LOCUS       NM_003898               7402 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens synaptojanin 2 (SYNJ2), transcript variant 1, mRNA.
ACCESSION   NM_003898
VERSION     NM_003898.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7402)
  AUTHORS   Hou,W., Li,G.S., Gao,L., Lu,H.P., Zhou,H.F., Kong,J.L., Chen,G.,
            Xia,S. and Wei,H.Y.
  TITLE     SYNJ2 is a novel and potential biomarker for the prediction and
            treatment of cancers: from lung squamous cell carcinoma to
            pan-cancer
  JOURNAL   BMC Med Genomics 15 (1), 114 (2022)
   PUBMED   35581615
  REMARK    GeneRIF: SYNJ2 is a novel and potential biomarker for the
            prediction and treatment of cancers: from lung squamous cell
            carcinoma to pan-cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7402)
  AUTHORS   Zhang,R., Mo,W.J., Huang,L.S., Chen,J.T., Wu,W.Z., He,W.Y. and
            Feng,Z.B.
  TITLE     Identifying the Prognostic Risk Factors of Synaptojanin 2 and Its
            Underlying Perturbations Pathways in Hepatocellular Carcinoma
  JOURNAL   Bioengineered 12 (1), 855-874 (2021)
   PUBMED   33641617
  REMARK    GeneRIF: Identifying the Prognostic Risk Factors of Synaptojanin 2
            and Its Underlying Perturbations Pathways in Hepatocellular
            Carcinoma.
REFERENCE   3  (bases 1 to 7402)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7402)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7402)
  AUTHORS   Du,Q., Guo,X., Zhang,X., Zhou,W., Liu,Z., Wang,J., Zhang,T.,
            Mao,Z., Luo,J., Jin,T. and Liu,C.
  TITLE     SYNJ2 variant rs9365723 is associated with colorectal cancer risk
            in Chinese Han population
  JOURNAL   Int J Biol Markers 31 (2), e138-e143 (2016)
   PUBMED   26616230
  REMARK    GeneRIF: Results, combined with previous studies, suggest that
            rs9365723, located on SYNJ2, is associated with the risk of CRC in
            a Chinese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7402)
  AUTHORS   Spaenij-Dekking,E.H., Van Delft,J., Van Der Meijden,E.,
            Hiemstra,H.S., Falkenburg,J.H., Koning,F., Drijfhout,J.W. and
            Kluin-Nelemans,J.C.
  TITLE     Synaptojanin 2 is recognized by HLA class II-restricted hairy cell
            leukemia-specific T cells
  JOURNAL   Leukemia 17 (12), 2467-2473 (2003)
   PUBMED   14562116
  REMARK    GeneRIF: Since Syn 2 is a phosphatidylinositol 4,5-biphosphatase
            involved in cell growth and rearrangement of actin filaments, the
            increased Syn 2 expression may correlate with the hairy cell
            leukemia etiology or the characteristic morphologic alterations.
REFERENCE   7  (bases 1 to 7402)
  AUTHORS   Zhong,R. and Ye,Z.H.
  TITLE     The SAC domain-containing protein gene family in Arabidopsis
  JOURNAL   Plant Physiol 132 (2), 544-555 (2003)
   PUBMED   12805586
REFERENCE   8  (bases 1 to 7402)
  AUTHORS   Rusk,N., Le,P.U., Mariggio,S., Guay,G., Lurisci,C., Nabi,I.R.,
            Corda,D. and Symons,M.
  TITLE     Synaptojanin 2 functions at an early step of clathrin-mediated
            endocytosis
  JOURNAL   Curr Biol 13 (8), 659-663 (2003)
   PUBMED   12699622
  REMARK    Erratum:[Curr Biol. 2003 Sep 30;13(19):1746]
REFERENCE   9  (bases 1 to 7402)
  AUTHORS   Nemoto,Y., Wenk,M.R., Watanabe,M., Daniell,L., Murakami,T.,
            Ringstad,N., Yamada,H., Takei,K. and De Camilli,P.
  TITLE     Identification and characterization of a synaptojanin 2 splice
            isoform predominantly expressed in nerve terminals
  JOURNAL   J Biol Chem 276 (44), 41133-41142 (2001)
   PUBMED   11498538
REFERENCE   10 (bases 1 to 7402)
  AUTHORS   Malecz,N., McCabe,P.C., Spaargaren,C., Qiu,R., Chuang,Y. and
            Symons,M.
