LOCUS       NM_145728               7353 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens synemin (SYNM), transcript variant A, mRNA.
ACCESSION   NM_145728
VERSION     NM_145728.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7353)
  AUTHORS   Zhou,J.
  TITLE     Synemin promotes pulmonary artery smooth muscle cell phenotypic
            switch in shunt-induced pulmonary arterial hypertension
  JOURNAL   ESC Heart Fail 9 (5), 3221-3231 (2022)
   PUBMED   35769011
  REMARK    GeneRIF: Synemin promotes pulmonary artery smooth muscle cell
            phenotypic switch in shunt-induced pulmonary arterial hypertension.
REFERENCE   2  (bases 1 to 7353)
  AUTHORS   Chen,S., Wu,Y., Wang,S., Wu,J., Wu,X. and Zheng,Z.
  TITLE     A risk model of gene signatures for predicting platinum response
            and survival in ovarian cancer
  JOURNAL   J Ovarian Res 15 (1), 39 (2022)
   PUBMED   35361267
  REMARK    GeneRIF: A risk model of gene signatures for predicting platinum
            response and survival in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7353)
  AUTHORS   Deville,S.S., Delgadillo Silva,L.F., Vehlow,A. and Cordes,N.
  TITLE     c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal
            Protein Synemin in Head and Neck Squamous Cell Carcinoma
            Radioresistance and DNA Repair
  JOURNAL   Int J Mol Sci 21 (19), 7277 (2020)
   PUBMED   33019757
  REMARK    GeneRIF: c-Abl Tyrosine Kinase Is Regulated Downstream of the
            Cytoskeletal Protein Synemin in Head and Neck Squamous Cell
            Carcinoma Radioresistance and DNA Repair.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7353)
  AUTHORS   Sward,K., Krawczyk,K.K., Moren,B., Zhu,B., Matic,L., Holmberg,J.,
            Hedin,U., Uvelius,B., Stenkula,K. and Rippe,C.
  TITLE     Identification of the intermediate filament protein synemin/SYNM as
            a target of myocardin family coactivators
  JOURNAL   Am J Physiol Cell Physiol 317 (6), C1128-C1142 (2019)
   PUBMED   31461342
  REMARK    GeneRIF: Synemin is a target of myocardin family coactivators.
REFERENCE   5  (bases 1 to 7353)
  AUTHORS   Zhang,S.B., Liu,Y.X., Fan,L.L., Huang,H., Li,J.J., Jin,J.Y. and
            Xiang,R.
  TITLE     A novel heterozygous variant p.(Trp538Arg) of SYNM is identified by
            whole-exome sequencing in a Chinese family with dilated
            cardiomyopathy
  JOURNAL   Ann Hum Genet 83 (2), 95-99 (2019)
   PUBMED   30276801
  REMARK    GeneRIF: a novel heterozygous missense mutation p.(Trp538Arg) of
            SYNM was identified and cosegregated with the affected members in a
            Chinese family
REFERENCE   6  (bases 1 to 7353)
  AUTHORS   Olive,M., Goldfarb,L., Dagvadorj,A., Sambuughin,N., Paulin,D.,
            Li,Z., Goudeau,B., Vicart,P. and Ferrer,I.
  TITLE     Expression of the intermediate filament protein synemin in
            myofibrillar myopathies and other muscle diseases
  JOURNAL   Acta Neuropathol 106 (1), 1-7 (2003)
   PUBMED   12669240
  REMARK    GeneRIF: Expression of the intermediate filament protein synemin in
            myofibrillar myopathies and other muscle diseases.
REFERENCE   7  (bases 1 to 7353)
  AUTHORS   Titeux,M., Brocheriou,V., Xue,Z., Gao,J., Pellissier,J.F.,
            Guicheney,P., Paulin,D. and Li,Z.
