LOCUS       NM_133477               7282 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synaptopodin 2 (SYNPO2), transcript variant 1, mRNA.
ACCESSION   NM_133477 XM_050219
VERSION     NM_133477.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7282)
  AUTHORS   Ye,G., Tu,L., Li,Z., Li,X., Zheng,X. and Song,Y.
  TITLE     SYNPO2 promotes the development of BLCA by upregulating the
            infiltration of resting mast cells and increasing the resistance to
            immunotherapy
  JOURNAL   Oncol Rep 51 (1) (2024)
   PUBMED   38038167
  REMARK    GeneRIF: SYNPO2 promotes the development of BLCA by upregulating
            the infiltration of resting mast cells and increasing the
            resistance to immunotherapy.
REFERENCE   2  (bases 1 to 7282)
  AUTHORS   Lohanadan,K., Assent,M., Linnemann,A., Schuld,J., Heukamp,L.C.,
            Krause,K., Vorgerd,M., Reimann,J., Schanzer,A., Kirfel,G.,
            Furst,D.O. and Van der Ven,P.F.M.
  TITLE     Synaptopodin-2 Isoforms Have Specific Binding Partners and Display
            Distinct, Muscle Cell Type-Specific Expression Patterns
  JOURNAL   Cells 13 (1), 85 (2023)
   PUBMED   38201288
  REMARK    GeneRIF: Synaptopodin-2 Isoforms Have Specific Binding Partners and
            Display Distinct, Muscle Cell Type-Specific Expression Patterns.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7282)
  AUTHORS   OuYang,C., Xie,Y., Fu,Q. and Xu,G.
  TITLE     SYNPO2 suppresses hypoxia-induced proliferation and migration of
            colorectal cancer cells by regulating YAP-KLF5 axis
  JOURNAL   Tissue Cell 73, 101598 (2021)
   PUBMED   34333382
  REMARK    GeneRIF: SYNPO2 suppresses hypoxia-induced proliferation and
            migration of colorectal cancer cells by regulating YAP-KLF5 axis.
REFERENCE   4  (bases 1 to 7282)
  AUTHORS   Gao,J., Zhang,H.P., Sun,Y.H., Guo,W.Z., Li,J., Tang,H.W., Guo,D.F.,
            Zhang,J.K., Shi,X.Y., Yu,D.S., Zhang,X.D., Wen,P.H., Shi,J.H. and
            Zhang,S.J.
  TITLE     Synaptopodin-2 promotes hepatocellular carcinoma metastasis via
            calcineurin-induced nuclear-cytoplasmic translocation
  JOURNAL   Cancer Lett 482, 8-18 (2020)
   PUBMED   32278815
  REMARK    GeneRIF: Synaptopodin-2 promotes hepatocellular carcinoma
            metastasis via calcineurin-induced nuclear-cytoplasmic
            translocation.
REFERENCE   5  (bases 1 to 7282)
  AUTHORS   Liu,J., Ye,L., Li,Q., Wu,X., Wang,B., Ouyang,Y., Yuan,Z., Li,J. and
            Lin,C.
  TITLE     Synaptopodin-2 suppresses metastasis of triple-negative breast
            cancer via inhibition of YAP/TAZ activity
  JOURNAL   J Pathol 244 (1), 71-83 (2018)
   PUBMED   28991374
  REMARK    GeneRIF: These findings uncover a suppressive role of SYNPO2 in
            triple-negative breast cancer (TNBC) metastasis via inhibition of
            YAP/TAZ, and suggest that SYNPO2 might provide a potential
            prognosis marker and novel therapeutic strategy.
REFERENCE   6  (bases 1 to 7282)
  AUTHORS   Sanchez-Carbayo,M., Schwarz,K., Charytonowicz,E., Cordon-Cardo,C.
            and Mundel,P.
  TITLE     Tumor suppressor role for myopodin in bladder cancer: loss of
            nuclear expression of myopodin is cell-cycle dependent and predicts
            clinical outcome
  JOURNAL   Oncogene 22 (34), 5298-5305 (2003)
   PUBMED   12917631
REFERENCE   7  (bases 1 to 7282)
  AUTHORS   Van Impe,K., De Corte,V., Eichinger,L., Bruyneel,E., Mareel,M.,
            Vandekerckhove,J. and Gettemans,J.