  TITLE     Synaptojanin 2, a novel Rac1 effector that regulates
            clathrin-mediated endocytosis
  JOURNAL   Curr Biol 10 (21), 1383-1386 (2000)
   PUBMED   11084340
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK294480.1, AF318616.1,
            AL139330.17 and AF086449.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003898.3.
            
            Summary: The gene is a member of the inositol-polyphosphate
            5-phosphatase family. The encoded protein interacts with the
            ras-related C3 botulinum toxin substrate 1, which causes
            translocation of the encoded protein to the plasma membrane where
            it inhibits clathrin-mediated endocytosis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). This variant (1) is
            also known as synaptojanin 2B or 2B2 (SJ2B2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF318616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355585.9/ ENSP00000347792.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK294480.1         8-31
            25-5056             AF318616.1         9-5040
            5057-6766           AL139330.17        1218-2927           c
            6767-7402           AF086449.1         4-639
FEATURES             Location/Qualifiers
     source          1..7402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..7402
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /note="synaptojanin 2"
                     /db_xref="GeneID:8871"
                     /db_xref="HGNC:HGNC:11504"
                     /db_xref="MIM:609410"
     exon            1..226
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..4590
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /EC_number="3.1.3.36"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inositol phosphate 5'-phosphatase 2; synaptic inositol
                     1,4,5-trisphosphate 5-phosphatase 2; phosphoinositide
                     5-phosphatase; inositol polyphosphate-5-phosphatase H"
                     /codon_start=1
                     /product="synaptojanin-2 isoform 1"
                     /protein_id="NP_003889.1"
                     /db_xref="CCDS:CCDS5254.1"
                     /db_xref="GeneID:8871"
                     /db_xref="HGNC:HGNC:11504"
                     /db_xref="MIM:609410"
                     /translation="MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAP
                     EEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITAT
                     DFYPLQEEAKEEERLIALKKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSF
                     FWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRF
                     HTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRG
                     LEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMIN
                     FDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDR
                     TNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEG
                     KAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALL
                     VTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLS
                     GATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILL
                     TSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFI
                     CSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFY
                     FVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTP
                     AWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHR
                     PVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTE
                     LMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLK
                     GLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPG
                     VSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFR
                     HRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLP
                     GAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLE
                     ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH
                     FTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP
                     PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVF
                     PQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDP
                     LDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLA
                     KT"
     exon            227..313
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            314..584
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            585..810
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            811..894
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            895..956
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1053
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1226
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1308
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1458
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1624
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1816
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1898
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2039
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2232
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2391
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2548
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2666
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2885
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2964
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3133
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3307
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3442
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3555
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3664
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3843
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..7402
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7377..7382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /note="hexamer: ATTAAA"
     polyA_site      7402
                     /gene="SYNJ2"
                     /gene_synonym="INPP5H"
                     /note="major polyA site"
ORIGIN      
        1 gaaactctgg caagttgcgg gcgcgcgggg agctgtcgcg ggcagcgcgc cctcgggagg
       61 acgtggcccc ggcccccgcc cgcagtgggc ccgaccctca tggccctgag caaagggctg
      121 cggctgctgg ggcgcctggg ggccgagggg gactgtagcg tgctgctgga ggcgcgcggc
      181 cgcgacgact gcctgctgtt cgaggccggc acggtggcca cgctggctcc agaagaaaag
      241 gaagtcatta aaggacagta tggcaagctc acggacgcgt acggctgcct gggggagctg
      301 aggctgaaat ctggtggcac gtctctgagc ttcctggtgt tggtgacagg ctgcacatct
      361 gtgggcagaa ttccagatgc tgaaatctac aaaatcactg ccactgactt ttaccctctt
      421 caggaagagg ccaaggagga ggaacgcctc atagctttga agaaaatcct cagctcgggg
      481 gtgttctatt tctcatggcc aaacgatggg tctcgctttg acctgactgt ccgcacgcag
      541 aagcaggggg atgacagctc tgaatggggg aactccttct tctggaacca gctgttgcac
      601 gtgcccttga ggcagcacca ggtgagctgc tgtgactggc tgctgaagat catctgcggg
      661 gtggtcacca tccgcaccgt gtatgcctcc cacaagcagg ccaaggcctg cctcgtctct
      721 cgcgttagct gtgagcgcac aggcactcgc ttccacaccc gtggcgtgaa cgacgacggc
      781 catgtgtcca acttcgtgga gacagagcag atgatttaca tggacgatgg agtgtcatct
      841 tttgtccaga tcagaggctc cgttccgctg ttctgggaac agccagggct tcaggttggc
      901 tcccatcatc tgagactcca cagaggcctg gaagccaatg cccctgcttt cgacaggcac
      961 atggtgcttc tgaaggagca gtacgggcag caggtggtcg tgaaccttct gggaagcaga
     1021 ggcggagagg aggtgctcaa cagagccttc aagaagctgc tctgggcttc ttgccacgcg
     1081 ggcgacacgc ctatgatcaa ttttgacttc catcagtttg ccaaaggtgg gaagctagag
     1141 aaattggaga ccctcttgag gccacagtta aagctgcact gggaagactt cgatgtgttc