  TITLE     Human synemin gene generates splice variants encoding two distinct
            intermediate filament proteins
  JOURNAL   Eur J Biochem 268 (24), 6435-6449 (2001)
   PUBMED   11737198
REFERENCE   8  (bases 1 to 7353)
  AUTHORS   Hesse,M., Magin,T.M. and Weber,K.
  TITLE     Genes for intermediate filament proteins and the draft sequence of
            the human genome: novel keratin genes and a surprisingly high
            number of pseudogenes related to keratin genes 8 and 18
  JOURNAL   J Cell Sci 114 (Pt 14), 2569-2575 (2001)
   PUBMED   11683385
REFERENCE   9  (bases 1 to 7353)
  AUTHORS   Mizuno,Y., Thompson,T.G., Guyon,J.R., Lidov,H.G., Brosius,M.,
            Imamura,M., Ozawa,E., Watkins,S.C. and Kunkel,L.M.
  TITLE     Desmuslin, an intermediate filament protein that interacts with
            alpha -dystrobrevin and desmin
  JOURNAL   Proc Natl Acad Sci U S A 98 (11), 6156-6161 (2001)
   PUBMED   11353857
REFERENCE   10 (bases 1 to 7353)
  AUTHORS   Mizuno,Y., Puca,A.A., O'Brien,K.F., Beggs,A.H. and Kunkel,L.M.
  TITLE     Genomic organization and single-nucleotide polymorphism map of
            desmuslin, a novel intermediate filament protein on chromosome
            15q26.3
  JOURNAL   BMC Genet 2, 8 (2001)
   PUBMED   11454237
  REMARK    GeneRIF: Genomic organization and single-nucleotide polymorphism
            map of desmuslin, a novel intermediate filament protein on
            chromosome 15q26.3.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB002351.2, AW292788.1 and
            AC036108.19.
            
            On May 17, 2019 this sequence version replaced NM_145728.2.
            
            Summary: The protein encoded by this gene is an intermediate
            filament (IF) family member. IF proteins are cytoskeletal proteins
            that confer resistance to mechanical stress and are encoded by a
            dispersed multigene family. This protein has been found to form a
            linkage between desmin, which is a subunit of the IF network, and
            the extracellular matrix, and provides an important structural
            support in muscle. Two alternatively spliced variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (A) encodes the longer isoform
            (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ310522.1, AB002351.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336292.11/ ENSP00000336775.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AB002351.2         39-565
            528-958             AW292788.1         91-521
            959-1182            AB002351.2         997-1220
            1183-7353           AC036108.19        20248-26418         c
FEATURES             Location/Qualifiers
     source          1..7353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..7353
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /note="synemin"
                     /db_xref="GeneID:23336"
                     /db_xref="HGNC:HGNC:24466"
                     /db_xref="MIM:606087"
     exon            1..930
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..4818
