LOCUS       NM_018373               7057 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synaptojanin 2 binding protein (SYNJ2BP), mRNA.
ACCESSION   NM_018373
VERSION     NM_018373.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7057)
  AUTHORS   Song,Y., Geng,W., Zhu,D., Liang,H., Du,Z., Tong,B., Wang,K., Li,S.,
            Gao,Y., Feng,X., Liao,Z., Mei,R. and Yang,C.
  TITLE     SYNJ2BP ameliorates intervertebral disc degeneration by
            facilitating mitochondria-associated endoplasmic reticulum membrane
            formation and mitochondrial Zn2+ homeostasis
  JOURNAL   Free Radic Biol Med 212, 220-233 (2024)
   PUBMED   38158052
  REMARK    GeneRIF: SYNJ2BP ameliorates intervertebral disc degeneration by
            facilitating mitochondria-associated endoplasmic reticulum membrane
            formation and mitochondrial Zn[2+] homeostasis.
REFERENCE   2  (bases 1 to 7057)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 7057)
  AUTHORS   Carr,H.S., Chang,J.T. and Frost,J.A.
  TITLE     The PDZ Domain Protein SYNJ2BP Regulates GRK-Dependent Sst2A
            Phosphorylation and Downstream MAPK Signaling
  JOURNAL   Endocrinology 162 (2) (2021)
   PUBMED   33313679
  REMARK    GeneRIF: The PDZ Domain Protein SYNJ2BP Regulates GRK-Dependent
            Sst2A Phosphorylation and Downstream MAPK Signaling.
REFERENCE   4  (bases 1 to 7057)
  AUTHORS   McKenna,M.J., Sim,S.I., Ordureau,A., Wei,L., Harper,J.W., Shao,S.
            and Park,E.
  TITLE     The endoplasmic reticulum P5A-ATPase is a transmembrane helix
            dislocase
  JOURNAL   Science 369 (6511) (2020)
   PUBMED   32973005
REFERENCE   5  (bases 1 to 7057)
  AUTHORS   Hartmann,C., Schwietzer,Y.A., Kummer,D., Kirschnick,N., Hoppe,E.,
            Thuring,E.M., Glaesner-Ebnet,M., Brinkmann,F., Gerke,V., Reuter,S.,
            Nakayama,M. and Ebnet,K.
  TITLE     The mitochondrial outer membrane protein SYNJ2BP interacts with the
            cell adhesion molecule TMIGD1 and can recruit it to mitochondria
  JOURNAL   BMC Mol Cell Biol 21 (1), 30 (2020)
   PUBMED   32303178
  REMARK    GeneRIF: The mitochondrial outer membrane protein SYNJ2BP interacts
            with the cell adhesion molecule TMIGD1 and can recruit it to
            mitochondria.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7057)
  AUTHORS   Matsuzaki,T., Hanai,S., Kishi,H., Liu,Z., Bao,Y., Kikuchi,A.,
            Tsuchida,K. and Sugino,H.
  TITLE     Regulation of endocytosis of activin type II receptors by a novel
            PDZ protein through Ral/Ral-binding protein 1-dependent pathway
  JOURNAL   J Biol Chem 277 (21), 19008-19018 (2002)
   PUBMED   11882656
REFERENCE   7  (bases 1 to 7057)
  AUTHORS   Lin,F., Yu,Y.P., Woods,J., Cieply,K., Gooding,B., Finkelstein,P.,
            Dhir,R., Krill,D., Becich,M.J., Michalopoulos,G., Finkelstein,S.
            and Luo,J.H.
  TITLE     Myopodin, a synaptopodin homologue, is frequently deleted in
            invasive prostate cancers
  JOURNAL   Am J Pathol 159 (5), 1603-1612 (2001)
   PUBMED   11696420
REFERENCE   8  (bases 1 to 7057)
  AUTHORS   Weins,A., Schwarz,K., Faul,C., Barisoni,L., Linke,W.A. and
            Mundel,P.