     1201 acaaaggggg agaacgtcag tccacgtttt cagaaaggca ctttgcggat gaactgtctt
     1261 gactgcctgg accgaaccaa cactgtgcag agcttcatcg cgctcgaggt cctgcatctg
     1321 cagctcaaga ccctggggct gagttcaaaa cccatcgttg accgctttgt ggagtccttc
     1381 aaagccatgt ggtctctgaa tggccacagc ctgagcaagg tgttcacagg cagcagagcc
     1441 ctggaaggga aggccaaggt ggggaagctg aaggatggag cccggtccat gtctcgaacc
     1501 atccagtcca acttcttcga cggggtgaag caggaggcca tcaagctgct gctggttggg
     1561 gacgtctacg gcgaggaggt ggcagacaaa gggggcatgc tgctggacag cacggcgctc
     1621 ctggtgactc ccaggatcct gaaagctatg actgagcgtc agtccgaatt cacaaatttc
     1681 aagcggatcc ggattgctat ggggacctgg aacgtgaacg gaggaaagca gttccggagc
     1741 aacgtgctca ggacggcgga gctgacagac tggctgctcg actcgcccca gctctcggga
     1801 gctaccgact cccaggatga cagcagccca gctgacatat ttgctgtggg gtttgaagag
     1861 atggtggaat tgagcgcagg gaatattgtc aatgccagta ctaccaacaa gaagatgtgg
     1921 ggtgaacagc ttcagaaagc catctcacgc tctcatagat acattctgtt gacttcggca
     1981 cagctggtgg gcgtctgtct ttatatcttt gtacgtccat accatgtccc gttcatcagg
     2041 gacgtagcca tcgacacagt gaagacgggc atggggggca aggcggggaa caagggcgcc
     2101 gtcggcatcc gcttccagtt ccacagcacc agcttctgct tcatatgtag tcacctgacg
     2161 gccgggcagt cccaggtgaa ggagcggaat gaagactaca aggagatcac ccagaaactc
     2221 tgcttcccaa tggggagaaa tgttttttct catgattatg tattttggtg tggcgatttc
     2281 aactaccgca ttgatcttac ttatgaagaa gtcttctatt ttgttaaacg ccaagactgg
     2341 aagaaacttc tggaatttga tcaactacag ctacagaaat caagtggaaa aatttttaag
     2401 gactttcacg aaggagccat taactttgga cccacctaca agtatgacgt tggctcagcc
     2461 gcctacgata caagcgacaa atgccgcacc cccgcctgga cagacagggt gctgtggtgg
     2521 aggaagaaac atccctttga taaaacagct ggagaactca accttctaga cagtgatcta
     2581 gatgttgaca ccaaagtcag acacacctgg tctcctggtg ccctgcagta ttatggtcgt
     2641 gcggagctac aagcgtctga tcacagacct gtgctggcga tcgtggaggt ggaagttcag
     2701 gaagtcgatg tgggtgctcg ggagagggtt ttccaggaag tgtcctcctt ccagggcccc
     2761 ctggatgcca ctgttgtagt aaaccttcaa tcaccgacct tagaagagaa aaacgagttt
     2821 ccagaggacc tgcgtactga gctcatgcag accttgggga gttatgggac aattgttctt
     2881 gtcaggatca accaagggca gatgctggta acttttgcag acagtcactc ggctctcagt
     2941 gtcctggacg tggacggtat gaaggtgaaa ggcagagcag tgaagattag accgaagacc
     3001 aaggactggc tgaaaggttt gcgagaggag atcattcgga aacgagacag catggccccc
     3061 gtgtctccca ctgccaactc ctgtttgctg gaggaaaact ttgacttcac aagtttggac
     3121 tatgagtcag aaggggatat tcttgaagac gatgaagact acttggtgga tgaattcaat
     3181 cagcctggag tctcggacag tgaactcggg ggagacgacc tctctgatgt ccccggcccc
     3241 acagcactgg ctcctcccag caagtcacct gctctcacca aaaagaagca gcatccaacg
     3301 tacaaagatg acgcggacct ggtggagctc aagcgggagc tggaagccgt cggggagttc
     3361 cgccaccgtt ctccgagcag gtctctgtcg gtccccaacc ggcctcggcc acctcaaccc
     3421 ccgcagagac ccccccctcc aaccggttta atggtgaaaa agtcggcttc agatgcgtcc
     3481 atctcctccg gcacccatgg acagtattca attttgcaga cggcaagact tctaccagga
     3541 gcacctcagc aacctcccaa ggctcggact ggaataagta aaccttataa tgtcaagcag
     3601 atcaaaacca ccaatgccca ggaggcagaa gcagcaatcc ggtgtctcct ggaagccaga
     3661 ggaggtgcct ccgaagaagc cctaagtgcc gtggccccaa gggaccttga agcatcctct
     3721 gaaccagagc ccacaccggg ggcagccaaa ccagagaccc cacaggcgcc cccactcctt
     3781 ccccgtcggc ccccacccag agttcctgcc atcaagaagc caaccttgag aaggacagga
     3841 aagcccctgt caccggaaga acagtttgag caacagactg tccattttac aatcgggccc
     3901 ccggagacaa gcgttgaggc ccctcctgtc gtgacagccc ctcgagtccc tcctgttccc
     3961 aaaccaagaa catttcagcc tgggaaagct gcagagaggc caagccacag gaagccagca
     4021 tcagacgaag cccctcctgg ggcaggagcc tctgtgccac cacctctgga ggcgccgcct
     4081 cttgtgccca aggtaccccc gaggaggaag aagtcagccc ccgcagcctt ccacctgcag
     4141 gtcctgcaga gcaacagcca gcttctccag ggcctcactt acaatagcag tgacagcccc
     4201 tctgggcacc cacctgccgc gggcaccgtc ttcccacaag gggactttct cagcacttca
     4261 tctgctacaa gccccgacag cgatggcacc aaagcgatga agccagaggc agccccactt