  TITLE     The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear
            export sequence present in structurally related proteins
  JOURNAL   J Biol Chem 278 (20), 17945-17952 (2003)
   PUBMED   12637565
REFERENCE   8  (bases 1 to 7282)
  AUTHORS   Weins,A., Schwarz,K., Faul,C., Barisoni,L., Linke,W.A. and
            Mundel,P.
  TITLE     Differentiation- and stress-dependent nuclear cytoplasmic
            redistribution of myopodin, a novel actin-bundling protein
  JOURNAL   J Cell Biol 155 (3), 393-404 (2001)
   PUBMED   11673475
REFERENCE   9  (bases 1 to 7282)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 7282)
  AUTHORS   Houlgatte,R., Mariage-Samson,R., Duprat,S., Tessier,A.,
            Bentolila,S., Lamy,B. and Auffray,C.
  TITLE     The Genexpress Index: a resource for gene discovery and the genic
            map of the human genome
  JOURNAL   Genome Res 5 (3), 272-304 (1995)
   PUBMED   8593614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833547.1, BC150629.1, AL833294.1 and AC107048.3.
            
            On Nov 23, 2018 this sequence version replaced NM_133477.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936673.1, BC150629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307142.9/ ENSP00000306015.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1345              AL833547.1         14-1358
            1346-1899           BC150629.1         1358-1911
            1900-3435           AL833294.1         1899-3434
            3436-3654           AL833547.1         3449-3667
            3655-4015           BC150629.1         3667-4027
            4016-7019           AC107048.3         8030-11033
            7020-7282           AL833547.1         7021-7283
FEATURES             Location/Qualifiers
     source          1..7282
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..7282
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /note="synaptopodin 2"
                     /db_xref="GeneID:171024"
                     /db_xref="HGNC:HGNC:17732"
                     /db_xref="MIM:620941"
     exon            1..288
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..3969
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /note="isoform a is encoded by transcript variant 1;
                     myopodin; genethonin-2; SYNPO2 intron sense-overlapping
                     lncRNA"
                     /codon_start=1
                     /product="synaptopodin-2 isoform a"
                     /protein_id="NP_597734.2"
                     /db_xref="CCDS:CCDS34054.1"
                     /db_xref="GeneID:171024"
                     /db_xref="HGNC:HGNC:17732"
                     /db_xref="MIM:620941"
                     /translation="MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASG
                     SGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENK
                     NLEHLTHGGYVESTTLQIRPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEET
                     GPSYQRAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVAL
                     PGAEKSKSPDPDPNLSHDRIVHINSIPTNEKADPFLRSSKIIQISSGRELRVIQESEA
                     GDAGLPRVEVILDCSDRQKTEGCRLQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTE
                     QGEDPRSEKDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSK
                     GVLMFKKRRRRARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELL
                     SDVDDNTQVVNFDWDSGLVDIEKKLNRGDKMEMLPDTTGKGALMFAKRRERMDQITAQ
                     KEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQ
                     QNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSA
                     VTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTG
                     ILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGA
                     EACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPS
                     KGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQP
                     GAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYS
                     SNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQL
                     NASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAY
                     TSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSGVTIQESGR
                     SLSLPGRSVPPPISTSPWVYQPTYSYSSKPTDGLEKANKRPTPWEAAAKSPLGLVDDA
                     FQPRNIQESIVANVVSAARRKVLPGPPEDWNERLSYIPQTQKAYMGSCGRQEYNVTAN
                     NNMSTTSQYGSQLPYAYYRQASRNDSAIMSMETRSDYCLPVADYNYNPHPRGWRRQT"
     exon            289..440
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /inference="alignment:Splign:2.1.0"
     exon            441..1252
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..3435
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..7282
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7259..7264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /note="hexamer: AATAAA"
     polyA_site      7282
                     /gene="SYNPO2"
                     /gene_synonym="SYISL"
                     /note="major polyA site"
ORIGIN      
        1 gcacaaattc gcagcaggcg gctggggcgg cggctggggc agcggctgca gcagcggcgg
       61 acgctctgca ttacccagtc ttgcgtcctc ggcaggcgcc cgaagctgag tgcgcatcct
      121 ctaccgcacc caagcttcgt ctgtctcgtc aagctcttca tgctgcccaa ctaaaaggaa
      181 aacatgggca caggggattt tatctgcatt tccatgactg gaggggcgcc ctgggggttc
      241 agattgcaag gtggcaagga gcagaagcag cccttacaag ttgcaaagat tcgaaatcag
      301 agcaaagcct ctgggtctgg gctctgtgag ggagatgaag tggtttccat caatggcaac
      361 ccttgtgcag atctcaccta ccctgaagtc atcaagctca tggaaagcat aacagactct
      421 ctccaaatgc tcatcaaaag accatccagt ggaataagtg aggctttgat atctgaaaat
      481 gaaaacaaaa acctcgagca tctcacacat gggggttatg tggaaagtac caccctgcag
      541 attcgaccgg ccacaaagac ccagtgcaca gaattcttcc tcgcccctgt caagactgaa
      601 gttcccctag ctgagaacca aagaagtggt cccgactgtg caggcagctt gaaagaagaa
      661 acaggcccga gctaccaaag ggctccccaa atgcctgact cccaaagagg acgcgtggca
      721 gaagagctga tcttaaggga gaaggtagaa gcggtacagc ctgggcctgt ggttgagctg
      781 caactgtccc tttcacagga gagacataag ggcgctagtg gccctttagt ggctctcccg
      841 ggagctgaaa aatctaagtc tcctgaccca gaccctaact tgtcacatga caggattgtc
      901 cacataaatt cgatccctac taatgagaaa gcagaccctt tcctgaggtc cagcaagata
      961 atccagatct ccagtggcag agagttgaga gtgatccagg aaagtgaagc aggagatgcg
     1021 ggactgcccc gggtggaagt gatcctcgac tgctctgaca ggcagaagac agaagggtgc
     1081 aggcttcagg caggaaagga gtgtgtggat tctccagtgg aaggagggca gtcagaagca
     1141 cctccttctc tggtatcctt tgccgtctca tcagaaggca cagagcaggg agaagatcca
     1201 cgctcggaaa aagatcacag cagacctcac aagcaccgag cgcggcatgc acggctcagg
     1261 aggagtgaaa gcctgtcaga aaaacaagtg aaggaagcaa aatctaaatg caaaagcatt
     1321 gcccttcttc taacggatgc tcccaacccc aactccaagg gggtgttgat gtttaagaag
     1381 cgacgtcgga gggccaggaa atacacccta gttagctacg gtactggcga gcttgagcga
     1441 gaggcggacg aggaggaaga aggtgacaag gaggatacat gtgaagtagc atttcttggt
     1501 gcaagcgaat cagaggtgga tgaagagtta ttgtctgacg ttgacgacaa cacacaagtt
     1561 gtgaactttg actgggattc tggactggtg gacattgaaa agaaactgaa cagaggggac
