LOCUS       NM_001202547            1955 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens SYNJ2BP-COX16 readthrough (SYNJ2BP-COX16), transcript
            variant 1, mRNA.
ACCESSION   NM_001202547
VERSION     NM_001202547.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Gu X, Guo X, Hwang
            SJ, Sijbrands E, Smith AV, Verwoert GC, Bragg-Gresham JL, Cadby G,
            Chen P, Cheng CY, Corre T, de Boer RA, Goel A, Johnson T, Khor CC,
            Lluis-Ganella C, Luan J, Lyytikainen LP, Nolte IM, Sim X, Sober S,
            van der Most PJ, Verweij N, Zhao JH, Amin N, Boerwinkle E, Bouchard
            C, Dehghan A, Eiriksdottir G, Elosua R, Franco OH, Gieger C, Harris
            TB, Hercberg S, Hofman A, James AL, Johnson AD, Kahonen M, Khaw KT,
            Kutalik Z, Larson MG, Launer LJ, Li G, Liu J, Liu K, Morrison AC,
            Navis G, Ong RT, Papanicolau GJ, Penninx BW, Psaty BM, Raffel LJ,
            Raitakari OT, Rice K, Rivadeneira F, Rose LM, Sanna S, Scott RA,
            Siscovick DS, Stolk RP, Uitterlinden AG, Vaidya D, van der Klauw
            MM, Vasan RS, Vithana EN, Volker U, Volzke H, Watkins H, Young TL,
            Aung T, Bochud M, Farrall M, Hartman CA, Laan M, Lakatta EG,
            Lehtimaki T, Loos RJ, Lucas G, Meneton P, Palmer LJ, Rettig R,
            Snieder H, Tai ES, Teo YY, van der Harst P, Wareham NJ, Wijmenga C,
            Wong TY, Fornage M, Gudnason V, Levy D, Palmas W, Ridker PM, Rotter
            JI, van Duijn CM, Witteman JC, Chakravarti A and Rao DC.
  CONSRTM   LifeLines Cohort Study
  TITLE     Gene-age interactions in blood pressure regulation: a large-scale
            investigation with the CHARGE, Global BPgen, and ICBP Consortia
  JOURNAL   Am. J. Hum. Genet. 95 (1), 24-38 (2014)
   PUBMED   24954895
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS ONE 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356804.4 and FY210787.1.
            
            On Feb 11, 2011 this sequence version replaced NM_001202547.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring SYNJ2BP (synaptojanin 2
            binding protein) and COX16 (COX16 cytochrome c oxidase assembly
            homolog (S. cerevisiae)) genes on chromosome 14. The read-through
            transcript produces a fusion protein that shares sequence identity
            with each individual gene product. Alternate splicing results in
            multiple transcript variants that encode different isoforms.
            [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FY210857.1, FY210787.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2142670,
                                           SAMEA2467148 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 51241, 55333
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AL356804.4         160211-160316       c
            107-546             FY210787.1         1-440
            547-547             AL356804.4         72439-72439         c
            548-601             FY210787.1         441-494
            602-1955            AL356804.4         68307-69660         c
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..1955
                     /gene="SYNJ2BP-COX16"
                     /note="SYNJ2BP-COX16 readthrough"
                     /db_xref="GeneID:100529257"
                     /db_xref="HGNC:HGNC:48350"
     exon            1..191
                     /gene="SYNJ2BP-COX16"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..703
                     /gene="SYNJ2BP-COX16"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="SYNJ2BP-COX16 protein isoform 1"
                     /protein_id="NP_001189476.1"
                     /db_xref="GeneID:100529257"
                     /db_xref="HGNC:HGNC:48350"