     4321 cttggtgatt atcaggaccc cttctggaac cttcttcacc accctaaact gttgaataac
     4381 acttggcttt ctaagagctc agaccctttg gactcaggaa ccaggagccc caaaagagat
     4441 cccatagacc cagtgtcagc tggcgcttca gctgccaagg cagagctgcc accagatcat
     4501 gaacacaaaa ccttaggtca ctgggtgaca atcagtgacc aagaaaagag gacagcactg
     4561 caggtgtttg acccactggc aaaaacatga ctgagcagct ttgaaggctg cagtcctata
     4621 gaatgcatac cttcctccct ctagacatcc ctccaccaga agagacatct atttaaaggc
     4681 acactggcca aaacgtttgt gcatctgtca ctctcgtgta gtttacaaaa atcgtgtctc
     4741 ttattcagta agatggttac tcagccacca aaatatattt cactcaaggc ttgtacatct
     4801 gaagtttgct cttcaaggaa tgggaacctt cctgttaaat tcggtgtatg gattttaaga
     4861 aaggaatcta gccaatgagg tccaagaagt tctcacccat tgaattttta aatggctgtt
     4921 cagttcatgt tgtacgtgat ggagatttgt cttttgtttt atttgcattt tacagatttg
     4981 gtataacatt ttggggagcc acctgaaggt tgatgtataa agtaaggatt agagaaagag
     5041 gtcgttgtga ccattagtag ctgtcctggc ccacttaaac aaggttacaa aaaatcagag
     5101 tcggaagcag ccaaataggt caacctaatg actagactgt acattcccat gagccttcat
     5161 gtttaagtgt gtacatgtgc gttaaccttg atgatgcgtg aatcccgagg gagccggtgg
     5221 catacaccgt tagcttaacc ttagcttaaa ctagctgaag gctcctgtgc catgtcttag
     5281 acattgcatg ccctatcaat tactataatc ctgagccatg gtgtgctact gaaaccaatt
     5341 tttatccacc atctagtcct tattaaatga aacctcacgg atcctttgtt ccgcttatat
     5401 tccatgcata ccacataaaa gcacacagtg cgaaaactct tgctgatacg cgatattgat
     5461 tctcattgtt agaatatgga gagtgtttca gcctcgtctg tccggctgga gcttcgggat
     5521 ggaaagtgct atgtgtccct gcatataaga atcaccaggc cagtgtttct gggtttgctt
     5581 gtctatatgt ttgtctatat tttttgccta tacatttttc ccacgtttcc aacagcactt
     5641 ctcacctatt caataactga aaaagacatt accatagtgc tttacatttt taaagtaatg
     5701 ttacaaggtc tggaatccat ttggagcaga taccgtgttt tcgctattta ataagaagtt
     5761 cagtagtgaa atcttactgt accgcctgtt gtatctggga gcctcgtaca gaggctcgca
     5821 cagcagtgat caagtgtcat cccttacgtg actgggggat gtctgtccta aaagctgact
     5881 gctaggatag taaggatcat cttgcctggg ctatgccact gtcttgttac caattagaca
     5941 tctggaattt cataattagt tttcattgtc actgtcaaga tatattgcag attacttaaa
     6001 tatggccatc aaaacaaaag ttacaacacg tatctctttt catctgaaaa ctaatacctg
     6061 gaaaaggata aaaaaaaaaa ggaatccgtg acccacagag ctagacagat aagatgcata
     6121 gttgaccagt cataaaaggc ggtgtttagg tgatcaggat gccgttggtg gcatttacgt
     6181 gctttatatg atttttacct ctgtaacaaa cacaagaaat aaacagaatg gtccttaaca
     6241 gagtttgggg gagagagcaa gatgggttcc ttggagaagc tgatttgcca agatgcacat
     6301 cgctattaac agccagagtc ataaatgaaa tgaaattgaa gaattcattc aaatgctctt
     6361 ttccctataa cctcttttct caccaaaaag gagataaatt tgaaaacaga taaatgtaac
     6421 aaccagtcaa agaagcaggg gaaaagtaag ctcctccaaa gttgcttgca gtgctggaaa
     6481 tagatctcat ttttaggttt tctcttcgtt ccagatacca aataaatggg acagagaata
     6541 aaatttttgt taaaatatgt gctcatctcc taagtagctc ttcagagtct gaccgtaagt
     6601 aaaaacacac agaattgtgt tgactggggg aggtgaatca caaaaaagtt acgaggagtt
     6661 taagagttaa atattatttg atcgtggctg tcaaatttag tgaacaacat agattggatt
     6721 tggagttggt agtaggtatg gttctcatac cagaattctc ttaaaaaaaa aaaaaaggac
     6781 aattggaatt gccttattta tttttaaaat caatgcttac tagttggtag gattcccagg
     6841 tcagcagcag ggttgattaa ataatcttga caatgagcag ctgccatctt gggggatttc
     6901 attctgtggt tttttaaatg tttcgtcttt gatgctacca tccagggctt cttattgtga
     6961 ccttgtagcc tattttgttc ctgctgttct ctaacatggt gcagttcacg cagactggtt
     7021 taggtacttc acaactcacc attgtctctc tgaccccaag cctagtccct tttacatcac
     7081 catcttctca gacttcttgc ctattcttaa aatatgtttt ggttaatgat tgaattagga
     7141 catcagctta agcaattcct gtaacggttt aacgttgttg aagttcaagg cacataataa
     7201 aattctccct gatgtgtgtg taagtataaa caaagtaatg tatcaaagcg ttcactttat
     7261 aatgaagtca tttcattggg aaggaaagct gcaaagatta ttgggggact agtgattaat
     7321 aaaatcctgt aatatttttg aagtgaaaat ttgtactgaa attgtacatg atacctatta
     7381 aatgtttttg tcttttttta aa
//