  TITLE     Differentiation- and stress-dependent nuclear cytoplasmic
            redistribution of myopodin, a novel actin-bundling protein
  JOURNAL   J Cell Biol 155 (3), 393-404 (2001)
   PUBMED   11673475
REFERENCE   9  (bases 1 to 7057)
  AUTHORS   Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
            Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J Biol Chem 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   10 (bases 1 to 7057)
  AUTHORS   Nemoto,Y. and De Camilli,P.
  TITLE     Recruitment of an alternatively spliced form of synaptojanin 2 to
            mitochondria by the interaction with the PDZ domain of a
            mitochondrial outer membrane protein
  JOURNAL   EMBO J 18 (11), 2991-3006 (1999)
   PUBMED   10357812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP195583.1, BC007704.2, AL356804.4 and BQ775922.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018373.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP195583.1, SRR1803613.130329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267756 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256366.6/ ENSP00000256366.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BP195583.1         1-98
            99-759              BC007704.2         1-661
            760-6528            AL356804.4         110254-116022       c
            6529-7057           BQ775922.1         18-546              c
FEATURES             Location/Qualifiers
     source          1..7057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..7057
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /note="synaptojanin 2 binding protein"
                     /db_xref="GeneID:55333"
                     /db_xref="HGNC:HGNC:18955"
                     /db_xref="MIM:609411"
     exon            1..191
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..565
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /note="activin receptor interacting protein 5;
                     mitochondrial outer membrane protein 25"
                     /codon_start=1
                     /product="synaptojanin-2-binding protein"
                     /protein_id="NP_060843.2"
                     /db_xref="CCDS:CCDS9803.1"
                     /db_xref="GeneID:55333"
                     /db_xref="HGNC:HGNC:18955"
                     /db_xref="MIM:609411"
                     /translation="MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYV
                     SRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQV
                     QNGPIGHRGEGDPSGIPIFMVLVPVFALTMVAAWAFMRYRQQL"
     exon            192..328
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            329..424
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /inference="alignment:Splign:2.1.0"
     exon            425..7057
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      735..740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /note="hexamer: AGTAAA"
     polyA_site      759
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /note="hexamer: ATTAAA"
     polyA_site      1140