     1621 aagatggaga tgttaccaga caccacaggc aagggagccc tcatgtttgc caagaggagg
     1681 gagagaatgg atcagatcac agcccaaaaa gaagaggaca aggtaggtgg aacgccaagc
     1741 agagaacaag atgctgccca gaccgatggc ctgagaacca cgacttctta ccaaagaaag
     1801 gaggaagagt cggtaagaac gcagagctct gtgagcaaaa gctacatcga ggtgagtcat
     1861 ggtcttggcc atgttcccca acagaatggc ttcagtggga catctgagac agcaaacatc
     1921 cagaggatgg tccccatgaa tagaacggcc aaacccttcc cagggtctgt gaatcagcca
     1981 gctaccccct tctcgccaac ccgaaacatg acgagtccca ttgctgactt tcctgcacct
     2041 ccaccttact ctgcagtcac tcctccccct gacgccttct ccagaggggt ttcaagtccg
     2101 attgctggcc cagcacagcc ccctccatgg ccccagcctg ccccgtggtc ccagccagcc
     2161 ttttacgatt cgtctgagcg aatagcttcc cgagatgaga ggatctcagt gccagcaaaa
     2221 agaacaggaa tattgcagga ggccaaaagg agaagcacga caaaacccat gtttactttt
     2281 aaagagccca aagtaagccc aaatcctgaa ctcttgtcac tccttcaaaa ttcagaaggc
     2341 aaacggggca ctggagctgg aggtgattcc ggaccggaag aagactacct cagcttgggg
     2401 gcagaggctt gtaatttcat gcaaagctcc tctgccaaac aaaagacccc tcctcctgtt
     2461 gctccaaaac ctgcagtcaa gtcctcatcc tcccaaccag taactccagt ttccccagtc
     2521 tggtctccag gagtggctcc cacccaacct cctgccttcc ccacatccaa cccatcaaag
     2581 ggcaccgttg tctcctccat caaaatagcc cagccttctt accctcctgc ccggcctgca
     2641 agtactttga acgtggctgg tcccttcaaa ggaccacaag cagcagtagc cagtcagaat
     2701 tacacaccca aaccaacagt ttccacacca acagtcaatg ctgttcagcc tggtgcagtg
     2761 ggaccatcca atgagcttcc aggaatgagt gggagaggag ctcagctctt tgctaaaagg
     2821 cagtcgagaa tggagaagta tgtggtcgat tcagacacgg tgcaggccca cgctgctcga
     2881 gctcagtctc ccactccatc tctcccggcc agttggaagt actcctccaa tgtccgagca
     2941 cctcctcctg tggcctataa tcctatccac tcgccgtctt acccactggc tgctctcaag
     3001 tctcagccat cagctgcaca gccctccaaa atgggcaaga aaaagggaaa gaaacccctc
     3061 aatgcattag atgtcatgaa gcaccaaccg tatcagctca atgcatcctt gtttactttc
     3121 caacctccag atgcaaagga tggcctcccc cagaagtcat cagtcaaggt caattcagcc
     3181 ctggccatga agcaagctct tcctccccgg ccagtgaatg ctgcctcacc tacgaatgtg
     3241 caggcttcgt cagtgtactc ggtaccagcc tatacctctc ctccttcctt ctttgcagag
     3301 gcctcctcac cagtcagtgc atccccagtg cctgtgggca ttcccacctc gccaaagcaa
     3361 gaatcagcct catcatctta ttttgtggca ccaaggccaa agttctcagc caagaaaagt
     3421 ggtgtcacaa ttcaggagag tgggcgctcc ctttctcttc ctggaagatc agtcccaccc
     3481 cccatttcta catctccttg ggtataccag cctacttata gttactctag taaaccaacc
     3541 gatggactag agaaagcaaa caagagacca actccttggg aagcagcagc aaagtctcct
     3601 ctcggtctag tggatgatgc tttccaaccc agaaacatcc aggaatccat tgtggcaaat
     3661 gtggtttcag cagctcggag gaaggtgctt ccagggcctc cagaggattg gaatgaaaga
     3721 ctgtcctata ttcctcaaac ccagaaggcc tatatgggct catgtggaag gcaagagtat
     3781 aatgtcacag ccaataataa tatgtccacc acctcccaat atggttcaca gttgccatat
     3841 gcatattata ggcaggcttc aagaaatgat tctgcaatca tgtccatgga aaccaggtct
     3901 gattactgtc ttccagtagc tgattacaac tacaacccac acccaagggg atggagacgc
     3961 caaacatgaa agttagaaga acggatcatg tgccaactgt agttttttaa aaaaaacgct
     4021 cctttgtagg gttttaaact tttctaatag atttagattc acttttggtc ttggcttgtt
     4081 ctcataagtc atttatctaa gtttgtgttt ctgtgtgtgt gtgtgtgtgt gtatgtatgt
     4141 gaatatacac acacacacac acacaggtga gtgtgaatac ttccttgttg gctgatccat
     4201 agagcattac ttggaagaaa atttcactat ttgcattgat gtgctggcat ttatatgtaa
     4261 ttcataattt tgattccatt aataggtagt ctatgcaaca aactctactc aattaaagta
     4321 aaactaagta tttcttcatt gtaccttagt ccaggaagaa attaatggaa tatggtgtgc
     4381 taattatcac tacctataac atgaggaata taacattgca gaaatttctc ataggggcat