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /note="isoform A is encoded by transcript variant A;
                     synemin beta; synemin alpha; desmuslin; synemin,
                     intermediate filament protein"
                     /codon_start=1
                     /product="synemin isoform A"
                     /protein_id="NP_663780.2"
                     /db_xref="CCDS:CCDS73787.1"
                     /db_xref="GeneID:23336"
                     /db_xref="HGNC:HGNC:24466"
                     /db_xref="MIM:606087"
                     /translation="MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELR
                     GRRGREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEE
                     RAARGRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAA
                     SLTMHFRARATGPAAPPPRLREVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQE
                     SRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCL
                     EDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGESNPEIVIWAEHVENMP
                     SEFRNKSYHYTDSLLQRENERNLFSRQKAPLASFNHSSALYSNLSGHRGSQTGTSIGG
                     DARRGFLGSGYSSSATTQQENSYGKAVSSQTNVRTFSPTYGLLRNTEAQVKTFPDRPK
                     AGDTREVPVYIGEDSTIARESYRDRRDKVAAGASESTRSNERTVILGKKTEVKATREQ
                     ERNRPETIRTKPEEKMFDSKEKASEERNLRWEELTKLDKEARQRESQQMKEKAKEKDS
                     PKEKSVREREVPISLEVSQDRRAEVSPKGLQTPVKDAGGGTGREAEARELRFRLGTSD
                     ATGSLQGDSMTETVAENIVTSILKQFTQSPETEASADSFPDTKVTYVDRKELPGERKT
                     KTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGKSAEQMIGDIINLGLKGREGR
                     AKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGPWGLVKEEEGYGESDVTFS
                     VNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPGGHDRDDGSVYGQIHIE
                     EESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEGDLGSTHWKEQARSG
                     EFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETLPERMREELSALT
                     REGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELSKDEASEMEKA
                     VESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGESEVAGGASH
                     SSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERMSYEGPT
                     AEVVEVSAGGDLSQAASPTGASRSVRHVTLGPGQSPLSREVIFLGPAPACPEAWGSPE
                     PGPAESSADMDGSGRHSTFGCRQFHAEKEIIFQGPISAAGKVGDYFATEESVGTQTSV
                     RQLQLGPKEGFSGQIQFTAPLSDKVELGVIGDSVHMEGLPGSSTSIRHISIGPQRHQT
                     TQQIVYHGLVPQLGESGDSESTVHGEGSADVHQATHSHTSGRQTVMTEKSTFQSVVSE
                     SPQEDSAEDTSGAEMTSGVSRSFRHIRLGPTETETSEHIAIRGPVSRTFVLAGSADSP
                     ELGKLADSSRTLRHIAPGPKETSFTFQMDVSNVEAIRSRTQEAGALGVSDRGSWRDAD
                     SRNDQAVGVSFKASAGEGDQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLY
                     LDNEEEENDGHWF"
     exon            931..1055
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1126
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..7353
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7329..7334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /note="hexamer: AATAAA"