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
     regulatory      7032..7037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /note="hexamer: AATAAA"
     polyA_site      7057
                     /gene="SYNJ2BP"
                     /gene_synonym="ARIP2; OMP25"
                     /note="major polyA site"
ORIGIN      
        1 cttttccggg tctcgaggct gctgaaaccg aaaccgctgt gctgtgggcg cagcgccgag
       61 attgattcac cttcacctgt gctgcactcc agctgaccca agtaggaagc cagacgagct
      121 gtaaaacatg aacggaagag tggattattt ggtcactgag gaagagatca atcttaccag
      181 agggccctca gggctgggct tcaacatcgt cggtgggaca gatcagcagt atgtctccaa
      241 cgacagtggc atctacgtca gccgcatcaa agaaaatggg gctgcggccc tggatgggcg
      301 gctccaggag ggtgataaga tcctttcggt aaatggccaa gacctaaaga acctgctgca
      361 ccaggatgct gtagacctct ttcgtaatgc aggctatgct gtgtctctga gagtgcagca
      421 caggttacag gtgcagaatg gacctatagg acatcgaggt gaaggggacc caagtggtat
      481 tcccatattt atggtgctgg tgccagtgtt tgccctcacc atggtagcag cctgggcttt
      541 catgagatac cggcaacaac tttgaaaaac ttgctctctt tcaatactcc caatgaagat
      601 acatttcact caccctccac ccctgctatt ctgccatgtc tttccctctc tctgcatagc
      661 cagatttgaa gtgactgata cccaccccaa accttgctgt tcacagtctc caattcttca
      721 tattctaatg ggaaagtaaa ggtattgttt gaaggaaaac tgaagaaaag acttggctta
      781 gaacaaatga ggagttatat attttactag gacttttgat agaaattcag ctacaaccca
      841 aagagagaaa gattgagtct tcctgtcacc ataggcaata ccttttttct tagctggcat
      901 gccataaagg ccagctatgt gatattagag gaagaaagga tttttctttt taatgatctt
      961 ccttgggaaa ttattgtggc ctttatttaa tttctaacta cgtacctggg tgcctatatc
     1021 gacaaagagt gagaagagca tttttacttt tttaaaaaag caaatacata tatacacata
     1081 cgtatgcaaa tattatagta taatagtgat ccctatggag aattaaaggt gagaaagcta
     1141 ctttgtggtg tctaggtttc tgataaaagg gatgatctta actgaagaat ttaaagagat
     1201 acttaaacag agcaaatgta gtaggaacaa gggagtgagc cttataagag gacgttcagt
     1261 ctcatttatt aaaataataa ctgagactgg gagaggtggc tcatgcctgt aaatcccagc
     1321 actttggtag cctgaagtgg gagattgctt gagtccagga gaccagcctg ggcaacatag
     1381 caaaacctca tctctattta aaaaaaaaat agaaaaaaat gtaataactg aagcaactaa
     1441 ttaaaaatct tagaagaaca atatttattc ttataacagc caactatggt gagttattat
     1501 aaggtaaatt gccataatcc agcgctgctc acatctaaaa aactttgagg tgtaaaggta
     1561 aatcgtacca atctctgggc tgccctagtg acttttttga tacctcagag tcctattgaa
     1621 gaaccaggtg gaatgattgt ggtaagggct atagtgctgg agccaaacac cccagcaaga
     1681 aaactctaaa aggacaaaag ataaggtagt gcctccaagg tggcacctga accctctcag
     1741 gctacttttt ggtttctact aacaaacctg agggaaggaa ctgcctccct ggcaggatgg
     1801 gcatcaaatc aactctggct tcagatttag ttaaaatgag gccgggtgca gcggctcaca
     1861 cctgtcatct cagcactttg ggaggccgag gcaggcagat cacaaggtca ggagttcaag
     1921 accagcctgg ccaacatggt gaaaccccat gtctactgaa aatacaaaaa ttacctggac
     1981 atggtggcgc gttcctgtaa ttccagctac tcaggaggct gaggcaggag aactgtttga
     2041 accaggacct gggagacgga ggttgcagtg agccaagatc acgccactgc actccagcct
     2101 gggctacaga gcaagactcc atctcaaaaa aagaaaggca tggattgcta gtatttttga