     4441 gccagtgagc aattacttta taaaaatatt ttccttggtg ttaagtattt ctctgcaact
     4501 tttttttttt tttttttttt tttttgagat ggagtcttgc tctgtcccac ccagtctgga
     4561 gtgcaatggt gcgatcttgg ctcactgcaa cctgcgcctc ctgggttcaa gcaattctcc
     4621 tgcctcagcc tcctgagtag ctgggattac aggcatgaac caccacacct ggataatttt
     4681 tgtattttta gtagacacaa agtttcacca tgttggtcag actggtcttg aactcctgac
     4741 ctcgtgatct gcccgcctca gcctcccaaa gtgctgggat tacaggcgtg agccaccaca
     4801 cctggccttt ctgcaacatt tttttaaaaa aatctaataa atcttagatt tttaaaaaag
     4861 aattaaaatg tgggagttct cagaaagaaa taaacacatg agaataagat tattacacat
     4921 tttggaagga cttttgagga atgatgtgat gtgtagagaa tagaaagatt tagatatatg
     4981 cctgtgacag gaatagattc tgggttcagg ggtccccatc tgtcaaatga gaagattgga
     5041 ttatctaatc ttttagatcc ttaacaactc tgatattctg agattctctc atttgtagaa
     5101 tgcccgctga tgcattgttt attttttttg ctcataatat aaatatcaga ttatgtttag
     5161 gagtggatta ggtaattagt gtcactacat gtatcattaa aggtcctaaa aggaattgtt
     5221 aggcggcagg ctttgtgtta cgtgttacat ggagtgaggg tagatgtgaa gatttaaaac
     5281 gattgatgga tttaaggaag tggtacataa atatgtctgt tattatgcaa tcgtaggtca
     5341 tgataattta ttcagttata gaaaacatgc cacagaagcc tatgtaacaa gtggtgcttc
     5401 tttagaaagt tgtcattaga atgttctgag gaagttaagc agctgcttca tcaatcccat
     5461 gacacatgcc ttgttagcat gcccatcaaa taatcagatc aaacacctgc tccttattgc
     5521 catacccacg aactgttaaa tataaaaaaa ttcaaagtat ttgacatctt aagcaaatat
     5581 ccagaatatt tttaagtaaa aaaccatctt aagtattcaa aatttccttg gttttttaaa
     5641 ggtgataatt ttgctttgtg ttactttttt gctcttgaat gtatcgttat gatggtctct
     5701 tataatcatg gtatctttca cagaataaaa attaaaaata atgccagggt gcaagtgacc
     5761 aaggccttat cttgaaagtt aaaaaaaaaa agtaaagaaa tcacagtaag ttctattagt
     5821 gatgatagaa ccagatataa aattgttcag tgatggagaa aagaaacgat aaatactttc
     5881 caaggttata ttgttaaatt atcttaaatt atcaaggtgt aagatgtaat gatcccaaga
     5941 gtttttatag aatcctaaaa aataacgcct gatgtataga ttagttagca aattctcaga
     6001 aatcccccac ataaaagcct tactttgttc aaaatttatt atagtggttt aatcatttta
     6061 gatttgaatg ttttaagata ggagagactt agcagaaaat acttggcttg ccagggccac
     6121 gttctacttc attgctttct tttataagtg caaggagtta tttccatcag ttgacataga
     6181 tattattcac taaaattttc agcagactca aaatagagag gagactttaa acttacatgt
     6241 tagcataaaa cagacttctc tctcattgca tgcactagat caatattatc atctgtatta
     6301 agctatctga atttattcga gacattaaga aaaagacagt acatggtggg aaagctgcac
     6361 atttctcaca aggaaaaaaa cattctatat ttgtagcaga aatcagtggt ttgaaaagtc
     6421 atactttgca gatatgaacc tgaaaatcaa agtgccattg ttaaatcatc ctaaagtgta
     6481 ctgtgggtat tctccagcat acttgaaaat gaataaagtt agattgctca cattgaagct
     6541 aatggttgag acaagacacc tgccagagtg aagtttgatt cctatgggtg agaagatgta
     6601 gatgactatt gttctcacta aagttctaaa ataatagcaa gtgtagagaa gagccgttgc
     6661 tttgaaaata cataccacat ttgttataaa gcatttgttt gttagtatca atcacatagg
     6721 tagaaagagt ttgagtttta ctgtggatta aaaagccttc cctaaaaaga gagcatgcca
     6781 gtcatagaga cactaatttg gcacttttcc tccttcttag gtttaaatgt tataccaatg
     6841 catgtgtttg aaatatccat taagatgatt taaaatttgt cttgtatttt gagtttctta
     6901 aatgcgtgga ttcttgttca tttatctctg aatatgtctc ttttatattt tggcacaatt
     6961 atacacattg gaaagggcca acctattagg gctcaagtat gtatatgcaa aaaaaaaaag
     7021 ttatatcaaa caggcacagt tattacaact agagagaaat tccagaaata tttgtttttt
     7081 taagagaaag taaattttca cattagattt ctattcaaag tactaatatc tacatggtcc
     7141 acacttttct attttaaaaa attgtgttct cttgttaaat agattaacat ttccacttct
     7201 gtttatcaca aaagactgta tttgaaatat gcatacggaa aattgaaatt atattagtaa
     7261 taaatgtaac ttgaaaaatc aa
//