     polyA_site      7353
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcggg cctccggggc agcggcgagg ccggagcgtc gcggcggaga ggacgagacc
       61 gggacaagac cagggcagga gggagccggc cagccgcgag aaccccgcac gcccggcaag
      121 atgctgtcct ggcggctgca gacgggcccc gagaaggccg agctccagga gctcaacgcc
      181 cggctctatg actacgtgtg tcgggtgcgg gagctggagc gcgaaaacct actcctggag
      241 gaggagctgc gcggccggcg cgggcgagag ggcctgtggg ccgaggggca ggcccgctgc
      301 gccgaggagg cgcgcagctt gcggcagcag ctggacgagc tgagctgggc cactgcgctg
      361 gcggagggcg agcgggacgc tctgcggcgc gagctgcggg agctgcagcg cctggatgcg
      421 gaggagcgcg ccgcccgcgg ccgcctggac gccgagctgg gtgcgcagca gcgcgagctg
      481 caggaggcgc tgggcgcgcg cgccgccctc gaggcgctgc tgggccggct gcaggccgag
      541 cgccgaggcc tcgacgcggc ccacgaacgc gacgtgaggg agctgcgcgc gcgcgccgcc
      601 agccttacca tgcatttccg cgcccgcgcc accggccccg ccgcgccgcc gccacgcctg
      661 cgggaggtgc acgacagcta cgcactgctg gtggccgagt cgtggcggga gacggtgcag
      721 ctgtacgagg acgaggtgcg cgagctggag gaggcgctgc ggcgcggcca ggagagcaga
      781 ctccaggcgg aggaagagac gcggctgtgc gcgcaggagg cagaggcgct gcggcgcgag
      841 gcgctcgggt tggagcagct gcgcgcgcgg ctggaggacg cgctgctgcg gatgcgcgag
      901 gagtacggga tacaggccga ggagcggcag agagtgattg actgcctgga ggatgagaag
      961 gcaaccctca ccttggccat ggctgactgg ctgcgggact atcaggacct cctgcaggtg
     1021 aagaccggcc tcagtctgga ggtggcgacc taccgggcct tattggaagg agaaagtaat
     1081 ccagagatag tgatctgggc tgagcacgtt gaaaacatgc cgtcagaatt cagaaacaaa
     1141 tcctatcact ataccgactc actactacag agggaaaatg aaaggaatct attttcaagg
     1201 cagaaagcac ctttggcaag tttcaatcac agctcggcac tgtattctaa cctgtcaggg
     1261 caccgtggat ctcagacggg cacatctatt ggaggtgatg ccagaagagg cttcttgggc
     1321 tcgggatatt cttcctcggc cactacccag caggaaaact catacggaaa agccgtcagc
     1381 agtcaaacca acgtcagaac tttctctcca acctatggcc ttttaagaaa tactgaggct
     1441 caagtgaaaa cattccctga cagaccaaaa gccggagata caagggaggt ccccgtttac
     1501 ataggtgaag attccacaat tgcccgcgag tcgtaccggg atcgccgaga caaggtggca
     1561 gcaggtgctt cggaaagcac acggtcaaat gagaggaccg tcattctggg aaagaaaaca
     1621 gaagtgaaag ccacgaggga gcaagaaaga aacagaccag aaaccatccg aacaaagcca
     1681 gaagagaaaa tgttcgattc taaagagaag gcttccgagg agagaaacct aagatgggaa
     1741 gaattgacaa agttagataa ggaagcgaga cagagagaaa gccagcagat gaaggagaag
     1801 gctaaggaga aggactcacc gaaggagaag agcgtgcgag agagagaggt gccgattagt
     1861 ctagaagtat cccaggacag aagagcagag gtgtccccga aaggtttgca gacgcctgtg
     1921 aaggatgctg gtggtgggac cggtagagag gcagaagcaa gagagctacg gttcaggttg
     1981 ggcaccagtg atgccactgg ttctctgcaa ggcgattcca tgacagaaac cgtagcagaa
     2041 aacatcgtta ccagtatcct gaagcagttc actcagtctc cagagacaga agcatctgct
     2101 gattcttttc cagacacaaa agtcacttac gtggacagga aagagcttcc tggggaaagg
     2161 aaaacaaaga ctgaaatagt tgtggagtct aaactgactg aggatgttga tgtttccgat
     2221 gaagctggcc tggactacct tttaagcaag gatattaagg aagtggggct gaaaggcaag
     2281 tcagccgagc agatgatagg agacatcatc aacctcggcc tgaaagggag ggaggggaga
     2341 gcaaaggtcg tcaacgtgga gatcgtggag gagcccgtga gttatgtcag cggggagaag