     2161 aaggctttat acactacata cggcttttaa taaacctttt tgcagcaaga gggaggaaaa
     2221 gagttttgtt tgctttagga ggtagggaaa tgtggtaggt gtttcatgcg gcctaggagg
     2281 aggatatgaa tgaatggata ctatggaatg ccagtgatct cgataaggtg ggaaccatcc
     2341 tgttcatgtt cttttaaggc tggttttaag cactatgggt agctgaattt tctggcttta
     2401 agaaaatcat ttccattagc caaatatatt ggccatacta taggcctttt ataattttgt
     2461 tagcaagatt atcaggactc aggcaatcaa ctgtatttca tttctagctt ggacagtctg
     2521 gtaattaaat gttgattgga catcagcttt gtcaagacac ttttacaaag aagtacagtg
     2581 catatcctcc atcccatagg gcttttgggt tccaactgcg aagacaacac tcttattggc
     2641 cacataggta ggacagtgta agtaggggtc atgtttatat tacagacagc aaaagagaaa
     2701 agttactgag aactggggcg tttgagaaag ttacgtggag gaaagggaca agttgaagac
     2761 ccttaagggc ctcacagcct agttaagaga attcataaac aggtgagaag ttaaaagtat
     2821 atcagcaggc taagtattga aaacaatatt aaaggggtac catgcaaaac acgatgcagc
     2881 aacaaagaag atatgcaggt aatcatcaca ttttctttta gaaattcagg gaaaaaaaga
     2941 tgtcacataa tggcatcagg ctcaattgga aagggaaggc ttttgaaaat aagaggtccg
     3001 gtaagacctt gcctctgggt cactactggt atagggagaa acttgcttta aacagtcctg
     3061 acataaagtg ccttttgaca tcaactattc aatacctttg agactcactt agacaactgg
     3121 actcattgta ggttccacag aaaaacacgg acaacattct agttgtcact ccaaccagcc
     3181 acactaggag ggcacagcct ctggtaccct ttctgttcct gaaggcatgt acagcggctt
     3241 ctacagcaag cttgcttacc tcccaggatt cacctcatgg tttggacact gattcctgag
     3301 agagccttga gacacacaaa gtgaaaaaaa tgtcaagcag gaatgaaagc tctagttttt
     3361 tgcttgttgg tatatgtaaa tttgtttaaa aagtatccat tctgtcgttg gtagaagttt
     3421 tgctttggtt gataatagag attctgatgt actcttataa cttaggtttt ctcagaaatt
     3481 aagtagcatt gaagatcaat gtaatacagt tttaagcagg tacactaatt atattattga
     3541 ttctatagaa aactaaaatt atagatgagg tatcaggatc cattataggt tgtaaaaaaa
     3601 ttcatgttct tcatagattg agtctaatat ttcttctata gattgcatct aatgttccta
     3661 ctacctaaat tattacgttc aaagttttga aaattgaacg aaggtatttt taagtactta
     3721 aaacatttct ctatcattct gtattacatg tataattata agatattgtt tgcttcaact
     3781 agctgtactt tgttttcctg tgaagtttca acttatgtgt tatcgattta acttaattgt
     3841 tccatctagc catgtataat ggaaaaagga agttaatatt tgttattgtg ttctatgcca
     3901 gggactgtac caaactctga ttggtacatt atttcatgtc tcataactct gggatctaag
     3961 tattgtcaca aagagactaa aaatgagaga aaaaattact tgactaggat tatgtaggtg
     4021 gtaataatag aatcaggatt taaactcagg acttcagatg ccagcatcaa tgatattctc
     4081 tcactggaag tggttctcaa agcaaggtcc tgacaaaagc atcagcgtta ctggggaact
     4141 tgttagaaaa gcaagttcat aggctgggca tggtggctca tgcctgtaat cccagcactc
     4201 taggaggcct aggcaggtgg gtcacttgag ctcaggagtt ttgagaccag cctgcacaat
     4261 gtggtgaaac cctgtcttta ctaaaagtca aacaaattag tggtgcattc ctgtaggccc
     4321 agctacacgg gaggattgct tgagcccagg agactgaggt gcagtgagcc gtgattgctc
     4381 cacttcattc tagcctgagc aacggagtga gaccttgtct caaaaacaaa aaaacaaaca
     4441 aacaaaaaac aaaaagcaag ttcccagaag agaaaaaaga agttccagac ctagtgaatc
     4501 aaaaactctg agcgtggcat ctcacaatct gtgtttttgt aatccttcca ggtgactgat
     4561 tcatgctaaa gtttgagact cattgctcta tgccagtcat cattcccttt gctcaggtta
