 ggcgaggggt gcagctcttt gaacagcagc gccagcgcgc agactccagc acccaggaac
     1321 tggcacgggt cgaaccagca gccatgctca acggggaagg cctgcagtca ccacctcggg
     1381 cccagagtgc tcccccagag gcagctgtgc tcccacccag ccccttgccg gcgcctgtag
     1441 ccagccccag acccttccaa ccaggtggtg gagccccgac cccagctcca agcatcttta
     1501 accggtcagc caggcccttt accccgggcc tacaagggca gcggccaact accacctcgg
     1561 ttattttccg gcctttagcc cccaaaaggg cgaacgacag cctggggggc ctcagccccg
     1621 ccccaccccc cttcttgtct tcgcaggggc ccacccctct gcccagcttc acttcagggg
     1681 ttcccagcca cgcgccagtc tctggttccc ccagcacccc acgctcctcg ggccctgtga
     1741 cagccaccag ctccctgtac atcccagccc ctagtcggcc tgtcacccca ggtggagctc
     1801 cagagccccc cgctcctcct agcgcagctg ccatgacctc caccgcttct atcttcctat
     1861 ctgcgccttt gcgaccctct gcgcgcccag aggcgcctgc cccaggccca ggggctcctg
     1921 agccccccag cgctcgcgag cagcgcatct ctgtgccagc tgcccgcacg ggtatcctgc
     1981 aggaggcccg gcgccggggg acccggaagc agatgttccg gccgggaaag gaggagacga
     2041 agaactcgcc caaccccgag ctgctatcgc tggtacagaa cctggatgaa aagcctcggg
     2101 ccgggggtgc agaatctggt cctgaagaag atgctctgag cctcggggct gaagcctgca
     2161 acttcatgca gccagtaggg gccaggagtt acaagaccct gcctcacgtg acacctaaga
     2221 ccccccctcc aatggctccc aagaccccgc cccctatgac tcctaagact ccacccccag
     2281 tggctcctaa gcccccatct cgagggctcc ttgatgggct cgtgaatggg gcagcctctt
     2341 cggctggaat ccctgagcca ccaaggctgc agggcagggg tggggagctg tttgctaagc
     2401 ggcagagccg tgcggacagg tatgtggtgg aaggtacacc tggtcctggt cttggccctc
     2461 ggcctagaag tccttctcct accccgtctc tgcccccttc ctggaaatat tcacccaaca
     2521 tccgtgcccc gcctcctatt gcttacaacc cactgctctc tccctttttc ccccaggcgg
     2581 cccgaactct ccctaaggcc caatcccagg ggcctcgggc aacacccaag cagggcatca
     2641 aggctctaga ttttatgcgg catcagccct atcaacttaa aactgccatg ttctgttttg
     2701 atgaggttcc cccgactcct ggccctatcg cctcagggtc ccccaaaact gcccgagtcc
     2761 aggagattcg ccggttttcc actccggcac cccagcccac tgcagaaccc ctggctccca
     2821 ctgtgcttgc cccccgagca gccactacac tggatgagcc catctggaga acagaactgg
     2881 cctcagcccc tgttcctagc ccagcccctc ctccagaggc tcccaggggc cttggggctt
     2941 ctcccagctc ctgcggtttc caggtagcca ggccccgatt ttcagccacc agaacaggat
     3001 tgcaagctca tgtgtggagg cctggggcag ggcaccagtg aacaggcaca ggtcccagga
     3061 ccaaggagag gtggaacatc cagttcctaa agttgcttct cctaccctat cccatcccct
     3121 gtcacgcatc tggaagctaa attgcctcct gccagagatg gtttccaagt tgatgtcccc
     3181 ttcccccacc ttcctcctca ctctctacct ccctgccgct ttccaaccaa gtatgtctgc
     3241 tttggtatct ttgcctctct ttgtctctgc atttcctttc ctggatctct gtctttattt
     3301 ccaggcttct ccacccatat tcctccacag atctctcttc cttgacattt gtgcttttct
     3361 ccctgggcct cattttaatg ttcagtgaga agtaaacaga gcagaagtga ccactgggac
     3421 ttcaggcaag aagctcacca ccaggcacac agcaaaggga ctgaactgac ccctgtttgc
     3481 actaagccac ccccaccccc cactctgctt tcccaagctt gactggcata tacctaggcc
     3541 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ctcttccgtc taaggcatga
     3601 ataagagggg aggtcaaaat aaagacccaa tctgaggccg ggcacggtgg ctcacgccgg
     3661 taatcccagc actttgggag gccgaggcgg gcggatcacg aggtcaggag atcgagacca
     3721 tcctggctaa cacggtgaaa ccccatttcc actaaaaata caaaaaatta gctgggcgtg
     3781 gtggcgagcg cctgtagtcc cagctactcg ggaggctgag gcaggagaat ggcatgaacc
     3841 tggaaggcgg agcttgcagt gagctgagat tgcgccactg cactccagcc tgggcgacgg
     3901 agcgagactc tgtctcaaaa caaacaaaca aacaaaagac ccaatctgag tcttatcgtt
     3961 gtactgatag aagggtcaga tatccccaca tggagttgag tgggagaaag agattcacta
     4021 gagaataact ccttagagac caatgtctgt agcaggtgta cagcatcttg tgaaagttat
     4081 ggagcatgaa aagactgaag ggccaggaca gtttgcatgg gctgagttat accagctaga
     4141 ccaggaatag aacaaagaat tctatacctc aggatttcaa aaagttagca acttgagagg
     4201 ccagtgctga gcaacccagt acccaggaaa tgaaaaaaag aaagaaaatt ccctccgaga
     4261 atgaacaaat cattggcttc attgcctcat gagcttgaga gaaaggagaa gagagccaga
     4321 gtgtggcaag tgaggccaaa atcagaagca tggcagaaat gagtgtaagt gattgagcca
     4381 cagacagaag tgtggcgagg gacaatgcca tattgggaga aggtaaagtt gagtaacaag
     4441 aaaccaaccg tgtgtgagag ggggattgga aaaaaatttg agggagaaga atgttagaat
     4501 ggaagggaat gatggtggaa gggaggtgtg agggtgtgtg ctgagtgttg aaagaacggt
     4561 tggtgtctgt gtgattttcc ttgagtctgt tcttcagtgt gtcttctgca gcttgccatg
     4621 actgcctggg aaagagtagg gaaataccca gagccaaaac ctcctttcag tcccacccca
     4681 tccctcaaaa ccccagctat tgcttctttt cagcttcagg tcctgatctc caatcttagt
     4741 atggactccc ttctcaccaa gaccaccacc agctacgttt gctgtgtaat ctggaaagtg
     4801 ataatttcct ttgcttgttg ggtgtgagtc acaatacttt ggtttgtgca caagaataaa
     4861 tttatgcccc ata
//