     2401 ccggaggagt tttccgtccc attcaaagtg gaggaggtcg aagatgtgtc gccaggcccc
     2461 tgggggttgg ttaaggagga ggaaggttat ggagaaagcg atgtcacatt ctcagttaat
     2521 cagcatcgaa ggaccaagca gcctcaggag aacacgactc acgtggaaga agtgacagag
     2581 gcaggtgatt cagagggcga gcagagttat tttgtgtcca ctccagatga acaccccggg
     2641 gggcacgaca gagatgacgg ctcggtgtac gggcagatcc acatcgagga ggaatccacc
     2701 atcaggtact cttggcagga tgaaatcgtg caggggactc gaaggaggac acagaaggac
     2761 ggtgcagtgg gcgagaaggt tgtgaagccc ttggatgtcc cagcgccctc tctggagggg
     2821 gacctgggtt ccactcactg gaaagaacaa gctagaagcg gtgaatttca tgccgaaccc
     2881 acagtcattg aaaaagaaat taaaataccc cacgaattcc acacctccat gaagggcatc
     2941 tcctccaagg agccccggca gcagctggtg gaggtcatcg ggcagctgga ggaaaccctt
     3001 cccgagcgca tgagggagga gctgtccgcc ctcaccagag aggggcaggg tgggccgggg
     3061 agcgtttccg tggatgtcaa gaaggtccag ggtgctggtg gcagttccgt gaccctggtt
     3121 gctgaagtca acgtctcaca aactgtggat gccgatcggt tagacctgga ggagctgagc
     3181 aaagatgagg ccagtgagat ggagaaggct gtggagtcgg tggttcggga gagcctgagc
     3241 aggcaacgca gcccagcgcc tggcagccca gatgaggaag gtggagcgga ggccccggct
     3301 gctggcattc gctttaggcg ttgggccacc cgggagctgt acatcccttc aggcgagagc
     3361 gaggttgctg gtggggcctc tcacagctcg ggacagcgca ctccccaggg cccagtgtcg
     3421 gccactgtgg aggtcagcag ccccacaggc tttgcccagt cacaggtgct ggaggatgtg
     3481 agccaggctg caaggcacat aaaactcggc ccctctgaag tctggaggac tgagcgaatg
     3541 tcatatgaag gacccactgc agaagtggtg gaggtaagtg cgggaggtga cctaagtcag
     3601 gcagcgagcc cgaccggagc cagccggtct gtgaggcatg tcacgctggg tcccggtcaa
     3661 agtccactgt ccagagaagt catcttccta ggccctgccc ctgcctgtcc agaggcatgg
     3721 ggctcgccag aacctggccc agcagagtct tctgcagata tggacggatc agggaggcac
     3781 agcacatttg gctgcagaca atttcatgct gaaaaggaga ttatttttca gggccccatt
     3841 tctgctgcag ggaaggttgg tgattatttt gcaacagaag agtcagtggg tacccagact
     3901 tctgtcaggc aactccagtt aggccctaaa gaagggttca gtgggcaaat ccagttcaca
     3961 gctccacttt cagacaaggt ggagttgggt gtcataggag attctgtaca catggaaggg
     4021 ttgccaggga gcagcacatc catcaggcac atcagcattg ggcctcagag gcatcagacc
     4081 acccagcaga tagtttacca tgggctggtt ccccaactgg gggaatctgg tgactcagag
     4141 agcactgtgc acggagaggg ctcagcagat gtgcaccagg ccactcacag tcatacctcg
     4201 ggtagacaaa ccgttatgac tgaaaagagc accttccaaa gtgtcgtttc tgaatctccc
     4261 caggaggata gtgcagagga cacatcaggg gcagaaatga catcgggtgt tagcagatcc
     4321 tttaggcaca ttcgactagg tcctacagaa acggaaacct ctgaacacat tgccatccgt
     4381 ggacccgtgt ccagaacatt tgtgcttgct ggttcagcgg actcccctga gctaggcaag
     4441 ttagcagaca gcagcagaac gctaaggcac attgcaccag ggcccaaaga aacttcgttt
     4501 acctttcaga tggatgtgag taacgtagag gcgatccgca gccggacaca ggaagcggga
     4561 gctctcggtg tgtctgaccg tggttcctgg agagacgcgg acagtaggaa tgaccaggca
     4621 gttggtgtga gctttaaggc ctctgctggg gaaggagacc aggcccacag agaacagggc
     4681 aaggagcagg ccatgtttga taagaaggtg cagctccaga gaatggtaga ccaaaggtcg
     4741 gtgatttcag atgaaaagaa agttgccctc ctctatctag acaatgagga ggaggagaat
     4801 gatgggcatt ggttttaata agcagaaaca ttttgtttta atggcagcct gttggcgacg