     4621 gaatcatctg gagagcttat aaacgtcccc atgcccaggc tgcacacaga tcaattaaaa
     4681 ggaacctctg agggtgggac tcaagcagca gtaaaataaa gttcattgag tgattctggt
     4741 gtgcagccgc agttgaaaat gttatatagc atttaaacaa gacactattt aattaaacac
     4801 tatttaaatt attaaattac atacattgct tcaggcaaaa caacaacaac aacaacaaca
     4861 acaaaaactt gggcctttag agcccagctt cctgagcttc tgcacgaagt aagtggaaca
     4921 ttcatttctt cctgatttgc taaggattga tcaacctcca gcaaaatgta tgattagtga
     4981 gtgtttcagt tggtgcatca attaaatgag aaccaatcat agaacattga agctaaaaag
     5041 gaccagagag cttctaggat gaatctgtct tagagatgag aaaaataaag gctcagagag
     5101 ggaagctaac ttaactctga tcagacttag tttgttgcag aagtgacctt tctgtctcat
     5161 atttatgtct tgaatatatt cactacatga atacacagac tacccatttt atcttagtct
     5221 acttctttct tctctctttg ggcctgaata aagaccagaa ctgatagaca gctaaaggat
     5281 attgcaagca tcattattgg aattgggaga ttccacagaa caatctgaga atgatctcat
     5341 atcaaatcca atcagatgag ttattctgag actaattcca atagttctag agactttttt
     5401 ttttatggtg gacattgttt ttattgtgta aataagcaat ttttaaagta tatttaaaga
     5461 aatgaaacat aaggaagtgt ataggctgtc aggtatgtgg ggaagtgaag ttcatgtagt
     5521 tttcatgtgg agcccataca gattttatta tagtcaattt tagtgaaatt tatcgttggt
     5581 cagatgaagg tttttttcct tcattcagca aataactaat gactgcctac tatgtgctag
     5641 gtgccgaaga tagagagata aataacactt agtcactcta agctgaaatt gctcagcata
     5701 tgaaagtgga ggaatatttg taggtgattt tgatgttaaa gtattttttt aacatcacct
     5761 ggtagtagaa gattgagtta tgaagctgtc tacctctcac ctgtaatagt tttagagttg
     5821 gttgctattt tggtgtaagt cttttttgct gttcctcttt taactgcaaa tctttttgag
     5881 accagcactc acatccaaaa gggcaattgt gataaaaaag aagacagtat tttaaggatt
     5941 ctgatcagaa ccagattctt ttcttttctt tttttttttt tttttttttt ttttgagacg
     6001 gagtcttgct ctgtcgccta ggctggagtg cagtggcacg atctcagctc actgcaatct
     6061 ctgccgcccg ggttcaagcg attctcctgc ctcagcctcc ccagtagttg ggattacagg
     6121 tgtgtgccac aacgcctggc taatttttgt atttttagta gacacggggt ttcagcatct
     6181 tggccaggct ggtcttgaat tcctgacctc gtgatccacc catctcggcc tcccaaagtg
     6241 cagaaccaga ttcttaactg ccacagactc ttgtattatg taatttatat acagaacaca
     6301 aagcacttga tttgcttaac tgatgtactt gatgatacta taaaacctat attatgagaa
     6361 agcattgctc cttcaaagga atcaagtgat agcaaacact cggtcctgtt tccaggtttt
     6421 cctcactgtt cattttgcct ttgttcttgc agggggagaa tgaaaggggc gagagctaaa
     6481 gtgtgttgtc aatgcaagtc aatccttaac caacaataat ttacaaaaga actttatatt
     6541 tgctgtaatc attaaattta gttactaatc ccaggaaaag ggttagtcct tcctcctagt
     6601 ttgtagattt gcaaatggag atgaataatt gaatcctatt ttaatctttt atctgcagta
     6661 atctgggctt cttattaccg gatatatttg cattttacct ccaggccatg ttagttctta
     6721 gaagattatt ttcctcatga accctgtttt gttttgcttc ctttctgctt caattctaat
     6781 gtcacattgc atacctggat gtaaacagca gtcagtttct cagatcaaat agagccctgt
     6841 agcaacttgg aagacacaga agacacacgg acataaaact gtatttatta tccagggaat
     6901 gtcactacgg attaattatg ttaatgaggc catcaaaatc tatggtaatc tttcaggctt
     6961 tgttgtttga taccagatac agcaaatgag ataataatgt gtctaattgt gcctagccag
     7021 tattggtatt taataaaact ttgtcattga atcttta
//