                     /translation="MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYV
                     SRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQV
                     QNGPIGHRGEGDPSGIPIFMVLVPVFALTMMDPELEKKLKENKISLESEYEKIKDSKF
                     DDWKNIRGPRPWEDPDLLQGRNPESLKTKTT"
     exon            192..328
                     /gene="SYNJ2BP-COX16"
                     /inference="alignment:Splign:2.1.0"
     exon            329..424
                     /gene="SYNJ2BP-COX16"
                     /inference="alignment:Splign:2.1.0"
     exon            425..523
                     /gene="SYNJ2BP-COX16"
                     /inference="alignment:Splign:2.1.0"
     exon            524..586
                     /gene="SYNJ2BP-COX16"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1955
                     /gene="SYNJ2BP-COX16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      940..945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNJ2BP-COX16"
                     /note="hexamer: AATAAA"
     polyA_site      968
                     /gene="SYNJ2BP-COX16"
                     /note="major polyA site"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNJ2BP-COX16"
                     /note="hexamer: AATAAA"
     polyA_site      1955
                     /gene="SYNJ2BP-COX16"
ORIGIN      
        1 cttttccggg tctcgaggct gctgaaaccg aaaccgctgt gctgtgggcg cagcgccgag
       61 attgattcac cttcacctgt gctgcactcc agctgaccca agtaggaagc cagacgagct
      121 gtaaaacatg aacggaagag tggattattt ggtcactgag gaagagatca atcttaccag
      181 agggccctca gggctgggct tcaacatcgt cggtgggaca gatcagcagt atgtctccaa
      241 cgacagtggc atctacgtca gccgcatcaa agaaaatggg gctgcggccc tggatgggcg
      301 gctccaggag ggtgataaga tcctttcggt aaatggccaa gacctaaaga acctgctgca
      361 ccaggatgct gtagacctct ttcgtaatgc aggctatgct gtgtctctga gagtgcagca
      421 caggttacag gtgcagaatg gacctatagg acatcgaggt gaaggggacc caagtggtat
      481 tcccatattt atggtgctgg tgccagtgtt tgccctcacc atgatggatc ctgagcttga
      541 aaaaaaactg aaagagaata aaatatcttt agagtcggaa tatgagaaaa tcaaagactc
      601 caagtttgat gactggaaga atattcgagg acccaggcct tgggaagatc ctgacctcct
      661 ccaaggaaga aatccagaaa gccttaagac taagacaact tgactctgct gattcttttt
      721 tccttttttt tttttttaaa taaaaatatt attaactgga cttcctaata tatacttcta
      781 tcaagtggaa aggaaattcc aggcccatgg aaacttggat atgggtaatt tgatgacaaa
      841 taatcttcac taaaggtcat gtacaggttt ttatacttcc cagctattcc atctgtggat
      901 gaaagtaaca atgttggcca cgtatatttt acacctcgaa ataaaaaatg tgaatactgc
      961 tccaaaaaca gagtcacgta ttccactctc caactaccca catattcctt ttgcaatagc
     1021 cattagggca tcattttgat atttcattct gatttctgat tctctgattt ctgattccta
     1081 atgaggacag taggtctgga tccaaattct cacagtaaaa tcaagcagta attttctctc
     1141 atatctatta gggaaagaaa aatgatcaca gtctgctaag agtcttgatt ttctttgtaa
     1201 tgcctcacat agtatgataa tcagtctcca aagcatcaca tgataattac aatgatacca
     1261 ttaacatgtc aaggaaatta tattatttat ggttgtcaaa aattatgaag tagtgtatga
     1321 ttataagcag atatggcaaa tttgttcagt aaatccatag atgactacat tttgagaaat
     1381 actaagataa tactaaaaat tatgccttag cataatttgc atgcaaaatt gccctctagt
     1441 gtttttgttt tgttttgaga catagtctcg ctctgttcgc ccaggctgga gtgcaggggc
     1501 acgatctctg ctcactgcaa gctctgcttc ccgggttcac accattctcc tgcctcagca
     1561 tcctgagtag ctgggactac aggcacatgc tgtcacaccc ggctaatttt ttgtatttag
     1621 tagagatggg gtttcaccac gttagccagg atggtctcca tctcctgacc ttgtgatccg
     1681 cccacctcgg cctcacaaat tgctgggatt acaggtgtga gccaccacgc ctggccgaaa
     1741 gttagttgtt ttgaactcat tttctccttt ttacccctgc ctttatcagc ttctaccttc
     1801 tggtttcatg ctgagttcta gttgcctaaa gtctccattg aaacactcct gttataattg
     1861 ccataaaatc ataaatccac tccccctttc tcctcctagt caaaatttgt attcttttca
     1921 gcaggttggt tttaataaaa agtaaattaa gttga
//
