LOCUS       NM_012451               1042 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens synaptogyrin 4 (SYNGR4), mRNA.
ACCESSION   NM_012451
VERSION     NM_012451.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Marques,R.F., Engler,J.B., Kuchler,K., Jones,R.A., Lingner,T.,
            Salinas,G., Gillingwater,T.H., Friese,M.A. and Duncan,K.E.
  TITLE     Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1
            in mutant TDP-43 amyotrophic lateral sclerosis models
  JOURNAL   Hum Mol Genet 29 (16), 2647-2661 (2020)
   PUBMED   32686835
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Smith,J.S., Tachibana,I., Pohl,U., Lee,H.K., Thanarajasingam,U.,
            Portier,B.P., Ueki,K., Ramaswamy,S., Billings,S.J.,
            Mohrenweiser,H.W., Louis,D.N. and Jenkins,R.B.
  TITLE     A transcript map of the chromosome 19q-arm glioma tumor suppressor
            region
  JOURNAL   Genomics 64 (1), 44-50 (2000)
   PUBMED   10708517
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Kedra,D., Pan,H.Q., Seroussi,E., Fransson,I., Guilbaud,C.,
            Collins,J.E., Dunham,I., Blennow,E., Roe,B.A., Piehl,F. and
            Dumanski,J.P.
  TITLE     Characterization of the human synaptogyrin gene family
  JOURNAL   Hum Genet 103 (2), 131-141 (1998)
   PUBMED   9760194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011514.3, BC106891.2 and
            AI222412.1.
            
            On May 17, 2019 this sequence version replaced NM_012451.3.
            
            Summary: This gene encodes an integral membrane protein. The gene
            belongs to the synaptogyrin gene family. Like other members of the
            family the protein contains four transmembrane regions. The exact
            function of this protein is unclear. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005695.1, BC106891.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344846.7/ ENSP00000344041.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC011514.3         11513-11657
            146-749             BC106891.2         1-604
            750-1042            AI222412.1         15-307              c
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1042
                     /gene="SYNGR4"
                     /note="synaptogyrin 4"
                     /db_xref="GeneID:23546"
                     /db_xref="HGNC:HGNC:11502"
                     /db_xref="MIM:608373"
     exon            1..171
                     /gene="SYNGR4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..371
                     /gene="SYNGR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..983
                     /gene="SYNGR4"
                     /note="testis tissue sperm-binding protein Li 72n"
                     /codon_start=1
                     /product="synaptogyrin-4"
                     /protein_id="NP_036583.2"
                     /db_xref="CCDS:CCDS12717.1"
                     /db_xref="GeneID:23546"
                     /db_xref="HGNC:HGNC:11502"
                     /db_xref="MIM:608373"
                     /translation="MHIPKSLQELANSEAVQFLRRPKTITRVFEGVFSLIVFSSLLTD
                     GYQNKMESPQLHCILNSNSVACSFAVGAGFLAFLSCLAFLVLDTQETRIAGTRFKTAF
                     QLLDFILAVLWAVVWFMGFCFLANQWQHSPPKEFLLGSSSAQAAIAFTFFSILVWIFQ
                     AYLAFQDLRNDAPVPYKRFLDEGGMVLTTLPLPSANSPVNMPTTGPNSLSYASSALSP
                     CLTAPKSPRLAMMPDN"
     exon            372..609
                     /gene="SYNGR4"
                     /inference="alignment:Splign:2.1.0"
     exon            610..749
                     /gene="SYNGR4"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1042
                     /gene="SYNGR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNGR4"
                     /note="hexamer: ACTAAA"
     polyA_site      998
                     /gene="SYNGR4"
     regulatory      1001..1006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SYNGR4"
                     /note="hexamer: AATAAA"
     polyA_site      1042
                     /gene="SYNGR4"
                     /note="major polyA site"
ORIGIN      
        1 gaggtggcgc tagggaccag gaggggtggg ggtggcgaaa ggaagggcgg gccctcaggt
       61 gacgcagatt ggccctccag agaaggggcg gccccttctc aggtgccgtc acccccaaac
      121 ctcagcactg ccattccagg tccttaaagg ggagaccgcg attctaagaa gcagccaagc
      181 ccagggctgg cctgaagccc ccggacggca gtgcccagca ggcagcgccc agcaccctgg
      241 ctcccacctc ccagtggccc caaaggaaaa cagctgccat gcacatcccc aaaagcctcc
      301 aggagctggc caacagcgaa gccgtgcagt ttctgagaag gcccaagacc atcacgcggg
      361 tcttcgaagg ggtcttctcc ctgatcgtct tctcctccct gctgaccgac ggctaccaga
      421 acaagatgga gtctccgcag ctccactgca ttctcaacag caacagcgtg gcctgcagct
      481 ttgccgtggg agccggcttc ctggccttcc tcagctgcct ggccttcctc gtcctggaca
      541 cacaggagac ccgcattgcc ggcacccgct tcaagacagc cttccagctc ctggacttca
      601 tcctggctgt tctctgggca gttgtctggt tcatgggttt ctgcttcctg gccaaccaat
      661 ggcagcattc gccgcccaaa gagttcctcc tggggagcag cagtgcccag gcagccatcg
      721 ccttcacctt cttctccatc cttgtctgga tattccaggc ctacctggca ttccaggacc
      781 tccgaaatga tgctccagtc ccttacaagc gcttcctgga tgagggtggc atggtgctga
      841 ccaccctccc cttgccctct gccaacagcc ctgtgaacat gcccaccact ggccccaaca
      901 gcctgagtta tgctagctct gccctgtccc cctgtctgac cgctccaaag tccccccggc
      961 ttgctatgat gcctgacaac taaatatcct tatccaaatc aataaagaga gaatcctccc
     1021 tccagaaggg tttctaaaaa ca
//