     4861 tgccaacatc caaaggcctt aacttatttt aagaggccga gggagtctat gaaaatctcc
     4921 ccttttttac ttttttaaag agtactcccg gcatggtcaa tttcctttat agttaatccg
     4981 taaaggtttc cagttaattc atgccttaaa aggcactgca attttatttt tgagttggga
     5041 cttttacaaa acactttttt ccctggagtc ttctctccac ttctggagat gaatttctat
     5101 gttttgcacc tggtcacaga catggcttgc atctgtttga aactacaatt aattatagat
     5161 gtcaaaacat taaccagatt aaagtaatat atttaagagt aaattttgct tgcatgtgct
     5221 aatatgaaat aacagactaa cattttaggg gaaaaataaa tacaatttag actctaaaaa
     5281 gtcttttcaa aaagaaatgg gaaataggca gactgtttat gttaaaaaaa ttcttgctaa
     5341 atgatttcat ctttaggaaa aaattacttg ccatatagag ctaaattcat cttaagactt
     5401 gaatgaattg ctttctatgt acagaacttt aaacaatata gtatttatgg cgaggacagc
     5461 tgtagtctgt tgtgatattt cacattctat ttgcacaggt tccctggcac tggtagggta
     5521 gatgattatt gggaatcgct tacagtacca tttcattttt tggcactagg tcattaagta
     5581 gcacacagtc tgaatgccct tttctggagt ggccagttcc tatcagactg tgcagacttg
     5641 cgcttctctg caccttatcc cttagcaccc aaacatttaa tttcactggt gggaggtaga
     5701 ccttgaagac aatgaagaga atgccgatac tcagactgca gctggaccgg caagctggct
     5761 gtgtacagga aaattggaag cacacagtgg actgtgcctc ttaaagatgc ctttcccaac
     5821 cctccattca tgggatgcag gtctttctga gctcaagggt gaaagatgaa tacaataaca
     5881 accatgaacc cacctcacgg aagctttttt tgcactttga acagaagtca ttgcagttgg
     5941 ggtgttttgt ccagggaaac agtttattaa atagaaggat gttttgggga aggaactgga
     6001 tatctctcct gcagcccagc accgagatac ccaggacggg cctggggggc gagaaaggcc
     6061 cccatgctca tgggccgcgg agtgtggacc tgtagatagg caccaccgag tttaagatac
     6121 tgggatgagc atgcttcatt ggattcattt tattttacac gtcagtattg ttttaaagtt
     6181 tctgtctgta aagtgtagca tcatatataa aaagagtttc gctagcagcg catttttttt
     6241 agttcaggct agcttctttc acataatgct gtctcagctg tatttccagt aacacagcat
     6301 catcgcactg actgtggcgc actggggaat aacagtctga gctagcacca ccctcagcca
     6361 ggctacaacg acagcactgg agggtcttcc ctctcagatt cacctggagg ccctcagacc
     6421 cccagggtgc acgtctcccc aggtcctggg agtggctacc gcaggtagtt tctggagagc
     6481 acgttttctt cattgataag tggaggagaa atgcagcaca gctttcaaga tactatttta
     6541 aaaacaccat gaatcagata gggaaagaaa gttgattgga atagcaagtt taaacctttg
     6601 ttgtccatct gccaaatgaa ctagtgattg tcagactggt atggaggtga ctgctttgta
     6661 aggttttgtc gtttctaata cagacagaga tgtgctgatt ttgttttagc tgtaacaggt
     6721 aatggttttt ggatagatga ttgactggtg agaatttggt caaggtgaca gcctcctgtc
     6781 tgatgacagg acagactggt ggtgaggagt ctaagtgggc tcagtttgat gtcagtgtct
     6841 gggctcatga cttgtaaatg gaagctgatg tgaacaggta attaatatta tgacccactt
     6901 ctatttactt tgggaaatat cttggatctt aattatcatc tgcaagtttc aagaagtatt
     6961 ctgccaaaag tatttacaag tatggactca tgagctattg ttggttgcta aatgtgaatc
     7021 acgcgggagt gagtgtgccc ttcacactgt gacattgtga cattgtgaca agctccatgt
     7081 cctttaaaat cagtcactct gcacacaaga gaaatcaact tcgtggttgg atggggccgg
     7141 aacacaacca gtctttttgt atttattgtt actgagacaa aacagtactc actgagtgtt
     7201 tttcagtttc ctactggtgg ttttgatatt gtttgtttaa gatgtatatt tagaatgaca
     7261 tcatctaaga agctgatttt gctaaactcc tgttccctac aatgggaaat gtcacaagaa
     7321 tgtgcaaaaa taaaaatctg aggaaaaaac cca
//
